RAB0671

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Hyperglucagonaemia analysed by glucagon sandwich ELISA: nonspecific interference or truly elevated levels?

Nicolai J Wewer Albrechtsen et al.

Diabetologia, 57(9), 1919-1926 (2014-06-04)

Hyperglucagonaemia is a characteristic of several clinical conditions (e.g. end-stage renal disease (ESRD), type 2 diabetes, obesity before and after Roux-en-Y gastric bypass (RYGB) and vagotomy with pyloroplasty), but the molecular nature of 'immunoreactive' glucagon is poorly characterised. The specific

Effect of LX4211 on glucose homeostasis and body composition in preclinical models.

David R Powell et al.

The Journal of pharmacology and experimental therapeutics, 350(2), 232-242 (2014-05-23)

Treatments that lower blood glucose levels and body weight should benefit patients with type 2 diabetes mellitus (T2DM). We developed LX4211 [(2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triol], an orally available small molecule that decreases postprandial glucose excursions by inhibiting intestinal sodium/glucose cotransporter 1 (SGLT1) and

GLP-1 secretion in acute ischemic stroke: association with functional outcome and comparison with healthy individuals.

Martin Larsson et al.

Cardiovascular diabetology, 18(1), 91-91 (2019-07-17)

Glucagon-like peptide-1 (GLP-1) treatment has been shown to reduce stroke incidence in diabetes and also to be neuroprotective in experimental stroke models. The prognostic value of endogenous levels of GLP-1 in the recovery phase after stroke remains to be elucidated. The

Hypercholesterolemia impairs the Glucagon-like peptide 1 action on platelets: Effects of a lipid-lowering treatment with simvastatin.

Cristina Barale et al.

Thrombosis research, 180, 74-85 (2019-06-24)

The incretin hormone Glucagon-like peptide 1(GLP-1) plays a pivotal role in maintaining glucose homeostasis with effects also on the cardiovascular system. GLP-1 influences platelet functions by increasing the inhibitory action of nitric oxide (NO) and reducing oxidative stress. To date

Carotid body denervation prevents fasting hyperglycemia during chronic intermittent hypoxia.

Mi-Kyung Shin et al.

Journal of applied physiology (Bethesda, Md. : 1985), 117(7), 765-776 (2014-08-12)

Obstructive sleep apnea causes chronic intermittent hypoxia (IH) and is associated with impaired glucose metabolism, but mechanisms are unknown. Carotid bodies orchestrate physiological responses to hypoxemia by activating the sympathetic nervous system. Therefore, we hypothesized that carotid body denervation would

Dipeptidyl peptidase IV inhibitor protects against renal interstitial fibrosis in a mouse model of ureteral obstruction.

Hye Sook Min et al.

Laboratory investigation; a journal of technical methods and pathology, 94(6), 598-607 (2014-04-02)

Dipeptidyl peptidase IV (DPPIV) is an exopeptidase that modulates the function of several substrates, among which insulin-releasing incretin hormones are the most well known. DPPIV also modulate substrates involved in inflammation, cell migration, and cell differentiation. Although DPPIV is highly

Ginsenoside metabolite compound K stimulates glucagon-like peptide-1 secretion in NCI-H716 cells via bile acid receptor activation.

Kyong Kim et al.

Archives of pharmacal research, 37(9), 1193-1200 (2014-03-05)

Compound K (CK) is a major metabolite of ginsenosides that is absorbed. CK has antidiabetic effects, although the mechanisms underlying the effects of CK have not fully been known. To elucidate the mechanisms underlying the antidiabetic effects of CK, we

Higher omega-3 index is associated with increased insulin sensitivity and more favourable metabolic profile in middle-aged overweight men.

Benjamin B Albert et al.

Scientific reports, 4, 6697-6697 (2014-10-22)

We assessed whether omega-3 index (red blood cell concentrations of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)) was associated with insulin sensitivity and other metabolic outcomes in 47 overweight men aged 46.5 ± 5.1 years. Participants were assessed twice, 16

Dietary sweet potato (Ipomoea batatas L.) leaf extract attenuates hyperglycaemia by enhancing the secretion of glucagon-like peptide-1 (GLP-1).

Rika Nagamine et al.

Food & function, 5(9), 2309-2316 (2014-07-30)

'Suioh', a sweet potato (Ipomoea batatas L.) cultivar developed in Japan, has edible leaves and stems. The sweet potato leaves contain polyphenols such as caffeoylquinic acid (CQA) derivatives. It has multiple biological functions and may help to regulate the blood

Cardiometabolic phenotyping of patients with familial hypocalcuric hypercalcemia.

Peter Wolf et al.

The Journal of clinical endocrinology and metabolism, 99(9), E1721-E1726 (2014-06-21)

Heterozygous inactivating mutations of the calcium-sensing receptor (CaSR) gene cause alterations in calcium metabolism [familial hypocalciuric hypercalcemia (FHH)]. In addition, calcium-sensing receptor is expressed in the myocardium and endocrine cells including pancreatic islets, enteroendocrine cells, and adipose tissue. To discern

Mechanisms underlying proglucagon gene expression.

Tianru Jin

The Journal of endocrinology, 198(1), 17-28 (2008-06-26)

The proglucagon gene (gcg) encodes a number of peptide hormones that are of cell-type specifically expressed in the pancreatic islets, the distal ileum and the large intestine, as well as certain brain neuronal cells. These hormones are important in controlling

Denatonium induces secretion of glucagon-like peptide-1 through activation of bitter taste receptor pathways.

Ki-Suk Kim et al.

Diabetologia, 57(10), 2117-2125 (2014-07-14)

This study was designed to ascertain whether human enteroendocrine cells express bitter taste receptors, and whether activation of these receptors with bitter-tasting ligands induces secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY). We used human enteroendocrine NCI-H716 cells, isolated

Association of GLP-1 secretion with anti-hyperlipidemic effect of ginsenosides in high-fat diet fed rats.

Can Liu et al.

Metabolism: clinical and experimental, 63(10), 1342-1351 (2014-07-26)

Ginsenosides, major bioactive constituents in Panax ginseng, have been shown to exert anti-hyperlipidemia effects. However, the underlying mechanism was not well-elucidated due to the low bioavailability of ginsenosides. Glucagon-like peptide-1 (GLP-1) was considered to be a critical regulator of energy

Spergularia marina induces glucagon-like peptide-1 secretion in NCI-H716 cells through bile acid receptor activation.

Kyong Kim et al.

Journal of medicinal food, 17(11), 1197-1203 (2014-09-27)

Spergularia marina Griseb. (SM) is a halophyte that grows in mud flats. The aerial portions of SM have been eaten as vegetables and traditionally used to prevent chronic diseases in Korea. However, there has been no scientific report that demonstrates

Pharmacokinetic and pharmacodynamic interaction between gemigliptin and metformin in healthy subjects.

Dongseong Shin et al.

Clinical drug investigation, 34(6), 383-393 (2014-03-15)

Gemigliptin is a novel dipeptidyl peptidase-4 (DPP-4) inhibitor used in the treatment of type 2 diabetes mellitus. This study evaluated possible pharmacodynamic and pharmacokinetic interactions between gemigliptin and metformin and investigated their tolerability. A randomized, open-label, multiple-dose, three-treatment, three-period, three-sequence

Biliopancreatic diversion with duodenal switch improves insulin sensitivity and secretion through caloric restriction.

Charles-Étienne Plourde et al.

Obesity (Silver Spring, Md.), 22(8), 1838-1846 (2014-04-25)

To assess the rapid improvement of insulin sensitivity and β-cell function following biliopancreatic diversion with duodenal switch (BPD-DS) and determine the role played by caloric restriction in these changes. Standard meals were administrated before and on day 3, 4, and

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