S4701

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Expression of the Reverse Transcriptase Domain of Telomerase Reverse Transcriptase Induces Lytic Cellular Response in DNA-Immunized Mice and Limits Tumorigenic and Metastatic Potential of Murine Adenocarcinoma 4T1 Cells.

Juris Jansons et al.

Vaccines, 8(2) (2020-06-24)

Telomerase reverse transcriptase (TERT) is a classic tumor-associated antigen overexpressed in majority of tumors. Several TERT-based cancer vaccines are currently in clinical trials, but immune correlates of their antitumor activity remain largely unknown. Here, we characterized fine specificity and lytic

Multiatlas approach with local registration goodness weighting for MRI-based electron density mapping of head and neck anatomy.

Reza Farjam et al.

Medical physics, 44(7), 3706-3717 (2017-04-27)

The growing use of magnetic resonance imaging (MRI) as a substitute for computed tomography-based treatment planning requires the development of effective algorithms to generate electron density maps for treatment planning and patient setup verification. The purpose of this work was

Oral immunotherapy tolerizes mice to enzyme replacement therapy for Morquio A syndrome.

Angela C Sosa et al.

The Journal of clinical investigation, 130(3), 1288-1300 (2019-11-20)

Immune response to therapeutic enzymes poses a detriment to patient safety and treatment outcome. Enzyme replacement therapy (ERT) is a standard therapeutic option for some types of mucopolysaccharidoses, including Morquio A syndrome caused by N-acetylgalactosamine-6-sulfate sulfatase (GALNS) deficiency. Current protocols

Slow-Binding Inhibition of Tyrosinase by Ecklonia cava Phlorotannins.

Jang Hoon Kim et al.

Marine drugs, 17(6) (2019-06-19)

Tyrosinase inhibitors improve skin whitening by inhibiting the formation of melanin precursors in the skin. The inhibitory activity of seven phlorotannins (1-7), triphlorethol A (1), eckol (2), 2-phloroeckol (3), phlorofucofuroeckol A (4), 2-O-(2,4,6-trihydroxyphenyl)-6,6'-bieckol (5), 6,8'-bieckol (6), and 8,8'-bieckol (7), from

The effect of classical swine fever virus NS5A and NS5A mutants on oxidative stress and inflammatory response in swine testicular cells.

Wang Dong et al.

Research in veterinary science, 112, 89-96 (2017-02-01)

Infection with classical swine fever virus (CSFV) results in highly significant economic losses; this infection is characterized by being highly contagious and accompanied by hyperthermia and systemic bleeding. Oxidative stress (OS) plays a critical role in the pathological process of

A Moderate Interleukin-6 Reduction, Not a Moderate Weight Reduction, Improves the Serum Iron Status in Diet-Induced Weight Loss with Fish Oil Supplementation.

Shih-Yi Huang et al.

Molecular nutrition & food research, 62(20), e1800243-e1800243 (2018-07-28)

Whether moderate weight loss or a reduction in IL-6 improves the serum iron status in overweight (OW) and obese adults supplemented with or without fish oil is explored. In total, 93 OW/obese Taiwanese adults with ≥2 metabolic components are randomized

The Association of Sleep Apnea and Cardiorespiratory Fitness With Long-Term Major Cardiovascular Events.

Maria Irene Barillas-Lara et al.

Mayo Clinic proceedings, 96(3), 636-647 (2021-03-07)

To determine the risk of long-term major adverse cardiovascular events (MACE) when sleep-disordered breathing (SDB) and decreased cardiorespiratory fitness (CRF) co-occur. We included consecutive patients who underwent symptom-limited cardiopulmonary exercise tests between January 1, 2005, and January 1, 2010, followed

Universal structure of dark matter haloes over a mass range of 20 orders of magnitude.

J Wang et al.

Nature, 585(7823), 39-42 (2020-09-04)

Cosmological models in which dark matter consists of cold elementary particles predict that the dark halo population should extend to masses many orders of magnitude below those at which galaxies can form1-3. Here we report a cosmological simulation of the

Quantitative Evaluation of Growth Plates around the Knees of Adolescent Soccer Players by Diffusion-Weighted Magnetic Resonance Imaging.

Zmago Krajnc et al.

BioMed research international, 2015, 482017-482017 (2015-12-23)

To quantitatively evaluate growth plates around the knees in adolescent soccer players utilizing the diffusion-weighted MR imaging (DWI). The knees and adjacent growth plates of eleven 14-year-old male soccer players were evaluated by MRI before (end of season's summer break)

Plant species richness and productivity determine the diversity of soil fungal guilds in temperate coniferous forest and bog habitats.

Indrek Hiiesalu et al.

Molecular ecology, 26(18), 4846-4858 (2017-07-25)

Fungi have important roles as decomposers, mycorrhizal root symbionts and pathogens in forest ecosystems, but there is limited information about their diversity and composition at the landscape scale. This work aimed to disentangle the factors underlying fungal richness and composition

Topical cyclodextrin reduces amyloid beta and inflammation improving retinal function in ageing mice.

Jaimie Hoh Kam et al.

Experimental eye research, 135, 59-66 (2015-04-30)

Retinal ageing results in chronic inflammation, extracellular deposition, including that of amyloid beta (Aβ) and declining visual function. In humans this can progress into age-related macular degeneration (AMD), which is without cure. Therapeutic approaches have focused on systemic immunotherapies without

Multiparametric mapping of white matter microstructure in catatonia.

Jakob Wasserthal et al.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 45(10), 1750-1757 (2020-05-06)

Catatonia is characterized by motor, affective and behavioral abnormalities. To date, the specific role of white matter (WM) abnormalities in schizophrenia spectrum disorders (SSD) patients with catatonia is largely unknown. In this study, diffusion magnetic resonance imaging (dMRI) data were

Monotherapy With Prasugrel After Dual-Antiplatelet Therapy for Japanese Percutaneous Coronary Intervention Patients With High Bleeding Risk　- A Prospective Cohort Study (PENDULUM mono Study).

Masato Nakamura et al.

Circulation journal : official journal of the Japanese Circulation Society, 85(1), 27-36 (2020-11-10)

The risks of bleeding and cardiovascular events in high bleeding risk (HBR) Japanese patients undergoing percutaneous coronary intervention (PCI) while receiving single-antiplatelet therapy (SAPT) remains unknown. We aimed to evaluate the frequency of bleeding and cardiovascular events associated with prasugrel

Exposure to pollutants altered glucocorticoid signaling and clock gene expression in female mice. Evidence of tissue- and sex-specificity.

Nathalie Vega et al.

Chemosphere, 262, 127841-127841 (2020-08-14)

Environmental pollutants suspected of disrupting the endocrine system are considered etiologic factors in the epidemic of metabolic disorders. As regulation of energy metabolism relies on the integrated action of a large number of hormones, we hypothesized that certain chemicals could

Design and rationale of the Management of High Bleeding Risk Patients Post Bioresorbable Polymer Coated Stent Implantation With an Abbreviated Versus Standard DAPT Regimen (MASTER DAPT) Study.

Enrico Frigoli et al.

American heart journal, 209, 97-105 (2019-02-01)

The optimal duration of antiplatelet therapy in high-bleeding risk (HBR) patients with coronary artery disease treated with newer-generation drug-eluting bioresorbable polymer-coated stents remains unclear. MASTER DAPT (clinicaltrial.govNCT03023020) is an investigator-initiated, open-label, multicenter, randomized controlled trial comparing an abbreviated versus a

Comparison of short-term clinical outcomes of proximal versus nonproximal lesion location in patients treated with primary percutaneous coronary intervention for ST-elevation myocardial infarction: The PROXIMITI study.

Samer Noaman et al.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 93(1), 32-40 (2018-07-19)

The objective of this study was to investigate the association of proximal and nonproximal location of culprit coronary lesions with clinical outcomes of patients presenting with ST-elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (PCI). Proximal culprit lesion

Correlation of Cerebral Microbleed Distribution to Amyloid Burden in Patients with Primary Intracerebral Hemorrhage.

Hsin-Hsi Tsai et al.

Scientific reports, 7, 44715-44715 (2017-03-18)

The underlying pathology of cerebral microbleeds (CMBs) with mixed lobar and deep distribution remains contentious. The aim of this study was to correlate CMBs distribution to β-amyloid burden in patients with primary intracerebral hemorrhage (ICH). Fourty-seven ICH patients underwent magnetic

TNFα and IL-1β but not IL-18 Suppresses Hippocampal Long-Term Potentiation Directly at the Synapse.

G Aleph Prieto et al.

Neurochemical research, 44(1), 49-60 (2018-04-06)

CNS inflammatory responses are linked to cognitive impairment in humans. Research in animal models supports this connection by showing that inflammatory cytokines suppress long-term potentiation (LTP), the best-known cellular correlate of memory. Cytokine-induced modulation of LTP has been previously studied

New Insights into the Inhibition Mechanism of Betulinic Acid on α-Glucosidase.

Huafang Ding et al.

Journal of agricultural and food chemistry, 66(27), 7065-7075 (2018-06-15)

Betulinic acid (BA), an important pentacyclic triterpene widely distributed in many foods, possesses high antidiabetic activity. In this study, BA was found to exhibit stronger inhibition of α-glucosidase than acarbose with an IC50 value of (1.06 ± 0.02) × 10-5

Imaging of PD-L1 in single cancer cells by SERS-based hyperspectral analysis.

Wei Zhang et al.

Biomedical optics express, 11(11), 6197-6210 (2020-12-08)

We developed a hyperspectral imaging tool based on surface-enhanced Raman spectroscopy (SERS) probes to determine the expression level and visualize the distribution of PD-L1 in individual cells. Electron-microscopic analysis of PD-L1 antibody - gold nanorod conjugates demonstrated binding the cell

Insight in genome-wide association of metabolite quantitative traits by exome sequence analyses.

Ayşe Demirkan et al.

PLoS genetics, 11(1), e1004835-e1004835 (2015-01-09)

Metabolite quantitative traits carry great promise for epidemiological studies, and their genetic background has been addressed using Genome-Wide Association Studies (GWAS). Thus far, the role of less common variants has not been exhaustively studied. Here, we set out a GWAS

Bizionia berychis sp. nov., isolated from intestinal tract of a splendid alfonsino (Beryx splendens).

Young-Ok Kim et al.

International journal of systematic and evolutionary microbiology, 68(4), 1227-1232 (2018-02-23)

A Gram-stain-negative, non-motile, aerobic and rod-shaped bacterial strain, designated RA3-3-1T, was isolated from splendid alfonsino (Beryxsplendens) collected from the North Pacific Ocean. Strain RA3-3-1T grew optimally at 25 °C, at pH 7.0-8.0 and in the presence of 1.0-3.0 % (w/v) NaCl. The

Prediction of Unexpected N2 Disease Associated With Clinical T1-2N0-1M0 Non-Small-Cell Lung Cancer.

Atsushi Kamigaichi et al.

Clinical lung cancer, 22(2), 120-126 (2021-01-25)

Despite the recent development of radiologic mediastinal staging modality, unexpected mediastinal lymph node metastasis still occurs. Preoperative accurate nodal staging is important to determine the optimal treatment. Therefore, this study aimed to identify predictors of unexpected N2 disease in non-small-cell

Purification and Characterization of Native and Vaccine Candidate Mutant Enterotoxigenic Escherichia coli Heat-Stable Toxins.

Morten L Govasli et al.

Toxins, 10(7) (2018-07-05)

Enterotoxigenic Escherichia coli (ETEC), which secretes the heat-stable toxin (ST) is among the four most important enteropathogens that cause moderate-to-severe diarrhea in children in low- and middle-income countries. ST is an intestinal molecular antagonist causing diarrhea and hence an attractive

A Chinese 4-herb formula, Yiqi-Huoxue granule, alleviates H2O2-induced apoptosis by upregulating uncoupling protein 2 in H9c2 cells.

Hong Wu et al.

Phytomedicine : international journal of phytotherapy and phytopharmacology, 53, 171-181 (2019-01-23)

Although the protective effects of Yiqi-Huoxue granule (YQHX), a Chinese 4-herb formula, on patients with ischemic heart diseases are related to the attenuation of oxidative stress injury, the mechanism(s) underlying these actions remains poorly understood. Our aim was to investigate

Crossover study of amputee stair ascent and descent biomechanics using Genium and C-Leg prostheses with comparison to non-amputee control.

Derek J Lura et al.

Gait & posture, 58, 103-107 (2017-08-02)

This study was a randomized crossover of stair ambulation of Transfemoral Amputees (TFAs) using the Genium and C-Leg prosthetic knees. TFAs typically have difficulty ascending and descending stairs, limiting community mobility. The objective of this study was to determine the

Geographic risk of general and abdominal obesity and related determinants in Iranian children and adolescents: CASPIAN-IV Study.

Maryam Yazdi et al.

Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit, 26(12), 1532-1538 (2020-12-24)

Obesity, as a risk factor for many noncommunicable diseases, is a common public health problem in developed and developing countries. Among Iranian children and adolescents, the prevalence of being overweight has increased by almost 50% in the past two decades.

1HNMR-Based metabolomic profiling method to develop plasma biomarkers for sensitivity to chronic heat stress in growing pigs.

Samir Dou et al.

PloS one, 12(11), e0188469-e0188469 (2017-11-28)

The negative impact of heat stress (HS) on the production performances in pig faming is of particular concern. Novel diagnostic methods are needed to predict the robustness of pigs to HS. Our study aimed to assess the reliability of blood

Update to Practice Standards for Electrocardiographic Monitoring in Hospital Settings: A Scientific Statement From the American Heart Association.

Kristin E Sandau et al.

Circulation, 136(19), e273-e344 (2017-10-05)

This scientific statement provides an interprofessional, comprehensive review of evidence and recommendations for indications, duration, and implementation of continuous electro cardiographic monitoring of hospitalized patients. Since the original practice standards were published in 2004, new issues have emerged that need

Influence of various bleaching regimes on surface roughness of resin composite and ceramic dental biomaterials.

Saad Qasim et al.

Technology and health care : official journal of the European Society for Engineering and Medicine, 24(2), 153-161 (2015-10-21)

Bleaching agents are commonly used in dentistry for treating the discolored teeth. A number of biomaterials and methods are in clinical applications. The major aim of this study was to evaluate the effects of two different bleaching agents on the

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