RAB0500

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关键词:'RAB0500'

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Evaluation of roscovitine anticancer agent as a reference compound for cancer and apoptosis studies

Taha H, et al.

JIMD Reports null

Design, synthesis, and cytotoxicity screening of 5-aryl-3-(2-(pyrrolyl) thiophenyl)-1, 2, 4-oxadiazoles as potential antitumor molecules on breast cancer MCF-7 cells.

Mohammed K Abd El Hameid et al.

Bioorganic chemistry, 86, 609-623 (2019-02-27)

The work representing the design and the cytotoxic screening of synthetic small molecules (SSMs) such as carbonitriles 3a-c, carboximidamides 4a-c, and oxadiazoles 5-19 as antitumor molecules. Molecules 4c, 9, 12, and 14 show promising cytotoxicity profiles against two cell lines

Doxorubicin and 5-fluorouracil induced accumulation and transcriptional activity of p53 are independent of the phosphorylation at serine 15 in MCF-7 breast cancer cells.

Matthew T Balmer et al.

Cancer biology & therapy, 15(8), 1000-1012 (2014-05-08)

The chemotherapeutic agents doxorubicin (dox) or 5-fluorouracil (5FU) are used to treat cancer cells as they cause irreparable DNA damage, inducing these aberrant cells to undergo cell death. The mediator of this process is presumed to be in part the

Design, Synthesis and Screening of 4,6-Diaryl Pyridine and Pyrimidine Derivatives as Potential Cytotoxic Molecules.

Mohammed K Abd Elhameid et al.

Chemical & pharmaceutical bulletin, 66(10), 939-952 (2018-08-17)

A new series of pyridine and pyrimidine derivatives is designed and synthesized as potential antitumor molecules. The tested compounds show promising in vitro cytotoxic activity against HL-60 cell line as eight compounds: 4, 6, 11, 13, 14, 15, 18 and

p53 at a glance.

Colleen A Brady et al.

Journal of cell science, 123(Pt 15), 2527-2532 (2010-10-14)

p53 in health and disease.

Karen H Vousden et al.

Nature reviews. Molecular cell biology, 8(4), 275-283 (2007-03-24)

As a component of the response to acute stress, p53 has a well established role in protecting against cancer development. However, it is now becoming clear that p53 can have a much broader role and can contribute to the development

A preliminary study of the effect of curcumin on the expression of p53 protein in a human multiple myeloma cell line.

Wei Li et al.

Oncology letters, 9(4), 1719-1724 (2015-03-20)

Curcumin is an inexpensive, natural plant ingredient with protease inhibitor effects. The present study aimed to analyze the inhibitory effects of curcumin on the multiple myeloma (MM) RPMI 8226 cell line, and examine the underlying mechanism that promotes the apoptosis

Anticancer activity of newly synthesized 1,1-disubstituted cyclohexane-1-carboxamides: in vitro caspases mediated apoptosis activators in human cancer cell lines and their molecular modeling.

Walaa Hamada Abd-Allah et al.

Drug development research, 80(7), 933-947 (2019-07-26)

Novel 1,1-disubstituted cyclohexane-1-carboxamides 6a-h, 7a-e, and 8a-b were designed and synthesized as apoptotic inducers. Cytotoxicity test revealed that some compounds have strong to moderate effect, while others displayed weak action against different cancer cell lines including, MCF-7, HepG2, A549, and

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