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SRP3177
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关键词:'SRP3177'
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Aggarwal, B.B., et al.
Cytokine Reference, 413-434 (2001)
K Mizrahi et al.
Bone marrow transplantation, 49(7), 942-949 (2014-04-30)
The influence of TNF-α and Fas-ligand (FasL) on viability and function was evaluated in fresh- and expanded-umbilical cord blood (UCB) cells. CD34(+) progenitors and T cells display outstanding survival, whereas ~30% and >50% B lymphocytes and myeloid cells undergo spontaneous
Rupsha Fraser et al.
Journal of reproductive immunology, 110, 54-60 (2015-05-26)
Decidual NK (dNK) cells are present during uterine spiral artery remodelling, an event that is crucial for successful placentation and the provision of an adequate blood supply to the developing fetus. Spiral artery remodelling is impaired in the pregnancy complication
David Jungck et al.
The Journal of pharmacology and experimental therapeutics, 353(3), 564-572 (2015-04-10)
Evidence is lacking on the differential effects of the two therapeutic concepts of endothelin receptor antagonists (ERAs): the blockade of only the endothelin receptor A (ETAR; selective antagonism) versus both ETAR and endothelin receptor B (ETBR; dual blockade). Ambrisentan, a
Brendan A S McIntyre et al.
Innate immunity, 21(5), 504-511 (2014-09-30)
The acquisition of innate immune response is requisite to having bona fide differentiation of airway epithelium. Procedures developed to differentiate lung airway from human pluripotent stem cells (hPSCs) have demonstrated anecdotal evidence for innate immune response, but an in-depth exploration
Xiaowei Shi et al.
Fish & shellfish immunology, 47(1), 611-622 (2015-10-13)
Nicotinic acetylcholine receptor (nAChR), the best-studied ionotropic neuron receptor protein, is a key player in neuronal communication, and it has been reported to play an important role in immunomodulation of vertebrates. Although nAChRs have also been identified in most invertebrates
Nikhil Panicker et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(27), 10058-10077 (2015-07-15)
Sustained neuroinflammation mediated by resident microglia is recognized as a key pathophysiological contributor to many neurodegenerative diseases, including Parkinson's disease (PD), but the key molecular signaling events regulating persistent microglial activation have yet to be clearly defined. In the present
Matilde Alique et al.
Clinical science (London, England : 1979), 127(1), 19-31 (2014-01-05)
ILK (integrin-linked kinase) is an intracellular serine/threonine kinase involved in cell-matrix interactions. ILK dysregulation has been described in chronic renal disease and modulates podocyte function and fibrosis, whereas data about its role in inflammation are scarce. AngII (angiotensin II) is
Effects of carrageenan on cell permeability, cytotoxicity, and cytokine gene expression in human intestinal and hepatic cell lines.
McKim JM Jr
Food And Chemical Toxicology, 96, 1-10 (2016)
Ming Chang et al.
Molecular immunology, 127, 186-192 (2020-09-30)
Asthma is a chronic respiratory disease which is susceptible to children and causes great harm to them. Recently, Interferon-related developmental regulator 1 (IFRD1) was proved to be participant in regulating lung diseases, and its abnormal expression was shown in pathological
Rahima Zennadi
PloS one, 9(10), e110306-e110306 (2014-10-21)
In sickle cell disease, sickle erythrocyte (SSRBC) interacts with endothelial cells, leukocytes, and platelets, and activates coagulation and inflammation, promoting vessel obstruction, which leads to serious life-threatening complications, including acute painful crises and irreversible damage to multiple organs. The mitogen-activated
Eun-Jin Lee et al.
Journal of cellular physiology, 229(11), 1744-1752 (2014-03-26)
Pentraxin-3 (PTX3), also known as tumor necrosis factor-stimulated gene 14 (TSG-14), is produced by immune and vascular cells in response to pro-inflammatory signals and is therefore a multipotent inflammatory mediator. The present study showed that during human osteoblast (OB) differentiation
Endogenous myeloperoxidase is a mediator of joint inflammation and damage in experimental arthritis.
Dragana Odobasic et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(4), 907-917 (2014-04-24)
Myeloperoxidase (MPO) is implicated as a local mediator of tissue damage when released extracellularly in many chronic inflammatory diseases. The purpose of this study was to explore the role of endogenous MPO in experimental rheumatoid arthritis (RA). K/BxN serum-transfer arthritis
Claudia Crosio et al.
PloS one, 6(3), e17187-e17187 (2011-03-30)
Motor neuron death in amyotrophic lateral sclerosis (ALS) is considered a "non-cell autonomous" process, with astrocytes playing a critical role in disease progression. Glial cells are activated early in transgenic mice expressing mutant SOD1, suggesting that neuroinflammation has a relevant
Cavit Agca et al.
BMC biology, 13, 30-30 (2015-04-25)
Photoreceptor degeneration is a main hallmark of many blinding diseases making protection of photoreceptors crucial to prevent vision loss. Thus, regulation of endogenous neuroprotective factors may be key for cell survival and attenuation of disease progression. Important neuroprotective factors in
Ashley R Maiuri et al.
Toxicological sciences : an official journal of the Society of Toxicology, 146(2), 265-280 (2015-05-09)
Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most frequent causes of idiosyncratic, drug-induced liver injury (IDILI). Mechanisms of IDILI are unknown, but immune responses are suspected to underlie them. In animal models of IDILI, the cytokines tumor necrosis factor-alpha (TNFα)
Mefunidone attenuates tubulointerstitial fibrosis in a rat model of unilateral ureteral obstruction.
Chunyan Liu et al.
PloS one, 10(6), e0129283-e0129283 (2015-06-05)
Inflammation has a crucial role in renal interstitial fibrosis, which is the common pathway of chronic kidney diseases. Mefunidone (MFD) is a new compound which could effectively inhibit the proliferation of renal fibroblasts in vitro. However, the overall effect of
Richard L Watson et al.
The Journal of experimental medicine, 212(7), 1021-1041 (2015-06-24)
CD99 is a critical regulator of leukocyte transendothelial migration (TEM). How CD99 signals during this process remains unknown. We show that during TEM, endothelial cell (EC) CD99 activates protein kinase A (PKA) via a signaling complex formed with the lysine-rich
Yue Zhou et al.
Nature communications, 6, 7679-7679 (2015-07-15)
Crosstalk between inflammatory signalling pathways and receptor tyrosine kinases has been revealed as an indicator of cancer malignant progression. In the present study, we focus on EphA2 receptor tyrosine kinase, which is overexpressed in many human cancers. It has been
F Tamarozzi et al.
Parasite immunology, 36(10), 494-502 (2014-06-10)
The host inflammatory response to the Onchocerca volvulus endosymbiont, Wolbachia, is a major contributing factor in the development of chronic pathology in humans (onchocerciasis/river blindness). Recently, the toll-like pattern recognition receptor motif of the major inflammatory ligands of filarial Wolbachia
Sufang Li et al.
Journal of molecular and cellular cardiology, 75, 49-57 (2014-07-08)
The activation of a hemostatic system plays a critical role in the incidence of acute coronary events. Hemostatic proteins may be regulated by microRNAs (miRNAs). Microparticles (MPs) are the major carrier of circulating miRNAs. The aim of this study was
Jun Liu et al.
PloS one, 9(4), e94912-e94912 (2014-04-12)
Cysteine-rich 61/connective tissue growth factor/nephroblastoma overexpressed (CCN) 3 has been recently reported to play a role in regulating inflammation of vascular endothelial cells. However, the role of CCN3 in atherosclerosis, which is characterized by vascular inflammation, remains unclear. Overexpression of
Adam Cisterne et al.
PloS one, 9(7), e103383-e103383 (2014-07-26)
Resistance to apoptosis remains a significant problem in drug resistance and treatment failure in malignant disease. NO-aspirin is a novel drug that has efficacy against a number of solid tumours, and can inhibit Wnt signaling, and although we have shown
Markers of endothelial dysfunction in patients with non-alcoholic fatty liver disease and coronary artery disease.
Elzafir Elsheikh et al.
Journal of gastroenterology and hepatology, 29(7), 1528-1534 (2015-01-15)
Masaru Karakawa et al.
Journal of cellular physiology, 229(12), 1935-1945 (2014-04-09)
The cutaneous T cell-attracting chemokine (CTACK)/CCL27 is indispensable in skin inflammation. CTACK/CCL27 is exclusively produced by epidermal keratinocytes to attract CCR10-expressing T lymphocytes to the skin. We investigated the mechanism of CTACK/CCL27 production from normal human epidermal keratinocytes (NHEKs) by
Stefan Schneider et al.
Lab on a chip, 21(20), 3963-3978 (2021-10-13)
Organ-on-chip (OoC) systems have become a promising tool for personalized medicine and drug development with advantages over conventional animal models and cell assays. However, the utility of OoCs in industrial settings is still limited, as external pumps and tubing for
Qiong Xue et al.
Science signaling, 8(381), ra59-ra59 (2015-06-18)
Macrophages not only produce multiple cytokines but also respond to multiple cytokines, which likely shapes the ultimate response of the population. To determine the role of paracrine signaling in shaping the profile of inflammatory cytokines secreted by macrophages in response
Mi Sook Jeong et al.
Annals of dermatology, 26(3), 296-302 (2014-06-27)
Although vitamin D analogs have been used in the topical treatment of psoriasis, their mechanisms of action are not well understand. Calcitriol, the hormonally active vitamin D3 metabolite, has been demonstrated to exert immunomodulatory effects in the skin by down-regulating
E-W Lee et al.
Cell death and differentiation, 22(9), 1463-1476 (2015-01-24)
Given their crucial role in apoptosis suppression, inhibitor of apoptosis proteins (IAPs) have recently become attractive targets for cancer therapy. Here, we report that cellular IAP2 (cIAP2) is specifically stabilized in several cancer cell lines, leading to resistance to Smac
Karine Enesa et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(5), 1869-1878 (2015-02-11)
A20 protects against pathologic vascular remodeling by inhibiting the inflammatory transcription factor NF-κB. A20's function has been attributed to ubiquitin editing of receptor-interacting protein 1 (RIP1) to influence activity/stability. The validity of this mechanism was tested using a murine model
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