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关键词:'S0900000'
显示 1-30 共 416 条结果 关于 "S0900000" 范围 论文
Yochana Srivari et al.
Journal of microencapsulation, 33(8), 689-701 (2016-10-07)
Though there are many albumin-based drug delivery systems (ABDDS) in the market, it is not known whether ABDDS can be applied across all chemical classes. In this study, we applied ABDDS to a poorly water-soluble drug betulinic acid (BA) to
Aaron C Schmidt et al.
Soft matter, 16(11), 2725-2735 (2020-03-03)
Transmembrane pH gradient poly(isoprene)-block-poly(ethylene glycol) (PI-b-PEG) polymersomes were investigated for their potential use in the detoxification of ammonia, a metabolite that is excessively present in patients suffering from urea cycle disorders and advanced liver diseases, and which causes neurotoxic effects
Mohammed A Alqumber
Saudi medical journal, 35(10), 1274-1277 (2014-10-16)
To determine Clostridium difficile (C. difficile) prevalence on retail surfaces and shoppers plastic bags. From 20 June to 10 August 2011, in a cross-sectional epidemiological study, 17 supermarkets from 2 cities, Albaha and Altaif, Saudi Arabia were sampled. A total
Haniyeh Etezadi et al.
International journal of pharmaceutics, 590, 119918-119918 (2020-10-09)
The objective of the present study was the development of self-emulsifying drug delivery systems (SEDDS) for oral delivery of therapeutic proteins providing storage stability. Horseradish peroxidase (HRP) serving as model protein was ion paired with docusate and incorporated into three
Xiaohong Wang et al.
International immunopharmacology, 24(2), 285-298 (2014-12-24)
To observe the protecting effects of Acanthopanax and Ulinastatin against severe acute pancreatitis (SAP)-induced brain injury in rats. SAP-modeled rats were equally randomized into three groups: model group, Acanthopanax-treated group and Ulinastatin-treated group. A sham-operation group was used as negative
Bing Han et al.
The FEBS journal, 283(4), 738-756 (2015-12-20)
Molecular hydrogen (H2 ) has been proven to be an effective agent that can cure multiple organ diseases by reducing oxidative stress. Although the protective effect of hydrogen on acute pancreatitis (AP) has been confirmed, its molecular mechanism is still
Jing Li et al.
Oxidative medicine and cellular longevity, 2020, 9217219-9217219 (2020-11-19)
Severe acute pancreatitis (SAP) is a serious and life-threatening disease associated with multiple organ failure and a high mortality rate and is accompanied by distinct oxidative stress and inflammatory responses. Saikosaponin A has strong antioxidant properties and can affect the
Yusuke Tanaka et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 157, 105604-105604 (2020-10-26)
The aim of this study is to clarify absorption mechanisms after oral administration of ritonavir (RTV) from different types of lipid-based formulations (LBFs) with particular emphasis on the effect of lipid digestion and drug permeation/re-dissolution on the oral absorption. Four
Peter P Rainer et al.
Heart (British Cardiac Society), 99(22), 1685-1692 (2013-07-31)
High bile acid serum concentrations have been implicated in cardiac disease, particularly in arrhythmias. Most data originate from in vitro studies and animal models. We tested the hypotheses that (1) high bile acid concentrations are arrhythmogenic in adult human myocardium
Kristine Bach Korsholm Knudsen et al.
Nutrients, 13(2) (2021-02-03)
Efficient lipid digestion in formula-fed infants is required to ensure the availability of fatty acids for normal organ development. Previous studies suggest that the efficiency of lipid digestion may depend on whether lipids are emulsified with soy lecithin or fractions
Liang Sun et al.
Molecular medicine reports, 18(4), 3818-3824 (2018-08-15)
The aim of the present study was to investigate the effects of Toll‑like receptor (TLR) 9 and CpG oligodeoxynucleotide (CpG‑ODN)1826 on sodium taurocholate‑induced acute pancreatitis (AP) rats at different time points. Pathological examination indicated that the severity of pancreatic tissue
Philipp A Elvang et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 120, 61-72 (2018-04-29)
Colloidal phases (self-assemblies) in aqueous dispersions of selected binary bile salt/phospholipid blends were studied utilizing the combined analytical approach of asymmetrical flow field-flow fractionation (AF4) and multi-angle laser light scattering (MALLS) in order to resolve the co-existence of different colloidal
R L Anisimov et al.
Protein expression and purification, 170, 105573-105573 (2020-01-26)
Antibodies specific to β-Glucocerebrosidase were selected from phage displayed naïve scFv libraries. Biopannings were performed against recombinant human protein β-Glucocerebrosidase immobilized on polystyrene surface, specific phages were eluted with 50% ethylene glycol in citrate buffer (pH 6.0). Several specific binders
Huan Yan et al.
Journal of virology, 87(14), 7977-7991 (2013-05-17)
Human hepatitis B virus (HBV) and its satellite virus, hepatitis D virus (HDV), primarily infect humans, chimpanzees, or tree shrews (Tupaia belangeri). Viral infections in other species are known to be mainly restricted at the entry level since viral replication
Can Yu et al.
Molecular medicine reports, 14(6), 5507-5513 (2016-11-24)
High-motility group box protein 1 (HMGB1) has an important role in autophagy; however, its exact role in acute necrotizing pancreatitis (ANP) remains unknown. The present study aimed to investigate the expression pattern of HMGB1 in ANP, and to determine its association
Philip Kohlmann et al.
The AAPS journal, 19(6), 1864-1877 (2017-10-04)
Prediction of the pharmacokinetics of orally administered drugs in children is of importance to optimize the efficacy and safety of pediatric medicines. Physiologically based pharmacokinetic (PBPK) models can be helpful for this purpose. However, application of these tools is limited
Xiao-Xia Fang et al.
Electrophoresis, 37(17-18), 2376-2383 (2016-07-06)
Here, a compact high-speed CE bioanalyzer based on a short capillary has been developed. Multiple modules of picoliter scale sample injection, high-speed CE separation, sample changing, LIF detection, as well as a custom designed tablet computer for data processing, instrument
Michela Terdoslavich et al.
Drug metabolism letters, 6(3), 165-173 (2013-03-09)
Hepatic disposition of bromosulfophthalein (BSP), bilirubin and bile salts partially overlap, as these anions share both uptake and excretion mechanisms. Multiple organic anion transporters mediate hepatic BSP uptake, i.e. members of the SLCO and SLC22 gene families and bilitranslocase (TCDB
Liwen Qiang et al.
Environmental science & technology, 50(21), 11627-11636 (2016-11-02)
As one of the most popular carbon-based nanomaterials, graphene oxide (GO) has the potential to be released in aquatic environment and interact with some coexistent organic pollutants, such as perfluorooctanesulfonate (PFOS), which is an emerging persistent organic pollutant. In this
Muhammad Imran Sohail et al.
Molecular pharmacology, 92(4), 401-413 (2017-08-09)
The bile salt export pump (BSEP/ABCB11) transports bile salts from hepatocytes into bile canaliculi. Its malfunction is associated with severe liver disease. One reason for functional impairment of BSEP is systemic administration of drugs, which as a side effect inhibit
Yupeng Yan et al.
Molecular medicine reports, 16(6), 8471-8476 (2017-10-11)
Severe acute pancreatitis (SAP) has a rapid onset and may cause multiple organ dysfunction syndrome (MODS), which has high mortality. Nucleotide binding oligomerization domain (NOD) receptor and Toll‑like receptor 9 (TLR9), a pattern recognition receptor in innate immunity, are involved
Aleksandra V Bukhovets et al.
Polymers, 12(7) (2020-07-08)
Interpolymer complexes (IPC) based on Eudragit® EPO and Eudragit® S100 were investigated as potential carriers for oral controlled drug delivery to the colon. IPC samples were prepared by mixing copolymer solutions in organic solvents (ethanol, isopropanol:acetone mixture (60:40, % v/v)
Yipshu Pui et al.
Molecular pharmaceutics, 15(7), 2754-2763 (2018-05-22)
Amorphous solid dispersion (ASD) is one of the most versatile supersaturating drug delivery systems to improve the dissolution rate and oral bioavailability of poorly water-soluble drugs. PVP based ASD formulation of nimodipine (NMD) has been marketed and effectively used in
Juan Li et al.
BMC gastroenterology, 14, 115-115 (2014-07-01)
Acute pancreatitis (AP) is a common inflammatory disease of the pancreas accompanied by serious metabolic disturbances. Nevertheless, the specific metabolic process of this disease is still unclear. Characterization of the metabolome may help identify biomarkers for AP. To identify potential
Regulation of bile acid metabolism: new insights from inside.
Pablo Quintero et al.
Hepatology (Baltimore, Md.), 58(5), 1850-1853 (2013-06-19)
Xiaozheng Yu et al.
Pancreas, 47(7), 892-897 (2018-06-19)
The aim of this study was to investigate the effects of emodin on attenuating autophagy response in acute pancreatitis (AP) models. Acute pancreatitis was induced in Wistar rats by injecting 3% sodium taurocholate into the biliopancreatic duct. Emodin (40 mg/kg
Ana Maria Mendonça Coelho et al.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 19(5), 638-645 (2019-06-18)
/Objectives: Evaluation of the local and systemic effects of aging on the severity of acute pancreatitis (AP) in an experimental rat model in elderly animals. AP was induced in Wistar rats by intraductal 2.5% taurocholate injection and divided into two
Jean-Louis Delaunay et al.
Hepatology (Baltimore, Md.), 65(2), 560-570 (2016-12-25)
ABCB4 (MDR3) is an adenosine triphosphate (ATP)-binding cassette (ABC) transporter expressed at the canalicular membrane of hepatocytes, where it mediates phosphatidylcholine (PC) secretion. Variations in the ABCB4 gene are responsible for several biliary diseases, including progressive familial intrahepatic cholestasis type
Alison B Kohan et al.
American journal of physiology. Gastrointestinal and liver physiology, 311(4), G648-G654 (2016-08-16)
It is not well understood how monosodium glutamate (MSG) affects gastrointestinal physiology, especially regarding the absorption and the subsequent transport of dietary lipids into lymph. Thus far, there is little information about how the ingestion of MSG affects the lipid
Mónica Narváez-Rivas et al.
Analytica chimica acta, 954, 140-150 (2017-01-14)
The confident identification and in-depth profiling of molecular lipid species remain to be a challenge in lipidomics analysis. In this work, an off-line two-dimensional mixed-mode and reversed-phase liquid chromatography (RPLC) method combined with high-field quadrupole orbitrap mass spectrometer (Q Exactive
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