T2009000

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Curcumin-Loaded Solid Lipid Nanoparticles Bypass P-Glycoprotein Mediated Doxorubicin Resistance in Triple Negative Breast Cancer Cells.

Gamal-Eldein Fathy Abd-Ellatef et al.

Pharmaceutics, 12(2) (2020-01-30)

Multidrug resistance (MDR) is a critical hindrance to the success of cancer chemotherapy. The main thing responsible for MDR phenotypes are plasma-membranes associated with adenosine triphosphate (ATP) Binding Cassette (ABC) drug efflux transporters, such as the P-glycoprotein (Pgp) transporter that

Identification of lipid- and protein-based binders in paintings by direct on-plate wet chemistry and matrix-assisted laser desorption ionization mass spectrometry.

Cosima Damiana Calvano et al.

Analytical and bioanalytical chemistry, 407(3), 1015-1022 (2014-12-01)

Direct on-target plate processing of small (ca. 100 μg) fragments of paint samples for MALDI-MS identification of lipid- and protein-based binders is described. Fragments were fixed on a conventional stainless steel target plate by colloidal graphite followed by in situ fast

Oral Nanostructured Lipid Carriers Loaded with Near-Infrared Dye for Image-Guided Photothermal Therapy.

Gang Chen et al.

ACS applied materials & interfaces, 8(38), 25087-25095 (2016-09-15)

Photothermal therapy exerts its anticancer effect by converting laser radiation energy into hyperthermia using a suitable photosensitizer. This study reports development of nanostructured lipid carriers (NLCs) suitable for noninvasive oral delivery of a near-infrared photosensitizer dye IR780. The carrier encapsulating

Antihyperglycaemic activity of 2,4:3,5-dibenzylidene-D-xylose-diethyl dithioacetal in diabetic mice.

Arie Gruzman et al.

Journal of cellular and molecular medicine, 16(3), 594-604 (2011-05-14)

We have recently generated lipophilic D-xylose derivatives that increase the rate of glucose uptake in cultured skeletal muscle cells in an AMP-activated protein kinase (AMPK)-dependent manner. The derivative 2,4:3,5-dibenzylidene-D-xylose-diethyl dithioacetal (EH-36) stimulated the rate of glucose transport by increasing the

Determination of Iodine Value in Hydrogenated Oils: Comparison of Titration and Gas Chromatography with Flame-Ionization Detection Methodologies.

Shaun P Kotoski et al.

Lipids, 53(7), 755-763 (2018-09-20)

The United States Food and Drug Administration (FDA) recently issued its final determination that partially hydrogenated oils (PHO) are no longer generally recognized as safe (GRAS) for any use in human food. Consequently, the discrimination between PHO and fully hydrogenated

Design and evaluation of lipoprotein resembling curcumin-encapsulated protein-free nanostructured lipid carrier for brain targeting.

Fanfei Meng et al.

International journal of pharmaceutics, 506(1-2), 46-56 (2016-04-21)

Many nanoparticle matrixes have been demonstrated to be efficient in brain targeting, but there are still certain limitations for them. To overcome the shortcomings of the existing nanoparticulate systems for brain-targeted delivery, a lipoprotein resembling protein-free nanostructured lipid carrier (PS80-NLC)

Nanostructured lipid carriers-mediated brain delivery of carbamazepine for improved in vivo anticonvulsant and anxiolytic activity.

Namrah Khan et al.

International journal of pharmaceutics, 577, 119033-119033 (2020-01-20)

The limited brain delivery of carbamezapine (CBZ) presents a major hurdle in the successful epilepsy treatment. The potential of carbamezapine-loaded nanostructured lipid carriers (CBZ-NLCs) for improved brain delivery is investigated in the current study. CBZ-NLCs were prepared by using binary

Development of Solid Lipid Nanoparticles by Cold Dilution of Microemulsions: Curcumin Loading, Preliminary In Vitro Studies, and Biodistribution.

Daniela Chirio et al.

Nanomaterials (Basel, Switzerland), 9(2) (2019-02-13)

Background: Solid lipid nanoparticles (SLNs) are attractive drug delivery systems for lipophilic molecules like curcumin (CURC) with low chemical stability. Methods: A simple, innovative, and cold-operating method, named "cold dilution of microemulsion" is developed by the authors to produce SLNs.

Prediction of Liquid Specific Heat Capacity of Food Lipids.

Xiaoyi Zhu et al.

Journal of food science, 83(4), 992-997 (2018-03-27)

Specific heat capacity (cp ) is a temperature dependent physical property of foods. Lipid-being a macromolecular component of food-provides some fraction of the food's overall heat capacity. Fats/oils are complex chemicals that are generally defined by carbon length and degree

Improved tumor targeting and antitumor activity of camptothecin loaded solid lipid nanoparticles by preinjection of blank solid lipid nanoparticles.

Dong-Jin Jang et al.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 80, 162-172 (2016-05-03)

This study aimed to enhance the in vivo antitumor effects of camptothecin (CPT), a strong antitumor agent whose delivery is limited by poor aqueous solubility and instability of the active lactone form. CPT was loaded into sterically stabilized, solid lipid

Monobody-Mediated Alteration of Lipase Substrate Specificity.

Shun-Ichi Tanaka et al.

ACS chemical biology, 13(6), 1487-1492 (2018-05-15)

Controlling the catalytic properties of enzymes remain an important challenge in chemistry and biotechnology. We have recently established a strategy for altering enzyme specificity in which the addition of proxy monobodies, synthetic binding proteins, modulates the specificity of an otherwise

Exploiting Lipid and Polymer Nanocarriers to Improve the Anticancer Sonodynamic Activity of Chlorophyll.

Federica Bosca et al.

Pharmaceutics, 12(7) (2020-07-08)

Sonodynamic therapy is an emerging approach that uses low-intensity ultrasound to activate a sonosensitizer agent triggering its cytotoxicity for selective cancer cell killing. Several molecules have been proposed as sonosensitizer agents, but most of these, as chlorophyll, are strongly hydrophobic

Identification and characterization of a new true lipase isolated through metagenomic approach.

Arnaldo Glogauer et al.

Microbial cell factories, 10, 54-54 (2011-07-19)

Metagenomics, the application of molecular genomics to consortia of non-cultivated microbes, has the potential to have a substantial impact on the search for novel industrial enzymes such as esterases (carboxyl ester hydrolases, EC 3.1.1.1) and lipases (triacylglycerol lipases, EC 3.1.1.3).

Mechanism and Structural Factors of Lipid and Surfactant in the Formation of Self-Emulsified Nanoemulsion.

Pulkit Khatri et al.

Journal of pharmaceutical sciences, 107(8), 2198-2207 (2018-04-08)

The study aims to elucidate the mechanism and the role of the molecular structure of surfactants and lipids in the formation of oil-in-water (o/w) self-emulsified nanoemulsions (SENs). The hypothesis is that the overall change of Gibb's free energy (ΔGf) during

Metabolomic and lipidomic plasma profile changes in human participants ascending to Everest Base Camp.

Katie A O'Brien et al.

Scientific reports, 9(1), 2297-2297 (2019-02-21)

At high altitude oxygen delivery to the tissues is impaired leading to oxygen insufficiency (hypoxia). Acclimatisation requires adjustment to tissue metabolism, the details of which remain incompletely understood. Here, metabolic responses to progressive environmental hypoxia were assessed through metabolomic and

Screening of Lipases with Unusual High Activity in the sn-2 Esterification of 1,3-Dicaprin under Mild Operating Conditions.

Daniel Alberto Sánchez et al.

Journal of agricultural and food chemistry, 65(24), 5010-5017 (2017-06-03)

In this work, the synthesis of acylglycerides with high nutritional value was carried out by enzymatic esterification at sn-2 position of 1,3-dicaprin with palmitic acid. A comparative study of the performance of several biocatalysts according to the obtained products was

Biochemical characterization and application of a new lipase and its cognate foldase obtained from a metagenomic library derived from fat-contaminated soil.

Janaina Marques Almeida et al.

International journal of biological macromolecules, 137, 442-454 (2019-06-30)

LipMF3 is a new lipase isolated from a metagenomic library derived from a fat-contaminated soil. It belongs to the lipase subfamily I.1 and has identities of 68% and 67% with lipases of Chromobacterium violaceum and C. amazonense, respectively. Genes encoding

QbD aided development of ibrutinib-loaded nanostructured lipid carriers aimed for lymphatic targeting: evaluation using chylomicron flow blocking approach.

Nagarjun Rangaraj et al.

Drug delivery and translational research, 10(5), 1476-1494 (2020-06-11)

Ibrutinib (IBR) is the choice of drug for the treatment of chronic lymphocytic leukaemia (CLL) and mantle cell lymphoma (MCL). IBR has low oral bioavailability of 2.9% owing to its high first pass metabolism. Present study was aimed to develop

Fatty acid and phospholipid syntheses are prerequisites for the cell cycle of Symbiodinium and their endosymbiosis within sea anemones.

Li-Hsueh Wang et al.

PloS one, 8(8), e72486-e72486 (2013-09-07)

Lipids are a source of metabolic energy, as well as essential components of cellular membranes. Although they have been shown to be key players in the regulation of cell proliferation in various eukaryotes, including microalgae, their role in the cell

Microwave assisted high performance liquid chromatography for the separation of triacylglycerols in vegetable oils using an evaporative light scattering detector.

Silvia Carballo-Marrero et al.

Food chemistry, 300, 125203-125203 (2019-07-23)

Microwave (MW) radiation was applied to perform the separation of triacylglycerols (TGs) in oil samples. The novelty of the work lies in the application of MW radiation to assist the separation of several non-polar compounds employing a totally organic mobile

Poly (N-isopropylacrylamide) based hydrogels as novel precipitation and stabilization media for solid lipid nanoparticles (SLNs).

Sushilkumar A Jadhav et al.

Journal of colloid and interface science, 541, 454-460 (2019-02-04)

In this work, poly(N-isopropylacrylamide) (PNIPAM) based chemically cross-linked hydrogels are used as novel precipitation and stabilization media for solid lipid nanoparticles (SLNs) for the first time. The hydrogels and the hybrid thermoresponsive composite hydrogels with SLNs were characterized by SEM

Structured Mono- and Diacylglycerols with a High Content of Medium Chain Fatty Acids.

Alaina A Esperón-Rojas et al.

Journal of oleo science, 66(9), 991-996 (2017-08-11)

In the present work, direct enzyme-catalysed esterification of medium chain fatty acids (MCFA) from three different sources (Medium chain triacylglycerols, MCT; saponified MCT and a mixture of free MCFA) was evaluated to obtain structured mono- and diacylglycerols. The esterifications were

Associations between the maternal circulating lipid profile in pregnancy and fetal imprinted gene alleles: a cohort study.

Clive J Petry et al.

Reproductive biology and endocrinology : RB&E, 16(1), 82-82 (2018-08-31)

Imprinted genes, which are expressed in a parent of origin-specific manner, are thought to mediate the genetic priorities of each parent in pregnancy. Recently we reported that some fetal imprinted gene variants are associated with maternal glucose concentrations and blood

Surface properties of artificial tear film lipid layers: effects of wax esters.

Pipsa Kulovesi et al.

Investigative ophthalmology & visual science, 55(7), 4448-4454 (2014-05-31)

The tear film lipid layer is believed to stabilize the tear film and to retard evaporation. Based on previous simple in vitro studies, the evidence for the latter property is scarce. In this study, we used complex lipid mixtures including

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