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Li Kiang Tan et al.
Diagnostics (Basel, Switzerland), 10(1) (2019-12-28)
Dengue virus (DENV) and Zika virus (ZIKV) are flaviviruses of public health relevance. Both viruses circulate in the same endemic settings and acute infections generally manifest similar symptoms. This highlights the importance of accurate diagnosis for clinical management and outbreak
Madhura Mukhopadhyay et al.
Journal of immunology (Baltimore, Md. : 1950), 199(10), 3437-3452 (2017-10-11)
Rare patients who spontaneously control HIV replication provide a useful model to inform HIV vaccine development. HIV controllers develop particularly efficient antiviral CD4
Maia Kavanagh Williamson et al.
Viruses, 10(3) (2018-03-10)
Infection of primary CD4+ T cells with HIV-1 coincides with an increase in glycolysis. We investigated the expression of glucose transporters (GLUT) and glycolytic enzymes in human CD4+ T cells in response to infection with HIV-1. We demonstrate the co-expression
Pavlína Kušnierová et al.
PloS one, 15(5), e0233519-e0233519 (2020-05-22)
Chitinase 3-like 1 (CHI3L1) is an extracellular monomeric single-chain glycoprotein expressed by many types of cells. Its elevated levels were found in cerebrospinal fluid in central nervous system (CNS) inflammatory diseases patients. The aim of the study was 1) to
Thanyawee Puthanakit et al.
Journal of acquired immune deficiency syndromes (1999), 83(3), 260-266 (2020-01-10)
Previous studies have shown low frequencies of seroreactivity to HIV diagnostic assays for infected infants treated with antiretroviral therapy (ART) early in infection. Fifty-eight HIV-infected infants treated with ART at a median age of 1.9 months (range: 0.2-5.4) for up
Bei Cao et al.
Frontiers in aging neuroscience, 10, 150-150 (2018-06-09)
Background: Given the overlap of clinical manifestations and pathological characteristics between Parkinson's disease (PD) and multiple system atrophy (MSA), we investigated the associations between five functional polymorphisms of nucleotide-binding oligomerization domain protein 2 (NOD2) which were associated with PD, and
Hiroaki Takaya et al.
BMC gastroenterology, 19(1), 167-167 (2019-10-23)
To investigate the von Willebrand factor to ADAMTS13 ratio as a potential biomarker for early detection of hepatocellular carcinoma (HCC) in cirrhosis. Serum levels of alpha-fetoprotein, des-γ-carboxy prothrombin, Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein (alpha-fetoprotein-L3%), vascular endothelial growth factor, and
Xi Kuang et al.
Frontiers in aging neuroscience, 9, 353-353 (2017-11-23)
Emerging evidence suggests that alpha-processing single transmembrane proteins, amyloid precursor protein (APP) and anti-aging protein Klotho, are likely to be involved in the progression of Alzheimer's disease (AD). The natural phthalide Ligustilide (LIG) has been demonstrated to protect against aging-
Sunan Li et al.
Journal of virology, 93(2) (2018-10-26)
Glycosylated Gag (glycoGag) is an accessory protein expressed by most gammaretroviruses, including murine leukemia virus (MLV). MLV glycoGag not only enhances MLV replication and disease progression but also increases human immunodeficiency virus type 1 (HIV-1) infectivity as Nef does. Recently
Mohamad Alaa Terkawi et al.
Scientific reports, 7, 41772-41772 (2017-02-10)
Understanding the molecular defense mechanism of macrophages and identifying their effector molecules against malarial parasites may provide important clues for the discovery of new therapies. To analyze the immunological responses of malarial parasite-induced macrophages, we used DNA microarray technology to
Nejat Siraj et al.
BMC infectious diseases, 18(1), 264-264 (2018-06-09)
Blood transfusion is associated with several risks particularly exposure to blood transfusion-transmissible infections (TTI), including: Hepatitis B virus (HBV), Hepatitis C virus (HCV), Human immunodeficiency virus (HIV) and Syphilis, among others. The threat posed by these blood-borne pathogens is disproportionately
Figen Sarigül et al.
Central European journal of public health, 27(3), 223-228 (2019-10-04)
Treponema pallidum and HIV are transmitted frequently through sexual contact, these agents with epidemiological similarities co-infect the same host. The current number of HIV-infected cases in Turkey is increasing. For this reason, we aimed to reveal the characteristics of syphilis
John Bosco Ruganzu et al.
Experimental neurology, 336, 113506-113506 (2020-10-17)
Overactivated microglia and neuroinflammation are considered to play a crucial role in the progression of Alzheimer's disease (AD). Triggering receptor expressed on myeloid cells-2 (TREM2), a type I transmembrane receptor, expressed uniquely by microglia in the brain, is involved in
David Devos et al.
Scientific reports, 9(1), 2918-2918 (2019-03-01)
Accurate patient stratification into prognostic categories and targeting Amyotrophic Lateral Sclerosis (ALS)-associated pathways may pave the way for promising trials. We evaluated blood-based prognostic indicators using an array of pathological markers. Plasma samples were collected as part of a large
É Csongrádi et al.
Nutrition, metabolism, and cardiovascular diseases : NMCD, 27(6), 571-580 (2017-04-22)
Some crucial associations between obesity-related altered adipokine levels and the main factors of atherosclerotic, atherothrombotic processes are not fully known. We analysed the relationships of classic adipokines, namely leptin, resistin, adiponectin, tumour necrosis factor-alpha (TNF-α), interleukin 6 (IL-6) with the
Michael Mitchell et al.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 30(1), 34-41 (2018-12-07)
: The objective was to examine the genotypic and phenotypic characteristics of individuals with hereditary factor X deficiency (FXD), a rare autosomal recessive bleeding disorder caused by mutations in the F10 gene located on chromosome 13q34-ter. To date, 149 F10
Christian Schoergenhofer et al.
Scientific reports, 9(1), 11136-11136 (2019-08-02)
Defibrotide is approved for the treatment of sinusoidal obstruction syndrome after allogeneic stem cell transplantation. The exact mode of action of defibrotide is unclear and human in vivo data are scarce. In this randomized, double blind, crossover trial we included
Jennifer Manne-Goehler et al.
AIDS and behavior, 23(8), 2072-2078 (2018-12-14)
There is increasing interest in home based testing and treatment of HIV to expand access to treatment in sub-Saharan Africa. Such programs rely on self-reported HIV history and use of antiretroviral therapy (ART). However, the accuracy of self-reported ART use
Leticia P Sanglard et al.
Frontiers in genetics, 11, 593804-593804 (2020-11-17)
Losses due to infectious diseases are one of the main factors affecting productivity in the swine industry, motivating the investigation of disease resilience-related traits for genetic selection. However, these traits are not expected to be expressed in the nucleus herds
Melike Yuksel et al.
Biochimie, 138, 82-89 (2017-05-02)
The excess accumulation of amyloid-β (Aβ) peptides derived from the sequential cleavage of amyloid precursor protein (APP) by secretases, is one of the toxic key events leading to neuronal loss in Alzheimer's disease (AD). Studies have shown that cholinergic activity
A C van Dijk et al.
Thrombosis research, 177, 130-135 (2019-03-22)
Von Willebrand Factor (VWF), ADAMTS13, fibrinogen and fibrinogen γ' are associated with an increased risk of ischemic stroke. Carotid atherosclerosis is an important risk factor for ischemic stroke. Characteristics of the vulnerable plaque; intraplaque hemorrhage (IPH), plaque ulceration and lipid-rich
Kevser Biberoglu et al.
Chemico-biological interactions, 299, 88-93 (2018-12-01)
Alzheimer's disease (AD), the most common form of dementia, is characterized by abundant deposition of amyloid-β (Aβ) peptide that is the result of sequential cleavage of amyloid precursor protein (APP) by β-secretase and γ-secretase. Several studies have documented that inhibition
Kee Thai Yeo et al.
Journal of immunology (Baltimore, Md. : 1950), 202(5), 1465-1478 (2019-01-25)
Infections during pregnancy can expose the fetus to microbial Ags, leading to inflammation that affects B cell development. Prenatal fetal immune priming may have an important role in infant acquisition of pathogen-specific immunity. We examined plasma proinflammatory biomarkers, the proportions
Tzu-Hua Wu et al.
Journal of psychopharmacology (Oxford, England), 34(1), 86-92 (2019-11-07)
Ghrelin is a peptide hormone that mediates glucose homeostasis and lipid metabolism. Acylated ghrelin (AG) and desacylated ghrelin (DAG) are the two main forms of ghrelin, which have opposing roles in energy homeostasis. The AG/DAG ratio has been proposed to
Anette Kraemer et al.
Clinical laboratory, 66(7) (2020-07-14)
Fecal calprotectin is a valuable non-invasive marker for intestinal inflammation and contributes to the selection of patients with suspected inflammatory bowel disease (IBD) for endoscopy. The aim of this study was to evaluate the performance of three automated immunoassays for
Michał Gondek et al.
Veterinary parasitology, 288, 109277-109277 (2020-11-02)
The aim of the present study was to evaluate the acute-phase protein (APP) response in three groups of pigs experimentally infected with a moderate infective dose, i.e. 1000 muscle larvae (ML) of Trichinella spiralis, 3000 ML of Trichinella britovi, and 2000 ML
Jennifer Manne-Goehler et al.
Journal of the International AIDS Society, 22(3), e25213-e25213 (2019-03-28)
Participation in antiretroviral therapy (ART) programmes has been associated with greater utilization of care for hypertension and diabetes in rural South Africa. The objective of this study was to assess whether people living with HIV on ART with comorbid hypertension
Panagiotis D Tassis et al.
BMC veterinary research, 13(1), 91-91 (2017-04-09)
Mycoplasma hyopneumoniae (M. hyo) and Porcine Circovirus Type 2 (PCV2) are major pathogens that cause significant health problems in swine worldwide. Maternal derived immunity (MDI) has been suggested as a significant immediate defence factor for newborn piglets and may interfere
Monika Ponikowska et al.
Clinical rheumatology, 38(3), 827-834 (2018-11-09)
The aim of the study was to evaluate the frequency of anti-mutated citrullinated vimentin antibodies (a-Sa), anti-citrullinated α-enolase peptide 1 antibodies (a-CEP-1), anti-filaggrin antibodies (AFAs), heterogeneous nuclear ribonucleoprotein compies/anti-RA33-antibodies (a-hnRNP/RA33), anti-carbamylated protein antibodies (a-CarP), and metalloproteinase (MMPs) activity in patients
Edurne Garcia-Vidal et al.
Antiviral research, 168, 18-27 (2019-05-12)
Midostaurin is a multi-kinase inhibitor with antineoplastic activity. We assessed the capacity of midostaurin to affect early and late steps of HIV-1 infection and to reactivate HIV-1 latently infected cells, alone or in combination with histone deacetylase inhibitors (HDACi) known
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