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Ivano Riva et al.
Journal of glaucoma, 29(6), 441-447 (2020-03-29)
Central corneal thickness (CCT) may increase over time in children affected by primary congenital glaucoma and treated with latanoprost for at least 30 months. The purpose of this study was to investigate CCT modification over time in a population of
Stephanie C Osinchuk et al.
Veterinary ophthalmology, 23(5), 872-878 (2020-08-20)
To determine the effect of intrsacameral epinephrine on heart rate, blood pressure, post-operative ocular hypertension, and complications following canine phacoemulsification. A prospective, double-blinded, controlled trial was carried out using 30 client-owned dogs undergoing phacoemulsification. Eyes were randomly assigned to a
Ichiro Kawaguchi et al.
PloS one, 12(10), e0186714-e0186714 (2017-10-20)
This study aimed to determine if rebamipide eyedrops can improve ocular surface damage caused by the use of glaucoma eyedrops. Female Kbl:Dutch rabbits were used to evaluate glaucoma eyedrop-induced ocular surface damage; one eye of each rabbit was untreated and
Serek Tekin et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 35(4), 216-222 (2019-02-14)
Purpose: To determine the effects of antiglaucomatous drops on the conjunctival thickness.
Christian Görgens et al.
Journal of pharmaceutical and biomedical analysis, 131, 482-496 (2016-10-04)
So far, in sports drug testing compounds of different classes are processed and measured using different screening procedures. The constantly increasing number of samples in doping analysis, as well as the large number of substances with doping related, pharmacological effects
Micki D Armour et al.
Veterinary ophthalmology, 22(4), 545-551 (2019-04-12)
To assess the efficacy of an endothelial keratoplasty procedure at defined intervals to 1 year postoperatively for the treatment of corneal endothelial dystrophy (CED) in a canine patient. A dog diagnosed with CED with progressive corneal edema underwent an endothelial keratoplasty.
Vaida Juozapaitienė et al.
Journal of biotechnology, 240, 31-42 (2016-10-25)
Human carbonic anhydrase XIV (CA XIV), a transmembrane protein, highly expressed in the central nervous system, is difficult to recombinantly express and purify in large scale for the measurements of inhibitor binding and drug design. CA XIV belongs to the
Riku P J Arvola et al.
Cornea, 35(4), 451-455 (2016-02-05)
Treating corneal neurotrophic ulcers is challenging. Topical application of matrix regeneration therapy (RGTA), which is a dextran derivative polymer and heparan sulfate analog, is a promising regenerative therapy and an alternative or additional therapeutic regimen when corneal healing is compromised.
Rodolfo Mastropasqua et al.
Ophthalmic surgery, lasers & imaging retina, 49(9), e20-e31 (2018-09-18)
The aim of the study was to determine optical coherence tomography angiography (OCTA) findings and to identify mutations in the RS1 gene in a three-generation family with X-linked juvenile retinoschisis (XLRS). Clinical and genetic assessments were performed in 12 family
Luciano Quaranta et al.
Journal of glaucoma, 26(11), 987-994 (2017-09-29)
To investigate the efficacy and safety of a treatment strategy with latanoprost and dorzolamide in primary pediatric glaucoma patients partially responsive to surgery. Children with primary pediatric glaucoma having postsurgical untreated intraocular pressure (IOP) between 22 and 26 mm Hg were eligible.
Paula Anne Newman-Casey et al.
Ophthalmology, 127(5), 589-598 (2019-11-27)
The majority of patients with glaucoma do not take their medications as prescribed. Estimates of the cost-utility value of adherence to prescribed glaucoma medication are vital to implement potentially effective interventions. Cost-utility analysis using Monte Carlo microsimulations incorporating a series
Melanin binding study of clinical drugs with cassette dosing and rapid equilibrium dialysis inserts.
Laura Pelkonen et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 109, 162-168 (2017-08-02)
Melanin pigment is a negatively charged polymer found in pigmented human tissues. In the eye, iris, ciliary body, choroid and retinal pigment epithelium (RPE) are heavily pigmented. Several drug molecules are known to bind to melanin, but larger sets of
Tara M Czepiel et al.
Veterinary ophthalmology, 24(1), 12-19 (2020-10-22)
To evaluate the effect of dorzolamide 2% ophthalmic solution on serum potassium and other hematologic parameters in cats. Part I: Medical records from a single institution were retrospectively reviewed. Inclusion criteria consisted of cats diagnosed with glaucoma for which appropriate
Boovizhikannan Thangabalan et al.
Journal of analytical methods in chemistry, 2018, 4596141-4596141 (2018-10-03)
A reversed phase liquid chromatographic method with UV detection at 254 nm for dorzolamide assay in ophthalmic solutions was developed and validated. Chromatographic separation was achieved on a Zorbax SB C18 (250 mm × 4.6 mm, 5 µm) column kept at 30°C with an isocratic mixture
Kyoung Jin Choi et al.
Biochemical pharmacology, 169, 113632-113632 (2019-09-09)
Glaucoma is one of the leading causes of preventable blindness, affecting > 2 million people in the United States. Recently, 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors were found to exert preventive effects against glaucoma. However, there is no evidence for
Ik-Hee Ryu et al.
BMC ophthalmology, 20(1), 296-296 (2020-07-20)
To evaluate corneal epithelial thickness change during medical treatment for eyes with myopic regression after femtosecond laser-assisted in situ keratomileusis (FS-LASIK). This study included 84 eyes of 54 subjects diagnosed with myopic regression after FS-LASIK and treated using topical steroid
Belal M Ali et al.
Naunyn-Schmiedeberg's archives of pharmacology, 388(12), 1271-1282 (2015-08-13)
The antitumor activity of carbonic anhydrase (CA) inhibitors is attributed to their ability to induce a state of intracellular acidification. In fact, acidic intracellular pH was demonstrated to upregulate several tumor suppressor proteins and increase the activity of many chemotherapies.
Yukari Yagi-Yaguchi et al.
Diagnostics (Basel, Switzerland), 10(1) (2020-01-08)
Anti-glaucoma eye drop treatment often induces dry eyes and can lead to poor medication adherence. This study aimed to investigate the effects of 3% diquafosol sodium eye drops on tear function and the ocular surface epithelium in Sod1-/- mice after
Frank Bochmann et al.
Journal of glaucoma, 26(11), 1051-1055 (2017-10-28)
A subluxation or dislocation of the intraocular lens (IOL) is a well-known complication after cataract surgery in patients with pseudoexfoliation syndrome (PEX). Capsular tension rings (CTR) are frequently used to prevent postoperative complications caused by zonular weakness. Here we present
Sancy Low et al.
Eye (London, England), 34(3), 577-583 (2019-08-29)
The availability and reduced cost of genotyping has improved gene susceptibility testing and our scientific understanding of disease pathophysiology. Whilst several personalised translational models exist within medical frameworks, genetic-based surgical therapy is a translational application not widely used in surgical
Meng Liu et al.
Biomedical chromatography : BMC, 34(9), e4876-e4876 (2020-05-10)
Magnetic solid-phase extraction (MSPE) employing a metal-organic framework (Fe3 O4 @UiO-66-OH) combined with high-performance liquid chromatography was developed for the determination of trace diuretics in urine. The structure and properties of Fe3 O4 @UiO-66-OH were investigated using X-ray diffraction, infrared
Gergő Dargó et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 128, 232-239 (2018-12-17)
The present study was aimed to develop an in vitro non-cell-based method, for the measurement of corneal permeability. To this avail, the parallel artificial membrane permeability assay (PAMPA) was used for studying the effects of composition of the artificial lipid
Pavel L Volodin et al.
Ophthalmic surgery, lasers & imaging retina, 51(9), 512-520 (2020-09-22)
A computational model has predicted parameters for using a navigated microsecond pulsing laser system to treat central serous chorioretinopathy (CSC). A prospective, single-center, interventional case series was conducted for patients with acute CSC who were enrolled following screening and informed
Prabhavathi Maddineni et al.
Molecular neurodegeneration, 15(1), 48-48 (2020-08-29)
Glaucoma is a leading neurodegenerative disease affecting over 70 million individuals worldwide. Early pathological events of axonal degeneration and retinopathy in response to elevated intraocular pressure (IOP) are limited and not well-defined due to the lack of appropriate animal models
Ya-Ru Dong et al.
International journal of ophthalmology, 11(5), 719-725 (2018-06-05)
To investigate if significant improvement of optic disc blood flow (ODBF) occurs after instillation of brinzolamide onto rabbit eyes. Testing of bilateral intraocular pressure (IOP) and left ODBF in 10 male rabbits took place every 3h over a 24h period.
Daniel B Moore et al.
BMC ophthalmology, 17(1), 78-78 (2017-05-24)
The purpose of this study is to evaluate the number of eyedrops available per bottle of a variety of commonly prescribed glaucoma medications. Six bottles of each glaucoma medication were tested: three each in the vertical and horizontal orientations. Bottles
Yumi Hashimoto et al.
Japanese journal of ophthalmology, 64(3), 304-311 (2020-04-28)
We aimed to investigate the toxicity of 6 fixed-combination drugs for glaucoma therapy using human corneal epithelial sheets (HCES). Experimental. We used 6 kinds of commercially available fixed-combination drugs: latanoprost/carteolol (LAT/CAR), latanoprost/timolol (LAT/TIM), tafluprost/timolol (TAF/TIM), travoprost/timolol (TRA/TIM), brinzolamide/timolol (BRZ/TIM), and
Jingxing Ou et al.
The Journal of clinical investigation, 125(7), 2891-2903 (2015-06-23)
Strategies aimed at invoking synaptic plasticity have therapeutic potential for several neurological conditions. The human retinal synaptic disease X-linked retinoschisis (XLRS) is characterized by impaired visual signal transmission through the retina and progressive visual acuity loss, and mice lacking retinoschisin
Johan Bondesson et al.
American journal of physiology. Heart and circulatory physiology, 320(2), H901-H911 (2021-01-01)
Chirality is a fundamental property in many biological systems. Motivated by previous observations of helical aortic blood flow, aortic tissue fibers, and propagation of aortic dissections, we introduce methods to characterize helical morphology of aortic dissections. After validation on computer-generated
Nobuo Takeda et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 37(2), 97-103 (2021-01-14)
Purpose: We sought to evaluate the effect of antiglaucoma ophthalmic solutions on the cornea with a corneal resistance device (CRD), and to compare the results with those by fluorescein staining. Methods: In 6 rabbit groups (n = 7 each), right eyes were
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