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M Okada et al.
Journal of hypertension, 18(12), 1815-1823 (2001-01-02)
To examine the chronic effects of a newly synthesized, potent and selective endothelin (ET) ETA receptor antagonist, J-1 05859, on mortality in salt-loaded Dahl salt-sensitive (DS) rats and to confirm the potential of this compound as an ETA antagonist Vehicle
Chunyu Zeng et al.
Kidney international, 68(2), 623-631 (2005-07-15)
The renin-angiotensin and endothelin systems interact to regulate blood pressure, in part, by affecting sodium transport in the kidney. Because angiotensin II type 1 (AT(1)) receptor activation increases ETB receptor expression in renal proximal tubule cells from Wistar-Kyoto (WKY) rat
Phuong N Quang et al.
Pain, 149(2), 254-262 (2010-03-09)
Endothelin-1 (ET-1) produced by various cancers is known to be responsible for inducing pain. While ET-1 binding to ETAR on peripheral nerves clearly mediates nociception, effects from binding to ETBR are less clear. The present study assessed the effects of
F E Strachan et al.
British journal of clinical pharmacology, 50(1), 27-30 (2000-07-25)
The aim of the study was to examine the effects of the ETB receptor selective agonists sarafotoxin S6c (SFTX6c) and BQ-3020 on the forearm resistance and capacitance vessels in healthy subjects in vivo. The local response to intra-arterial or intravenous
Q T Nguyen et al.
Circulation, 104(17), 2075-2081 (2001-10-24)
Some controversy exists as to the effects of endothelin (ET) receptor antagonism on long-term post-myocardial infarction (MI) evolution, particularly as it relates to the timing of the intervention after MI (<24 hours versus 10 days). Sham rats and rats surviving
Peter Johnström et al.
Experimental biology and medicine (Maywood, N.J.), 231(6), 736-740 (2006-06-03)
The endothelin (ET) receptor system has been shown to play a role in a number of vascular diseases. We have synthesized 18F-and 11C-labeled radioligands to enable in vivo imaging of the fundamental processes involved in ET receptor pharmacology in normal
Yan Liu et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 32(10), 846-852 (2009-08-08)
The kidney is important in the long-term regulation of blood pressure and sodium homeostasis. Stimulation of ETB receptors in the kidney increases sodium excretion, in part, by decreasing sodium transport in the medullary thick ascending limb of Henle and in
A. Bjorklund
Peptides (New York, NY, United States) (2000)
G Mazzocchi et al.
International journal of molecular medicine, 7(1), 55-59 (2000-12-15)
The secretagogue effect of endothelins (ETs) on the rat adrenal cortex is mediated by the ETB receptor. ETB receptors are coupled with nitric oxide (NO) synthase (NOS), and NO is known to inhibit steroid-hormone secretion from adrenal cortex. We investigated
Kåre-Olav Stensløkken et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 290(3), R852-R860 (2005-10-15)
By observing gill blood flow using epi-illuminating microscopy, in parallel with cardiovascular recordings and immunohistochemistry, we have tried to identify the receptor mediating endothelin (ET) type 1 (ET1)-induced pillar cell contraction in the lamellae of the Atlantic cod (Gadus morhua).
A K S Eriksson et al.
International journal of obesity (2005), 33(1), 67-74 (2008-11-05)
Levels of the vascular peptide endothelin-1 (ET-1) are significantly elevated in obesity. Adipose tissue-derived ET-1 attenuates insulin-mediated antilipolysis in human visceral adipocytes through the activation of the ET receptor B (ET(B)R), thereby linking ET-1 to insulin resistance. Whether ET-1 has
Anthony P Davenport et al.
Journal of cardiovascular pharmacology, 44 Suppl 1, S276-S278 (2005-04-20)
Autoradiographical images of whole body sections from control mice (29 +/- 3 days old) revealed high ETA densities within the cardiovascular system, with ETB receptors predominating in the kidney. A similar distribution of ETA receptors was found in ETB-deficient mice
Rhoda Kuc et al.
Journal of cardiovascular pharmacology, 44 Suppl 1, S224-S226 (2005-04-20)
Molecular studies have predicted the existence in human tissue of splice variants and modifications to the amino acid sequence of endothelin receptors that may modulate function. Endothelin-A (ETA) receptors were visualized by ligand binding and autoradiography to the renal vasculature
Paola G Andreis et al.
Peptides, 23(3), 561-566 (2002-02-12)
Evidence has been provided that the 21-amino acid hypertensive peptide endothelin (ET)-1 exerts a potent secretagogue effect on human adrenocortical zona glomerulosa (ZG), acting through two receptor subtypes, called ET(A) and ET(B), the signaling mechanism(s) of which has (have) not
A novel radioligand [125I]BQ-3020 selective for endothelin (ETB) receptors.
Ihara M
Life Sciences, 51(6) (1992)
Jörg Kleeberg et al.
American journal of physiology. Heart and circulatory physiology, 286(4), H1339-H1346 (2003-12-06)
Recently, it has been shown that brain topical superfusion of endothelin (ET)-1 at concentrations around 100 nM induces repetitive cortical spreading depressions (CSDs) in vivo. It has remained unclear whether this effect of ET-1 is related to a primary neuronal/astroglial
Nini Skovgaard et al.
The Journal of experimental biology, 208(Pt 19), 3739-3746 (2005-09-20)
The effects of endothelin-1 (ET-1) on systemic and pulmonary circulation were investigated in anaesthetised freshwater turtles (Trachemys scripta) instrumented with arterial catheters and blood flow probes. Bolus intra-arterial injections of ET-1 (0.4-400 pmol kg(-1)) caused a dose-dependent systemic vasodilatation that
Ana Sánchez et al.
European journal of pharmacology, 640(1-3), 190-196 (2010-05-25)
Since endothelin-1 (ET-1) is involved in prostatic disorders, the current study investigated the mechanisms underlying the ET-1-induced effects in pig prostatic small arteries. The experiments were performed in rings mounted in microvascular myographs containing physiological saline solution at 37oC for
Hypertension, diabetes mellitus, hypercholesterolemia, and endothelin B receptor-mediated renal nitric oxide release.
M Barton et al.
Circulation, 101(23), E228-E229 (2000-06-14)
José Luis Arteaga et al.
Neurourology and urodynamics, 31(5), 688-694 (2012-03-31)
The involvement of endothelin receptors in the contraction of the lower urinary tract smooth muscle is well established. There is scarce information, however, about endothelin receptors mediating relaxation of the bladder outlet region. The current study investigates the possible existence
G P Rossi et al.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 48(5), 343-350 (2000-09-09)
The mechanisms and factors leading to enhanced aldosterone secretion and ultimately to neoplastic transformation of the adrenal cortex are poorly defined. Angiotensin-II (Ang-II) and endothelin-1 (ET-1) have emerged as likely candidates among potential aldosterone secretagogues and adrenocortical growth-promoting factors. We
G Mazzocchi et al.
FEBS letters, 487(2), 194-198 (2001-01-11)
Endothelin-1 (ET-1)[1-31] is a novel hypertensive peptide that mimics many of the vascular effects of the classic 21 amino acid peptide ET-1[1-21]. However, at variance with ET-1[1-21] that enhances aldosterone secretion from cultured rat zona glomerulosa (ZG) cells by acting
Sandrine Joly et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(51), 13765-13774 (2008-12-19)
Survival and death of photoreceptors in degenerative diseases of the retina is controlled by a multitude of genes and endogenous factors. Some genes may be involved in the degenerative process itself whereas others may be part of an endogenous defense
Najam A Sharif et al.
Current eye research, 36(5), 462-468 (2011-04-20)
The receptor-coupled signal transduction systems present in isolated human choroidal melanocytes (HCOMs) were investigated. [(3)H]-inositol phosphates ([(3)H]-IPs) generated in the cells were measured by ion-exchange chromatography. cAMP generated in the cells was quantified using an enzyme immunoassay. Initially, HCOM cells
Joanna Rozyczka et al.
Brain pathology (Zurich, Switzerland), 14(4), 406-414 (2004-12-21)
Glutamate is the main excitatory neurotransmitter in the mammalian central nervous system which at high extracellular levels leads to neuronal over-stimulation and subsequent excitotoxic neuronal cell death. Both the termination of glutamatergic neurotransmission and the prevention of neurotoxic extracellular glutamate
Syntheses of the first endothelin-A- and -B-selective radioligands for positron emission tomography.
P Johnström et al.
Journal of cardiovascular pharmacology, 36(5 Suppl 1), S58-S60 (2000-11-15)
We have synthesized two potential positron emission tomography (PET) radioligands for the endothelin (ET) receptor. [11C]-PD156707 was produced by O-methylation of PD169390 using [11C]iodomethane. Radiochemical conversions of the order of 74 +/- 3.2% (n = 8) were obtained. The radiochemical
Akira Hirose et al.
Current eye research, 32(6), 585-591 (2007-07-07)
The physiological properties of endothelin-1 in ocular choroidal melanocytes are not well-known, although endothelin-1 increases the intracellular calcium concentration through endothelin-B receptors in skin melanocytes. We studied the effect of endothelin-1 on choroidal melanocytes in rabbit ocular suprachoroidal tissue. Fura-2
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