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显示 1-30 共 164 条结果 关于 "S7049" 范围 论文
Paola Bruni et al.
Handbook of experimental pharmacology, (216)(216), 457-467 (2013-04-09)
Studies performed in the last fifteen years have clearly established that the bioactive sphingolipid sphingosine 1-phosphate (S1P) affects various different biological properties of myogenic precursor cells as well as physiological features of adult skeletal muscle. Noticeably, in myogenic precursor cells
H Li et al.
Cell death & disease, 4, e830-e830 (2013-10-05)
Asymmetric dimethylarginine (ADMA) is synthesized by protein arginine methyltransferases during methylation of protein arginine residues and released into blood upon proteolysis. Higher concentrations of ADMA in blood have been observed in patients with metabolic diseases and certain cancers. However, the
Paolo Neviani et al.
The Journal of clinical investigation, 123(10), 4144-4157 (2013-09-04)
The success of tyrosine kinase inhibitors (TKIs) in treating chronic myeloid leukemia (CML) depends on the requirement for BCR-ABL1 kinase activity in CML progenitors. However, CML quiescent HSCs are TKI resistant and represent a BCR-ABL1 kinase-independent disease reservoir. Here we
Dianer Yang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(49), 16467-16481 (2014-12-05)
Intrauterine infection (chorioamnionitis) aggravates neonatal hypoxic-ischemic (HI) brain injury, but the mechanisms linking systemic inflammation to the CNS damage remain uncertain. Here we report evidence for brain influx of T-helper 17 (TH17)-like lymphocytes to coordinate neuroinflammatory responses in lipopolysaccharide (LPS)-sensitized
Anneliese O Speak et al.
Blood, 123(1), 51-60 (2013-11-16)
Niemann-Pick type C (NPC) is a neurodegenerative lysosomal storage disorder caused by defects in the lysosomal proteins NPC1 or NPC2. NPC cells are characterized by reduced lysosomal calcium levels and impaired sphingosine transport from lysosomes. Natural killer (NK) cells kill
Mei-Hong Li et al.
Pediatric blood & cancer, 60(9), 1418-1423 (2013-05-25)
Neuroblastoma (NB) is the most common extra-cranial solid tumor in childhood. Poor outcomes for children with advanced disease underscore the need for novel therapeutic strategies. FTY720, an immunomodulating drug approved for multiple sclerosis, has been investigated in oncology with promising
Clemens Warnke et al.
Neurology, 83(23), 2153-2157 (2014-11-02)
To assess whether pretreatment-lymphocyte counts, treatment before fingolimod, age, sex, or body mass index (BMI) affects the risk of fingolimod-induced lymphopenia in patients with relapsing-remitting multiple sclerosis (RRMS). Data were obtained from a German multicenter, single-arm, open-label study of patients
Management of fingolimod-associated macular edema.
Jeanie Chui et al.
JAMA ophthalmology, 131(5), 694-696 (2013-03-30)
Katrin Sobel et al.
The Journal of biological chemistry, 288(21), 14839-14851 (2013-04-17)
Synthetic sphingosine 1-phosphate receptor 1 modulators constitute a new class of drugs for the treatment of autoimmune diseases. Sphingosine 1-phosphate (S1P) signaling, however, is also involved in the development of fibrosis. Using normal human lung fibroblasts, we investigated the induction
Arthur S Leitzke et al.
Stroke, 44(12), 3587-3590 (2013-10-24)
This study investigated whether isoflurane ameliorates neurological sequelae after germinal matrix hemorrhage (GMH) through activation of the cytoprotective sphingosine kinase/sphingosine-1-phosphate receptor/Akt pathway. GMH was induced in P7 rat pups by intraparenchymal infusion of bacterial collagenase (0.3 U) into the right
Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the
Yang Liu et al.
The Journal of pathology, 230(4), 365-376 (2013-07-11)
The hepatic growth factor hepatopoietin Cn (HPPCn) prevents liver injury induced by carbon tetrachloride in rats. Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid produced by sphingosine kinase (SphK). S1P and S1P receptors (S1PRs) are involved in liver fibrogenesis and oxidative
Patrick Münzer et al.
American journal of physiology. Cell physiology, 307(10), C920-C927 (2014-09-19)
Sphingosine 1-phosphate (S1P) is a powerful regulator of platelet formation. Enzymes generating S1P include sphingosine kinase 1. The present study thus explored the role of sphingosine kinase 1 in platelet formation and function. Activation-dependent platelet integrin αIIbβ3 activation and secretion
Young-Il Kim et al.
Molecular and cellular biology, 34(24), 4368-4378 (2014-10-15)
Antimicrobial peptides (AMP) are ubiquitous innate immune elements in epithelial tissues. We recently discovered that a signaling lipid, the ceramide metabolite sphingosine-1-phosphate (S1P), regulates production of a major AMP, cathelicidin antimicrobial peptide (CAMP), in response to a subtoxic level of
Daniel Plano et al.
Journal of medicinal chemistry, 57(13), 5509-5524 (2014-01-30)
Sphingosine kinase (SphK) is an oncogenic lipid kinase that regulates the sphingolipid metabolic pathway that has been shown to play a role in numerous hyperproliferative/inflammatory diseases. The SphK isoforms (SphK1 and SphK2) catalyze the conversion of the proapoptotic substrate d-erythrosphingosine
Susannah H Kassmer et al.
Nature communications, 6, 8565-8565 (2015-10-13)
The colonial ascidian Botryllus schlosseri continuously regenerates entire bodies in an asexual budding process. The germ line of the newly developing bodies is derived from migrating germ cell precursors, but the signals governing this homing process are unknown. Here we
Georg Pilz et al.
Neurology, 81(19), 1654-1658 (2013-10-08)
To report about a possible association between fingolimod treatment and tumefactive demyelinating lesions (TDL) as seen in a patient developing repeated TDL on continued fingolimod therapy. We performed serial clinical and radiologic assessments and immunophenotyping of blood and CSF immune
Huang Guo et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(14), 6181-6190 (2013-04-05)
Activated protein C (APC) is a protease with anticoagulant and cell-signaling activities. In the CNS, APC and its analogs with reduced anticoagulant activity but preserved cell signaling activities, such as 3K3A-APC, exert neuroprotective, vasculoprotective, and anti-inflammatory effects. Murine APC promotes
Jessie W Yester et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(12), 4853-4865 (2015-08-08)
The neuroinflammation associated with multiple sclerosis involves activation of astrocytes that secrete and respond to inflammatory mediators such as IL-1. IL-1 stimulates expression of many chemokines, including C-C motif ligand (CCL) 5, that recruit immune cells, but it also stimulates
T I Iakushina et al.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 113(2 Pt 2), 61-65 (2013-03-27)
The working experience of the Moscow oblast center for multiple sclerosis is analyzed. Along with standard methods of treatment efficacy evaluation, a cytokines (tumor necrosis factor alpha, gamma-interferon, interleukins 10 and 17) measurement, a morphological study of CD4 and CD8
Colin K Skepper et al.
Bioorganic & medicinal chemistry letters, 20(6), 2029-2032 (2010-02-23)
Analogues of the antifungal marine natural product (E)-dysidazirine were prepared and evaluated in broth ro-dilution assays against a panel of fungal pathogens. A simple structure-activity relationship was developed which provides insight into the mechanism of action of long-chain 2H-azirine carboxylates.
Makoto Kurano et al.
Biochimica et biophysica acta, 1841(9), 1217-1226 (2014-05-13)
High-density lipoprotein (HDL) has been proposed to enhance β-cell functions. Clinical studies have suggested that apolipoprotein M (apoM), which rides mainly on HDL, is involved in diabetes; however, the underlying mechanism has not yet been elucidated. Recently, apoM was shown
Carole A Oskeritzian
Molecular immunology, 63(1), 104-112 (2014-04-29)
Mast cells (MC) are found in all vascularized tissues at homeostasis and, until recently, were viewed only as effector cells of allergic reactions via degranulation, the canonical process through which MC release mediators, including histamine and pre-formed proteases and cytokines
Alexandra J Dickinson et al.
Analytical and bioanalytical chemistry, 406(27), 7027-7036 (2014-07-02)
Sphingosine kinase (SK) is a promising therapeutic target in a number of cancers, including leukemia. Traditionally, SK has been measured in bulk cell lysates, but this technique obscures the cellular heterogeneity present in this pathway. For this reason, SK activity
M Motiur Rahman et al.
Biochemical and biophysical research communications, 462(2), 159-164 (2015-05-09)
In an attempt to identify secretory products of osteoclasts that mediate the coupling of bone formation to resorption, we found that along with osteoclast differentiation, PDGF-A gene expression increase occurred first, by 12 h after stimulation of bone marrow macrophages
Shuli Zheng et al.
Experimental neurology, 272, 160-169 (2015-03-24)
Sphingosine kinases (Sphks) are the rate-limiting kinases in the generation of sphingosine-1-phosphate, which is a well-established intracellular pro-survival lipid mediator. Sphk2 has been reported to be protective following experimental stroke. We investigated the role of Sphk1 in cerebral ischemia using
A genome-scale gain-of-function CRISPR screen in CD8 TA cells identifies proline metabolism as a means to enhance CAR-T therapy.
Ye, et al.
Cell Metabolism, 34, 595-614 (2023)
Min Wang et al.
Experimental and molecular pathology, 97(2), 218-224 (2014-07-19)
FTY720, sphingosine 1 phosphate (S1P) receptor agonist, is a potent immunosuppressive agent. Numerous studies have documented a relationship between S1P and cardioprotection. We therefore hypothesized that a S1P analogue FTY720 would attenuate hypoxia/reoxygenation (H/R) induced cadiomyocyte apoptosis. H9C2 cardiomyocytes were
Jori Ruuskanen et al.
Duodecim; laaketieteellinen aikakauskirja, 129(14), 1457-1464 (2013-08-22)
Multiple sclerosis will usually calm down during pregnancy, but the number of relapses again increases immediately after childbirth. Among the conventional immunomodulatory drugs, there is experience already for over 15 years of the use of interferon-beta and glatiramer. No indications
Junichi Kikuta et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(17), 7009-7013 (2013-04-10)
The migration and positioning of osteoclast precursor monocytes are controlled by the blood-enriched lipid mediator sphingosine-1-phosphate (S1P) and have recently been shown to be critical points of control in osteoclastogenesis and bone homeostasis. Here, we show that calcitriol, which is
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