T6277

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Two distinct phosphorylation events govern the function of muscle FHOD3.

Thomas Iskratsch et al.

Cellular and molecular life sciences : CMLS, 70(5), 893-908 (2012-10-12)

Posttranslational modifications such as phosphorylation are universally acknowledged regulators of protein function. Recently we characterised a striated muscle-specific isoform of the formin FHOD3 that displays distinct subcellular targeting and protein half-life compared to its non-muscle counterpart and which is dependent

Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion.

Noumeira Hamoud et al.

Nature communications, 9(1), 4470-4470 (2018-10-28)

Myoblast fusion is tightly regulated during development and regeneration of muscle fibers. BAI3 is a receptor that orchestrates myoblast fusion via Elmo/Dock1 signaling, but the mechanisms regulating its activity remain elusive. Here we report that mice lacking BAI3 display small

Electrical Stimulation Prevents Preferential Skeletal Muscle Myosin Loss in Steroid-Denervation Rats.

Takashi Yamada et al.

Frontiers in physiology, 9, 1111-1111 (2018-08-28)

Severe muscle weakness concomitant with preferential depletion of myosin has been observed in several pathological conditions. Here, we used the steroid-denervation (S-D) rat model, which shows dramatic decrease in myosin content and force production, to test whether electrical stimulation (ES)

Effect of Different Roughage Sources in Fermented Total Mixed Ration and Energy Intake on Meat Quality, Collagen Solubility, Troponin T Degradation, and Fatty Acids of Native Thai Cattle Longissimus Muscle.

Achara Lukkananukool et al.

Foods (Basel, Switzerland), 12(18) (2023-09-28)

The effects of roughage sources in the fermented total mixed ration (FTMR) and the level of energy intake on meat quality, collagen solubility, and troponin T degradation in longissimus thoracis (LT) muscle of native Thai cattle (NTC) were investigated. Results

Sudden death due to troponin T mutations.

J C Moolman et al.

Journal of the American College of Cardiology, 29(3), 549-555 (1997-03-01)

This study was designed to verify initial observations of the clinical and prognostic features of hypertrophic cardiomyopathy caused by cardiac tropnin T gene mutations. The most common cause of sudden cardiac death in the young is hypertrophic cardiomyopathy, which is

Postmortem protein degradation is a key contributor to fresh pork loin tenderness.

K B Carlson et al.

Journal of animal science, 95(4), 1574-1586 (2017-05-04)

The objective of this study was to determine factors that influence tenderness independent of variation in pH, color, or marbling. To achieve the objective, 2 sample groups were chosen from a population of 159 pork loins aged 11 to 16

Transendocardial autologous bone marrow mononuclear cell injection in ischemic heart failure: postmortem anatomicopathologic and immunohistochemical findings.

Hans F R Dohmann et al.

Circulation, 112(4), 521-526 (2005-07-20)

Cell-based therapies for treatment of ischemic heart disease are currently under investigation. We previously reported the results of a phase I trial of transendocardial injection of autologous bone marrow mononuclear (ABMM) cells in patients with end-stage ischemic heart disease. The

Acute heart failure with cardiomyocyte atrophy induced in adult mice by ablation of cardiac myosin light chain kinase.

Michael T Massengill et al.

Cardiovascular research, 111(1), 34-43 (2016-03-31)

Under pressure overload, initial adaptive hypertrophy of the heart is followed by cardiomyocyte elongation, reduced contractile force, and failure. The mechanisms governing the transition to failure are not fully understood. Pressure overload reduced cardiac myosin light chain kinase (cMLCK) by

Mouse Model of Human Congenital Heart Disease: Progressive Atrioventricular Block Induced by a Heterozygous Nkx2-5 Homeodomain Missense Mutation.

Rajib Chowdhury et al.

Circulation. Arrhythmia and electrophysiology, 8(5), 1255-1264 (2015-08-01)

Heterozygous human NKX2-5 homeodomain (DNA-binding domain) missense mutations are highly penetrant for varied congenital heart defects, including progressive atrioventricular (AV) block requiring pacemaker implantation. We recently replicated this genetic defect in a murine knockin model, in which we demonstrated highly

Expression and functional assessment of a truncated cardiac troponin T that causes hypertrophic cardiomyopathy. Evidence for a dominant negative action.

H Watkins et al.

The Journal of clinical investigation, 98(11), 2456-2461 (1996-12-01)

Mutations in the beta-myosin heavy chain gene are believed to cause hypertrophic cardiomyopathy (HCM) by acting as dominant negative alleles. In contrast, a truncated cardiac troponin T (TnT) that causes HCM implies that altered stoichiometry of contractile proteins may also

Elucidating the involvement of apoptosis in postmortem proteolysis in porcine muscles from two production cycles using metabolomics approach.

Danyi Ma et al.

Scientific reports, 11(1), 3465-3465 (2021-02-12)

Apoptosis has been suggested as the first step in the process of conversion of muscle into meat. While a potential role of apoptosis in postmortem proteolysis has been proposed, the underlying mechanisms by which metabolome changes in muscles would influence

Dynamics of the skeletal muscle secretome during myoblast differentiation

Henningsen J, et al.

Molecular and Cellular Proteomics, 9(11), 2482-2496 (2010)

The FSHD atrophic myotube phenotype is caused by DUX4 expression.

Céline Vanderplanck et al.

PloS one, 6(10), e26820-e26820 (2011-11-05)

Facioscapulohumeral muscular dystrophy (FSHD) is linked to deletions in 4q35 within the D4Z4 repeat array in which we identified the double homeobox 4 (DUX4) gene. We found stable DUX4 mRNAs only derived from the most distal D4Z4 unit and unexpectedly

Modulation of L-type calcium channel expression during retinoic acid-induced differentiation of H9C2 cardiac cells.

C Ménard et al.

The Journal of biological chemistry, 274(41), 29063-29070 (1999-10-03)

The molecular mechanisms underlying the developmental regulation of L-type voltage-dependent Ca(2+) channels (VDCCs) are still unknown. In this study, we have characterized the expression patterns of skeletal (alpha(1S)) and cardiac (alpha(1C)) L-type VDCCs during cardiogenic differentiation in H9C2 cells that

The Effect of µ/m-Calpain on Protein Degradation of Chicken Breast Meat.

Jichao Huang et al.

Journal of food science, 84(5), 1054-1059 (2019-05-03)

This study was designed to determine the effects of µ/m-calpain on the degradation of cytoskeletal proteins in pectoralis major. Four chickens were slaughtered and the breasts were removed and stored for 12 hr at 4 °C. Each sample was divided into three

The role of Pitx2 and Pitx3 in muscle stem cells gives new insights into P38α MAP kinase and redox regulation of muscle regeneration.

Aurore L'honoré et al.

eLife, 7 (2018-08-15)

Skeletal muscle regeneration depends on satellite cells. After injury these muscle stem cells exit quiescence, proliferate and differentiate to regenerate damaged fibres. We show that this progression is accompanied by metabolic changes leading to increased production of reactive oxygen species

Preclinical model of type 1 diabetes and myocardial ischemia/reperfusion injury in conscious rabbits-demonstration of cardioprotection with rapamycin.

Arun Samidurai et al.

STAR protocols, 2(3), 100772-100772 (2021-09-07)

We developed a preclinical model of myocardial ischemia/reperfusion (I/R) injury in conscious diabetic rabbits to identify an early pharmacological intervention for patients with diabetes and acute myocardial infarction (AMI). Here, we describe a reproducible protocol for induction of diabetes with

Differential Protein Metabolism and Regeneration in Gastrocnemius Muscles in High-fat Diet Fed Mice and Pre-hibernation Daurian Ground Squirrels: A Comparison between Pathological and Healthy Obesity.

Xia Yan et al.

Zoological studies, 60, e6-e6 (2021-08-14)

We focused on pathological obesity induced by excessive fat intake (nutritional obesity) in non-hibernator and healthy obesity due to pre-hibernation (PRE) fat storage in hibernator to study the effects of different types of obesity on skeletal muscle protein metabolism and

Impacts of in Utero Heat Stress on Carcass and Meat Quality Traits of Market Weight Gilts.

Jacob R Tuell et al.

Animals : an open access journal from MDPI, 11(3) (2021-04-04)

This study evaluated the impacts of in utero heat stress (IUHS) on the carcass and meat quality traits of offspring when market weight was reached. Twenty-four F1 Landrace × Large White gilts were blocked by body weight and allocated among

Unique morphogenetic signatures define mammalian neck muscles and associated connective tissues.

Eglantine Heude et al.

eLife, 7 (2018-11-20)

In vertebrates, head and trunk muscles develop from different mesodermal populations and are regulated by distinct genetic networks. Neck muscles at the head-trunk interface remain poorly defined due to their complex morphogenesis and dual mesodermal origins. Here, we use genetically

Slow skeletal troponin I gene transfer, expression, and myofilament incorporation enhances adult cardiac myocyte contractile function.

M V Westfall et al.

Proceedings of the National Academy of Sciences of the United States of America, 94(10), 5444-5449 (1997-05-13)

The functional significance of the developmental transition from slow skeletal troponin I (ssTnI) to cardiac TnI (cTnI) isoform expression in cardiac myocytes remains unclear. We show here the effects of adenovirus-mediated ssTnI gene transfer on myofilament structure and function in

A distinct cardiopharyngeal mesoderm genetic hierarchy establishes antero-posterior patterning of esophagus striated muscle.

Glenda Comai et al.

eLife, 8 (2019-09-20)

In most vertebrates, the upper digestive tract is composed of muscularized jaws linked to the esophagus that permits food ingestion and swallowing. Masticatory and esophagus striated muscles (ESM) share a common cardiopharyngeal mesoderm (CPM) origin, however ESM are unusual among

The use of vitamin D3 to improve beef tenderness.

J L Montgomery et al.

Journal of animal science, 78(10), 2615-2621 (2000-10-26)

An experiment was designed to test the hypothesis that short-term oral administration of dietary vitamin D3 to beef cattle before slaughter would increase beef tenderness through greater calcium-activated calpain activity in postmortem aged skeletal muscle. Thirty continental crossbred steers were

Troponin: structure, properties, and mechanism of functioning.

V L Filatov et al.

Biochemistry. Biokhimiia, 64(9), 969-985 (1999-10-16)

This review discusses the structure and properties of the isolated components of troponin, their interaction, and the mechanisms of regulation of contractile activity of skeletal and cardiac muscle. Data on the structure of troponin C in crystals and in solution

Superoxide dismutase/catalase mimetic EUK-134 prevents diaphragm muscle weakness in monocrotalin-induced pulmonary hypertension.

Koichi Himori et al.

PloS one, 12(2), e0169146-e0169146 (2017-02-06)

Patients with pulmonary hypertension (PH) suffer from inspiratory insufficiency, which has been associated with intrinsic contractile dysfunction in diaphragm muscle. Here, we examined the role of redox stress in PH-induced diaphragm weakness by using the novel antioxidant, EUK-134. Male Wistar

Genome-wide survey by ChIP-seq reveals YY1 regulation of lincRNAs in skeletal myogenesis.

Leina Lu et al.

The EMBO journal, 32(19), 2575-2588 (2013-08-15)

Skeletal muscle differentiation is orchestrated by a network of transcription factors, epigenetic regulators, and non-coding RNAs. The transcription factor Yin Yang 1 (YY1) silences multiple target genes in myoblasts (MBs) by recruiting Ezh2 (Enhancer of Zeste Homologue2). To elucidate genome-wide

Genotype-specific pathogenic effects in human dilated cardiomyopathy.

Ilse A E Bollen et al.

The Journal of physiology, 595(14), 4677-4693 (2017-04-25)

Mutations in genes encoding cardiac troponin I (TNNI3) and cardiac troponin T (TNNT2) caused altered troponin protein stoichiometry in patients with dilated cardiomyopathy. TNNI3p.98trunc resulted in haploinsufficiency, increased Ca2+ -sensitivity and reduced length-dependent activation. TNNT2p.K217del caused increased passive tension. A

Effect of extended postmortem aging and steak location on myofibrillar protein degradation and Warner-Bratzler shear force of beef M. semitendinosus steaks.

K J Phelps et al.

Journal of animal science, 94(1), 412-423 (2016-01-27)

The objective of this study was to evaluate the effect of steak location and postmortem aging on cooked meat tenderness and myofibrillar protein degradation of steaks from M. semitendinosus (ST). Following harvest and a 6 d chill period, the left

Posterior axis formation requires Dlx5/Dlx6 expression at the neural plate border.

Nicolas Narboux-Neme et al.

PloS one, 14(3), e0214063-e0214063 (2019-03-20)

Neural tube defects (NTDs), one of the most common birth defects in human, present a multifactorial etiology with a poorly defined genetic component. The Dlx5 and Dlx6 bigenic cluster encodes two evolutionary conserved homeodomain transcription factors, which are necessary for

Biochemical and myofilament responses of the right ventricle to severe pulmonary hypertension.

Lori A Walker et al.

American journal of physiology. Heart and circulatory physiology, 301(3), H832-H840 (2011-05-31)

Right ventricular (RV) failure is one of the strongest predictors of mortality both in the presence of left ventricular decompensation and in the context of pulmonary vascular disease. Despite this, there is a limited understanding of the biochemical and mechanical

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