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Yuqin Fan et al.
Immunopharmacology and immunotoxicology, 43(1), 58-67 (2020-12-08)
Glutathione is a potential therapy for systemic lupus erythematosus, but its role in allergic rhinitis (AR) has not been determined. This report probed into the actions of glutathione in AR, so as to supplement evidence for a therapeutical countermeasure for
Murine In vitro Memory T Cell Differentiation
Kim MV et al.
Bio-protocol, 4, 1-4 (2014)
Lingling Pang et al.
International journal of clinical and experimental pathology, 12(10), 3700-3709 (2020-01-15)
The purpose of this study was to investigate the anti-inflammatory potential of the natural flavonoid apigenin to mitigate the airway inflammation in asthmatic mice exposed to particulate matter (PM) 2.5, and examine the possible mechanisms involved. BALB/c mice were sensitized
Padmini Jayaraman et al.
Oncoimmunology, 7(10), e1490853-e1490853 (2018-10-06)
Cancer-induced myeloid-derived suppressor cells (MDSC) play an important role in tumor immune evasion. MDSC programming or polarization has been proposed as a strategy for leveraging the developmental plasticity of myeloid cells to reverse MDSC immune suppressive functions, or cause them
Qiao Wang et al.
Cell host & microbe, 28(2), 335-349 (2020-06-07)
Although there is no effective cure for chronic hepatitis B virus (HBV) infection, antibodies are protective and correlate with recovery from infection. To examine the human antibody response to HBV, we screened 124 vaccinated and 20 infected, spontaneously recovered individuals.
Soluble peptide treatment reverses CD8 T-cell-induced disease in a mouse model of spontaneous tissue-selective autoimmunity
Paek SY, et al.
The Journal of Investigative Dermatology, 132(3), 677-686 (2012)
Yunjiao Zhou et al.
STAR protocols, 1(3), 100129-100129 (2020-12-31)
The isolation of human antibodies with naturally paired heavy and light chains is crucial for understanding the human antibody immune response. Here, we present a protocol for antibody cloning from the sorted single human memory B cells recognizing hepatitis B
P-F Yu et al.
European review for medical and pharmacological sciences, 23(4), 1688-1697 (2019-03-07)
We aimed to investigate whether PM2.5 has the potential to exacerbate neutrophil airway inflammation and to analyze the underlying mechanisms. The high-volume air sampler (Laoying 2033B, Qingdao, China) was used to collect PM2.5 from January 01, 2016 to December 21
Marie Jo Halaby et al.
Science immunology, 4(42) (2019-12-15)
General control nonderepressible 2 (GCN2) is an environmental sensor controlling transcription and translation in response to nutrient availability. Although GCN2 is a putative therapeutic target for immuno-oncology, its role in shaping the immune response to tumors is poorly understood. Here
Yuanzhang Fang et al.
The Journal of clinical investigation, 131(1) (2020-09-30)
Immune evasion is a pivotal event in tumor progression. To eliminate human cancer cells, current immune checkpoint therapy is set to boost CD8+ T cell-mediated cytotoxicity. However, this action is eventually dependent on the efficient recognition of tumor-specific antigens via
Jiali Yu et al.
Nature medicine, 27(1), 152-164 (2021-01-06)
Metastasis is the primary cause of cancer mortality, and cancer frequently metastasizes to the liver. It is not clear whether liver immune tolerance mechanisms contribute to cancer outcomes. We report that liver metastases diminish immunotherapy efficacy systemically in patients and
Zhaohui Shi et al.
Bioscience reports, 40(11) (2020-10-06)
Allergic rhinitis (AR) is a non-infectious chronic inflammatory disease of nasal mucosa provoking T helper cell (Th) 17 response. Chlorogenic acid (CGA), one of the most abundant polyphenol compounds in various agricultural products, possesses antiviral, anti-inflammatory, and antibacterial properties. However
Carlos Barrera-Avalos et al.
BioMed research international, 2021, 6626851-6626851 (2021-02-25)
Active immunotherapy against cancer is based on immune system stimulation, triggering efficient and long-lasting antigen-specific immune responses. Immunization strategies using whole dead cells from tumor tissue, containing specific antigens inside, have become a promising approach, providing efficient lymphocyte activation through
Mattia Gallizioli et al.
Cell reports, 33(3), 108291-108291 (2020-10-22)
Brain CD11c+ cells share features with microglia and dendritic cells (DCs). Sterile inflammation increases brain CD11c+ cells, but their phenotype, origin, and functions remain largely unknown. We report that, after cerebral ischemia, microglia attract DCs to the inflamed brain, and
Primary in vivo responses to ovalbumin. Probing the predictive value of the Kb binding motif.
Lipford GB, et al.
Journal of Immunology, 150(4), 1212-1222 (1993)
Daniella M Schwartz et al.
Immunity, 50(1), 106-120 (2019-01-17)
CD4+ T helper (Th) differentiation is regulated by diverse inputs, including the vitamin A metabolite retinoic acid (RA). RA acts through its receptor RARα to repress transcription of inflammatory cytokines, but is also essential for Th-mediated immunity, indicating complex effects
Dead Tumor Cells Expressing Infectious Salmon Anemia Virus Fusogenic Protein Favor Antigen Cross-Priming In Vitro
Morales J, et al.
Frontiers in immunology, 8, 1170-1170 (2017)
Lei Wang et al.
Cancer immunology research, 9(3), 348-361 (2021-01-15)
Conventional dendritic cells (cDC) play a central role in T-cell antitumor responses. We studied the significance of Notch-regulated DC immune responses in a mouse model of colitis-associated colorectal cancer in which there is epithelial downregulation of Notch/Hes1 signaling. This defect
Small interfering RNA directed against microRNA-155 delivered by a lentiviral vector attenuates asthmatic features in a mouse model of allergic asthma
Chen H, et al.
Experimental and Therapeutic Medicine, 14(5), 4391-4396 (2017)
Samarth Hegde et al.
Cancer cell, 37(3), 289-307 (2020-03-19)
Here, we utilized spontaneous models of pancreatic and lung cancer to examine how neoantigenicity shapes tumor immunity and progression. As expected, neoantigen expression during lung adenocarcinoma development leads to T cell-mediated immunity and disease restraint. By contrast, neoantigen expression in pancreatic
Jing Guo et al.
Experimental and therapeutic medicine, 21(6), 590-590 (2021-04-23)
Paeoniflorin (PF) has been reported to be effective against several skin disorders, such as allergic contact dermatitis and psoriasis; however, it remains unclear whether PF can protect against urticarial lesions. Herein, the effects of PF on rats with urticarial lesions
Feilin Dong et al.
Medical science monitor : international medical journal of experimental and clinical research, 26, e923358-e923358 (2020-09-02)
BACKGROUND Allergic rhinitis (AR) is a prevalent atopic disorder caused by immune imbalance. Chlorogenic acid (CGA) has antibacterial, antiviral, antioxidative and immunoregulatory effects, but its role in anaphylactic disease remains unclear. The current study aimed to investigate the function of
An evolutionarily conserved function of polycomb silences the MHC class I antigen presentation pathway and enables immune evasion in cancer
Burr ML, et al.
Cancer Cell, 36(4), 385-401 (2019)
Lucas Ferrari de Andrade et al.
Cancer immunology research, 8(6), 769-780 (2020-03-27)
Resistance to cytotoxic T cells is frequently mediated by loss of MHC class I expression or IFNγ signaling in tumor cells, such as mutations of B2M or JAK1 genes. Natural killer (NK) cells could potentially target such resistant tumors, but
Zhanfeng Yan et al.
Aging, 13(14), 18423-18441 (2021-07-28)
We investigated the mechanisms underlying the therapeutic effects of Yiqi Jiemin decoction (YJD), a traditional Chinese medicine (TCM), in the ovalbumin (OVA)-induced allergic rhinitis (AR) model in guinea pigs. YJD significantly decreased infiltration of mast cells and eosinophils into the
Bingbing Dai et al.
Cell reports. Medicine, 2(8), 100381-100381 (2021-09-02)
Anti-integrins are therapeutically effective for inflammatory bowel disease, yet the relative contribution of α4β7 and αEβ7 to gut lymphocyte trafficking is not fully elucidated. Here, we evaluate the effect of α4β7 and αEβ7 blockade using a combination of murine models
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