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Gerald W Hart
The Journal of biological chemistry, 289(50), 34422-34423 (2014-10-23)
The dynamic cycling of N-acetylglucosamine (termed O-GlcNAcylation) on serine or threonine residues of nuclear or cytoplasmic proteins serves as a nutrient sensor, both independently and also via its interplay with other post-translational modifications, to regulate signaling, transcription, and cellular physiology.
N-acetylglucosamine prevents IL-β-mediated activation of human chondrocytes
Shikhman AR, et al.
Journal of Immunology, 166(8), 5155-5160 (2001)
Maria D'Apolito et al.
Atherosclerosis, 239(2), 393-400 (2015-02-16)
The pathogenic events responsible for accelerated atherosclerosis in patients with chronic renal failure (CRF) are poorly understood. Here we investigate the hypothesis that concentrations of urea associated with CRF and increased ROS production in adipocytes might also increase ROS production
John C Chatham et al.
Biochimica et biophysica acta, 1800(2), 57-66 (2009-07-18)
The modification of serine and threonine residues of nuclear and cytoplasmic proteins by O-linked beta-N-acetylglucosamine (O-GlcNAc) has emerged as a highly dynamic post-translational modification that plays a critical role in regulating numerous biological processes. Much of our understanding of the
Yuko Tashima et al.
The Journal of biological chemistry, 289(16), 11132-11142 (2014-02-28)
The transfer of N-acetylglucosamine (GlcNAc) to Ser or Thr in cytoplasmic and nuclear proteins is a well known post-translational modification that is catalyzed by the O-GlcNAc transferase OGT. A more recently identified O-GlcNAc transferase, EOGT, functions in the secretory pathway
Lowiese M B Desmarets et al.
The Journal of general virology, 95(Pt 9), 1911-1918 (2014-05-31)
To initiate infections, many coronaviruses use sialic acids, either as receptor determinants or as attachment factors helping the virus find its receptor underneath the heavily glycosylated mucus layer. In the present study, the role of sialic acids in serotype I
Krithika Vaidyanathan et al.
The Journal of biological chemistry, 289(50), 34466-34471 (2014-10-23)
In this minireview, we will highlight work in the last 30 years that has clearly demonstrated that the O-GlcNAc modification is nutrient-responsive and plays multiple roles in metabolic regulation of signaling and gene expression. Further, we will examine recent studies
M A Bartlomiejczyk et al.
Clinical and experimental immunology, 178(2), 310-319 (2014-07-22)
We have demonstrated that mannose-binding lectin (MBL) recognizes various slow-growing, pathogenic mycobacteria [Mycobacterium tuberculosis (MTB), M. bovis, M. kansasii, M. gordonae] as well as non-pathogenic M. smegmatis. Recognition resulted in activation of the lectin pathway (LP) of complement and an enhancement of phagocytosis (shown for
Maria Cristina Gambetta et al.
Developmental cell, 31(5), 629-639 (2014-12-04)
The glycosyltransferase Ogt adds O-linked N-Acetylglucosamine (O-GlcNAc) moieties to nuclear and cytosolic proteins. Drosophila embryos lacking Ogt protein arrest development with a remarkably specific Polycomb phenotype, arising from the failure to repress Polycomb target genes. The Polycomb protein Polyhomeotic (Ph)
Carolina Fontana et al.
Carbohydrate research, 403, 174-181 (2014-06-10)
The structure of the O-antigen polysaccharide (PS) from Escherichia coli O42 has been investigated by NMR spectroscopy as the main method, which was complemented with sugar analysis, mass spectrometry, and analysis of biosynthetic information. The O-specific chain of the O-deacylated
Masayuki Shimojima et al.
Archives of virology, 159(8), 2023-2031 (2014-03-14)
Infection with West Nile virus and dengue virus, two mosquito-borne flaviviruses, is enhanced by two calcium-dependent lectins: dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN), and its related molecule (DC-SIGNR). The present study examined the relationship between Japanese encephalitis virus (JEV)
Jia-Xuan Qiu et al.
Drug design, development and therapy, 9, 349-417 (2015-01-23)
Plumbagin (PLB) has exhibited a potent anticancer effect in preclinical studies, but the molecular interactome remains elusive. This study aimed to compare the quantitative proteomic responses to PLB treatment in human prostate cancer PC-3 and DU145 cells using the approach
Han Na Suh et al.
Journal of cellular physiology, 229(10), 1557-1568 (2014-03-05)
The aim of this study is to determine whether GlcN could recover the endoplasmic reticulum (ER) stress-induced dysfunction of Na(+) /glucose cotransporter (SGLT) in renal proximal tubule cells (PTCs) under hypoxia. With the rabbit model, the renal ischemia induced tubulointerstitial
Bin Guo et al.
Nature cell biology, 16(12), 1215-1226 (2014-11-25)
The mechanism by which nutrient status regulates the fusion of autophagosomes with endosomes/lysosomes is poorly understood. Here, we report that O-linked β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) mediates O-GlcNAcylation of the SNARE protein SNAP-29 and regulates autophagy in a nutrient-dependent manner. In
Rolf Lood et al.
Antimicrobial agents and chemotherapy, 58(6), 3073-3084 (2014-03-19)
Bacteriophage endolysins have shown great efficacy in killing Gram-positive bacteria. PlyC, a group C streptococcal phage lysin, represents the most efficient lysin characterized to date, with a remarkably high specificity against different streptococcal species, including the important pathogen Streptococcus pyogenes.
L Wells et al.
Cellular and molecular life sciences : CMLS, 60(2), 222-228 (2003-04-08)
The ability to regulate energy balance at both the cellular and whole body level is an essential process of life. As western society has shifted to a higher caloric diet and more sedentary lifestyle, the incidence of type 2 diabetes
Sabrina Duranti et al.
Applied and environmental microbiology, 80(19), 6080-6090 (2014-07-27)
Bifidobacteria are members of the gut microbiota, but the genetic basis for their adaptation to the human gut is poorly understood. The analysis of the 2,203,222-bp genome of Bifidobacterium adolescentis 22L revealed a nutrient acquisition strategy that targets diet/plant-derived glycans
Pablo T Radermacher et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(15), 5592-5597 (2014-04-08)
Effects of temperature on biological processes are complex. Diffusion is less affected than the diverse enzymatic reactions that have distinct individual temperature profiles. Hence thermal fluctuations pose a formidable challenge to ectothermic organisms in which body temperature is largely dictated
Scott A Yuzwa et al.
Journal of molecular biology, 426(8), 1736-1752 (2014-01-22)
The aggregation of the microtubule-associated protein tau into paired helical filaments to form neurofibrillary tangles constitutes one of the pathological hallmarks of Alzheimer's disease. Tau is post-translationally modified by the addition of N-acetyl-D-glucosamine O-linked to several serine and threonine residues
Maja Kosanović et al.
BioTechniques, 57(3), 143-149 (2014-09-12)
Urine is a readily available source of relatively large quantities of extracellular vesicles (EVs). However, the isolation of urinary EVs (uEVs) is complicated by the presence of Tamm-Horsfall protein (THP), which polymerizes and co-precipitates as a contaminant. This may make
Hua Xian et al.
Life sciences, 103(1), 34-40 (2014-03-19)
To investigate the anti-apoptotic effect of MADP, an analog of salidroside, against glutamate induced apoptosis in the cultured rat hippocampal neurons. Cytotoxicity was determined by the MTT method and lactate dehydrogenase release to the medium. Cell apoptosis was evaluated by
Liming Wu et al.
Applied and environmental microbiology, 80(24), 7512-7520 (2014-09-28)
Harmful algal blooms, caused by massive and exceptional overgrowth of microalgae and cyanobacteria, are a serious environmental problem worldwide : In the present study, we looked for Bacillus strains with sufficiently strong anticyanobacterial activity to be used as biocontrol agents.
Noboru Mizushima
Nature cell biology, 16(12), 1132-1133 (2014-12-02)
Autophagy is an intracellular degradation system that is mediated by orchestrated functions of membranes and proteins. A genetic screen in Caenorhabditis elegans revealed that O-linked N-acetylglucosamine modification of the SNARE protein SNAP-29 negatively regulates SNARE-dependent fusion between autophagosomes and lysosomes.
Yanping Zhu et al.
The Journal of biological chemistry, 289(50), 34472-34481 (2014-10-23)
Regional glucose hypometabolism is a defining feature of Alzheimer disease (AD). One emerging link between glucose hypometabolism and progression of AD is the nutrient-responsive post-translational O-GlcNAcylation of nucleocytoplasmic proteins. O-GlcNAc is abundant in neurons and occurs on both tau and
Min-Jung Park et al.
The Journal of biological chemistry, 289(19), 13519-13530 (2014-03-13)
Carbohydrate response element-binding protein (ChREBP) is a transcription factor responsible for carbohydrate metabolism in the liver. However, the role of ChREBP in diabetic nephropathy has not been elucidated. Thus, we investigated the role of ChREBP in mesangial cells in diabetic
Rebecca Herzog et al.
Journal of the American Society of Nephrology : JASN, 25(12), 2778-2788 (2014-05-24)
The ability of cells to respond and survive stressful conditions is determined, in part, by the attachment of O-linked N-acetylglucosamine (O-GlcNAc) to proteins (O-GlcNAcylation), a post-translational modification dependent on glucose and glutamine. This study investigates the role of dynamic O-GlcNAcylation
Adipogenesis stimulates the nuclear localization of EWS with an increase in its O-GlcNAc glycosylation in 3T3-L1 cells.
Li Q and Kamemura K
Biochemical and Biophysical Research Communications, 450(1), 588-592 (2014)
Sarah Förster et al.
Biochimica et biophysica acta, 1842(9), 1333-1339 (2014-05-27)
The potential role of the posttranslational modification of proteins with O-linked N-acetyl-β-d-glucosamine (O-GlcNAc) in the pathogenesis of Alzheimer disease (AD) has been studied extensively, yet the exact function of O-GlcNAc in AD remains elusive. O-GlcNAc cycling is facilitated by only
Determination of N-acetylglucosamine in cosmetic formulations and skin test samples by hydrophilic interaction liquid chromatography and UV detection
Pedrali A, et al.
Journal of Pharmaceutical and Biomedical Analysis, 107(8), 125-130 (2015)
J A Hanover
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 15(11), 1865-1876 (2001-09-05)
The addition of O-linked N-acetylglucosamine (O-GlcNAc) to target proteins may serve as a signaling modification analogous to protein phosphorylation. Like phosphorylation, O-GlcNAc is a dynamic modification occurring in the nucleus and cytoplasm. Various analytical methods have been developed to detect
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