Edilson Ribeiro de Oliveira Junior et al.
Drug delivery and translational research, 10(6), 1688-1699 (2020-07-03)
Intranasal administration of mucus-penetrating nanoparticles is an emerging trend to increase drug delivery to the brain. In order to overcome rapid nasal mucociliary clearance, low epithelial permeation, and local enzymatic degradation, we investigated the influence of PEGylation on nose-to-brain delivery