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S A Ferraro et al.
Neurotoxicology, 53, 108-114 (2016-01-17)
Epidemiological studies have shown a positive correlation between environmental particulate matter and adverse health effects. In particular, residual oil fly ash (ROFA) induces inflammation and reactive oxygen species (ROS), exerting not only local, but also systemic adverse effects. Previously, in
Statin treatment and diabetes.
Richard L Kennedy et al.
Journal of the American College of Cardiology, 61(18), 1933-1934 (2013-03-19)
Mario J N M Ouwens et al.
Current medical research and opinion, 31(12), 2273-2285 (2015-09-24)
To assess the efficacy of fenofibrate and statin dual therapy versus a double or equivalent dose of statin monotherapy. A systematic literature search and meta-analysis was performed for publications before 1 January 2014 in MEDLINE, Embase, and BIOSIS Previews, among
Thijs van der Vaart et al.
The Lancet. Neurology, 12(11), 1076-1083 (2013-10-05)
Neurofibromatosis type 1 is a common genetic disorder characterised by neurocutaneous manifestations and cognitive and behavioural problems. Statins were shown to reduce analogous learning deficits in a mouse model of the disease, but a short-term trial in humans was inconclusive.
Annalisa Bonifacio et al.
Biochimica et biophysica acta, 1853(8), 1841-1849 (2015-04-29)
Statins are drugs that lower blood cholesterol levels and reduce cardiovascular morbidity and mortality. They are generally well-tolerated, but myopathy is a potentially severe adverse reaction of these compounds. The mechanisms by which statins induce myotoxicity are not completely understood
Chang-Sook Hong et al.
Journal of extracellular vesicles, 9(1), 1800979-1800979 (2020-09-19)
Most patients with acute myeloid leukaemia (AML) experience disease recurrence after chemotherapy largely due to the development of drug resistance. Small extracellular vesicles (sEVs) are known to play a significant role in leukaemia drug resistance by delivery of anti-apoptotic proteins
Luiz Sergio F Carvalho et al.
Atherosclerosis, 237(2), 777-783 (2014-12-03)
Recent data suggests that cholesteryl ester transfer protein (CETP) activity may interact with acute stress conditions via inflammatory-oxidative response and thrombogenesis. We investigated this assumption in patients with ST-elevation myocardial infarction (STEMI). Consecutive patients with STEMI (n = 116) were
Theodosios D Filippatos et al.
Expert opinion on pharmacotherapy, 12(12), 1945-1958 (2011-07-09)
Statin use results in a significant reduction of cardiovascular disease (CVD) risk. However, patients still have residual CVD risk, even if they are receiving optimal statin treatment. This review, based on a Pubmed/Scopus search, discusses the available evidence regarding the
Xin Yang et al.
Clinical and experimental pharmacology & physiology, 41(12), 950-955 (2014-08-15)
The 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) pathway is an important metabolic route that is present in almost every organism. However, whether HMGCR affects the expression of interferon (IFN)-responsive genes is unclear. In the present study, expression levels of IFN-responsive genes were
Murat Kesim et al.
JPMA. The Journal of the Pakistan Medical Association, 62(11), 1187-1191 (2013-07-23)
To study the effect of simvastatin on picrotoxin-induce seizures in mice in order to understand the impact of gabaergic system on neuronal cell death. The study was held between July and September 2011, at the Karadeniz Technical University in Trabzon
Masanobu Tsubaki et al.
American journal of cancer research, 5(10), 3186-3197 (2015-12-23)
Metastatic melanoma is a life-threatening disease for which no effective treatment is currently available. In melanoma cells, Rho overexpression promotes invasion and metastasis. However, the effect of statins on spontaneous metastasis and tumor growth remains unclear. In the present study
[Statins after drug discontinuation are usually well tolerated].
Johann Steurer
Praxis, 102(13), 813-813 (2013-06-19)
Helmut Steinberg et al.
Vascular health and risk management, 9, 273-282 (2013-06-14)
The risk of death due to heart disease and stroke is up to four times higher in individuals with diabetes compared to individuals without diabetes. Most guidelines that address treatment of dyslipidemia in patients with diabetes consider diabetes a cardiovascular
Teresa Neuparth et al.
Aquatic toxicology (Amsterdam, Netherlands), 155, 337-347 (2014-08-05)
Simvastatin (SIM), a hypocholesterolaemic drug, is among the most widely used pharmaceuticals worldwide and is therefore of emerging environmental concern. Despite the ubiquitous nature of SIM in the aquatic ecosystems, significant uncertainties exist about sublethal effects of the drug in
Roger A Vaughan et al.
Journal of physiology and biochemistry, 71(4), 679-689 (2015-09-25)
Exercise offers several benefits for health, including increased lean body mass and heightened energy expenditure, which may be partially attributable to secretory factors known as myokines. Irisin, a recently identified myokine, was shown to increase metabolic rate and mitochondrial content
Parvaneh Mehrbod et al.
International journal of molecular medicine, 34(1), 61-73 (2014-05-03)
Influenza A virus is one of the most important health risks that lead to significant respiratory infections. Continuous antigenic changes and lack of promising vaccines are the reasons for the unsuccessful treatment of influenza. Statins are pleiotropic drugs that have
Simvastatin in moderate-to-severe COPD.
Gerard J Criner et al.
The New England journal of medicine, 371(10), 970-971 (2014-09-04)
Carol P Y Lau et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 38(2), 297-310 (2019-09-01)
Giant cell tumor of bone (GCTB) is a locally aggressive destructive bone lesion. The management of pulmonary metastasis and local recurrence after the surgical treatment of GCTB remains a challenge. Pathologically, stromal cells in GCTB are known as primary neoplastic
Dana Cramariuc et al.
Heart (British Cardiac Society), 101(3), 209-214 (2014-10-11)
Women with severe aortic valve stenosis (AS) have better LV systolic function and more concentric LV geometry than their male counterparts. However, sex differences in cardiovascular (CV) outcome during progression of AS have not been reported from a longitudinal prospective
Gemma Mestres et al.
Materials science & engineering. C, Materials for biological applications, 58, 88-96 (2015-10-20)
Calcium phosphate cements are synthetic bone graft substitutes able to set at physiological conditions. They can be applied by minimally invasive surgery and can also be used as drug delivery systems. Consequently, the drug release pattern from the cement paste
Daniel Sliż et al.
Kardiologia polska, 71(3), 253-259 (2013-04-12)
According to epidemiological studies, dyslipidaemia is the commonest risk factor of atherosclerosis in the Polish population. It is estimated that 18 million adult Poles are affected by dyslipidaemia. The purpose of this study was to evaluate the quality of the
Koichi Yoshimura et al.
International journal of molecular sciences, 16(5), 11213-11228 (2015-05-21)
HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme A) reductase inhibitors (statins) have been suggested to attenuate abdominal aortic aneurysm (AAA) growth. However, the effects of statins in human AAA tissues are not fully elucidated. The aim of this study was to investigate the direct effects
Veluchamy A Barathi et al.
Investigative ophthalmology & visual science, 55(1), 460-468 (2014-01-09)
To determine the effect of a statin (simvastatin) on the ultrastructure and function of the RPE, Bruch's membrane (BM), and photoreceptor interface in a high-fat atherogenic mouse model of thickened BM. Wild-type C57BL/6 mice (6-weeks old) were divided into three
A Marot et al.
Acta clinica Belgica, 66(2), 134-136 (2011-06-03)
Myopathy, including rhabdomyolysis, is a well-known, albeit rare complication of statin therapy. Predisposing factors include comorbidities and the concomitant use of cytochrome P-450 (CYP) 3A4 inhibitors. We report a case of severe simvastatin-induced rhabdomyolysis triggered by the addition of amiodarone
Elizabeth Theusch et al.
Pharmacogenetics and genomics, 24(10), 492-500 (2014-08-05)
Statins stimulate transcription of proprotein convertase subtilisin/kexin type 9 (PCSK9), a negative regulator of the low-density lipoprotein receptor, thus blunting the cholesterol-lowering effects of statin treatment. Although there is interindividual variation in PCSK9 statin response, little is known about ancestral
Ying Zhang et al.
The American journal of sports medicine, 47(3), 729-739 (2019-01-23)
Tendons and ligaments are joined to bone in a specialized interface that transmits force from muscle to bone and permits body movement. Tendon/ligament injuries always occur in the interface areas, and injured tendons/ligaments have a limited healing response because the
Vanessa F Langness et al.
Molecular biology of the cell, 32(3), 247-259 (2020-12-10)
Amyloid beta (Aβ) is a major component of amyloid plaques, which are a key pathological hallmark found in the brains of Alzheimer's disease (AD) patients. We show that statins are effective at reducing Aβ in human neurons from nondemented control
[Pharmacogenetic analysis can predict adverse effects of statins].
Daniel Garwicz et al.
Lakartidningen, 110(19-20), 951-952 (2013-06-12)
Noemí Serra et al.
PloS one, 10(7), e0133875-e0133875 (2015-07-25)
The composition and structure of the extracellular matrix (ECM) in the vascular wall and in the atherosclerotic plaque are important factors that determine plaque stability. Statins can stabilize atherosclerotic plaques by modulating ECM protein expression. Fibulins are important components of
Clinical reasoning: a 62-year-old man with right wrist drop.
Giovanni Cirillo et al.
Neurology, 81(11), e81-e84 (2013-09-11)
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