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Yochana Srivari et al.
Journal of microencapsulation, 33(8), 689-701 (2016-10-07)
Though there are many albumin-based drug delivery systems (ABDDS) in the market, it is not known whether ABDDS can be applied across all chemical classes. In this study, we applied ABDDS to a poorly water-soluble drug betulinic acid (BA) to
Juan Li et al.
BMC gastroenterology, 14, 115-115 (2014-07-01)
Acute pancreatitis (AP) is a common inflammatory disease of the pancreas accompanied by serious metabolic disturbances. Nevertheless, the specific metabolic process of this disease is still unclear. Characterization of the metabolome may help identify biomarkers for AP. To identify potential
Jean-Louis Delaunay et al.
Hepatology (Baltimore, Md.), 65(2), 560-570 (2016-12-25)
ABCB4 (MDR3) is an adenosine triphosphate (ATP)-binding cassette (ABC) transporter expressed at the canalicular membrane of hepatocytes, where it mediates phosphatidylcholine (PC) secretion. Variations in the ABCB4 gene are responsible for several biliary diseases, including progressive familial intrahepatic cholestasis type
Xiaozheng Yu et al.
Pancreas, 47(7), 892-897 (2018-06-19)
The aim of this study was to investigate the effects of emodin on attenuating autophagy response in acute pancreatitis (AP) models. Acute pancreatitis was induced in Wistar rats by injecting 3% sodium taurocholate into the biliopancreatic duct. Emodin (40 mg/kg
Chan Hee Moon et al.
International journal of ophthalmology, 11(9), 1435-1439 (2018-09-19)
To investigate the ocular biodistribution and clearance of topically administered 7-taurocholic acid conjugated low-molecular weight heparin (LHT7) in a neovascularized mouse cornea using an in vivo optical imaging system. A total of 10 eyes of 6 to 8-week-old BALB/c mice
Christer Tannergren et al.
Journal of pharmaceutical sciences, 105(11), 3314-3323 (2016-09-18)
AZD1175 and AZD2207 are 2 highly lipophilic compounds with a significant risk of not achieving therapeutic plasma concentrations due to solubility-limited absorption. The compounds have the same molecular weight and minimal structural differences. The aim of the present work was
Mónica Narváez-Rivas et al.
Analytica chimica acta, 954, 140-150 (2017-01-14)
The confident identification and in-depth profiling of molecular lipid species remain to be a challenge in lipidomics analysis. In this work, an off-line two-dimensional mixed-mode and reversed-phase liquid chromatography (RPLC) method combined with high-field quadrupole orbitrap mass spectrometer (Q Exactive
Muhammad Imran Sohail et al.
Molecular pharmacology, 92(4), 401-413 (2017-08-09)
The bile salt export pump (BSEP/ABCB11) transports bile salts from hepatocytes into bile canaliculi. Its malfunction is associated with severe liver disease. One reason for functional impairment of BSEP is systemic administration of drugs, which as a side effect inhibit
Jong Bong Lee et al.
Journal of controlled release : official journal of the Controlled Release Society, 286, 10-19 (2018-07-18)
The intestinal lymphatic system plays an important role in the pathophysiology of multiple diseases including lymphomas, cancer metastasis, autoimmune diseases, and human immunodeficiency virus (HIV) infection. It is thus an important compartment for delivery of drugs in order to treat
W H Kwok et al.
Journal of chromatography. A, 1490, 89-101 (2017-02-22)
A fast method for the direct analysis of enzyme-hydrolysed horse urine using an automated on-line solid-phase extraction (SPE) coupled to a liquid-chromatography/high resolution mass spectrometer was developed. Over 100 drugs of diverse drug classes could be simultaneously detected in horse
Taku Kobayashi et al.
Drug metabolism and pharmacokinetics, 32(2), 157-163 (2017-03-21)
Organic anion transporting polypeptide 2B1 (OATP2B1) is the major uptake transporter in the intestine, and transports various clinically used therapeutic agents. Insulin acts through the insulin receptor in targeted cells, and Rab8A is one of the insulin signaling pathways. The
Pradip W Dhore et al.
Pharmaceutical development and technology, 22(1), 90-102 (2016-06-14)
In the present study, a lyophilized milk-based solid dispersion (SD) of ritonavir (RTV) was developed with the goal of improving its aqueous solubility. The SD was prepared by lyophilization, and characterized for its physicochemical and functional properties. Fourier transform infrared
Yuri Kashima et al.
PloS one, 9(8), e105073-e105073 (2014-08-22)
Royal jelly (RJ) intake lowers serum cholesterol levels in animals and humans, but the active component in RJ that lowers serum cholesterol level and its molecular mechanism are unclear. In this study, we set out to identify the bile acid-binding
Lovleen Tina Joshi et al.
PloS one, 9(8), e104334-e104334 (2014-08-28)
Clostridium difficile is the primary cause of antibiotic associated diarrhea in humans and is a significant cause of morbidity and mortality. Thus the rapid and accurate identification of this pathogen in clinical samples, such as feces, is a key step
Maureen A Williams et al.
Oecologia, 194(1-2), 65-74 (2020-09-03)
Parasites are ecologically ubiquitous and, by modifying the physiology and behavior of their host organisms, act as key regulators of the dynamics and stability of ecosystems. It is, however, as yet unclear how parasitic relationships will act to moderate or
Yiwei Kong et al.
Shock (Augusta, Ga.), 49(5), 572-579 (2017-07-19)
Antithrombin III (ATIII), the predominant coagulation factor inhibitor, possesses anti-inflammatory properties and exerts renoprotective effects on renal ischemia-reperfusion injury in animal models. However, the ATIII's protective effects of ATIII on acute kidney injury (AKI) following severe acute pancreatitis (SAP) need
Eleanor Clancy-Thompson et al.
Journal of immunology (Baltimore, Md. : 1950), 199(1), 159-171 (2017-06-04)
Invariant NKT (iNKT) cell functional subsets are defined by key transcription factors and output of cytokines, such as IL-4, IFN-γ, IL-17, and IL-10. To examine how TCR specificity determines iNKT function, we used somatic cell nuclear transfer to generate three
Hanady Ajine Bibi et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 117, 300-307 (2017-05-10)
The simultaneous processes of lipid digestion and absorption together determine the oral bioavailability of drugs incorporated into lipid based drug delivery systems (LBDDS). A number of slightly different protocols for in vitro lipolysis are widely accepted; however, the permeation process
S Li et al.
Human & experimental toxicology, 39(10), 1345-1354 (2020-05-01)
The present study was aimed to explore the effects and the underlying mechanism of prophylactic low-molecular-weight heparin (LMWH) treatment on taurocholate-induced severe acute pancreatitis (SAP) in a rat model. Rat SAP model was induced by injection of 4% sodium taurocholate
Tran Nguyen-Ho-Bao et al.
Parasitology, 147(10), 1065-1070 (2020-05-05)
The transfection of Cryptosporidium represents a major challenge, and current protocols are based on electroporation of freshly excysted sporozoites using a rather large amount of plasmid DNA which typically has a very poor yield. In this study, we report a
Alexander S Tatikolov et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 216, 190-201 (2019-03-23)
Spectral-fluorescent properties of polymethine dye probes anionic 3,3'-di(sulfopropyl)-4,5,4',5'-dibenzo-9-ethylthiacarbocyanine-betaine (DEC) and cationic 3,3',9-trimethylthiacarbocyanine iodide (Cyan 2) in the presence of biological surfactants, bile salts sodium cholate (NaC), sodium deoxycholate (NaDC) and sodium taurocholate (NaTC), as well as sodium dodecyl sulfate (SDS)
Seigo Sanoh et al.
Biological & pharmaceutical bulletin, 42(8), 1366-1375 (2019-08-02)
Drug-induced liver injury (DILI) is a common side effect of several medications and is considered a major factor responsible for the discontinuation of drugs during their development. Cholestasis is a DILI that results from impairment of bile acid transporters, such
Flavia D Toledo et al.
Archives of toxicology, 91(6), 2391-2403 (2016-12-04)
In previous studies, we showed that the pro-oxidant model agent tert-butyl hydroperoxide (tBuOOH) induces alterations in hepatocanalicular secretory function by activating Ca
Bin Wang et al.
Molecular medicine reports, 23(4) (2021-03-03)
Severe acute pancreatitis (SAP) is a common acute abdominal disease accompanied by systemic inflammatory response syndrome, which may be complicated by acute kidney injury (AKI). Isoacteoside (ISO) is the active ingredient of Monochasma savatieri Franch. ex Maxim and has been reported to have
Yiping Zhang et al.
Journal of pharmaceutical and biomedical analysis, 164, 155-163 (2018-11-06)
Previous studies have indicated that dietary fucoxanthin is mainly converted into fucoxanthinol (the deacetylated form) in mammals, but the pharmacokinetics of fucoxanthinol remains unknown. In this study, after intravenous (i.v.) and intragastric gavage (i.g.) administration of fucoxanthinol to rats at
Bing Han et al.
The FEBS journal, 283(4), 738-756 (2015-12-20)
Molecular hydrogen (H2 ) has been proven to be an effective agent that can cure multiple organ diseases by reducing oxidative stress. Although the protective effect of hydrogen on acute pancreatitis (AP) has been confirmed, its molecular mechanism is still
Jing Li et al.
Oxidative medicine and cellular longevity, 2020, 9217219-9217219 (2020-11-19)
Severe acute pancreatitis (SAP) is a serious and life-threatening disease associated with multiple organ failure and a high mortality rate and is accompanied by distinct oxidative stress and inflammatory responses. Saikosaponin A has strong antioxidant properties and can affect the
Yusuke Tanaka et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 157, 105604-105604 (2020-10-26)
The aim of this study is to clarify absorption mechanisms after oral administration of ritonavir (RTV) from different types of lipid-based formulations (LBFs) with particular emphasis on the effect of lipid digestion and drug permeation/re-dissolution on the oral absorption. Four
Yoshiyuki Akiyama et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 155, 105543-105543 (2020-09-15)
The purpose of the present study was to quantitatively predict the negative food effect induced by bile micelle binding on the oral absorption of hydrophilic cationic drugs. The intrinsic membrane permeability and bile micelle unbound fraction of 12 model drugs
Satomi Yamaguchi Ikeuchi et al.
Biological & pharmaceutical bulletin, 41(11), 1708-1715 (2018-11-02)
The purpose of this research was to establish an in vitro dissolution testing method to predict the oral pharmacokinetic (PK) profiles and food effects of gabapentin enacarbil formulated as wax matrix extended-release (ER) tablets in humans. We adopted various biorelevant
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