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Christina M Birch et al.
Scientific reports, 5, 11347-11347 (2015-07-02)
Plasmodium falciparum malaria parasites invade and remodel human red blood cells (RBCs) by trafficking parasite-synthesized proteins to the RBC surface. While these proteins mediate interactions with host cells that contribute to disease pathogenesis, the infected RBC surface proteome remains poorly
Yong Yang et al.
Journal of cardiovascular pharmacology, 65(6), 571-578 (2015-01-31)
Ca is a crucial factor in the regulation of smooth muscle contraction. Store-operated Ca entry (SOCE) is one pathway that mediates Ca influx and smooth muscle contraction. Vessel contraction function usually alters with aging to cause severe vascular-related diseases. However
Qian Liang et al.
Electrophoresis, 36(5), 731-736 (2014-11-26)
Although the existing theories have predicted enhancement of electrophoretic mobility of microparticles near a solid wall, the relevant experimental studies are rare. This is mainly due to difficulties in experimentally controlling and measuring particle-wall separations under dynamic electrophoretic conditions. This
In-Sun Choi et al.
Neuropharmacology, 93, 94-102 (2015-02-07)
Purine nucleotides, such as ATP and ADP, activate ionotropic P2X and metabotropic P2Y receptors to regulate neurotransmitter release in the peripheral as well as central nervous system. Here we report another type of ATP-induced presynaptic modulation of glutamate release in
Jenni Lahtela et al.
Disease models & mechanisms, 8(4), 393-401 (2015-02-26)
Treatment of non-small cell lung cancer (NSCLC) is based on histological analysis and molecular profiling of targetable driver oncogenes. Therapeutic responses are further defined by the landscape of passenger mutations, or loss of tumor suppressor genes. We report here a
Marko A Popovic et al.
Nature communications, 6, 8436-8436 (2015-10-06)
Thousands of dendritic spines on individual neurons process information and mediate plasticity by generating electrical input signals using a sophisticated assembly of transmitter receptors and voltage-sensitive ion channel molecules. Our understanding, however, of the electrical behaviour of spines is limited
Anca M Paşca et al.
Nature methods, 12(7), 671-678 (2015-05-26)
The human cerebral cortex develops through an elaborate succession of cellular events that, when disrupted, can lead to neuropsychiatric disease. The ability to reprogram somatic cells into pluripotent cells that can be differentiated in vitro provides a unique opportunity to
Kate L Lee et al.
Endocrinology, 156(3), 1194-1199 (2014-12-30)
The search for an islet β-cell growth factor has been a key objective in recent diabetes research, because the ability to regenerate and/or protect the functioning β-cell population in patients could result in a great advancement for diabetes treatment. IGF-I
Megan Kelly et al.
mBio, 6(2) (2015-03-26)
The malaria parasite Plasmodium falciparum contains a nonphotosynthetic plastid organelle that possesses plant-like metabolic pathways. Plants use the plastidial isoprenoid biosynthesis pathway to produce volatile odorants, known as terpenes. In this work, we describe the volatile chemical profile of cultured
Lester H Lambert et al.
Infection and immunity, 82(11), 4842-4853 (2014-08-27)
Clinical immunity to pregnancy associated-malaria (PAM) in multigravida women has been attributed to antibodies that recognize VAR2CSA on the infected erythrocyte (IE) surface. The size and complexity of VAR2CSA have focused efforts on selecting one or more of its six
Maren Lindner et al.
Brain : a journal of neurology, 138(Pt 7), 1875-1893 (2015-04-25)
Remyelination failure plays an important role in the pathophysiology of multiple sclerosis, but the underlying cellular and molecular mechanisms remain poorly understood. We now report actively demyelinating lesions in patients with multiple sclerosis are associated with increased glial expression of
Shen-An Hwang et al.
International journal of immunopathology and pharmacology, 28(4), 452-468 (2015-09-01)
Lactoferrin (LF), an iron binding protein with immune modulatory activities, has adjuvant activity to enhance vaccine efficacy. Tuberculosis (TB) is a pulmonary disease caused by the pathogen Mycobacterium tuberculosis (MTB). Progressive TB disease is clinically defined by damaging pulmonary pathology
Leobardo Manuel Gómez-Oliván et al.
Environmental monitoring and assessment, 186(11), 7259-7271 (2014-07-10)
Toxicity in natural ecosystems is usually not due to exposure to a single substance, but is rather the result of exposure to mixtures of toxic substances. Knowing the effects of contaminants as a mixture compared to their effects in isolated
Darin C Bennett et al.
Poultry science, 94(9), 2288-2296 (2015-07-29)
Traditionally, native Australian aborigines have used emu oil for the treatment of inflammation and to accelerate wound healing. Studies on mice suggest that topically applied emu oil may have anti-inflammatory properties and may promote wound healing. We investigated the effects
Damião Pergentino de Sousa et al.
Natural product communications, 10(11), 1893-1896 (2016-01-12)
Aromatic plants produce volatile substances with high therapeutic potential. In view of the need for new respiratory and cardiovascular system pharmacological agents, the present study reports on the spasmolytic activity of two enantiomers of carvone and limonene, constituents of essential
Girish Ramachandran et al.
PLoS neglected tropical diseases, 9(1), e3394-e3394 (2015-01-09)
Invasive non-typhoidal Salmonella (iNTS) are an important cause of septicemia in children under the age of five years in sub-Saharan Africa. A novel genotype of Salmonella enterica subsp. enterica serovar Typhimurium (multi-locus sequence type [ST] 313) circulating in this geographic
J Matos et al.
Environmental research, 143(Pt B), 123-129 (2015-09-28)
This study aimed to identify the benefit and risk associated with raw and cooked blue shark consumption taking into account the bioaccessibility of Se, Hg and MeHg, by using in vitro digestion method. Selenium, Hg and MeHg levels were higher
I A Szijártó et al.
Free radical research, 48(7), 749-757 (2014-03-19)
The oxidative state has been implicated in the signaling of various vasomotor functions, yet its role regarding the vasomotor action of insulin is less known. To investigate the insulin-evoked relaxations of consecutive arterial segments of different oxidative state and the
Susmita Kaushik et al.
Nature cell biology, 17(6), 759-770 (2015-05-12)
Chaperone-mediated autophagy (CMA) selectively degrades a subset of cytosolic proteins in lysosomes. A potent physiological activator of CMA is nutrient deprivation, a condition in which intracellular triglyceride stores or lipid droplets (LDs) also undergo hydrolysis (lipolysis) to generate free fatty
Weiwei Zhu et al.
Journal of immunology (Baltimore, Md. : 1950), 194(10), 4825-4835 (2015-04-05)
Viral infections of the epididymis may impair male fertility and spread sexually transmitted pathogens. The innate antiviral immune responses in the epididymis have yet to be intensively investigated. This study found that mouse epididymal epithelial cells (EECs) constitutively express several
Sodium bicarbonate--the swings and roundabouts will not stop without randomized evidence.
Burkhard Simma et al.
Critical care medicine, 41(9), 2242-2243 (2013-08-28)
Noriko Koganezawa et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(48), 15860-15874 (2015-12-04)
The postrhinal cortex (POR) provides substantial input to the entorhinal cortex, mainly targeting superficial layers of the medial entorhinal cortex (MEC). Major inputs to POR originate in the visual and parietal cortex, thus providing neurons in MEC with a subset
Keita Takahashi et al.
Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 201(4), 385-394 (2014-12-08)
Accessory lobes are protrusions located at the lateral sides of the spinal cord of chicks and it has been proposed that they play a role as a sensory organ for equilibrium during walking. We have reported that functional neurons exist
Erin E Schirtzinger et al.
Virology, 476, 54-60 (2014-12-22)
RNA interference (RNAi) is the major defense of many arthropods against arthropod-borne RNA viruses (arboviruses), but the role of RNAi in vertebrate immunity to arboviruses is not clear. RNA viruses can trigger RNAi in vertebrate cells, but the vertebrate interferon
Hongbo Jiang et al.
Annals of biomedical engineering, 42(8), 1717-1728 (2014-04-30)
Strain/stress induced tissue softening is usually referred to irreversible softening. The aim of this study was to investigate whether stress softening in rat esophagus is reversible after potassium chloride (KCl) induced contraction. Three series of inflation-deflation loadings were carried out
Christopher R So et al.
ACS nano, 9(6), 5782-5791 (2015-05-15)
The recognition of atomically distinct surface features by adsorbed biomolecules is central to the formation of surface-templated peptide or protein nanostructures. On mineral surfaces such as calcite, biomolecular recognition of, and self-assembly on, distinct atomic kinks and steps could additionally
Rana N El-Danaf et al.
Neural development, 10, 19-19 (2015-07-16)
The dorsal lateral geniculate nucleus (dLGN) of the mouse has been an important experimental model for understanding thalamic circuit development. The developmental remodeling of retinal projections has been the primary focus, however much less is known about the maturation of
Chen Su et al.
Molecular brain, 8, 46-46 (2015-08-12)
A variety of pain conditions have been found to be associated with depressed mood in clinical studies. Depression-like behaviors have also been described in animal models of persistent or chronic pain. In rodent chronic neuropathic pain models, elevated levels of
Christian Wölk et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 16(10), 2115-2126 (2015-05-12)
The aggregation behavior of a cationic lipid, N-[6-amino-1-oxo-1-(N-tetradecylamino)hexan-(2S)-2-yl]-N'-{2-[N,N-bis(2-aminoethyl)amino]ethyl}-2,2-ditetradecylpropandiamide (DiTT4), is investigated in aqueous dispersions at different pH values (5, 7.3, and 10). An unusual aggregation behavior is observed whereby DiTT4 forms bilayer structures at pH 10 and 7.3. At pH
Kim E Light et al.
Cerebellum (London, England), 14(4), 398-412 (2015-02-11)
Ethanol exposures during the early postnatal period of the rat result in significant death of Purkinje cells (PCs). The magnitude, time-course, and lobular specificity of PC death have been well characterized in several studies. Additionally, significant reduction of climbing fiber
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