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关键词:'R0404'
显示 1-30 共 73 条结果 关于 "R0404" 范围 论文
W Linz et al.
Zeitschrift fur Kardiologie, 83 Suppl 4, 53-56 (1994-01-01)
ACE inhibitors induce an increase in kinin levels with subsequent release of nitric oxide (NO) and prostacyclin, as shown in cultured endothelial cells and isolated rat hearts. Isolated perfused working rat hearts continuously release kinins and prostacyclin. During ischemia after
Brian Rayner
Current medical research and opinion, 20(3), 359-367 (2004-03-18)
Hypertension in combination with clinically overt diabetes mellitus is recognized as a particularly powerful combination of risk factors that greatly increases cardiovascular vulnerability. There is also evidence that presumed pre-diabetic conditions such as insulin resistance, hyperinsulinaemia and compensatory hyperglycaemia may
[Dual blockade of the renin-angiotensin system in hypertensive treatment: yes].
M Middeke
Deutsche medizinische Wochenschrift (1946), 137(48), 2498-2498 (2012-11-22)
Response to nondipping and cardiovascular risk after morning renin–angiotensin blockade.
Giuseppe Mancia
Hypertension (Dallas, Tex. : 1979), 61(2), e16-e16 (2013-02-28)
Paolo Verdecchia et al.
Therapeutic advances in cardiovascular disease, 4(3), 193-200 (2010-04-27)
Aliskiren is an orally active direct renin inhibitor which inhibits the synthesis of angiotensin I by linking to active renin on a deep cleft of its molecular structure, the site of hydrolysis of the Leu10-Val11 bond of angiotensinogen. At variance
Nonpharmacologic treatment is an indispensable part of antihypertensive therapy in all hypertensive children.
Tomás Seeman
American journal of hypertension, 26(12), 1460-1461 (2013-11-06)
Philip Kam-Tao Li et al.
The American journal of medicine, 126(2), 162-168 (2013-01-22)
The treatment of immunoglobulin A (IgA) nephropathy with normal renal function and minimal proteinuria is unknown. We randomly assigned 60 patients with IgA nephropathy, proteinuria <0.5 g/day, normal blood pressure and renal function to ramipril 2.5 mg daily or no
R Seidel
Der Anaesthesist, 61(11), 954-957 (2012-11-09)
This article reports the successful use of C1 esterase inhibitor in the treatment of capillary leak syndrome. The coincidence of exposure to latex during surgery and medication with ramipril led to prolonged shock complicated by secondary hyperfibrinolysis, capillary leak syndrome
Yueru Li et al.
The American journal of pathology, 190(9), 1971-1981 (2020-06-27)
Leakage of retinal blood vessels, which is an essential element of diabetic retinopathy, is driven by chronic elevation of vascular endothelial growth factor (VEGF). VEGF quickly relaxes the endothelial cell barrier by triggering signaling events that post-translationally modify pre-existing components
Moving dietary management of diabetes forward.
Holly Kramer et al.
JAMA internal medicine, 173(18), 1692-1693 (2013-08-14)
Carla Zoja et al.
American journal of physiology. Renal physiology, 304(6), F808-F819 (2012-11-09)
Bardoxolone methyl is an antioxidant inflammation modulator acting through induction of Keap1-Nrf2 pathway. Results from a recent phase IIb clinical trial reported that bardoxolone methyl was associated with improvement in the estimated glomerular filtration rate in patients with advanced chronic
Marijana Zivko et al.
Collegium antropologicum, 37(3), 765-770 (2013-12-07)
Proteinuria is the hallmark of renal disease. In essential hypertension the onset of de novo proteinuria is associated with faster rate of progression of disease. Some authors have suggested that the DD genotype of the angiotensin-converting enzyme (ACE) gene would
James J Dinicolantonio et al.
Postgraduate medicine, 125(4), 154-168 (2013-08-13)
Angiotensin-converting enzyme (ACE) inhibitors are a heterogeneous class, varying in pharmacologic properties, which have different therapeutic impacts on patient profiles, including lipophilicity, tissue-ACE binding, duration of action, half-life, and increased bradykinin availability. Among the ACE inhibitor class, the agent perindopril
Nondipping and cardiovascular risk after morning renin-angiotensin blockade.
Francesco Portaluppi et al.
Hypertension (Dallas, Tex. : 1979), 61(2), e15-e15 (2012-12-19)
Mădălina Vieriu et al.
Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, 116(4), 1218-1222 (2013-05-25)
Ramipril is a drug of the angiotensin converting enzyme inhibitor class. A new molecular absorbance spectrometric method was developed for the assay of ramipril using molybdophosphoric acid in acidic medium. The reaction product showed a maximum absorbance at 361 nm.
Joshua I Barzilay et al.
Clinical journal of the American Society of Nephrology : CJASN, 8(2), 233-240 (2012-11-28)
The microvascular circulation plays an important role in bone health. This study examines whether albuminuria, a marker of renal microvascular disease, is associated with incident hip and pelvic fractures. This study reanalyzed data from the Ongoing Telmisartan Alone and in
Antonios Douros et al.
American journal of hypertension, 26(9), 1070-1075 (2013-06-12)
Ramipril, an inhibitor of the angiotensin-converting enzyme (ACEI), is a drug commonly used in the therapy of hypertension. ACEI-induced hepatotoxicity is rare, and most of the reported cases are associated with captopril. Here, we present the first case of ramipril-induced
Michael J Rokoss et al.
Expert opinion on pharmacotherapy, 6(11), 1911-1919 (2005-09-08)
Ramipril is an angiotensin-converting enzyme inhibitor that has been extensively studied in randomised, controlled clinical trials in patients with cardiovascular diseases. Therapy with ramipril in patients with various cardiovascular disorders has demonstrated significant and clinically important reductions in cardiovascular death
Tushar A Premchandani et al.
Acta poloniae pharmaceutica, 71(1), 95-106 (2014-05-02)
The present work attempts to formulate and evaluate hollow microcapsules of an antihypertensive drug--ramipril, which will remain in vicinity of absorption site. The emulsion diffusion solvent evaporation method was employed for preparation of microspheres using Eudragit E100. Glycerol monostearate and
Paweł Szpot et al.
Acta pharmaceutica (Zagreb, Croatia), 65(2), 159-169 (2015-05-27)
This report presents the application of ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry with positive electrospray ionization, to determine ramipril in human plasma. First, the proteins in human plasma were precipitated using acetonitrile, then the supernatant was extracted
Maria Nassiri et al.
The Journal of allergy and clinical immunology, 135(2), 491-499 (2014-12-03)
Cofactors contribute to the elicitation of anaphylaxis. β-Blockers and angiotensin-converting enzyme (ACE) inhibitors are widely used cardiovascular drugs. We specially designed a mouse model to further analyze the cofactor potential of these drugs. We sought to test the hypothesis that
Karolina Hus et al.
Frontiers in plant science, 11, 614-614 (2020-06-09)
The CRISPR/Cas9 system enables precise genome editing and is a useful tool for functional genomic studies. Here we report a detailed protocol for targeted genome editing in the model grass Brachypodium distachyon and its allotetraploid relative B. hybridum, describing gRNA
Ramipril for treatment of intermittent claudication.
Pavel Poredos
VASA. Zeitschrift fur Gefasskrankheiten, 42(4), 237-238 (2013-07-05)
Mahboob Rahman et al.
Hypertension (Dallas, Tex. : 1979), 61(1), 82-88 (2012-11-23)
The objective of our study was to determine the effects of 2 antihypertensive drug dose schedules (PM dose and add-on dose) on nocturnal blood pressure (BP) in comparison with usual therapy (AM dose) in blacks with hypertensive chronic kidney disease
Eun Hui Bae et al.
The American journal of pathology, 185(5), 1423-1435 (2015-03-18)
Blockade of the renin-angiotensin system attenuates the progression of experimental and clinical Alport syndrome (AS); however, the underlying mechanism(s) remains largely unknown. We evaluated the renin-angiotensin system in 4- and 7-week-old homozygous for collagen, type IV, α3 gene (Col4A3(-/-)) and
Paolo Verdecchia et al.
Hypertension (Dallas, Tex. : 1979), 65(1), 108-114 (2014-10-22)
Excessively high and low achieved blood pressure (BP) may be associated with a bad outcome in patients with coronary artery disease, the J curve phenomenon. The effect of BP changes from baseline in relation with the subsequent risk of stroke
Gregory T Warner et al.
Drugs, 62(9), 1381-1405 (2002-06-22)
Ramipril, an angiotensin-converting enzyme (ACE) inhibitor, is a prodrug which is rapidly hydrolysed after absorption to the active metabolite ramiprilat. Earlier trials have shown that ACE inhibitors, when given to patients with low ejection fractions, have reduced the relative risk
Vanessa R Anderson et al.
American journal of cardiovascular drugs : drugs, devices, and other interventions, 6(6), 417-432 (2006-12-29)
Ramipril is an oral, non-sulfhydryl ACE inhibitor thought to act in the renin-angiotensin-aldosterone system to decrease vasopressor activity, aldosterone secretion, and bradykinin degradation. Ramipril is generally well tolerated and effective in the treatment of patients aged > or =55 years
W H Smith et al.
International journal of clinical practice, 54(4), 255-260 (2000-07-27)
Ramipril is a long-acting, lipophylic angiotensin converting enzyme inhibitor, its principle action is to inhibit the conversion of angiotensin I to the active angiotensin II. Ramipril is indicated in the treatment of hypertension, congestive cardiac failure (including that following acute
Gábor Simonyi
Orvosi hetilap, 154(42), 1658-1664 (2013-10-15)
Hypertension is one of the most frequent chronic disease in Hungary and one of the most important cardiovascular risk factor. Treatment of blood pressure to target value lowers significantly the risk of coronary artery disease, stroke and chronic renal disease
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