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Polyxeni Alexiou et al.
Archiv der Pharmazie, 347(11), 798-805 (2014-08-28)
SPD-304 was discovered as a promising tumor necrosis factor alpha (TNF) antagonist that promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. However, SPD-304 contains a potentially toxic 3-alkylindole moiety, which can be bioactivated
Chandra S Boosani et al.
Molecular biology reports, 42(9), 1365-1376 (2015-06-07)
Previously we found decreased expression of SOCS3 in neointimal hyperplastic region following balloon angioplasty in atherosclerotic micro swine. In our recent in vitro studies using human coronary artery smooth muscle cells (HCASMC), we observed the inhibition of SOCS3 expression in
Eri Takahashi et al.
Investigative ophthalmology & visual science, 56(4), 2449-2458 (2015-03-19)
The purpose of this study was to investigate the function of merlin, which is a binding partner of the hyaluronan receptor CD44, during the epithelial-to-mesenchymal transition (EMT) of human retinal pigment epithelium (ARPE-19) cells. Human retinal pigment epithelium cells were
B Vandanmagsar et al.
Diabetes, obesity & metabolism, 16(8), 728-738 (2014-02-14)
Bioactives of Artemisia dracunculus L. (termed PMI 5011) have been shown to improve insulin action by increasing insulin signalling in skeletal muscle. However, it was not known if PMI 5011's effects are retained during an inflammatory condition. We examined the
Kanako Moriyama et al.
Laboratory investigation; a journal of technical methods and pathology, 94(11), 1200-1211 (2014-09-30)
Galectins are a unique family of lectins bearing one or two carbohydrate recognition domains (CRDs) that have the ability to bind molecules with β-galactoside-containing carbohydrates. It has been shown that galectins regulate not only cell growth and differentiation but also
Qian Sun et al.
Biochimica et biophysica acta, 1861(1 Pt A), 2912-2921 (2016-10-23)
Oxidative stress plays a crucial role in the development of alcoholic liver disease (ALD), however effective pharmacological treatment for oxidative injury is still lacking. The objective of this study was to determine whether inhibition of NADPH oxidase activity could reverse
Lillian Seu et al.
Journal of virology, 89(13), 6656-6672 (2015-04-17)
The extreme stability of the latent HIV-1 reservoir in the CD4(+) memory T cell population prevents viral eradication with current antiretroviral therapy. It has been demonstrated that homeostatic T cell proliferation and clonal expansion of latently infected T cells due
Inhibition of the insulin-like growth factor system is a potential therapy for rheumatoid arthritis.
Satoshi Suzuki et al.
Autoimmunity, 48(4), 251-258 (2014-10-30)
We have shown that connective tissue growth factor (CTGF) plays an important role in the pathogenesis of rheumatoid arthritis (RA). Insulin-like growth factor binding proteins (IGFBPs) are modules of CTGF. IGFBPs bind IGF-I and IGF-II. IGF-I plays a role in
Huey Wen Ooi et al.
Analytical biochemistry, 456, 6-13 (2014-04-12)
A novel metal-based chelating method has been used to provide an order of magnitude increase in immunoassay performance on cyclic olefin copolymer (COC) plastics compared with passive binding. COCs are hydrophobic, and without surface modification they are often unsuitable for
Nirupama Silswal et al.
Biochemical and biophysical research communications, 334(4), 1092-1101 (2005-07-26)
Resistin, a recently discovered 92 amino acid protein involved in the development of insulin resistance, has been associated with obesity and type 2 diabetes. The elevated serum resistin in human diabetes is often associated with a pro-inflammatory milieu. However, the
Rebeca Martín et al.
Microbiology (Reading, England), 161(Pt 4), 708-718 (2015-01-31)
The vaginal microbiota of healthy, fertile women is dominated by lactobacilli. As a defence mechanism, these bacteria produce H₂O₂ to discourage colonization of the vagina by undesirable micro-organisms. In particular, Lactobacillus jensenii CECT 4306 is a strong producer of H₂O₂
Pierre Duffau et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(12), 3146-3157 (2015-09-01)
Polymorphisms in the transcription factor interferon regulatory factor 5 (IRF5) are associated with an increased risk of developing rheumatoid arthritis (RA). This study was undertaken to determine the role of IRF5 in a mouse model of arthritis development. K/BxN serum-transfer
Nada Alaaeddine et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 64(9), 721-731 (2015-07-21)
Local inflammation plays a role in the pathophysiology of osteoarthritis (OA) and chemokines exert catabolic effects on articular cartilage either through paracrine and/or autocrine mechanisms. We sought to compare the expression levels of the chemokine (C-C motif) ligand 20 (CCL20)
A Fauster et al.
Cell death & disease, 6, e1767-e1767 (2015-05-23)
Necroptosis is a form of regulated necrotic cell death mediated by receptor-interacting serine/threonine-protein kinase 1 (RIPK1) and RIPK3. Necroptotic cell death contributes to the pathophysiology of several disorders involving tissue damage, including myocardial infarction, stroke and ischemia-reperfusion injury. However, no
Evelyn Gaffal et al.
Experimental dermatology, 23(6), 401-406 (2014-04-23)
Atopic dermatitis is a chronic inflammatory disease characterized by an impaired epidermal barrier function combined with a chronic Th2-type inflammatory response and an intense pruritus. Here, we used an experimental mouse model for Th2-type contact hypersensitivity (CHS) to fluorescein isothiocyanate
Yong-Deok Jeon et al.
BMC complementary and alternative medicine, 15, 196-196 (2015-06-25)
Ixeris dentata Nakai has been used for the treatment of mithridatism, calculous, indigestion, pneumonia, hepatitis, and tumors in Korea, China, and Japan. However, the effect of a water extract of Ixeris dentata (ID) and its molecular mechanism on allergic inflammation
Hyunjae Lee et al.
Biomicrofluidics, 8(5), 054102-054102 (2014-10-22)
Understanding the mechanism behind cancer metastasis is a major challenge in cancer biology. Several in vitro models have been developed to mimic a cancer microenvironment by engineering cancer-endothelial cell (EC) and cancer-stromal cell interactions. It has been challenging to realistically
Sun Ah Chung et al.
Journal of cancer prevention, 26(3), 195-206 (2021-10-28)
Pancreatic stellate cells (PSCs) are activated by inflammatory stimuli, such as TNF-α or viral infection. Activated PSCs play a crucial role in the development of chronic pancreatitis. Polyinosinic-polycytidylic acid (poly (I:C)) is structurally similar to double-stranded RNA and mimics viral
Koichi Shimizu et al.
Human vaccines & immunotherapeutics, 10(4), 970-976 (2014-01-15)
The recurrence rate after surgery in patients with hepatocellular carcinoma (HCC) is very high, while prognosis is quite poor. However, there is no standard treatment to prevent recurrence of HCC after a curative operation. In this study, we investigated the
Slava Rom et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 35(12), 1957-1965 (2015-07-02)
Pathologic conditions in the central nervous system, regardless of the underlying injury mechanism, show a certain level of blood-brain barrier (BBB) impairment. Endothelial dysfunction is the earliest event in the initiation of vascular damage caused by inflammation due to stroke
Ofra Malka Ohana et al.
Cancer biology & therapy, 16(11), 1651-1659 (2015-09-30)
Hodgkin's lymphoma is believed to spread in an orderly fashion within the lymphatic compartment. In a minority of cases, after reaching the spleen, the neoplasm disseminates, reminiscent of metastasis. In the spleen, the Hodgkin-Reed-Sternberg tumor cells come across platelets in
Marcela Cataldi et al.
Virology, 485, 340-354 (2015-09-04)
Vesicular stomatitis virus (VSV) is an effective oncolytic virus against most human pancreatic ductal adenocarcinoma (PDAC) cell lines. However, some PDAC cell lines are highly resistant to oncolytic VSV-ΔM51 infection. To better understand the mechanism of resistance, we tested a
Jin Sook Suh et al.
Biomaterials, 35(24), 6287-6298 (2014-05-17)
Targeting tissues/cells using probing materials to detect diseases such as cancer and inflammatory disease has been attempted with some success. Most of the molecular targets used in diagnosis and therapy were identified through the discovery of intracellular signaling pathways. Among
Juhee Jeon et al.
Biochemical pharmacology, 89(4), 515-525 (2014-04-17)
The ligation of interleukin-1 receptor (IL-1R) or tumor necrosis factor receptor 1 (TNFR1) induces the recruitment of adaptor proteins and their concomitant ubiquitination to the proximal receptor signaling complex, respectively. Such are upstream signaling events of IKK that play essential
Victor H Ferreira et al.
The Journal of infectious diseases, 211(11), 1745-1756 (2014-12-30)
Although clinical and experimental evidence indicates that female sex hormones and hormonal contraceptives regulate susceptibility to human immunodeficiency virus type 1 (HIV-1) infection, the underlying mechanism remains unknown. Genital epithelial cells (GECs) are the first cells to encounter HIV during
Martijn F Hoes et al.
European journal of heart failure, 22(11), 2102-2111 (2019-12-05)
Cathepsin D is a ubiquitous lysosomal protease that is primarily secreted due to oxidative stress. The role of circulating cathepsin D in heart failure (HF) is unknown. The aim of this study is to determine the association between circulating cathepsin
Kevin Wilhelmsen et al.
Science signaling, 8(391), ra86-ra86 (2015-08-27)
Inflammatory critical illness is a syndrome that is characterized by acute inflammation and organ injury, and it is triggered by infections and noninfectious tissue injury, both of which activate innate immune receptors and pathways. Although reports suggest an anti-inflammatory role
Immunogenicity of Anti-TNF-alpha agents in autoimmune diseases.
Emi Aikawa N
Clinical Reviews in Allergy & Immunology, 38, 82-89 (2010)
Zhi Chen et al.
Journal of cellular physiology, 234(11), 19977-19989 (2019-04-05)
Inflammation is one of the major causes of intervertebral disc degeneration (IDD). Emerging evidence has revealed that increase in the levels of pro-inflammatory cytokines, such as interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α), can activate a variety of
N Yousaf et al.
Clinical and experimental immunology, 180(2), 289-304 (2014-12-30)
Endoplasmic reticulum aminopeptidase 1 (ERAP1) processes peptides for major histocompatibility complex (MHC) class I presentation and promotes cytokine receptor ectodomain shedding. These known functions of ERAP1 may explain its genetic association with several autoimmune inflammatory diseases. In this study, we
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