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关键词:'RAB0288'
显示 1-23 共 23 条结果 关于 "RAB0288" 范围 论文
Chen Liu et al.
Molecular medicine reports, 10(3), 1323-1328 (2014-07-26)
Melatonin, a widespread physiological mediator, has been demonstrated to exhibit a dose‑dependent immunoregulatory effect in vitro and in vivo, including mediating physiological circadian rhythms, neutralizing free radicals and exerting antisenescence actions. In the present study, the efficacy and mechanism of
Azita Haddadi et al.
Nanotechnology, 25(35), 355101-355101 (2014-08-15)
Mannan (MN) is the natural ligand for mannose receptors, which are widely expressed on dendritic cells (DCs). The purpose of this study was to assess the effect of formulation parameters on the immunogenicity of MN-decorated poly (D, L-lactide-co-glycolide) (PLGA) nanoparticles
Shuang Guan et al.
Immunopharmacology and immunotoxicology, 36(4), 290-296 (2014-06-27)
Abstract Alpinetin, a flavonoid compound extracted from the seeds of Alpinia katsumadai Hayata, has been known to possess antibacterial, anti-inflammatory and other important therapeutic activities. In the current study, we investigated alpinetin for its immunosuppressive effect on activation and cytokines
Michael Weber et al.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 20(11), 1696-1704 (2014-08-19)
Graft-versus-host disease (GVHD) is a frequent life-threatening complication after allogeneic hematopoietic stem cell transplantation (HSCT) and induced by donor-derived T cells that become activated by host antigen-presenting cells. To address the relevance of host dendritic cell (DC) populations in this
Protein kinases JAK and ERK mediate protective effect of interleukin-2 upon ganglion cells of the developing rat retina.
Marra C, et al.
Journal of Neuroimmunology, 2011, 120-126 (2011)
Vinit Raj et al.
Cytokine, 118, 144-159 (2018-03-28)
We attempted a preclinical study using DMH-induced CRC rat model to evaluate the antitumor potential of our recently synthesized 1,3,4-thiadiazoles. The molecular insights were confirmed through ELISA, qRT-PCR and western blot analyses. The CRC condition was produced in response to
Olivia M Kenny et al.
Life sciences, 92(13), 775-782 (2013-03-05)
The potato glycoalkaloids, α-chaconine, α-solanine and solanidine, along with potato peel extracts were investigated for potential anti-inflammatory effects in vitro. Their potential to reduce two biomarkers of inflammation, cytokine and nitric oxide (NO) productions, were assessed in the stimulated Jurkat
Wei-Xin Zhao et al.
Molecular medicine reports, 16(2), 1559-1564 (2017-10-27)
Diosgenin is a steroidal saponin extract from numerous plants, including Solanum and Dioscorea species, and has been reported to possess neuroprotective activity. However, the role of diosgenin in neuropathic pain remains unclear. The present study examined the effects of diosgenin
Ning Zhao et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 34(4), 1359-1372 (2014-10-11)
Acacetin, a natural flavonoid compound, has been proven to exert anti-inflammatory and immunomodulatory effects. Kv1.3 channels, highly expressed in human T cells, are attractive therapeutic targets to treat inflammatory and immunological disorders. The present study was designed to characterize the
Vimal Maurya et al.
Chemico-biological interactions, 308, 120-129 (2019-05-28)
A preclinical study using DEN-induced HCC rat model was attempted to evaluate the antitumor potential of zolmitriptan (ZOL). The molecular insights were investigated using ELISA, qRT-PCR and Western blot techniques. The result confirmed that the HCC condition was developed in
Annemie Deiteren et al.
Gut, 63(12), 1873-1882 (2014-02-25)
Substantial evidence implicates mast cells and their main constituent histamine in the pathogenesis of visceral hypersensitivity. We explored the specific contribution of histamine H4 (H4R) and H1 (H1R) receptors to visceral hypersensitivity in a postinflammatory rat model. Trinitrobenzenesulfonic acid (TNBS)-colitis
Novel 1, 4-benzothazines obliterate COX-2 mediated JAK-2/STAT-3 signals with potential regulation of oxidative and metabolic stress during colorectal cancer.
Rai A, et al.
Pharmacological Research, 132, 188-203 (2018)
Decreased c-rel activation contributes to aberrant interleukin-2 expression in CD4+ T cells of aged rats.
Gong Z, et al.
Molecular Immunology, 61(1), 1-6 (2014)
Dynamics of the IL-2 cytokine network and T-cell proliferation. (2010)
Pranesh Kumar et al.
Regulatory toxicology and pharmacology : RTP, 109, 104489-104489 (2019-10-13)
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwideand haslimited treatment options. In view of this, zafirlukast (ZAF) was administered orally to DEN-induced HCC rats to evaluate its antineoplastic properties. ELISA, qRT-PCR and Western blot were used to
Yujo Kawashita et al.
Radiation research, 182(2), 191-200 (2014-06-28)
Hepatocellular carcinoma (HCC) often presents as a diffuse or multifocal tumor making it difficult to control by surgery or radiation. Radio-inducible herpes simplex virus thymidine kinase (HSV-TK) gene therapy has been shown to enhance local tumor control after radiation therapy
Acute exhaustive exercise regulates IL-2, IL-4 and MyoD in skeletal muscle but not adipose tissue in rats.
Neto J, et al.
Lipids in Health and Disease, 10(1), 97-97 (2011)
Lauriane Padet et al.
Immunobiology, 219(9), 687-694 (2014-05-31)
Allograft rejection and graft-versus-host disease (GvHD) are frequent complications following solid organ or stem cell transplantation in which T cell activation plays a central role. Despite the development of new immunosuppressive drugs that improve the success rate of transplantation, allograft
Sandeep Sharma et al.
Tuberculosis (Edinburgh, Scotland), 94(4), 389-396 (2014-06-02)
Piperine a trans-trans isomer of 1-piperoyl-piperidine was evaluated for its immunomodulatory activity to enhance the efficacy of rifampicin in a murine model of Mycobacterium tuberculosis infection. In-vitro immunomodulation of piperine was tested on mouse splenocytes for lymphocyte proliferation, cytokine production
Igor Maricic et al.
Journal of immunology (Baltimore, Md. : 1950), 193(9), 4580-4589 (2014-09-28)
Lipids presented by the MHC class I-like molecule, CD1d, are recognized by NK T (NKT) cells, which can be broadly categorized into two subsets. The well-characterized type I NKT cells express a semi-invariant TCR and can recognize both α- and
Stacey X Xu et al.
Infection and immunity, 82(9), 3588-3598 (2014-06-11)
Staphylococcus aureus is a versatile bacterial pathogen that produces T cell-activating toxins known as superantigens (SAgs). Although excessive immune activation by SAgs can induce a dysregulated cytokine storm as a component of what is known as toxic shock syndrome (TSS)
Song Gao et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 63(6), 441-450 (2014-02-06)
CD200 is expressed on various cell types, including T cells, while the CD200 receptor (CD200R) is expressed on myeloid cells such as monocytes-derived macrophages (MDMs). The CD200-CD200R interaction has been shown to play an important role in the prevention of
Jinxu Wang et al.
Journal of ethnopharmacology, 155(1), 405-415 (2014-06-21)
Shenqi Fuzheng Injection (SFI) is an injectable traditional Chinese herbal formula comprised of two Chinese herbs, Radix codonopsis and Radix astragali, which were commonly used to improve immune functions against chronic diseases in an integrative and holistic way in China
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