CN
Search Within
T5016
应用筛选条件
关键词:'T5016'
显示 1-30 共 31 条结果 关于 "T5016" 范围 论文
Rahul Nair et al.
Lipids in health and disease, 11, 72-72 (2012-06-15)
The present work aims at preparing aqueous suspension of Solid lipid Nanoparticles containing Chitosan (CT) which is a biopolymer that exhibits a number of interesting properties which include controlled drug delivery. Carbamezapine (CBZ) is a lipophilic drug which shows it
Eric Da Silva et al.
Chemistry and physics of lipids, 157(2), 113-119 (2008-12-06)
Raman spectroscopy was used to distinguish the differences in the molecular organization of the alpha, beta' and beta polymorphs, as well as the liquid state, of tristearin with focus placed on the C=O, C-H and C-C Raman-active stretching regions. The
Tatsiana Lobovkina et al.
ACS nano, 5(12), 9977-9983 (2011-11-15)
Small interfering RNA (siRNA) is a highly potent drug in gene-based therapy with a challenge of being delivered in a sustained manner. Nanoparticle drug delivery systems allow for incorporating and controlled release of therapeutic payloads. We demonstrate that solid lipid
Silvia Petersen et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 79(1), 150-161 (2011-04-05)
Although lipid nanoparticles represent potent drug carriers, for many formulations toxicity data are rare. Thus, in this study, the effect of different lipid nanoparticles on the cell viability of L929 mouse fibroblasts was systematically investigated using the MTT assay. The
Stefano Salmaso et al.
International journal of pharmaceutics, 379(1), 51-58 (2009-06-24)
Homogeneous dispersions of insulin and recombinant human growth hormone (rh-GH) in tristearin/phosphatidylcholine/PEG mixtures (1.3:1.3:0.25:0.15 w/w ratio) were processed by supercritical carbon dioxide gas micro-atomisation to produce protein-loaded lipid particles. The process yielded spherical particles, with a 197+/-94 nm mean diameter
Rita Cortesi et al.
International journal of pharmaceutics, 431(1-2), 176-182 (2012-04-20)
The purpose of this study was to investigate the potential of new positively charged solid lipid nanoparticles (SLN) to convey nucleic acids. The cationic character of SLN was obtained by adding as cationic molecules two different long-chain cationic phosphines (CP)
Safal Jain et al.
Drug delivery, 17(6), 443-451 (2010-05-22)
Topical application of the drugs at the pathological sites offers potential advantages of delivering the drug directly to the site of action. The main aim of this work was to formulate and evaluate Miconazole nitrate (MN) loaded solid lipid nanoparticles
M H A Jahurul et al.
Food chemistry, 154, 323-329 (2014-02-13)
The blending effects of mango seed fat (MSF), extracted using supercritical fluid, and palm stearin (PS) to formulate hard cocoa butter replacers (CBRs), were investigated. The triglycerides (TG), thermal properties and solid fat content (SFC) of the formulated blends were
Quantitative Mapping of Triacylglycerol Chain Length and Saturation Using Broadband CARS Microscopy.
Alexandra Paul et al.
Biophysical journal, 116(12), 2346-2355 (2019-06-04)
Lipid droplets (LDs), present in many cell types, are highly dynamic organelles that store neutral lipids, primarily triacylglycerols (TAGs). With the discovery of new LD functions (e.g., in immune response, protein clearage, and occurrence with disease), new methods to study
Maike Windbergs et al.
International journal of pharmaceutics, 381(2), 184-191 (2009-09-29)
A monoacid triglyceride and a partial glyceride were extruded below their melting ranges alone and together in different mixture ratios to investigate the influence of the chemical composition of the lipid matrix on the solid-state properties and dissolution characteristics. The
Amir Malaki Nik et al.
Journal of agricultural and food chemistry, 60(16), 4126-4135 (2012-03-10)
The stability, crystallization, and melting behavior of canola stearin (CaSt) solid lipid nanoparticle dispersions (SLN) and canola oil-in-water emulsions (COE) with 10 wt % Poloxamer 188 (P188) or Tween 20 (T20) with and without 0.1 wt % β-carotene (BC) were
Hanna Salminen et al.
Food chemistry, 141(3), 2934-2943 (2013-07-23)
A major challenge for food and pharmaceutical industries is the engineering of nanostructures that can efficiently encapsulate bioactive compounds with enhanced physical and chemical stability, and high load. The influence of surfactant properties on the physical and chemical stability of
Maike Windbergs et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 37(5), 555-562 (2009-05-02)
Different combinations of monoacid triglycerides and polyethylene glycol powders of different molecular weights were successfully extruded below their melting temperatures as a basis for oral dosage forms. The incorporated polyethylene glycols exhibiting different mean molecular weights were compared with respect
Andreas Noack et al.
International journal of pharmaceutics, 423(2), 440-451 (2011-12-27)
Curcuminoid-loaded solid lipid nanoparticles (SLN) were produced by melt-homogenization. The used lipid matrices were medium chain triglycerides, trimyristin and tristearin. The resulting nanoparticles had an anisometric shape and a platelet-like structure. Curcuminoid-loaded trimyristin particles did not solidify when stored at
Xiao-Qiang Zou et al.
Journal of agricultural and food chemistry, 59(11), 6055-6063 (2011-05-17)
Human milk fat substitutes (HMFSs) were synthesized by lipozyme RM IM-catalyzed acidolysis of chemically interesterified palm stearin (mp = 58 °C) with mixed FAs from rapeseed oil, sunflower oil, palm kernel oil, stearic acid, and myristic acid in a solvent-free
Marcello Di Sabatino et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 46(5), 346-356 (2012-04-03)
The spray-congealing technique, a solvent-free drug encapsulation process, was successfully employed to obtain lipid-based particulate systems with high (10-20% w/w) protein loading. Bovine serum albumin (BSA) was utilised as model protein and three low melting lipids (glyceryl palmitostearate, trimirystin and
Prakash Adhikari et al.
Journal of food science, 77(12), C1285-C1292 (2012-11-13)
Total of 3 different mixtures of rice bran oil (RBO), sheaolein (SO), and palm stearin (PS) (RBO : SO : PS, 40 : 35 : 25; 15 : 40 : 45; 10 : 35 : 55) were modified by enzymatic
Matthieu Adam-Berret et al.
Journal of agricultural and food chemistry, 59(5), 1767-1773 (2011-02-15)
Model systems composed of tristearin in solid state and tricaprin in liquid state with different solid-fat content (SFC) and storage time have been investigated by relaxation NMR and NMR diffusometry. The T(2) relaxation of the tricaprin in the melt exhibited
Narifumi Akaza et al.
The Journal of dermatology, 41(12), 1069-1076 (2014-11-13)
To clarify the influence of the fatty acid composition of sebum in acne vulgaris, we investigated the amounts and fatty acid compositions of triglycerides (TG) and free fatty acids (FFA), and the amounts of cutaneous superficial Propionibacterium acnes in acne
Franco Pattarino et al.
International journal of pharmaceutics, 473(1-2), 87-94 (2014-06-28)
The work is aimed at investigating the polymorphism and the phase transition kinetics of binary lipid mixtures with potential application in controlled drug delivery. The lipid systems, constituted of glyceryl tristearate (GTS) added with different amounts (1.0-7.5% w/w) of a
Manoj K Rawat et al.
Therapeutic delivery, 1(1), 63-73 (2010-07-01)
To study the effect of different types of lipid on the entrapment efficiency (EE) and physical stability of repaglinide (RG)-loaded solid lipid nanoparticles (SLNs). RG-loaded SLNs were prepared by modified solvent injection method using stearic acid (RSA), glycerol monosteratae (RGM)
N A M Yanty et al.
Journal of oleo science, 60(7), 333-338 (2011-06-28)
Lard being an edible fat could be used in different forms in food systems. In this study, composition and thermal analysis of lard stearin (LS) and lard olein (LO) were undertaken to determine some common parameters which would enable their
Sinan Güres et al.
International journal of pharmaceutics, 412(1-2), 77-84 (2011-04-26)
The influence of different types of release modifiers on the dissolution from solid lipid extrudates was investigated. Diprophylline was extruded together with 45% tristearin and 5% (w/w) of a release modifier to suitable extrudates. Three groups of release modifiers were
Yihui Yang et al.
Journal of colloid and interface science, 374(1), 297-307 (2012-03-13)
Solid lipid nanoparticles (SLNs) have applications in drug delivery and the encapsulation of bioactive, lipophilic compounds. However, SLNs tend to aggregate when stored due to the lipid crystals undergoing a polymorphic transformation from the unstable α form to the stable
Santo Scalia et al.
Journal of microencapsulation, 29(3), 225-233 (2012-01-03)
The aim of this study was to prepare lipid microparticles (LMs) loaded with the polar bronchodilator agent salbutamol, and designed for sustained release pulmonary delivery. The microparticles were produced by melt emulsification followed by a sonication step, using different biocompatible
Sinan Güres et al.
International journal of pharmaceutics, 436(1-2), 877-879 (2012-06-26)
The aim of the present study was to develop a semi-empirical mathematical model, which is able to predict the release profiles of solid lipid extrudates of different dimensions. The development of the model was based on the application of ANNs
Anil B Jindal et al.
International journal of pharmaceutics, 489(1-2), 246-251 (2015-05-03)
Asymmetric lipid polymer nanostructures (LIPOMER) comprising glyceryl monostearate (GMS) as lipid and Gantrez AN 119 (Gantrez) as polymer, revealed enhanced splenic accumulation. In the present paper, we attempt to explain the formation of asymmetric GMS LIPOMER using real time imaging.
Ling-Zhi Cheong et al.
Journal of the science of food and agriculture, 90(13), 2310-2317 (2010-07-28)
Diacylglycerol (DAG), which has health-enhancing properties, is sometimes added to bakery shortening to produce baked products with enhanced physical functionality. Nevertheless, the quantity present is often too little to exert any positive healthful effects. This research aimed to produce bakery
Santo Scalia et al.
Journal of pharmaceutical and biomedical analysis, 54(2), 345-350 (2010-10-12)
Lipid microparticles loaded with the complex between hydroxypropyl-β-cyclodextrin (HP-β-CD) and the sunscreen agent, butyl methoxydibenzoylmethane (BMDBM) were evaluated for their effect on the UV filter percutaneous penetration. The microparticles were prepared by the melt emulsification technique using tristearin as lipidic
Alessandro Dalpiaz et al.
Journal of pharmaceutical sciences, 99(11), 4730-4737 (2010-09-17)
The oral or peripheral administration of dopamine for the treatment of Parkinson's disease is hampered by its extensive metabolism and inability to cross the blood-brain barrier. Consequently, the enhancement of dopamine stability in physiologic environments and its brain targeting appear
1/2