T0667

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Carbon-14 radiolabeling and in vivo biodistribution of a potential anti-TB compound.

Molahlehi S Sonopo et al.

Journal of labelled compounds & radiopharmaceuticals, 58(2), 23-29 (2015-02-19)

A potential anti-TB compound bearing a nitroimidazole moiety from iThemba Pharmaceuticals TB chemical library exhibits promising in vitro activity in the microplate almar blue assay (MABA) with a minimum inhibitory concentration (MIC) value of 3 µg/mL. It is equipotent to the

Arcobacter population dynamics in pigs on farrow-to-finish farms.

Sarah De Smet et al.

Applied and environmental microbiology, 77(5), 1732-1738 (2011-01-11)

Healthy pigs are an important reservoir for the emerging human pathogen Arcobacter which can result in contamination of porcine carcasses and pork and the spread of arcobacters into the environment. Up to now, the excretion of arcobacters by pigs has

Listeria monocytogenes strains selected on ciprofloxacin or the disinfectant benzalkonium chloride exhibit reduced susceptibility to ciprofloxacin, gentamicin, benzalkonium chloride, and other toxic compounds.

Mira Rakic-Martinez et al.

Applied and environmental microbiology, 77(24), 8714-8721 (2011-10-18)

Listeria monocytogenes is a leading agent for severe food-borne illness and death in the United States and other nations. Even though drug resistance has not yet threatened therapeutic interventions for listeriosis, selective pressure associated with exposure to antibiotics and disinfectants

Multimodal determinants of phase-locked dynamics across deep-superficial hippocampal sublayers during theta oscillations.

Andrea Navas-Olive et al.

Nature communications, 11(1), 2217-2217 (2020-05-07)

Theta oscillations play a major role in temporarily defining the hippocampal rate code by translating behavioral sequences into neuronal representations. However, mechanisms constraining phase timing and cell-type-specific phase preference are unknown. Here, we employ computational models tuned with evolutionary algorithms

DrugBank 3.0: a comprehensive resource for 'omics' research on drugs.

Craig Knox et al.

Nucleic acids research, 39(Database issue), D1035-D1041 (2010-11-10)

DrugBank (http://www.drugbank.ca) is a richly annotated database of drug and drug target information. It contains extensive data on the nomenclature, ontology, chemistry, structure, function, action, pharmacology, pharmacokinetics, metabolism and pharmaceutical properties of both small molecule and large molecule (biotech) drugs.

Class IIa HDACs regulate learning and memory through dynamic experience-dependent repression of transcription.

Yongchuan Zhu et al.

Nature communications, 10(1), 3469-3469 (2019-08-04)

The formation of new memories requires transcription. However, the mechanisms that limit signaling of relevant gene programs in space and time for precision of information coding remain poorly understood. We found that, during learning, the cellular patterns of expression of

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