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Pue Farooque et al.
Pediatric neurology, 42(3), 215-218 (2010-02-18)
This report describes a 9-year-old child with status epilepticus and cat scratch disease. This patient's focal seizures and electroencephalographic changes persisted for 18 months after status epilepticus. This patient represents the third reported case of persistent focal seizures or electroencephalographic
Jun Tanaka et al.
European journal of clinical pharmacology, 69(3), 489-497 (2012-08-25)
We performed a population pharmacokinetic analysis of phenytoin after intravenous administration of fosphenytoin sodium in healthy, neurosurgical, and epileptic subjects, including pediatric patients, and determined the optimal dose and infusion rate for achieving the therapeutic range. We used pooled data
L B Cohen
Alimentary pharmacology & therapeutics, 27(7), 597-608 (2008-01-16)
An effective agent is needed that provides rapid onset of sedation and quick recovery for patients undergoing colonoscopy. To assess the efficacy and safety of fospropofol disodium in providing sedation in patients undergoing colonoscopy. A randomized, double-blind, multicentre trial evaluated
Video recording devices as a diagnostic aid.
Jeremy Strohkirch et al.
The Journal of emergency medicine, 40(4), e87-e87 (2009-04-07)
Andro Zangaladze et al.
Epilepsy & behavior : E&B, 17(2), 293-295 (2010-01-15)
Familial hemiplegic migraine (FHM) is a clinically and genetically heterogeneous disease most commonly linked to CACNA1A gene mutation. Epilepsy rarely occurs in FHM and is seen predominantly with specific CACNA1A gene mutations. Here we report a sporadic case of FHM1
What is the relative value of the standard anticonvulsants: Phenytoin and fosphenytoin, phenobarbital, valproate, and levetiracetam?
Eugen Trinka
Epilepsia, 50 Suppl 12, 40-43 (2009-11-28)
Haodan Yuan et al.
Drug metabolism and disposition: the biological fate of chemicals, 37(7), 1443-1447 (2009-04-18)
Generating a phosphate prodrug is one of the common approaches for circumventing poor solubility issues of a parent drug. Alkaline phosphatase (ALP) level was determined in rat intestine mucosa scraps, human colon carcinoma (Caco-2) cells, and Madin-Darby canine kidney (MDCK)
Thomas Bleck et al.
Epilepsia, 54 Suppl 6, 89-92 (2013-09-06)
Benzodiazepine-refractory status epilepticus (established status epilepticus, ESE) is a relatively common emergency condition with several widely used treatments. There are no controlled, randomized, blinded clinical trials to compare the efficacy and tolerability of currently available treatments for ESE. The ESE
Effect of an educational initiative on physicians' use of weight-based fosphenytoin loading doses in the emergency department.
April D Miller et al.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 67(1), 15-16 (2010-01-02)
Clinical pharmacology of parenteral use of antiepileptic drugs.
Meir Bialer
Epilepsia, 48 Suppl 8, 46-48 (2008-03-11)
Case 3-2009: a 9-month-old boy with seizures.
Ajit Singh Kashyap et al.
The New England journal of medicine, 360(15), 1572-1572 (2009-04-10)
Linda A Steinbaugh et al.
Epilepsy & behavior : E&B, 23(3), 280-284 (2012-02-22)
Continuous electroencephalography (cEEG) is increasingly used to detect both clinical and subclinical seizures in patients with traumatic brain injury (TBI) or subarachnoid hemorrhage (SAH). We assess whether EEG findings predict outcomes in TBI/SAH patients enrolled in a levetiracetam (LEV) vs.
Advisers recommend improved labeling for phenytoin, fosphenytoin.
Kate Traynor
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 67(24), 2086-2086 (2010-12-01)
Fatal errors with cerebyx.
Kellie Taylor et al.
Journal of emergency nursing: JEN : official publication of the Emergency Department Nurses Association, 34(5), 460-461 (2008-09-23)
Jens P Bankstahl et al.
Epilepsy research, 82(1), 70-85 (2008-09-02)
Status epilepticus (SE) is a neurological emergency, characterized by continuous or intermittent seizures without full recovery of consciousness between seizures, which can result in death or neurological sequelae. In about one third of patients, SE is unresponsive to sequential treatment
Aatif M Husain
Epilepsia, 54 Suppl 6, 84-88 (2013-09-06)
Nonconvulsive seizures (NCS) and nonconvulsive status epilepticus (NCSE) are electrographic seizures (ESz) that are not associated with overt clinical seizure activity. NCS are distinct ESz, whereas NCSE has ongoing, continuous electrographic seizure activity. Both are common in critically ill patients
Patrick Michael Aaronson et al.
The American journal of emergency medicine, 29(9), 983-988 (2010-08-06)
A comparison of length of stay in an emergency department (ED) after loading patients at risk for seizures with either intravenous (IV) phenytoin or intramuscular (IM) fosphenytoin was studied. This was a retrospective observational cohort study that was conducted over
Suzette M LaRoche et al.
Seizure, 20(6), 505-508 (2011-04-05)
Subacute encephalopathy with seizures in chronic alcoholism (SESA) was first described in 1981 by Niedermeyer who reported alcoholic patients presenting with confusion, seizures and focal neurological deficits and is quite distinct from patients presenting with typical alcohol withdrawal seizures. EEG
Amanda M Ranzino et al.
Journal of pharmacy practice, 23(2), 140-143 (2011-04-22)
Thrombocytopenia, defined as a platelet count less than 150 000/µL, occurs as a result of decreased production, sequestration, or peripheral destruction. Drug-induced thrombocytopenia is a clinically important adverse drug event involving many drugs including hydantoins. This report details an acute
FDA: Epilepsy drugs may carry skin risks for Asians.
Bridget M Kuehn
JAMA, 300(24), 2845-2845 (2008-12-26)
Meir Bialer
Epilepsia, 53 Suppl 8, 3-11 (2012-12-12)
Phenobarbital has been in clinical use as an antiepileptic drug (AED) since 1912. The initial clinical success of phenobarbital and other barbiturates affected the design of subsequent AEDs (e.g., phenytoin, primidone, ethosuximide), developed between 1938 and 1962, the chemical structures
Sandeep Soni et al.
Pediatric blood & cancer, 59(4), 762-764 (2012-03-02)
Anti-seizure prophylaxis is routinely utilized during busulfan administration for HSCT. We evaluated the feasibility and efficacy of levetiracetam in children undergoing HSCT. A total of 28 children and young adults received levetiracetam during HSCT and the outcomes and costs were
Minimum requirements for approval of a drug in status epilepticus.
Michel Baulac et al.
Epilepsia, 50 Suppl 12, 77-78 (2009-11-28)
Marc P DiFazio et al.
Journal of child neurology, 22(12), 1367-1370 (2008-01-05)
Rotavirus infection is a frequent cause of gastroenteritis in children and accounts for significant morbidity and mortality, especially in the developing world. Less well recognized is the association of rotavirus-induced central nervous system dysfunction, which has been associated with seizure
Tomoyuki Akiyama et al.
Brain and nerve = Shinkei kenkyu no shinpo, 62(5), 519-526 (2010-05-11)
In this review study, second-generation antiepileptic drugs (AEDs) (levetiracetam, gabapentin, topiramate, lamotrigine, zonisamide, oxcarbazepine, vigabatrin, pregabalin, rufinamide, tiagabine, lacosamide, and felbamate) and injectable AEDs (levetiracetam, lacosamide, fosphenytoin, lorazepam, and valproic acid) available in North America were compared with those available
Kai Eriksson et al.
Expert opinion on drug metabolism & toxicology, 5(6), 695-701 (2009-05-29)
Fosphenytoin, phosphate ester pro-drug of phenytoin, was developed to overcome complications associated with parenteral phenytoin administration in treatment of acute symptomatic seizures, short-term prophylaxis and treatment of repetitive or prolonged seizures and status epilepticus. To evaluate the current position of
Mounzer Y Kassab et al.
Epilepsy research, 87(2-3), 268-271 (2009-10-27)
To study the incidence and extent of the occasionally noted hypotension after intravenous (IV) infusions of fosphenytoin (FOS) and levetiracetam (LEV) in patients presenting with acute cerebral symptoms. Retrospective data collection of consecutive patients with acute cerebral symptoms who received
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