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Yochana Srivari et al.
Journal of microencapsulation, 33(8), 689-701 (2016-10-07)
Though there are many albumin-based drug delivery systems (ABDDS) in the market, it is not known whether ABDDS can be applied across all chemical classes. In this study, we applied ABDDS to a poorly water-soluble drug betulinic acid (BA) to
Huan Yan et al.
Journal of virology, 87(14), 7977-7991 (2013-05-17)
Human hepatitis B virus (HBV) and its satellite virus, hepatitis D virus (HDV), primarily infect humans, chimpanzees, or tree shrews (Tupaia belangeri). Viral infections in other species are known to be mainly restricted at the entry level since viral replication
Regulation of bile acid metabolism: new insights from inside.
Pablo Quintero et al.
Hepatology (Baltimore, Md.), 58(5), 1850-1853 (2013-06-19)
Chan Hee Moon et al.
International journal of ophthalmology, 11(9), 1435-1439 (2018-09-19)
To investigate the ocular biodistribution and clearance of topically administered 7-taurocholic acid conjugated low-molecular weight heparin (LHT7) in a neovascularized mouse cornea using an in vivo optical imaging system. A total of 10 eyes of 6 to 8-week-old BALB/c mice
Ana Maria Mendonça Coelho et al.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 19(5), 638-645 (2019-06-18)
/Objectives: Evaluation of the local and systemic effects of aging on the severity of acute pancreatitis (AP) in an experimental rat model in elderly animals. AP was induced in Wistar rats by intraductal 2.5% taurocholate injection and divided into two
Xiaozheng Yu et al.
Pancreas, 47(7), 892-897 (2018-06-19)
The aim of this study was to investigate the effects of emodin on attenuating autophagy response in acute pancreatitis (AP) models. Acute pancreatitis was induced in Wistar rats by injecting 3% sodium taurocholate into the biliopancreatic duct. Emodin (40 mg/kg
Muhammad Imran Sohail et al.
Molecular pharmacology, 92(4), 401-413 (2017-08-09)
The bile salt export pump (BSEP/ABCB11) transports bile salts from hepatocytes into bile canaliculi. Its malfunction is associated with severe liver disease. One reason for functional impairment of BSEP is systemic administration of drugs, which as a side effect inhibit
Juan Li et al.
BMC gastroenterology, 14, 115-115 (2014-07-01)
Acute pancreatitis (AP) is a common inflammatory disease of the pancreas accompanied by serious metabolic disturbances. Nevertheless, the specific metabolic process of this disease is still unclear. Characterization of the metabolome may help identify biomarkers for AP. To identify potential
Mónica Narváez-Rivas et al.
Analytica chimica acta, 954, 140-150 (2017-01-14)
The confident identification and in-depth profiling of molecular lipid species remain to be a challenge in lipidomics analysis. In this work, an off-line two-dimensional mixed-mode and reversed-phase liquid chromatography (RPLC) method combined with high-field quadrupole orbitrap mass spectrometer (Q Exactive
Bin Wang et al.
Molecular medicine reports, 23(4) (2021-03-03)
Severe acute pancreatitis (SAP) is a common acute abdominal disease accompanied by systemic inflammatory response syndrome, which may be complicated by acute kidney injury (AKI). Isoacteoside (ISO) is the active ingredient of Monochasma savatieri Franch. ex Maxim and has been reported to have
Yiping Zhang et al.
Journal of pharmaceutical and biomedical analysis, 164, 155-163 (2018-11-06)
Previous studies have indicated that dietary fucoxanthin is mainly converted into fucoxanthinol (the deacetylated form) in mammals, but the pharmacokinetics of fucoxanthinol remains unknown. In this study, after intravenous (i.v.) and intragastric gavage (i.g.) administration of fucoxanthinol to rats at
Flavia D Toledo et al.
Archives of toxicology, 91(6), 2391-2403 (2016-12-04)
In previous studies, we showed that the pro-oxidant model agent tert-butyl hydroperoxide (tBuOOH) induces alterations in hepatocanalicular secretory function by activating Ca
Liang Sun et al.
Molecular medicine reports, 18(4), 3818-3824 (2018-08-15)
The aim of the present study was to investigate the effects of Toll‑like receptor (TLR) 9 and CpG oligodeoxynucleotide (CpG‑ODN)1826 on sodium taurocholate‑induced acute pancreatitis (AP) rats at different time points. Pathological examination indicated that the severity of pancreatic tissue
Peter P Rainer et al.
Heart (British Cardiac Society), 99(22), 1685-1692 (2013-07-31)
High bile acid serum concentrations have been implicated in cardiac disease, particularly in arrhythmias. Most data originate from in vitro studies and animal models. We tested the hypotheses that (1) high bile acid concentrations are arrhythmogenic in adult human myocardium
Z-G Luan et al.
Clinical and experimental immunology, 172(3), 417-426 (2013-04-23)
In this study, we examined the effect of ethyl pyruvate (EP) on pulmonary inflammation in rats with severe pancreatitis-associated acute lung injury (ALI). Severe acute pancreatitis (SAP) was induced in rats by the retrograde injection of 5% sodium taurocholate into
Johan Linders et al.
Laboratory investigation; a journal of technical methods and pathology, 100(12), 1618-1630 (2020-07-28)
Neutrophil extracellular traps (NETs) play a key role in the development of acute pancreatitis (AP). In the present study, we studied the role of extracellular cold-inducible RNA-binding protein (eCIRP), a novel damage-associated-molecular-pattern molecule, in severe AP. C57BL/6 mice underwent retrograde
Lovleen Tina Joshi et al.
PloS one, 9(8), e104334-e104334 (2014-08-28)
Clostridium difficile is the primary cause of antibiotic associated diarrhea in humans and is a significant cause of morbidity and mortality. Thus the rapid and accurate identification of this pathogen in clinical samples, such as feces, is a key step
Alexander S Tatikolov et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 216, 190-201 (2019-03-23)
Spectral-fluorescent properties of polymethine dye probes anionic 3,3'-di(sulfopropyl)-4,5,4',5'-dibenzo-9-ethylthiacarbocyanine-betaine (DEC) and cationic 3,3',9-trimethylthiacarbocyanine iodide (Cyan 2) in the presence of biological surfactants, bile salts sodium cholate (NaC), sodium deoxycholate (NaDC) and sodium taurocholate (NaTC), as well as sodium dodecyl sulfate (SDS)
Yupeng Yan et al.
Molecular medicine reports, 16(6), 8471-8476 (2017-10-11)
Severe acute pancreatitis (SAP) has a rapid onset and may cause multiple organ dysfunction syndrome (MODS), which has high mortality. Nucleotide binding oligomerization domain (NOD) receptor and Toll‑like receptor 9 (TLR9), a pattern recognition receptor in innate immunity, are involved
Aleksandra V Bukhovets et al.
Polymers, 12(7) (2020-07-08)
Interpolymer complexes (IPC) based on Eudragit® EPO and Eudragit® S100 were investigated as potential carriers for oral controlled drug delivery to the colon. IPC samples were prepared by mixing copolymer solutions in organic solvents (ethanol, isopropanol:acetone mixture (60:40, % v/v)
Yipshu Pui et al.
Molecular pharmaceutics, 15(7), 2754-2763 (2018-05-22)
Amorphous solid dispersion (ASD) is one of the most versatile supersaturating drug delivery systems to improve the dissolution rate and oral bioavailability of poorly water-soluble drugs. PVP based ASD formulation of nimodipine (NMD) has been marketed and effectively used in
Philipp A Elvang et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 120, 61-72 (2018-04-29)
Colloidal phases (self-assemblies) in aqueous dispersions of selected binary bile salt/phospholipid blends were studied utilizing the combined analytical approach of asymmetrical flow field-flow fractionation (AF4) and multi-angle laser light scattering (MALLS) in order to resolve the co-existence of different colloidal
Jing Li et al.
Oxidative medicine and cellular longevity, 2020, 9217219-9217219 (2020-11-19)
Severe acute pancreatitis (SAP) is a serious and life-threatening disease associated with multiple organ failure and a high mortality rate and is accompanied by distinct oxidative stress and inflammatory responses. Saikosaponin A has strong antioxidant properties and can affect the
Yusuke Tanaka et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 157, 105604-105604 (2020-10-26)
The aim of this study is to clarify absorption mechanisms after oral administration of ritonavir (RTV) from different types of lipid-based formulations (LBFs) with particular emphasis on the effect of lipid digestion and drug permeation/re-dissolution on the oral absorption. Four
Inha Heo et al.
Nature microbiology, 3(7), 814-823 (2018-06-28)
Stem-cell-derived organoids recapitulate in vivo physiology of their original tissues, representing valuable systems to model medical disorders such as infectious diseases. Cryptosporidium, a protozoan parasite, is a leading cause of diarrhoea and a major cause of child mortality worldwide. Drug
Xiaohong Wang et al.
International immunopharmacology, 24(2), 285-298 (2014-12-24)
To observe the protecting effects of Acanthopanax and Ulinastatin against severe acute pancreatitis (SAP)-induced brain injury in rats. SAP-modeled rats were equally randomized into three groups: model group, Acanthopanax-treated group and Ulinastatin-treated group. A sham-operation group was used as negative
Yoshiyuki Akiyama et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 155, 105543-105543 (2020-09-15)
The purpose of the present study was to quantitatively predict the negative food effect induced by bile micelle binding on the oral absorption of hydrophilic cationic drugs. The intrinsic membrane permeability and bile micelle unbound fraction of 12 model drugs
Satomi Yamaguchi Ikeuchi et al.
Biological & pharmaceutical bulletin, 41(11), 1708-1715 (2018-11-02)
The purpose of this research was to establish an in vitro dissolution testing method to predict the oral pharmacokinetic (PK) profiles and food effects of gabapentin enacarbil formulated as wax matrix extended-release (ER) tablets in humans. We adopted various biorelevant
Tine Tricot et al.
Cells, 9(3) (2020-03-04)
Acute and chronic liver failure is a highly prevalent medical condition with high morbidity and mortality. Currently, the therapy is orthotopic liver transplantation. However, in some instances, chiefly in the setting of metabolic diseases, transplantation of individual cells, specifically functional
M C García et al.
Food & function, 7(11), 4693-4701 (2016-10-27)
Stones from olives and Prunus genus fruits are cheap and sustainable sources of proteins and could be potential sources of bioactive peptides. The main limitation to the use of these seeds is the presence of amygdalin. This work proposes to
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