CN
Search Within
T54801
应用筛选条件
关键词:'T54801'
显示 1-30 共 42 条结果 关于 "T54801" 范围 论文
Sophie Scheidecker et al.
Human mutation, 40(10), 1826-1840 (2019-05-23)
Mutations in genes encoding aminoacyl-tRNA synthetases have been reported in several neurological disorders. KARS is a dual localized lysyl-tRNA synthetase and its cytosolic isoform belongs to the multiple aminoacyl-tRNA synthetase complex (MSC). Biallelic mutations in the KARS gene were described
Ronan Garlantézec et al.
Occupational and environmental medicine, 69(1), 62-70 (2011-06-28)
To describe urine levels of metabolites of glycol ethers and chlorinated solvents in a sample of pregnant women from the general population, to study their occupational and non-occupational determinants and to compare them with the results of indirect assessment methods
Mariella Carrieri et al.
Archives of toxicology, 81(7), 529-532 (2007-02-08)
Nonfatal acute inhalation of trichloroethylene (TRI) at work was described. The subject, male, 54 years old, was drawn unconscious by a metal-degreasing machine and immediately sheltered in intensive care unit. Other than basic life support and common laboratory indices, blood
Apryl Bronley-DeLancey et al.
Environmental health perspectives, 114(8), 1237-1242 (2006-08-03)
Trichloroethylene (TCE) is a suspected human carcinogen and a common groundwater contaminant. Chloral hydrate (CH) is the major metabolite of TCE formed in the liver by cytochrome P450 2E1. CH is metabolized to the hepatocarcinogen trichloroacetate (TCA) by aldehyde dehydrogenase
Hong Sik Yoo et al.
Journal of toxicology and environmental health. Part A, 78(1), 32-49 (2014-11-27)
Trichloroethylene (TCE) is a well-known environmental and occupational toxicant that is classified as carcinogenic to humans based on the epidemiological evidence of an association with higher risk of renal-cell carcinoma. A number of scientific issues critical for assessing human health
Ernest Marco-Urrea et al.
Chemosphere, 70(3), 404-410 (2007-08-19)
The white-rot fungus Trametes versicolor degraded trichloroethylene (TCE), a highly oxidized chloroethene, and produced 2,2,2-trichloroethanol and carbon dioxide as the main products of degradation, based on the results obtained using [13C]-TCE as the substrate. For a range of concentrations of
`BF3-etherate induced formation of 2, 2, 2-trichloroethyl glycopyranosides. Selective visualization of carbohydrate derivatives on TLC plates.
Magnusson, et al.
Acta Chemica Scandinavica. Series B, 35(3) (1981)
C Eric Hack et al.
Regulatory toxicology and pharmacology : RTP, 46(1), 63-83 (2006-08-08)
Bayesian population analysis of a harmonized physiologically based pharmacokinetic (PBPK) model for trichloroethylene (TCE) and its metabolites was performed. In the Bayesian framework, prior information about the PBPK model parameters is updated using experimental kinetic data to obtain posterior parameter
Edward A Lock et al.
Toxicology, 230(2-3), 234-243 (2006-12-13)
The industrial solvent trichloroethylene (TCE) and its major metabolites have been shown to cause formic aciduria in male rats. We have examined whether chloral hydrate (CH) and trichloroacetic acid (TCA), known metabolites of TCE, produce an increase in formic acid
Ning Chen et al.
Biochimica et biophysica acta, 1854(7), 827-833 (2015-02-25)
Autism is a human developmental brain disorder characterized by impaired social interaction and communication. Contactin-associated protein-like 2 (Caspr2, CNTNAP2) is a known genetic risk factor of autism. However, how this protein might contribute to pathology is unclear. In this study
Osamu Inoue et al.
Industrial health, 44(1), 207-214 (2006-04-14)
The aim of the present study was to develop a method of urinalysis for trichloroacetic acid (TCA) and trichloroethanol (TCE), and therefore total trichloro-compounds (TTC) as the sum, with least use of hazardous chemicals, being green in that sense. After
e-EROS Encyclopedia of Reagents for Organic Synthesis. null
Meenu Varshney et al.
Environmental science and pollution research international, 20(12), 8709-8716 (2013-05-31)
The genotoxic effects of oxidative metabolites of trichloroethylene (TCE), namely chloral hydrate, trichloroacetic acid (TCA), dichloroacetic acid (DCA), and trichloroethanol (TCEOH) were examined in human peripheral blood lymphocytes. In this context, lymphocytes were exposed in vitro to 25, 50, and
Anand Chopra et al.
Scientific reports, 9(1), 13923-13923 (2019-09-29)
The incorporation of 2,2,2-trichloroethanol in polyacrylamide gels allows for fluorescent visualization of proteins following electrophoresis. Ultraviolet-light exposure, in the presence of this trichlorinated compound, results in a covalent modification of the tryptophan indole ring that shifts the fluorescent emission into
Carol L Ladner et al.
Analytical chemistry, 78(7), 2388-2396 (2006-04-04)
Proteins visualized by 2,2,2-trichloroethanol (TCE) on two-dimensional electrophoresis gels are efficiently identified by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS) and MS/MS. In a previous study, a method was developed that placed TCE in the polyacrylamide gel so that
Xiang-Qun Hu et al.
The Journal of pharmacology and experimental therapeutics, 324(3), 1011-1018 (2007-12-21)
Ligand-gated ion channels participate in synaptic transmission, and they are involved in neurotransmitter release. The functions of the channels are regulated by a variety of modulators. The interaction of 2,2,2-trichloroethanol, the active hypnotic metabolite of chloral hydrate, with the 5-hydroxytryptamine
John W Barton et al.
Chemosphere, 73(11), 1737-1740 (2008-10-22)
We report measurements of solubility limits for benzene, toluene, and TCE in systems that contain varying levels of biomass up to 0.13 g mL(-1) for TCE and 0.25 g mL(-1) for benzene and toluene. The solubility limit increased from 21
Volodya Hayrapetyan et al.
Brain research. Molecular brain research, 142(2), 146-150 (2005-11-01)
Allosteric modulation of mouse 5-Hydroxytryptamine(3A) (5-HT(3A)) and 5-HT(3A/B) receptor function by ethanol and trichloroethanol (TCEt) was assessed in HEK293 cells with whole cell patch-clamp electrophysiological recordings. Ethanol enhanced 5-HT(3A) receptor function, but had no effect on mouse 5-HT(3A/B) receptor mediated
Noreen Yaqoob et al.
Toxicology, 323, 70-77 (2014-06-14)
Trichloroethylene (TCE) is widely used as a cleaning and decreasing agent and has been shown to cause liver tumours in rodents and a small incidence of renal tubule tumours in male rats. The basis for the renal tubule injury is
Nikhil K Parelkar et al.
The Journal of pharmacology and experimental therapeutics, 332(3), 803-810 (2009-12-04)
Trichloroacetaldehyde monohydrate [chloral hydrate (CH)] is a sedative/hypnotic that increases cerebral blood flow (CBF), and its active metabolite 2,2,2-trichloroethanol (TCE) is an agonist for the nonclassical two-pore domain K(+) (K(2P)) channels TREK-1 and TRAAK. We sought to determine whether TCE
Sultan Dogan-Duyar et al.
Clinical biochemistry, 43(3), 328-330 (2009-09-15)
Chloral hydrate is used worldwide as a first-line agent for procedural sedation in paediatric patients undergoing painless diagnostic investigations. Chloral hydrate overdoses in children and adults have been reported to cause various toxicities, including central nervous system, respiratory and cardiac
Yu-Syuan Luo et al.
Toxicology, 409, 33-43 (2018-07-28)
Trichloroethylene (TCE) and tetrachloroethylene (PCE) are structurally similar chemicals that are metabolized through oxidation and glutathione conjugation pathways. Both chemicals have been shown to elicit liver and kidney toxicity in rodents and humans; however, TCE has been studied much more
e-EROS Encyclopedia of Reagents for Organic Synthesis null
Joyce Y Buikhuisen et al.
Cancers, 13(4) (2021-03-07)
Colorectal cancer (CRC) is a heterogeneous disease that can currently be subdivided into four distinct consensus molecular subtypes (CMS) based on gene expression profiling. The CMS4 subtype is marked by high expression of mesenchymal genes and is associated with a
Xiang-Qun Hu et al.
British journal of pharmacology, 148(1), 88-101 (2006-03-08)
1 The goal of this study was to determine whether mutations of L293 at the 15' position of TM2 in the 5-HT(3A) receptor alter macroscopic current kinetics, and if these changes could account for alterations in alcohol modulation. Receptor function
Gavin Harrold et al.
Journal of contaminant hydrology, 80(1-2), 1-17 (2005-08-16)
The wettability of aquifer rocks is a key physical parameter which exerts an important control on the transport, residual trapping, distribution and eventual fate of chlorinated hydrocarbon solvents (CHSs) released into the subsurface. Typically chlorinated solvents are assumed to be
Francisco Gasteazoro et al.
Analytical biochemistry, 471, 44-50 (2014-12-03)
Ethylene is a key molecule in organic synthesis currently produced by steam cracking of fossil hydrocarbons. In nature, ethylene is produced in higher plants by 1-aminocyclopropane-1-carboxylic acid oxidase (ACCO). Biocatalytic alternatives for ethylene production are still far from being competitive
Preparation of N1?Phenylacetamidine 4?Bromobenzoate Using 2, 2, 2?Trichloroethyl Acetimidate Hydrochloride.
Wei L & Caron S.
Organic Syntheses, 174-181 null
Synthesis and protection of aryl sulfates using the 2, 2, 2-trichloroethyl moiety.
Liu Y, et al.
Organic Letters, 6(2), 209-212 (2004)
A K Salous et al.
British journal of pharmacology, 158(5), 1395-1404 (2009-10-01)
Alcohol produces its behavioural effects in part due to inhibition of N-methyl-d-aspartate (NMDA) receptors in the CNS. Previous studies have identified amino acid residues in membrane-associated domains 3 (M3) and 4 (M4) of the NMDA receptor that influence ethanol sensitivity.
1/2