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Brendon J Monahan et al.
Nature structural & molecular biology, 15(8), 873-880 (2008-07-16)
SWI/SNF chromatin-remodeling complexes have crucial roles in transcription and other chromatin-related processes. The analysis of the two members of this class in Saccharomyces cerevisiae, SWI/SNF and RSC, has heavily contributed to our understanding of these complexes. To understand the in
Rafael Gozalbes et al.
Bioorganic & medicinal chemistry, 18(19), 7078-7084 (2010-09-03)
Solubility plays a very important role in the selection of compounds for drug screening. In this context, a QSAR model was developed for predicting water solubility of drug-like compounds. First, a set of relevant parameters for establishing a drug-like chemical
Denis Fourches et al.
Chemical research in toxicology, 23(1), 171-183 (2009-12-18)
Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this
Jinnan Zhang et al.
Die Pharmazie, 68(12), 962-968 (2014-01-10)
Thiabendazole, an orally available antifungal drug, has been used in clinical practice for 40 years. Previous studies indicated its potential in inhibiting angiogenesis in both animal models and in human cells. Malignant melanoma is associated with angiogenesis and it is
Nan Shang et al.
Wei sheng yan jiu = Journal of hygiene research, 40(3), 365-367 (2011-06-24)
To explore the distribution and elimination of thiabendazole and its metabolite 5-hydrothiabendazole residues in the hens tissues including liver, muscle, heart, fat, as well as in eggs. Laying hens were orally administred thiabendazole for 5 consecutive days (100mg per hen
Craig Knox et al.
Nucleic acids research, 39(Database issue), D1035-D1041 (2010-11-10)
DrugBank (http://www.drugbank.ca) is a richly annotated database of drug and drug target information. It contains extensive data on the nomenclature, ontology, chemistry, structure, function, action, pharmacology, pharmacokinetics, metabolism and pharmaceutical properties of both small molecule and large molecule (biotech) drugs.
Maki Kanda et al.
Journal of AOAC International, 98(1), 230-247 (2015-04-11)
Residues of 37 polar veterinary drugs belonging to six families (quinolones, tetracyclines, macrolides, lincosamides, sulfonamides, and others) in livestock and fishery products were determined using a validated LC-MS/MS method. There were two key points in sample preparation. First, extraction was
W H Gera Hol et al.
Ecology, 96(8), 2042-2048 (2015-09-26)
The contribution of low-abundance microbial species to soil ecosystems is easily overlooked because there is considerable overlap between metabolic abilities (functional redundancy) of dominant and subordinate microbial species. Here we studied how loss of less abundant soil bacteria affected the
E J Llorent-Martínez et al.
Talanta, 96, 190-194 (2012-07-24)
Thiabendazole is a benzimidazole fungicide of general use that is specifically used to control mushroom diseases, mainly cobweb diseases, which is caused by members of the genus Cladobotryum. Although this compound is legislated and its maximum residue limit established at
Lili He et al.
Food chemistry, 148, 42-46 (2013-11-23)
We developed a rapid and simple method which combines a surface swab capture method and surface-enhanced Raman spectroscopy for recovery and quantitative detection of thiabendazole on apple surfaces. The whole apple surface was swabbed and the swab was vortexed in
Sharon Rossiter et al.
Bioorganic & medicinal chemistry letters, 15(21), 4806-4808 (2005-09-17)
2,4-Disubstituted quinolines with additional substituents in positions 5-8 have been found to have anthelmintic properties. A number of 2,4-dimethoxy-6- or 8-arylquinolines have potent activity against the sheep nematode Haemonchus contortus, with LD99 values of the same order of magnitude as
Hye Ji Cha et al.
PLoS biology, 10(8), e1001379-e1001379 (2012-08-29)
Studies in diverse organisms have revealed a surprising depth to the evolutionary conservation of genetic modules. For example, a systematic analysis of such conserved modules has recently shown that genes in yeast that maintain cell walls have been repurposed in
Qiangjun Zhou et al.
Protein & cell, 2(7), 531-542 (2011-08-09)
The mitochondrial respiratory complex II or succinate: ubiquinone oxidoreductase (SQR) is a key membrane complex in both the tricarboxylic acid cycle and aerobic respiration. Five disinfectant compounds were investigated with their potent inhibition effects on the ubiquinone reduction activity of
Noriko Furusho et al.
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences, (130)(130), 46-49 (2012-12-19)
The method prescribed in the 8th edition of Japan's Specifications and Standards for Food Additives (JSSFA) for the quantitative analysis of thiabendazole was improved by eliminating the use of toxic reagents such as mercuric acetate and chromium trioxide. For exclusion
Francisco Barahona et al.
Journal of chromatography. A, 1218(40), 7065-7070 (2011-08-23)
In this paper, a novel format for selective solid-phase extraction based on a molecularly imprinted polymer (MIP) is described. A small amount of MIP has been synthesized within the pores of commercial polyethylene (PE) frits and attached to its surface
Bullous cutaneous larva migrans.
Aldo Morrone et al.
Acta dermatovenerologica Croatica : ADC, 19(2), 120-121 (2011-06-28)
Rafael Igual-Adell et al.
Expert opinion on pharmacotherapy, 5(12), 2615-2619 (2004-12-02)
Treatment of strongyloidiasis has been traditionally based on thiabendazole, despite its frequent gastrointestinal side effects and failure to achieve eradication of the parasite from faeces in approximately 30% of cases. Ivermectin has been shown to be more effective for treating
Katsuhiro Tanae et al.
FEBS letters, 586(23), 4190-4196 (2012-10-24)
An H3/H4 histone chaperone, Asf1, plays an essential role in maintaining genomic stability in many species, including fission yeast. Here, we showed that overexpression of a CENP-A chaperone Sim3 suppressed the temperature sensitive phenotype of asf1-33 and asf1-30 mutants and
[Thiabendazole, large-spectrum anthelmintic; its indications and its limitations: general review of 253 cases].
J Thomas et al.
Medecine tropicale : revue du Corps de sante colonial, 29(1), 7-36 (1969-01-01)
Evolution-based drug discovery: antifungal also disrupts blood vessel formation.
Robin Mejia
PLoS biology, 10(8), e1001380-e1001380 (2012-08-29)
Thiabendazole in the treatment and control of parasitic infections in man.
W C Campbell et al.
Texas reports on biology and medicine, 27, Suppl 2:665+-Suppl 2:665+ (1969-11-01)
P A Olounladé et al.
Parasitology research, 110(4), 1427-1433 (2011-10-01)
The need for new anthelmintic with no chemical residues is becoming urgent. In a program aiming at the evaluation of plant as sources of new active molecules, the anthelmintic activities of the essential oils (EOs) obtained from either Zanthoxylum zanthoxyloides
Miin-Huey Lee et al.
International journal of food microbiology, 150(2-3), 157-163 (2011-08-27)
Penicillium digitatum causes green mold on citrus, resulting in severe postharvest fruit decay and economic losses in many citrus-producing areas of the world. Forty isolates of P. digitatum were cultured from citrus groves, packinghouses, and local markets in Taiwan, and
Nerea Escala et al.
European journal of medicinal chemistry, 208, 112554-112554 (2020-09-25)
Gastrointestinal nematode infections are the main diseases in herds of small ruminants. Resistance to the main established drugs has become a worldwide problem. The purpose of this study is to obtain and evaluate the in vitro ovicidal and larvicidal activity of
Pau Calatayud-Vernich et al.
The Science of the total environment, 541, 33-41 (2015-09-24)
Samples of dead honey bees (Apis mellifera L.) were collected periodically from 4 different locations during citrus and stone fruit trees blooming season to evaluate the potential impact of agrochemicals on honey bee death rate. For the determination of mortality
Roslyn S Thelingwani et al.
Drug metabolism and disposition: the biological fate of chemicals, 37(6), 1286-1294 (2009-03-21)
Thiabendazole (TBZ) and its major metabolite 5-hydroxythiabendazole (5OH-TBZ) were screened for potential time-dependent inhibition (TDI) against CYP1A2. Screen assays were carried out in the absence and presence of NADPH. TDI was observed with both compounds, with k(inact) and K(I) values
P Fonderie et al.
Parasitology, 139(10), 1301-1308 (2012-06-22)
Studies on anthelmintic resistance in equine parasites do not include facultative parasites. Halicephalobus gingivalis is a free-living bacterivorous nematode and a known facultative parasite of horses with a strong indication of some form of tolerance to common anthelmintic drugs. This
Thiabendazole: toxicological, pharmacological and antifungal properties.
H J Robinson et al.
Texas reports on biology and medicine, 27, Suppl 2:537+-Suppl 2:537+ (1969-11-01)
Andrea Peano et al.
Veterinary dermatology, 23(2), 131-135 (2012-02-09)
In this study, we evaluated the antifungal susceptibility of Malassezia pachydermatis to clotrimazole (CTZ), miconazole (MCZ), and thiabendazole (TBD), azole derivatives employed in aural formulations labeled for treatment of canine otitis. The procedure for in vitro testing was based on
Ann-Kathrin Wluka et al.
Environmental science and pollution research international, 23(21), 21894-21907 (2016-08-18)
The main objective of this study was the development of simple multi-parameter methods for the analyses of biocides in various environmental matrices (wastewater, surface water, and sewage sludge) for measurement and monitoring activities. Eight target substances (triclosan, methyltriclosan (transformation product
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