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显示 1-30 共 53 条结果 关于 "SRP3069" 范围 论文
Nuno Jorge Lamas et al.
PloS one, 9(10), e110324-e110324 (2014-10-23)
Human motor neurons derived from embryonic and induced pluripotent stem cells (hESCs and hiPSCs) are a potentially important tool for studying motor neuron survival and pathological cell death. However, their basic survival requirements remain poorly characterized. Here, we sought to
Mélodie Diot et al.
Reproduction (Cambridge, England), 150(1), 53-63 (2015-04-29)
In mammals, nicotinamide phosphoribosyltransferase (NAMPT) is an adipokine produced by adipose tissue that is found in intracellular and extracellular compartments. The intracellular form of NAMPT is a nicotinamide phosphoribosyltransferase, whereas the extracellular form is considered an adipokine. In humans, NAMPT
Dan Tian et al.
BMC systems biology, 8, 98-98 (2014-08-15)
The insulin-like growth factor (IGF) system impacts cell proliferation and is highly activated in ovarian cancer. While an attractive therapeutic target, the IGF system is complex with two receptors (IGF1R, IGF2R), two ligands (IGF1, IGF2), and at least six high
Synergistic effect of fadrozole and insulin-like growth factor-I on female-to-male sex reversal and body weight of broiler chicks.
Mohammadrezaei M
PLoS ONE, 9, e103570-e103570 (2014)
Richard Birk et al.
In vivo (Athens, Greece), 28(5), 795-802 (2014-09-06)
Tissue engineering represents a promising research field, targeting the creation of new functional muscle tissue in vitro. The aim of the present study was to show the influence of static magnetic fields (SMF) and insulin-like growth factor-1 (IGF1), as enhancing
Paul Fiorilli et al.
Laboratory investigation; a journal of technical methods and pathology, 88(11), 1143-1156 (2008-09-17)
Medulloblastoma spreads by leptomeningeal dissemination rather than by infiltration that characterizes other CNS tumors, eg, gliomas. This study represents an initial attempt to identify both the molecules that mediate medulloblastoma adhesion to leptomeninges and the pathways that are key to
Xiaoshuai Huang et al.
Molecular and cellular endocrinology, 416, 36-45 (2015-08-19)
Insulin-like peptides (ILPs) have been proved to exist extensively in invertebrates and play critical roles in regulating growth, metabolism and reproduction. ILP signaling system has been well defined in insects, with all key components homologous with vertebrate IGF signaling; however
Agnieszka Rak et al.
Biology of reproduction, 92(6), 142-142 (2015-05-01)
Resistin, a hormone secreted by adipocytes, is thought to be important in reproduction. Our previous study demonstrated resistin expression in porcine ovarian follicles and its direct effect on steroidogenesis. The aim of the current study was to evaluate the effect
Shuiliang Shi et al.
Journal of cellular biochemistry, 116(7), 1391-1400 (2015-02-25)
Chondrogenic polypeptide growth factors influence articular chondrocyte functions that are required for articular cartilage repair. Sox9 is a transcription factor that regulates chondrogenesis, but its role in the growth factor regulation of chondrocyte proliferation and matrix synthesis is poorly understood.
Daniele M Gilkes et al.
Molecular and cellular biology, 28(6), 1999-2010 (2008-01-04)
MDMX is an important regulator of p53 transcriptional activity and stress response. MDMX overexpression and gene amplification are implicated in p53 inactivation and tumor development. Unlike MDM2, MDMX is not inducible by p53, and little is known about its regulation
Jakob H Mikkelsen et al.
Oncotarget, 5(4), 1014-1025 (2014-02-28)
The insulin-like growth factor (IGF) signaling pathway is involved in certain human cancers, and the feasibility of directly targeting the IGF receptor has been actively investigated. However, recent evidence from clinical trials suggests that this approach can be problematic. We
Yoshikazu Haramoto et al.
Scientific reports, 5, 11603-11603 (2015-06-27)
Insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF1R) signalling is required for normal embryonic growth and development. Previous reports indicated that the IGF/IGF1R/MAPK pathway contributes to neural induction and the IGF/IGF1R/PI3K/Akt pathway to eye development. Here, we report the
Maria C Olianas et al.
Biochemical pharmacology, 95(4), 311-323 (2015-04-19)
Different lines of evidence indicate that the lysophosphatidic acid (LPA) receptor LPA1 is involved in neurogenesis, synaptic plasticity and anxiety-related behavior, but little is known on whether this receptor can be targeted by neuropsychopharmacological agents. The present study investigated the
The generation of insulin-like growth factor-1--sensitive cells by growth hormone action.
Zezulak KM and Green H
Science, 233, 551-553 (1986)
Rie Harboe Nielsen et al.
Journal of applied physiology (Bethesda, Md. : 1985), 117(7), 694-698 (2014-08-12)
The classic form of Ehlers-Danlos syndrome (cEDS) is an inherited connective tissue disorder, where mutations in type V collagen-encoding genes result in abnormal collagen fibrils. Thus the cEDS patients have pathological connective tissue morphology and low stiffness, but the rate
Zhiwei Huang et al.
Leukemia & lymphoma, 55(8), 1876-1883 (2013-11-12)
It has been recently shown that the type I insulin-like growth factor receptor (IGF-IR) contributes significantly to the survival of T lymphoblastic leukemia/lymphoma (T-LBL) cells, and it was therefore suggested that IGF-IR could represent a legitimate therapeutic target in this
Effects of insulin and insulin-like growth factors on cultured human hair follicles: IGF-I at physiologic concentrations is an important regulator of hair follicle growth in vitro.
Philpott MP
The Journal of Investigative Dermatology, 102, 857-861 (1994)
Maria Cecilia Ramirez et al.
Endocrinology, 156(3), 1040-1051 (2014-12-30)
Liver sexual gene dimorphism, which depends mainly on specific patterns of GH secretion, may underlie differential susceptibility to some liver diseases. Because GH and prolactin secretion are regulated by dopaminergic pathways, we studied the participation of brain and lactotrope dopamine
Hiroki Otani et al.
PloS one, 10(6), e0129838-e0129838 (2015-06-20)
TAE226, a bis-anilino pyrimidine compound, has been developed as an inhibitor of focal adhesion kinase (FAK) and insulin-like growth factor-I receptor (IGF-IR). In this study, we investigated the effect of TAE226 on non-small-cell lung cancer (NSCLC), especially focusing on the
Julie C McNally et al.
Theriogenology, 82(9), 1263-1272 (2014-09-28)
Progesterone treatments are used to increase submission rates in postpartum dairy cows; however, in many cases the protocol is used as a blanket therapy for all cows without regard for physiological or disease state. The objective of this study was
Ahmadreza Rahaie et al.
Cells, tissues, organs, 206(4-5), 218-228 (2019-04-26)
Insulin-like growth factor-1 (IGF1) and anti-aromatase synergistically increase the rate and stability of female-to-male sex reversal as well as pre- and postnatal weight gains in hatched chickens. This study aimed at assessing gene expression profiles of chicken embryos treated with
Carolin Maria Frisch et al.
Endocrine-related cancer, 22(4), 609-621 (2015-06-27)
Insulin plays an important role as a growth factor and its contribution to tumor proliferation is intensely discussed. It acts via the cognate insulin receptor (IR) but can also activate the IGF1 receptor (IGF1R). Apart from increasing proliferation, insulin might
The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signaling.
Saegusa J
The Journal of Biological Chemistry, 284, 24106-24114 (2009)
Proteolytic processing of the 600 kd low density lipoprotein receptor-related protein (LRP) occurs in a trans-Golgi compartment.
Herz J
The Embo Journal, 9, 1769-1776 (1990)
Ahmadreza Rahaie et al.
Cells, tissues, organs, 206(4-5), 218-228 (2019-04-26)
Insulin-like growth factor-1 (IGF1) and anti-aromatase synergistically increase the rate and stability of female-to-male sex reversal as well as pre- and postnatal weight gains in hatched chickens. This study aimed at assessing gene expression profiles of chicken embryos treated with
Evangelos Konstantinidis et al.
Journal of neuroinflammation, 20(1), 3-3 (2023-01-03)
Astrocytes are crucial for maintaining brain homeostasis and synaptic function, but are also tightly connected to the pathogenesis of Alzheimer's disease (AD). Our previous data demonstrate that astrocytes ingest large amounts of aggregated amyloid-beta (Aβ), but then store, rather than
Michele R Hutchison et al.
Endocrinology, 156(2), 499-510 (2014-11-19)
Prostaglandins, particularly PGE2, are important to adult bone and joint health, but how prostaglandins act on growth plate cartilage to affect bone growth is unclear. We show that growth plate cartilage is distinct from articular cartilage with respect to cyclooxygenase
Takeshi Kobayashi et al.
Experimental eye research, 135, 109-117 (2015-02-17)
Interactions between stromal and epithelial cells play important roles in the development, homeostasis, and pathological conditions of the cornea. Soluble cytokines are critical factors in stromal-epithelial interactions, and growth factors secreted from corneal stromal cells contribute to the regulation of
Aimee J Varewijck et al.
European journal of endocrinology, 173(2), 119-127 (2015-05-08)
Previously we demonstrated that IGF1 receptor stimulating activity (IGF1RSA) offers advantages in diagnostic evaluation of adult GH deficiency (GHD). It is unknown whether IGF1RSA can be used to monitor GH therapy. To investigate the value of circulating IGF1RSA for monitoring
J L Anderson et al.
Journal of dairy science, 98(8), 5709-5719 (2015-06-16)
The objective of this study was to determine if increased dietary fat from dried distillers grains with solubles (DDGS) in diets of growing heifers affected metabolic profile, plasma fatty acid profile, and reproductive maturation. Thirty-three Holstein heifers (133±18 d of
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