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显示 61-90 共 416 条结果 关于 "S0900000" 范围 论文
Tine Tricot et al.
Cells, 9(3) (2020-03-04)
Acute and chronic liver failure is a highly prevalent medical condition with high morbidity and mortality. Currently, the therapy is orthotopic liver transplantation. However, in some instances, chiefly in the setting of metabolic diseases, transplantation of individual cells, specifically functional
Satomi Yamaguchi Ikeuchi et al.
Biological & pharmaceutical bulletin, 41(11), 1708-1715 (2018-11-02)
The purpose of this research was to establish an in vitro dissolution testing method to predict the oral pharmacokinetic (PK) profiles and food effects of gabapentin enacarbil formulated as wax matrix extended-release (ER) tablets in humans. We adopted various biorelevant
Yoshiyuki Akiyama et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 155, 105543-105543 (2020-09-15)
The purpose of the present study was to quantitatively predict the negative food effect induced by bile micelle binding on the oral absorption of hydrophilic cationic drugs. The intrinsic membrane permeability and bile micelle unbound fraction of 12 model drugs
Hanady Ajine Bibi et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 117, 300-307 (2017-05-10)
The simultaneous processes of lipid digestion and absorption together determine the oral bioavailability of drugs incorporated into lipid based drug delivery systems (LBDDS). A number of slightly different protocols for in vitro lipolysis are widely accepted; however, the permeation process
S Li et al.
Human & experimental toxicology, 39(10), 1345-1354 (2020-05-01)
The present study was aimed to explore the effects and the underlying mechanism of prophylactic low-molecular-weight heparin (LMWH) treatment on taurocholate-induced severe acute pancreatitis (SAP) in a rat model. Rat SAP model was induced by injection of 4% sodium taurocholate
Ting Han et al.
International journal of clinical and experimental pathology, 6(3), 503-509 (2013-02-16)
To investigate the effect of glutamine (Gln) on pro-inflammatory cytokines (TNF-α, IL-2 and IL-10) and the balance between pro-inflammatory cytokines and anti-inflammatory cytokines in severe acute pancreatitis (SAP) rats receiving nutritional support in different ways. Male SD rats (n=80) were
Yu Zhao et al.
Journal of lipid research, 56(3), 644-652 (2015-01-21)
ABCB4, which is specifically expressed on the canalicular membrane of hepatocytes, exports phosphatidylcholine (PC) into bile. Because SM depletion increases cellular PC content and stimulates PC and cholesterol efflux by ABCA1, a key transporter involved in generation of HDL, we
Qing Zhao et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 40(3-4), 621-632 (2016-11-30)
Sulodexide is a powerful antithrombin agent with reno-protective property. However, whether it has beneficial effects on Contrast-Induced Nephropathy (CIN) remained elusive. In the current study, we evaluated the therapeutic effects of Sulodexide on CIN and investigated the potential mechanisms. CIN
Yiwei Kong et al.
Shock (Augusta, Ga.), 49(5), 572-579 (2017-07-19)
Antithrombin III (ATIII), the predominant coagulation factor inhibitor, possesses anti-inflammatory properties and exerts renoprotective effects on renal ischemia-reperfusion injury in animal models. However, the ATIII's protective effects of ATIII on acute kidney injury (AKI) following severe acute pancreatitis (SAP) need
Inha Heo et al.
Nature microbiology, 3(7), 814-823 (2018-06-28)
Stem-cell-derived organoids recapitulate in vivo physiology of their original tissues, representing valuable systems to model medical disorders such as infectious diseases. Cryptosporidium, a protozoan parasite, is a leading cause of diarrhoea and a major cause of child mortality worldwide. Drug
Xiaohong Wang et al.
International immunopharmacology, 24(2), 285-298 (2014-12-24)
To observe the protecting effects of Acanthopanax and Ulinastatin against severe acute pancreatitis (SAP)-induced brain injury in rats. SAP-modeled rats were equally randomized into three groups: model group, Acanthopanax-treated group and Ulinastatin-treated group. A sham-operation group was used as negative
Atcharaporn Ontawong et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 52, 187-197 (2019-01-03)
Coffea arabica pulp (CP) is the first by-product obtained from coffee berries during coffee processing. The major constituents of CP, including chlorogenic acid, caffeine, and epicatechin exhibit anti-hyperlipidemic effects in in vitro and in vivo models. Whether Coffea arabica pulp
María García-Díaz et al.
International journal of pharmaceutics, 482(1-2), 84-91 (2014-12-03)
Polymeric nanoparticles are widely investigated as drug delivery systems for oral administration. However, the hydrophobic nature of many polymers hampers effective loading of the particles with hydrophilic macromolecules such as insulin. Thus, the aim of this work was to improve
Ying Chen et al.
International immunopharmacology, 87, 106771-106771 (2020-07-20)
Acute pancreatitis during pregnancy (APIP) rarely occurs but may lead to preterm delivery and be associated with high fetal mortality. Macrophage migration inhibitory factor (MIF) participates in various inflammatory diseases as a pro-inflammatory cytokine. In this study, we aimed to
Christer Tannergren et al.
Journal of pharmaceutical sciences, 105(11), 3314-3323 (2016-09-18)
AZD1175 and AZD2207 are 2 highly lipophilic compounds with a significant risk of not achieving therapeutic plasma concentrations due to solubility-limited absorption. The compounds have the same molecular weight and minimal structural differences. The aim of the present work was
Eleanor Clancy-Thompson et al.
Journal of immunology (Baltimore, Md. : 1950), 199(1), 159-171 (2017-06-04)
Invariant NKT (iNKT) cell functional subsets are defined by key transcription factors and output of cytokines, such as IL-4, IFN-γ, IL-17, and IL-10. To examine how TCR specificity determines iNKT function, we used somatic cell nuclear transfer to generate three
M Vázquez et al.
Toxicology, 311(3), 147-153 (2013-06-25)
Food is the main pathway of exposure to mercury for most of the population. In food, mercury is generally present as inorganic mercury [Hg(II)] or methylmercury [MeHg]. Both chemical forms have some degree of toxicity, especially MeHg, which is considered
Shunsuke Nashimoto et al.
Drug metabolism and pharmacokinetics, 35(6), 527-533 (2020-10-11)
Ubiquinone, which is a component in the electron-transport systems of mitochondria, is essential for various activities related to energy metabolism, but the detailed absorption mechanism of ubiquinone is not clear. On the other hand, Niemann-Pick C1 Like 1 (NPC1L1) is
M C García et al.
Food & function, 7(11), 4693-4701 (2016-10-27)
Stones from olives and Prunus genus fruits are cheap and sustainable sources of proteins and could be potential sources of bioactive peptides. The main limitation to the use of these seeds is the presence of amygdalin. This work proposes to
Guodong Song et al.
Life sciences, 223, 9-21 (2019-03-14)
Severe acute pancreatitis (SAP) is an acute disease of the digestive system accompanied by pancreatic necrosis. We have found that bone marrow-derived mesenchymal stem cells (BMSCs) can attenuate SAP, but the underlying mechanism remains unclear. The present study was conducted
Apurva Kanneganti et al.
The Journal of experimental medicine, 215(6), 1519-1529 (2018-05-26)
Pyroptosis is an inflammasome-induced lytic cell death mode, the physiological role of which in chronic inflammatory diseases is unknown. Familial Mediterranean Fever (FMF) is the most common monogenic autoinflammatory disease worldwide, affecting an estimated 150,000 patients. The disease is caused
W H Kwok et al.
Journal of chromatography. A, 1490, 89-101 (2017-02-22)
A fast method for the direct analysis of enzyme-hydrolysed horse urine using an automated on-line solid-phase extraction (SPE) coupled to a liquid-chromatography/high resolution mass spectrometer was developed. Over 100 drugs of diverse drug classes could be simultaneously detected in horse
Pradip W Dhore et al.
Pharmaceutical development and technology, 22(1), 90-102 (2016-06-14)
In the present study, a lyophilized milk-based solid dispersion (SD) of ritonavir (RTV) was developed with the goal of improving its aqueous solubility. The SD was prepared by lyophilization, and characterized for its physicochemical and functional properties. Fourier transform infrared
Hyuck Jun Jung et al.
Molecules (Basel, Switzerland), 23(4) (2018-03-23)
The oral bioavailability of entecavir (EV), an anti-viral agent commonly prescribed to treat hepatitis B infections, is drastically reduced under a post-prandial state. This is primarily due to its low permeability in the gastrointestinal tract. To reduce the food effect
Raluca Ica et al.
Journal of mass spectrometry : JMS, 55(5), e4502-e4502 (2020-01-22)
We have developed here a superior approach based on high-resolution (HR) mass spectrometry (MS) for monitoring the changes occurring with development and aging in the composition and structure of cerebellar gangliosidome. The experiments were focused on the comparative screening and
Doreen Braun et al.
Endocrinology, 156(12), 4720-4730 (2015-09-15)
Monocarboxylate transporter 8 (MCT8) is a thyroid hormone transmembrane transporter expressed in many cell types, including neurons. Mutations that inactivate transport activity of MCT8 cause severe X-linked psychomotor retardation in male patients, a syndrome originally described as the Allan-Herndon-Dudley syndrome.
Christian Carlucci et al.
Scientific reports, 9(1), 885-885 (2019-01-31)
Many cases of Clostridioides difficile infection (CDI) are poorly responsive to standard antibiotic treatment strategies, and often patients suffer from recurrent infections characterized by severe diarrhea. Our group previously reported the successful cure of two patients with recurrent CDI using
Jong Bong Lee et al.
Journal of controlled release : official journal of the Controlled Release Society, 286, 10-19 (2018-07-18)
The intestinal lymphatic system plays an important role in the pathophysiology of multiple diseases including lymphomas, cancer metastasis, autoimmune diseases, and human immunodeficiency virus (HIV) infection. It is thus an important compartment for delivery of drugs in order to treat
Taku Kobayashi et al.
Drug metabolism and pharmacokinetics, 32(2), 157-163 (2017-03-21)
Organic anion transporting polypeptide 2B1 (OATP2B1) is the major uptake transporter in the intestine, and transports various clinically used therapeutic agents. Insulin acts through the insulin receptor in targeted cells, and Rab8A is one of the insulin signaling pathways. The
Ping Chen et al.
Digestive diseases and sciences, 61(3), 758-766 (2015-11-20)
We tested our hypothesis that Myc-interacting zinc finger protein 1 (MIZ1), a cell cycle regulator, suppressed inflammation, and therefore, represented a useful prognostic marker in patients with acute necrotizing pancreatitis (ANP) complicated by acute lung injury. Sprague-Dawley rats were randomly
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