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PHR1392
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显示 1-30 共 44 条结果 关于 "PHR1392" 范围 论文
Rozália Takács et al.
Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, 16(1), 43-46 (2014-04-02)
We report a successful treatment with lamotrigine of a patient with hereditary coproporphyria presenting with affective and psychotic symptoms. M.F., a 38-year-old, single woman was admitted to an acute psychiatric ward because of suddenly emerging psychosis. Ms F's hereditary coproporphyria
Philip J Wiffen et al.
The Cochrane database of systematic reviews, 12(12), CD006044-CD006044 (2013-12-04)
This is an update of the original Cochrane review entitled Lamotrigine for acute and chronic pain published in Issue 2, 2007, and updated in Issue 2, 2011. Some antiepileptic medicines have a place in the treatment of neuropathic pain (pain
Zhi-fei Wang et al.
Acta pharmacologica Sinica, 32(12), 1433-1445 (2011-11-08)
The mood stabilizers lithium, valproate and lamotrigine are traditionally used to treat bipolar disorder. However, accumulating evidence suggests that these drugs have broad neuroprotective properties and may therefore be promising therapeutic agents for the treatment of neurodegenerative diseases, including stroke.
Marisol López et al.
Drug metabolism and drug interactions, 26(1), 5-12 (2011-05-12)
Patients treated with antiepileptic drugs can exhibit large interindividual variability in clinical efficacy or adverse effects. This could be partially due to genetic variants in genes coding for proteins that function as drug metabolizing enzymes, drug transporters or drug targets.
James Layne Moore et al.
Expert opinion on pharmacotherapy, 13(8), 1213-1216 (2012-05-19)
Lamotrigine is a sodium-channel-modulating, antiepileptic drug (AED), which was approved in the USA in 1994 for use in partial-onset seizures. It was ultimately approved for monotherapy in 1998. Lamotrigine has gained widespread use in the USA as both an immediate
Andrea E Spencer et al.
The Journal of clinical psychiatry, 75(11), 1226-1241 (2014-10-02)
As the major excitatory neurotransmitter in the brain, glutamate plays a critical role in normal brain function; thus, its dysregulation could lead to psychopathology in youth. A growing body of literature has investigated the role of glutamate in the pathophysiology
Masamichi Ishioka et al.
Clinical neuropharmacology, 36(4), 131-132 (2013-06-21)
This case report describes a 54-year-old man with bipolar I disorder who was treated with aripiprazole (ARP) and lithium. The patient was admitted to our hospital because of aggravation of depressive symptoms, and treatment with lamotrigine (LTG) was initiated. Two
Jacqueline A French et al.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 9(1), 176-184 (2011-12-06)
The efficacy and safety of lamotrigine extended-release tablets (LTG XR) as monotherapy for partial seizures were evaluated using the conversion-to-monotherapy design, and historical data as the control. This methodology was recently approved by the United States Food and Drug Administration
Philip J Wiffen et al.
The Cochrane database of systematic reviews, (2)(2), CD006044-CD006044 (2011-02-18)
This is an update of the original Cochrane review published in Issue 2, 2007. Some antiepileptic medicines have a place in the treatment of neuropathic pain (pain due to nerve damage). This updated review adds five new additional studies looking
P N Vlasov et al.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 111(5 Pt 2), 38-42 (2011-01-01)
The paper presents the review of literature on the age aspect of using lamotrigine in pubertal period, in women of reproductive age, during pregnancy and lactation and in climacteric period. Special attention is drawn to the low teratogenic potential of
Terence A Ketter et al.
Journal of affective disorders, 169 Suppl 1, S24-S33 (2014-12-24)
Bipolar depression is more pervasive than mania, but has fewer evidence-based treatments. Using data from multicenter, randomized, double-blind, placebo-controlled trials and meta-analyses, we assessed the number needed to treat (NNT) for response and the number needed to harm (NNH) for
Sensitive spectrophotometric determination of lamotrigine in bulk drug and pharmaceutical formulations using bromocresol green
Rajendraprasad N, et al.
Ecletica Quimica , 35(1), 55-66 (2010)
Jennifer G Reid et al.
The Journal of clinical psychiatry, 74(7), 675-684 (2013-08-16)
Owing to the prevalence of medication side effects and treatment resistance, prescribers often consider off-label uses of US Food and Drug Administration (FDA)-approved agents for the treatment of persistent symptoms. The authors review the available literature on the FDA-approved and
Patient-reported side effects of lamotrigine during routine clinic visits.
Nur A Daud et al.
Neurosciences (Riyadh, Saudi Arabia), 17(3), 269-270 (2012-07-10)
Mark A Frye et al.
Journal of affective disorders, 169 Suppl 1, S17-S23 (2014-12-24)
Depression is the predominant pole of illness disability in bipolar disorder and, compared with acute mania, has less systematic research guiding treatment development. The aim of this review is to present the therapeutic options currently available for managing bipolar depression
Sudarat Nimitvilai et al.
Neuropharmacology, 82, 28-40 (2014-03-25)
Neurons of the ventral tegmental area (VTA) are the source of dopaminergic (DAergic) input to important brain regions related to addiction. Prolonged exposure of these VTA neurons to moderate concentrations of dopamine (DA) causes a time-dependent decrease in DA-induced inhibition
Charles L Bowden et al.
Expert opinion on pharmacotherapy, 13(17), 2565-2571 (2012-11-13)
Over the past decade the use of lamotrigine in bipolar disorder has increased. However, the evidence base suggests a more limited role for lamotrigine as part of an overall treatment regimen in bipolar disorder. We reviewed publications of randomized clinical
Andrew Curtright et al.
PloS one, 10(1), e0116766-e0116766 (2015-01-15)
Acute and chronic pain conditions are often debilitating, inflicting severe physiological, emotional and economic costs and affect a large percentage of the global population. However, the development of therapeutic analgesic agents based primarily on targeted drug development has been largely
Jessica M Wong et al.
Therapeutic drug monitoring, 37(2), 188-197 (2014-08-28)
Recent concerns have been raised by neurologists and patients with epilepsy regarding the bioequivalence of generic lamotrigine to the brand Lamictal. Bioequivalence studies require the quantification of lamotrigine in human plasma, including in the presence of other drugs, for studies
Laura J Bonnett et al.
Journal of neurology, neurosurgery, and psychiatry, 85(6), 603-610 (2013-12-03)
To develop prognostic models for time to 12-month remission and time to treatment failure after initiating antiepileptic drug monotherapy for generalised and unclassified epilepsy. We analysed data from the Standard and New Antiepileptic Drug (arm B) study, a randomised trial
Adam Daniel Zavodnick et al.
The Psychiatric quarterly, 83(3), 371-383 (2012-02-11)
To review the available data behind the use of lamotrigine in unipolar depression and common comorbid conditions. A PubMed based literature review was conducted using keywords related to lamotrigine, depression, anxiety, post traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), and
Panagiota Nikolaou et al.
Journal of pharmaceutical and biomedical analysis, 102, 25-32 (2014-09-23)
A sensitive and accurate gas chromatography-mass spectrometric method was developed and validated for the simultaneous determination of levetiracetam and lamotrigine in whole blood. A solid-phase extraction (SPE) procedure using HF Bond Elut C18 columns followed by derivatization using N-methyl-N-tert-butyldimethylsilyl-trifluoroacetamide (MTBSTFA)
Linda Dalic et al.
Developmental medicine and child neurology, 57(2), 200-202 (2014-09-23)
Dravet syndrome, a severe infantile epilepsy syndrome, is typically resistant to anti-epileptic drugs (AED). Lamotrigine (LTG), an AED that is effective for both focal and generalized seizures, has been reported to aggravate seizures in Dravet syndrome. Therefore, LTG is usually
Jian-Sheng Liu et al.
International journal of nanomedicine, 9, 3923-3935 (2014-08-26)
P-glycoprotein (P-gp) mediated drug efflux across the blood-brain barrier (BBB) is an important mechanism underlying poor brain penetration of certain antiepileptic drugs (AEDs). Nanomaterials, as drug carriers, can overcome P-gp activity and improve the targeted delivery of AEDs. However, their
Lamotrigine.
Kevin Beattie et al.
Profiles of drug substances, excipients, and related methodology, 37, 245-285 (2012-04-04)
Allyson K Friedman et al.
Science (New York, N.Y.), 344(6181), 313-319 (2014-04-20)
Typical therapies try to reverse pathogenic mechanisms. Here, we describe treatment effects achieved by enhancing depression-causing mechanisms in ventral tegmental area (VTA) dopamine (DA) neurons. In a social defeat stress model of depression, depressed (susceptible) mice display hyperactivity of VTA
Jonathan M Stokes et al.
eLife, 3, e03574-e03574 (2014-09-19)
While small molecule inhibitors of the bacterial ribosome have been instrumental in understanding protein translation, no such probes exist to study ribosome biogenesis. We screened a diverse chemical collection that included previously approved drugs for compounds that induced cold sensitive
Christopher A Reid et al.
Brain : a journal of neurology, 137(Pt 6), 1701-1715 (2014-04-22)
Epileptic encephalopathies, including Dravet syndrome, are severe treatment-resistant epilepsies with developmental regression. We examined a mouse model based on a human β1 sodium channel subunit (Scn1b) mutation. Homozygous mutant mice shared phenotypic features and pharmaco-sensitivity with Dravet syndrome. Patch-clamp analysis
Marte Helene Bjørk et al.
Epilepsia, 56(1), 28-39 (2014-12-20)
To assess incidence, prevalence, risk factors, and prognosis of peripartum depression and anxiety in a prospective study of women with epilepsy. Pregnancies in women with epilepsy (n=706) were compared to pregnancies in all women without epilepsy (n=106,511) including women with
Takako Ohkura et al.
Drug metabolism and pharmacokinetics, 29(5), 373-378 (2014-04-04)
We investigated the utility of three-dimensional (3D) spheroid cultures of human hepatocytes in discovering drug metabolites. Metabolites of acetaminophen, diclofenac, lamotrigine, midazolam, propranolol and salbutamol were analyzed by liquid chromatography-tandem mass spectrometry (LC/MS/MS) to measure enzyme activities in this system
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