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T9034
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关键词:'T9034'
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Y Sai et al.
Journal of cell science, 112 ( Pt 24), 4535-4545 (1999-11-27)
The bile canalicular membrane contains several ATP-dependent transporters that are involved in biliary secretion. Canalicular transporters are synthesized in ER, modified in Golgi and transported to the apical plasma membrane. However, the route and regulation of intracellular trafficking of ATP-dependent
M-K Choi et al.
Xenobiotica; the fate of foreign compounds in biological systems, 39(2), 171-181 (2009-03-04)
1. The purpose of this study was to investigate the involvement of rat Mrp2 and human MRP2 in benzylpenicillin transport using canalicular liver plasma membrane (cLPM) vesicles isolated from Sprague-Dawley or Easai hyperbilirubinemic (EHBR) rats, and MDCKII cells overexpressing MRP2.
Xin Chen et al.
American journal of physiology. Gastrointestinal and liver physiology, 303(2), G199-G208 (2012-05-12)
Reflux of acid and bile acids contributes to epithelial tissue injury in gastro-esophageal reflux disease. However, the influence of refluxed material on human esophageal stratified epithelial barrier function and tight junction (TJ) proteins has not been fully elucidated. Here, we
Pernille Barbre Pedersen et al.
Pharmaceutical research, 31(8), 2044-2053 (2014-02-20)
To develop a minimally-invasive method for direct visualization of drug delivery systems in the human stomach and to compare the obtained results with an established in vitro model. The method should provide the capsule rupture, dispersion characteristics, and knowledge regarding
Sebastiaan Bijttebier et al.
Food chemistry, 165, 371-378 (2014-07-21)
Food processing enterprises produce enormous amounts of organic waste that contains valuable phytochemicals (e.g. C17-polyacetylenes). Knowledge on the phytochemicals content is a first step towards valorisation. Quantification of C17-polyacetylenes is however often hampered by the lack of commercially available standards
Judit Gil-Zamorano et al.
Scientific reports, 10(1), 18921-18921 (2020-11-05)
The role of miRNAs in intestinal lipid metabolism is poorly described. The small intestine is constantly exposed to high amounts of dietary lipids, and it is under conditions of stress that the functions of miRNAs become especially pronounced. Approaches consisting
Mehmet Ali Kosekli et al.
Revista da Associacao Medica Brasileira (1992), 65(2), 204-210 (2019-03-21)
The effects of Certolizumab, a pegylated monoclonal antibody to tumor necrosis factor α, on experimentally induced acute pancreatitis (AP) were examined. Thirty-six Wistar Albino male rats were randomly divided into four groups. Group I was the control group and no
Susan A Joyce et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(20), 7421-7426 (2014-05-07)
Alterations in the gastrointestinal microbiota have been implicated in obesity in mice and humans, but the key microbial functions influencing host energy metabolism and adiposity remain to be determined. Despite an increased understanding of the genetic content of the gastrointestinal
Paloma Benito-Gallo et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 93, 353-362 (2015-05-06)
Triglycerides (TG) are one of the most common excipients used in oral lipid-based formulations. The chain length of the TG plays an important role in the oral bioavailability of the co-administered drug. Fatty acid (FA) chain-length specificity of porcine pancreatic
Xuan Guo et al.
Rejuvenation research, 18(3), 211-224 (2015-01-06)
Pluripotent human hepatic stem cells have broad research and clinical applications, which are, however, restricted by both limited resources and technical difficulties with respect to isolation of stem cells from the adult or fetal liver. In this study, we developed
María Luz Gómez-Pérez et al.
Journal of chromatography. A, 1389, 133-138 (2015-03-10)
Retrospective analysis has been applied in different samples, including honey, meat, feed and nutraceutical products from ginkgo biloba, soya, royal jelly and green tea, with the aim of searching transformation products of pesticides and veterinary drugs, which were not included
Jacquelene Chu et al.
International journal of pharmaceutics, 471(1-2), 92-102 (2014-05-09)
Lecithin-linker microemulsions are formulations produced with soybean lecithin in combination with a highly lipophilic (lipophilic linker) and highly hydrophilic (hydrophilic linkers) surfactant-like additives. In this work, lecithin-linker systems were formulated to produce self-emulsifying delivery systems for β-carotene and β-sitosterol. The
Noushin Dianat et al.
Hepatology (Baltimore, Md.), 60(2), 700-714 (2014-04-10)
Cholangiocytes are biliary epithelial cells, which, like hepatocytes, originate from hepatoblasts during embryonic development. In this study we investigated the potential of human embryonic stem cells (hESCs) to differentiate into cholangiocytes and we report a new approach, which drives differentiation
Michele Visentin et al.
The Journal of pharmacology and experimental therapeutics, 355(2), 145-151 (2015-09-04)
The somatostatin analog octreotide can lead to hyperbilirubinemia without evidence of liver injury. Here we investigate whether octreotide inhibits the main sinusoidal/canalicular bilirubin carriers and whether it is a transport substrate. Octreotide showed the most potent inhibitory effect toward OATP1B1-mediated
Alejandro Fernández-Pumarega et al.
Journal of chromatography. A, 1418, 167-176 (2015-10-05)
Toxicity has been emulated in tadpole species through chromatographic systems. The parameter studied to evaluate the non-specific toxicity of a compound is the narcosis concentration (Cnar), which is defined as the concentration needed for the immobilization of the organism. Because
Meng-Mei Ma et al.
Food chemistry, 194, 237-246 (2015-10-17)
This study evaluated the effects of alkali extraction, enzymatic hydrolysis, shear emulsifying assisted enzymatic hydrolysis, and particle size distribution on the chemical composition and the structural, physicochemical, and functional properties of deoiled cumin dietary fibers (AEDF, EHDF and SEDF). Compared
Nathalie Nicod et al.
The Journal of nutritional biochemistry, 26(2), 165-172 (2014-12-04)
High-density lipoproteins (HDLs) are atheroprotective because of their role in reverse cholesterol transport. The intestine is involved in this process because it synthesizes HDL, removes cholesterol from plasma and excretes it into the lumen. We investigated the role of selected
Nermina Vejzagić et al.
Parasitology research, 114(7), 2705-2714 (2015-05-27)
Eggs of the pig whipworm, Trichuris suis ova (TSO), are currently tested in human clinical trials for their potential immunomodulatory capacity. The biological potency of TSO (egg viability and infectivity) is traditionally assessed in Göttingen minipigs as the establishment of
Ian David Woolsey et al.
Parasitology research, 114(7), 2777-2780 (2015-04-22)
Invertebrate models provide several important advantages over their vertebrate counterparts including fewer legislative stipulations and faster, more cost-effective experimental procedures. Furthermore, various similarities between insect and mammalian systems have been highlighted. To obtain maximum use of invertebrate models in pharmacology
Michael D Aleo et al.
Journal of applied toxicology : JAT, 39(8), 1192-1207 (2019-05-28)
Marketed (bosentan, ambrisentan) and discontinued (sitaxsentan, CI-1034) endothelin receptor antagonists were examined in the human micropatterned hepatocyte co-culture (MPCC) model HepatoPac® . Differences across hepatocellular health (cellular adenosine triphosphate/glutathione content), function (urea production/albumin secretion) and taurocholic acid transport (biliary clearance/excretion
Carsten Kneuer et al.
Pflugers Archiv : European journal of physiology, 454(4), 587-594 (2007-03-03)
Cholestatic liver disease and increased serum bile acid concentrations are known to trigger various adaptive responses including the induction of hepatic, intestinal and renal bile acid transport proteins, but renal P-glycoprotein (Pgp, multidrug resistance protein 1, MDR1) remained uninvestigated in
Line Hagner Nielsen et al.
Drug delivery and translational research, 4(3), 268-274 (2015-03-20)
Amorphous indomethacin was prepared by melting the γ-form of indomethacin, spatially confined within microcontainers (inner diameter of 223 μm), followed by cooling of the melt at a rate of 14, 23 or 36 K/min. The physical stability of the amorphous indomethacin within
Line Hagner Nielsen et al.
International journal of pharmaceutics, 490(1-2), 334-340 (2015-06-01)
A glass solution of the amorphous sodium salt of furosemide (ASSF) and polyvinylpyrrolidone (PVP) (80:20 w/w%) was prepared by spray drying. It was investigated if PVP was able to stabilise ASSF during storage and dissolution and whether this influenced the
Noelia López-Gutiérrez et al.
Food chemistry, 173, 607-618 (2014-12-04)
A method has been developed and validated for the simultaneous detection and quantification of phytochemicals in nutraceutical products obtained from green tea. For that purpose, ultra-high performance liquid chromatography coupled to single-stage Orbitrap high resolution mass spectrometry (UHPLC-Orbitrap-MS) has been
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