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Paola Devoto et al.
Addiction biology, 19(4), 612-622 (2013-01-08)
The dopamine-beta-hydroxylase inhibitor nepicastat has been shown to reproduce disulfiram ability to suppress the reinstatement of cocaine seeking after extinction in rats. To clarify its mechanism of action, we examined the effect of nepicastat, given alone or in association with
Jiejun Shi et al.
Nucleic acids research, 42(15), 9730-9739 (2014-08-02)
ATP-dependent chromatin remodeling complexes regulate nucleosome organizations. In Drosophila, gene Brm encodes the core Brahma complex, the ATPase subunit of SWI/SNF class of chromatin remodelers. Its role in modulating the nucleosome landscape in vivo is unclear. In this study, we
Malcolm A Young et al.
Postgraduate medicine, 126(3), 35-46 (2014-06-12)
Chronic kidney disease is frequently present in patients with type 2 diabetes mellitus (T2DM). New therapeutic options in this patient subpopulation are needed. Assess the effect of renal impairment on the pharmacokinetics (PK), efficacy, and safety of albiglutide in single-
Tatsuhiro Masaoka et al.
PloS one, 9(5), e95879-e95879 (2014-05-14)
Recent reports indicate the presence of low grade inflammation in functional gastrointestinal disorders (FGID), in these cases often called "post-inflammatory" FGIDs. However, suitable animal models to study these disorders are not available. The Biobreeding (BB) rat consists of a diabetes-resistant
Lea M Beaulieu et al.
PloS one, 10(7), e0131688-e0131688 (2015-07-07)
Diverse and multi-factorial processes contribute to the progression of cardiovascular disease. These processes affect cells involved in the development of this disease in varying ways, ultimately leading to atherothrombosis. The goal of our study was to compare the differential effects
Guiling Zhao et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(34), E4792-E4801 (2015-08-12)
In ventricular myocytes, the physiological function of stromal interaction molecule 1 (STIM1), an endo/sarcoplasmic reticulum (ER/SR) Ca(2+) sensor, is unclear with respect to its cellular localization, its Ca(2+)-dependent mobilization, and its action on Ca(2+) signaling. Confocal microscopy was used to
Jian-Wei Xie et al.
Journal of cancer research and clinical oncology, 141(10), 1809-1817 (2015-03-27)
Tumor stem cell surface marker CD44v6, a member of the CD44 protein family, is causally involved in the metastasis of cancer. Little is known about the functions of CD44v6 in gastric cancer. The aim of this study was to evaluate
Pella C Söderhielm et al.
Molecular pharmacology, 88(4), 676-688 (2015-07-16)
The serotonin transporter (SERT) regulates neurotransmission by the biogenic monoamine neurotransmitter serotonin (5-HT, 5-hydroxytryptamine) in the central nervous system, and drugs inhibiting SERT are widely used for the treatment of a variety of central nervous system diseases. The conformational dynamics
An optimized method for measurement of gamma-H2AX in blood mononuclear and cultured cells.
Muslimovic A, et al.
Nature Protocols, 3(7), 1187-1193 (2008)
Andrew Holzman et al.
Journal of cataract and refractive surgery, 41(5), 1044-1049 (2015-05-04)
To evaluate the incidence of epithelial disruptions during primary laser in situ keratomileusis (LASIK) with the use of a preoperative hyperosmotic treatment comprising sodium chloride 5% ophthalmic ointment (Muro-128) and to identify the incidence of epithelial disruptions in various demographic
Yoshiaki Yamamoto et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(21), 4845-4855 (2015-06-25)
Lipid nanoparticle (LNP) formulations facilitate tumor uptake and intracellular processing through an enhanced permeation and retention effect (EPR), and currently multiple products are undergoing clinical evaluation. Clusterin (CLU) is a cytoprotective chaperone induced by androgen receptor (AR) pathway inhibition to
Shuhong Guo et al.
Journal of immunology (Baltimore, Md. : 1950), 195(10), 4999-5010 (2015-10-16)
Gut-derived bacterial LPS plays an essential role in inducing intestinal and systemic inflammatory responses and have been implicated as a pathogenic factor in necrotizing enterocolitis and inflammatory bowel disease. The defective intestinal tight junction barrier was shown to be an
Jan E Janecka et al.
The Journal of experimental biology, 218(Pt 15), 2402-2409 (2015-08-08)
Genetically based modifications of hemoglobin (Hb) function that increase blood-O2 affinity are hallmarks of hypoxia adaptation in vertebrates. Among mammals, felid Hbs are unusual in that they have low intrinsic O2 affinities and reduced sensitivities to the allosteric cofactor 2,3-diphosphoglycerate
Michele Scarola et al.
Nature communications, 6, 7631-7631 (2015-07-15)
Pseudogene-derived, long non-coding RNAs (lncRNAs) act as epigenetic regulators of gene expression. Here we present a panel of new mouse Oct4 pseudogenes and demonstrate that the X-linked Oct4 pseudogene Oct4P4 critically impacts mouse embryonic stem cells (mESCs) self-renewal. Sense Oct4P4
Fattah Sotoodehnejadnematalahi et al.
PloS one, 10(6), e0125799-e0125799 (2015-06-10)
Hypoxia is a hallmark of many pathological tissues. Macrophages accumulate in hypoxic sites and up-regulate a range of hypoxia-inducible genes. The matrix proteoglycan versican has been identified as one such gene, but the mechanisms responsible for hypoxic induction are not
Guohua Gong et al.
American journal of physiology. Heart and circulatory physiology, 309(7), H1166-H1177 (2015-08-16)
Mitochondrial respiration through electron transport chain (ETC) activity generates ATP and reactive oxygen species in eukaryotic cells. The modulation of mitochondrial respiration in vivo or under physiological conditions remains elusive largely due to the lack of appropriate approach to monitor
Almudena Crooke et al.
Current eye research, 40(1), 56-65 (2014-06-04)
We have investigated the effect of melatonin and its analogues on rabbit corneal epithelial wound healing. New Zealand rabbits were anaesthetised and wounds were made by placing Whatman paper discs soaked in n-heptanol on the cornea. Melatonin and analogues (all
Hamid Mahmoud Hashemi et al.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 73(1), 18-21 (2014-09-25)
Povidone iodine is used primarily as an antiseptic to decrease surgical site infection. Its hemostatic and antiedematous properties in oral surgery also have been investigated recently. A randomized controlled clinical trial was performed in 30 patients undergoing mandibular third molar
Qian Huang et al.
Autophagy, 17(7), 1753-1767 (2020-07-18)
Spermiogenesis is the longest phase of spermatogenesis, with dramatic morphological changes and a final step of spermiation, which involves protein degradation and the removal of excess cytoplasm; therefore, we hypothesized that macroautophagy/autophagy might be involved in the process. To test
Emre Yildirim et al.
Behavioural pharmacology, 26(3), 241-248 (2014-11-27)
Nicotine withdrawal produces cognitive deficits that can predict relapse. Amelioration of these cognitive deficits emerges as a target in current smoking cessation therapies. In rodents, withdrawal from chronic nicotine disrupts contextual fear conditioning (CFC), whereas acute nicotine enhances this hippocampus-specific
Y Fujikawa et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 27(7), 1010-1023 (2015-05-12)
Enteric glial cells (EGCs) play important roles in enteric integrity and regulation of gastrointestinal function. However, whether EGCs undergo pathophysiological changes in stress-associated gastrointestinal disorders is unknown. We investigated structural and functional alterations in colonic EGCs and their roles in
Sonja Aits et al.
Autophagy, 11(8), 1408-1424 (2015-06-27)
Lysosomal membrane permeabilization (LMP) contributes to tissue involution, degenerative diseases, and cancer therapy. Its investigation has, however, been hindered by the lack of sensitive methods. Here, we characterize and validate the detection of galectin puncta at leaky lysosomes as a
Ana Gordon et al.
Reproduction (Cambridge, England), 149(6), 615-623 (2015-05-01)
Administration of human FSH (hFSH) during the diestrus phase in cyclic rats is followed by a reduction in the preovulatory LH surge. This inhibitory action of FSH involves a decrease in the stimulatory effect of gonadotrope progesterone receptor (PR) activation
M J Melchers et al.
Antimicrobial agents and chemotherapy, 59(6), 3373-3376 (2015-04-01)
Ceftolozane is a new cephalosporin with activity against Gram-negative and Gram-positive microorganisms. However, the compound is susceptible to degradation by extended-spectrum beta-lactamases (ESBLs). Tazobactam is an ESBL inhibitor and is combined with ceftolozane to broaden its activity. Surprisingly, although tazobactam
Jagmohan Singh et al.
American journal of physiology. Gastrointestinal and liver physiology, 309(5), G292-G300 (2015-07-04)
Changes in oxidative stress may affect basal tone and relaxation of the internal anal sphincter (IAS) smooth muscle in aging. We examined this issue by investigating the effects of the oxidative stress inducer 6-anilino-5,8-quinolinedione (LY-83583) in basal as well as
Kim Henriksen et al.
Journal of Alzheimer's disease : JAD, 43(4), 1331-1341 (2014-08-30)
Enzyme-generated fragments of tau have been linked to neuronal death and may serve as serum biomarkers of cognitive loss. Two competitive ELISAs detecting an ADAM10-generated fragment (Tau-A) or a caspase-3-generated fragment (Tau-C) were measured in baseline serum samples from patients
Sudha Saryu Malhotra et al.
Scientific reports, 5, 11210-11210 (2015-06-09)
The aim of the present study is to delineate the role of human chorionic gonadotropin (hCG) in trophoblast fusion. In this direction, using shRNA lentiviral particles, α- and β-hCG silenced 'BeWo' cell lines were generated. Treatment of both α- and
Development and evaluation of electromembrane extraction across a hollow polymer inclusion membrane.
Nor Akma Mamat et al.
Journal of chromatography. A, 1406, 34-39 (2015-07-05)
In this work, a new variation of the electromembrane extraction (EME) approach employing a hollow polymer inclusion membrane (HPIM) was developed. In this method, a HPIM was prepared by casting a solution of the desired proportions of cellulose acetate (CTA)
Daniel K C Chung et al.
Nature communications, 6, 7742-7742 (2015-07-25)
DNA double-strand breaks (DSBs) are often targeted to nuclear pore complexes (NPCs) for repair. How targeting is achieved and the DNA repair pathways involved in this process remain unclear. Here, we show that the kinesin-14 motor protein complex (Cik1-Kar3) cooperates
Anindya Sarkar et al.
The Journal of biological chemistry, 290(35), 21615-21628 (2015-07-03)
Heat shock protein 90 (hsp90) drives heme insertion into the β1 subunit of soluble guanylate cyclase (sGC) β1, which enables it to associate with a partner sGCα1 subunit and mature into a nitric oxide (NO)-responsive active form. We utilized fluorescence
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