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Karin Vered et al.
BMC genomics, 15, 865-865 (2014-10-07)
Klebsiella pneumoniae (Kp) is a bacterium causing severe pneumonia in immunocompromised hosts and is often associated with sepsis. With the rise of antibiotic resistant bacteria, there is a need for new effective and affordable control methods; understanding the genetic architecture
Daniel J O'Neill et al.
Epigenetics, 9(7), 942-950 (2014-04-23)
The lysine methyltransferase SETD6 modifies the histone variant H2AZ, a key component of nuclear receptor-dependent transcription. Herein, we report the identification of several factors that associate with SETD6 and are implicated in nuclear hormone receptor signaling. Specifically, SETD6 associates with
Matthew B Brecher et al.
Protein science : a publication of the Protein Society, 24(1), 117-128 (2014-10-30)
Methylation of flavivirus RNA is vital for its stability and translation in the infected host cell. This methylation is mediated by the flavivirus methyltransferase (MTase), which methylates the N7 and 2'-O positions of the viral RNA cap by using S-adenosyl-l-methionine
Karen Gaester et al.
Scientific reports, 4, 6592-6592 (2014-10-18)
Human papillomavirus is one of the most common sexually transmitted diseases worldwide. The natural history of oral HPV infection is unclear, and its risk factors have not been explored. Immunocompromised individuals, as exemplified by HIV patients, are at high risk
Zhengyu Ma et al.
PloS one, 9(11), e112292-e112292 (2014-11-11)
Antigen recognition by T cells relies on the interaction between T cell receptor (TCR) and peptide-major histocompatibility complex (pMHC) at the interface between the T cell and the antigen presenting cell (APC). The pMHC-TCR interaction is two-dimensional (2D), in that
Caterina Peraldo-Neia et al.
BMC cancer, 14, 918-918 (2014-12-07)
Standard chemotherapy in unresectable biliary tract carcinoma (BTC) patients is based on gemcitabine combined with platinum derivatives. However, primary or acquired resistance is inevitable and no second-line chemotherapy is demonstrated to be effective. Thus, there is an urgent need to
Linda Vignozzi et al.
The journal of sexual medicine, 11(7), 1694-1708 (2014-05-23)
In subjects with erectile dysfunction responding poorly to sildenafil, metformin was reported to improve erections. The aim of this study is to investigate metformin's mechanism of action on erectile function, particularly focusing on adenosine (ADO) and nitric oxide (NO) signaling
Lies Vanden Broeck et al.
Neurobiology of aging, 36(2), 1121-1129 (2014-12-03)
The human TAR DNA binding protein 43 (TDP-43), encoded by the gene TARDBP, plays a central role in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. TDP-43 inclusions are also found in up to approximately 60% of Alzheimer's disease (AD) brains.
M Leirós et al.
ACS chemical neuroscience, 6(2), 331-338 (2014-11-13)
Bromoalkaloids are secondary metabolites with a demonstrated high activity in several therapeutic areas. In this research, we probe the neuroprotective and antioxidant activities of hymenialdisine and hymenin. Both structures were tested in an oxidative stress cellular model, consisting of cortical
Mingkun Fu et al.
Journal of pharmaceutical and biomedical analysis, 107, 370-377 (2015-02-07)
An accelerated stress approach utilizing the moisture-modified Arrhenius equation and JMP statistical software was utilized to quantitatively assess the solid state stability of an investigational oncology drug MLNA under the influence of temperature (1/T) and humidity (%RH). Physical stability of
A Sánchez-Aguilera et al.
The Journal of physiology, 592(13), 2845-2864 (2014-04-24)
Changes in neuronal activity often trigger compensatory mechanisms aimed at regulating network activity homeostatically. Here we have identified and characterized a novel form of compensatory short-term plasticity of membrane excitability, which develops early after the eye-opening period in rats (P16-19
E Bezati et al.
Lupus, 24(1), 32-41 (2014-08-21)
Quinine, a quinoline derivative, is an ancient antipyretic drug with antimalarial properties that has been phased out by more effective synthetic candidates. In previous studies we discovered that hydroxychloroquine (HCQ), a synthetic antimalarial with structural similarities to quinine, reduced the
Li-Rong Zhao et al.
Molecular medicine reports, 11(3), 1859-1864 (2014-11-15)
Omentin is a novel adipokine, which is expressed in and released from omental adipose tissue. In the present study, the effect of omentin on neural stem cells (NSCs) was investigated. NSCs are a subtype of stem cell in the nervous
S Orlandini et al.
Journal of chromatography. A, 1380, 177-185 (2015-01-15)
Quality by design (QbD) concepts, in accordance with International Conference on Harmonisation Pharmaceutical Development guideline Q8(R2), represent an innovative strategy for the development of analytical methods. In this paper QbD principles have been comprehensively applied in the set-up of a
Deborah Michel et al.
Journal of pharmaceutical and biomedical analysis, 107, 229-235 (2015-01-27)
A simple, fast and sensitive quantification method for the drug metformin in dog serum was developed using flow injection analysis (FIA)-tandem mass spectrometry (MS/MS). The method was fully validated according to industry standards. It is the first time that FIA-MS/MS
Hye Jin Kang et al.
The Journal of biological chemistry, 289(43), 29961-29974 (2014-09-07)
To define the upstream and downstream signaling specificities of metabotropic glutamate receptors (mGluR), we have examined the ability of representative mGluR of group I, II, and III to be activated by endogenous amino acids and catalyze activation of G proteins
Jean-Louis Vincent et al.
Critical care medicine, 43(1), 57-64 (2014-08-02)
To compare the effectiveness and safety of the hemoglobin-based nitric oxide scavenger, pyridoxalated hemoglobin polyoxyethylene, against placebo in patients with vasopressor-dependent distributive shock. Multicenter, randomized, placebo-controlled, open-label study. Sixty-one participating ICUs in six European countries (Austria, Belgium, Germany, the Netherlands
Alba Hykollari et al.
Electrophoresis, 35(15), 2116-2129 (2014-02-28)
In this study, we have performed the first mass spectrometric analysis of N-glycans of the M31 mutant strain of the cellular slime mould Dictyostelium discoideum, previously shown to have a defect in glucosidase II. Together with glucosidase I, this enzyme
Rui Xue et al.
Steroids, 94, 51-59 (2015-01-04)
Non-small cell lung cancer is the most common type of lung cancer and the most common cause of cancer-related death in humans. TXA9, which is a natural product separated from an anti-tumor-active fraction of the roots of Streptocaulon juventas, may
Taoguang Huo et al.
Biomedical chromatography : BMC, 28(9), 1254-1262 (2014-09-23)
An online microdialysis (MD)–dansyl chloride (Dns) derivatization–high-performance liquid chromatography (HPLC) and fluorescence detection (FD) system was developed for simultaneous determination of eight extracellular amino acid neurotransmitters in hippocampus. The MD probe was implanted in hippocampal CA1 region. Dialysate and Dns
Widya Mulyasasmita et al.
Tissue engineering. Part A, 20(15-16), 2102-2114 (2014-02-05)
Peptide mimics of growth factors represent an emerging class of therapeutic drugs due to high biological specificity and relative ease of synthesis. However, maintaining efficacious therapeutic dosage at the therapy site has proven challenging owing to poor intestinal permeability and
Antiangiogenic cancer drug sunitinib exhibits unexpected proangiogenic effects on endothelial cells.
Kerri-Ann Norton et al.
OncoTargets and therapy, 7, 1571-1582 (2014-09-18)
Angiogenesis, the formation of new blood vessels, is an essential step for cancer progression, but antiangiogenic therapies have shown limited success. Therefore, a better understanding of the effects of antiangiogenic treatments on endothelial cells is necessary. In this study, we
Martin Lochner et al.
The Journal of pharmacology and experimental therapeutics, 351(3), 674-684 (2014-10-04)
Proguanil is an antimalarial prodrug that is metabolized to 4-chlorophenyl-1-biguanide (CPB) and the active metabolite cycloguanil (CG). These compounds are structurally related to meta-chlorophenyl biguanide (mCPBG), a 5-hydroxytryptamine 3 (5-HT3) receptor agonist. Here we examine the effects of proguanil and
Sabrina Haag et al.
Journal of immunology (Baltimore, Md. : 1950), 194(6), 2539-2550 (2015-02-13)
Rheumatoid arthritis (RA) is associated with amino acid variants in multiple MHC molecules. The association to MHC class II (MHC-II) has been studied in several animal models of RA. In most cases these models depend on T cells restricted to
Aline Rideau Batista Novais et al.
PloS one, 9(9), e106302-e106302 (2014-09-04)
Maternal inflammation during pregnancy is associated with the later development of cognitive and behavioral impairment in the offspring, reminiscent of the traits of schizophrenia or autism spectrum disorders. Hippocampal long-term potentiation and long-term depression of glutamatergic synapses are respectively involved
Rui Liang et al.
Scientific reports, 5, 8078-8078 (2015-01-30)
Oxidative stress and apoptosis are involved in Ochratoxin A (OTA)-induced renal cytotoxicity. Apoptosis signal-regulating kinase 1 (ASK1) is a Mitogen-Activated Protein Kinase Kinase Kinase (MAPKKK, MAP3K) family member that plays an important role in oxidative stress-induced cell apoptosis. In this
Marjolein Bijlard et al.
Molecular and cellular biology, 35(4), 675-687 (2014-12-17)
Myelination of axons by oligodendrocytes is essential for saltatory nerve conduction. To form myelin membranes, a coordinated synthesis and subsequent polarized transport of myelin components are necessary. Here, we show that as part of the mechanism to establish membrane polarity
Z Molnár et al.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 122(10), 575-581 (2014-07-24)
The extracellular ion milieu determines the exocytosis mechanism that is coupled to spontaneous electrical activity. The K(+) ion plays crucial role in this mechanism: as the potassium current is associated with membrane hyperpolarization and hormone release through protein cascade activation.
Kaihua Zhang et al.
Oncotarget, 5(19), 9281-9294 (2014-09-23)
In head and neck squamous cell cancer (HNSCC), four intrinsic subtypes (or groups) have been identified, and each one possesses a unique biology that will require specific treatment strategies. We previously reported that mesenchymal (group 2) tumors exhibit reduced levels
Daniela D'Angelo et al.
BMC cancer, 14, 851-851 (2014-11-21)
Development of resistance to conventional drugs and novel biological agents often impair long-term chemotherapy. HMGA gene overexpression is often associated with antineoplastic drug resistance and reduced survival. Inhibition of HMGA expression in thyroid cancer cells reduces levels of ATM protein
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