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T9250
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Qing Song Hu et al.
Biomedical and environmental sciences : BES, 28(4), 253-262 (2015-05-15)
This study was aimed to investigate the effects of carbon monoxide releasing molecule (CORM-2), a novel carbon monoxide carrier, on the reendothelialization of carotid artery in rat endothelial denudation model. Male rats subjected to carotid artery balloon injury were treated
Jeannine Gerhardt et al.
Experimental cell research, 334(2), 283-293 (2015-05-03)
The chromosomal DNA replication in eukaryotic cells begins at replication initation sites, which are marked by the assembly of the pre-replication complexes in early G1. At the G1/S transition, recruitment of additional replication initiation proteins enables origin DNA unwinding and
Euan R O Allan et al.
Journal of immunology (Baltimore, Md. : 1950), 192(11), 4989-5001 (2014-04-30)
The chemistries within phagosomes of APCs mediate microbial destruction as well as generate peptides for presentation on MHC class II. The antimicrobial effector NADPH oxidase (NOX2), which generates superoxide within maturing phagosomes, has also been shown to regulate activities of
Cécile Gasse et al.
Bioorganic & medicinal chemistry, 16(11), 6075-6085 (2008-05-10)
A series of N(1)-(4-substituted-benzyl)-pyrimidines were synthesized as potential inhibitors of thymidine monophosphate kinase of Mycobacterium tuberculosis (TMPKmt). Key SAR parameters included the chain length substitution in para position of the benzyl ring, the functional group terminating the alkyl chain, and
Christine B Yoo et al.
Journal of medicinal chemistry, 51(23), 7593-7601 (2008-11-14)
We report herein the application of the phosphoramidate ProTide technology to improve the metabolism of the DNA methytransferase inhibitor, zebularine (Z). Zebularine is a riboside that must undergo a complex metabolic transformation before reaching the critical 2'-deoxyzebularine 5'-triphosphate (dZTP). Because
Keon-Il Im et al.
Journal of immunology (Baltimore, Md. : 1950), 194(11), 5223-5232 (2015-04-26)
Graft-versus-host disease (GVHD) is a major complication associated with allogeneic hematopoietic stem cell transplantation. Despite the prominent role of the adaptive immune system, the importance of controlling the innate immune system in the pathogenesis of GVHD has recently been rediscovered.
M Ailenberg et al.
British journal of pharmacology, 172(15), 3748-3763 (2015-04-09)
Dynasore has been used extensively as an inhibitor of clathrin-mediated endocytosis. While studying the role of endocytosis in LPS-induced signalling events, we discovered that dynasore itself induced activation of NF-κB, independently of its effects on endocytosis and without involving the
Lucía Vigezzi et al.
Reproductive toxicology (Elmsford, N.Y.), 52, 83-92 (2015-02-11)
We assessed the long-term effect of perinatal exposure to bisphenol A (BPA) on the rat uterus and the uterine response to estrogen (E2) replacement therapy. BPA (0.5 or 50μg/kg/day) was administered in the drinking water from gestational day 9 until
Xiangjing Gao et al.
PloS one, 9(5), e97174-e97174 (2014-05-14)
Paraspeckle protein 1 (PSPC1) was first identified as a structural protein of the subnuclear structure termed paraspeckle. However, the exact physiological functions of PSPC1 are still largely unknown. Previously, using a proteomic approach, we have shown that exposure to cisplatin
David Lam et al.
Biochemical and biophysical research communications, 363(3), 536-541 (2007-09-25)
How is one to investigate autophagic or necrotic cell death in the absence of interference from the apoptosis machinery? In the protist Dictyostelium, a model for the study of these two cell death types, we previously showed that autophagic cell
Lucia Natarelli et al.
PloS one, 10(11), e0142421-e0142421 (2015-11-07)
Epidemiological studies suggest that moderate and prolonged consumption of coffee is associated with a reduced risk of developing type 2 diabetes but the molecular mechanisms underlying this effect are not known. In this study, we report the effects of physiological
Juozas Nainys et al.
BMC biotechnology, 14, 100-100 (2014-12-10)
Porcine circovirus type 2 (PCV2) is considered to be an important emerging pathogen associated with a number of different syndromes and diseases in pigs known as PCV2-associated diseases. It has been responsible for significant mortality among pigs and remains a
Z Han et al.
Journal of viral hepatitis, 20 Suppl 1, 58-64 (2013-03-15)
The aim of this study was to evaluate the efficacy and safety of telbivudine 600 mg/day compared with lamivudine 100 mg/day for 48 weeks of treatment in patients with hepatitis B-related cirrhosis. Data were reviewed retrospectively from 165 hepatitis B-related
Jian Sun et al.
Hepatology (Baltimore, Md.), 59(4), 1283-1292 (2014-01-03)
An optimization strategy based on the Roadmap concept is supposed to improve the clinical outcomes of patients with suboptimal antiviral response. The aim of this study was to prove the concept with a multicenter, open-label, randomized, controlled study. In all
Xuesen Fan et al.
Journal of medicinal chemistry, 49(14), 4052-4054 (2006-07-11)
Two privileged drug scaffolds have been hybridized to create the novel heteromorphic nucleoside 5-(2-amino-3-cyano-5-oxo-5,6,7,8-tetrahydro-4H-chromen-4-yl)-1-(2-deoxypentofuranosyl)pyrimidine-2,4(1H,3H)-dione (2). Compound 2 inhibited the replication of two orthopoxviruses, vaccinia virus (VV) (EC(50) = 4.6 +/- 2.0 microM), and cowpox virus (CV) (EC(50) = 2.0 +/-
Junichi Hoshino et al.
Journal of nanoscience and nanotechnology, 13(7), 4593-4600 (2013-08-02)
Thymidine derivatives with carboxylic acid and pyridyl groups were synthesized for constructing one-dimensional network structure based on hydrogen bonding in crystalline state. The solid sate structures and hydrogen bonding networks of the thymidine derivatives were characterized by single X-ray diffraction
Ashraf S Al-Madhoun et al.
Mini reviews in medicinal chemistry, 4(4), 341-350 (2004-05-12)
Deoxynucleoside analogues need activation by deoxynucleoside kinases to serve as antiviral or anticancer agents. Here we review the properties of cellular cytoplasmic thymidine kinase 1, mitochondrial thymidine kinase 2, the multisubstrate deoxynucleoside kinase from Drosophila melanogaster and Herpes virus 1
Thomas H King et al.
PloS one, 9(7), e101904-e101904 (2014-07-23)
Chronic hepatitis B infection (CHB) is characterized by sub-optimal T cell responses to viral antigens. A therapeutic vaccine capable of restoring these immune responses could potentially improve HBsAg seroconversion rates in the setting of direct acting antiviral therapies. A yeast-based
Justus Reunanen et al.
Applied and environmental microbiology, 81(11), 3655-3662 (2015-03-22)
Akkermansia muciniphila is a Gram-negative mucin-degrading bacterium that resides in the gastrointestinal tracts of humans and animals. A. muciniphila has been linked with intestinal health and improved metabolic status in obese and type 2 diabetic subjects. Specifically, A. muciniphila has
Eivind Valen Egeland et al.
Clinical & experimental metastasis, 32(8), 755-767 (2015-09-10)
S100A4 promotes metastasis in several types of cancer, but the involved molecular mechanisms are still incompletely described. The protein is associated with a wide variety of biological functions and it locates to different subcellular compartments, including nuclei, cytoplasm and extracellular
Xiaolong Zhuo et al.
The Journal of cell biology, 210(5), 727-735 (2015-09-02)
During the G2 to M phase transition, a portion of mitotic regulator Plk1 localizes to the kinetochores and regulates the initiation of kinetochore-microtubule attachments for proper chromosome alignment. Once kinetochore-microtubule attachment is achieved, this portion of Plk1 is removed from
Nan Li et al.
Molecular medicine reports, 12(2), 3177-3183 (2015-05-09)
Sonodynamic therapy (SDT) with 5-aminolevulinic acid (5-ALA) can effectively inhibit various types of tumor in vitro and in vivo. However, the association between the efficacy of SDT and the phase of the cell cycle remains to be elucidated. 5-ALA may
Fumitaka Sato et al.
Cellular immunology, 292(1-2), 85-93 (2014-12-03)
We established a novel model of myocarditis induced with Theiler’s murine encephalomyelitis virus (TMEV), which has been used as a viral model for multiple sclerosis and seizure/epilepsy. Following TMEV infection, C3H mice developed severe myocarditis with T cell infiltration, while
Julie M Bailis et al.
Molecular and cellular biology, 28(5), 1724-1738 (2008-01-09)
The minichromosome maintenance (MCM) complex plays essential, conserved roles throughout DNA synthesis: first, as a component of the prereplication complex at origins and, then, as a helicase associated with replication forks. Here we use fission yeast (Schizosaccharomyces pombe) as a
Yuhui Sun et al.
Neuropharmacology, 72, 20-28 (2013-05-04)
Antidepressant agents such as fluoxetine have been shown to produce neurogenic effects involving transcriptional and translational changes that direct molecular and cellular plasticity. These cellular and molecular events appear necessary to mediate the therapeutic effects of fluoxetine and may be
Ending vertical transmission of hepatitis B: the third trimester intervention.
Monika Sarkar et al.
Hepatology (Baltimore, Md.), 60(2), 448-451 (2014-03-29)
Maja Mustapic et al.
Human molecular genetics, 23(23), 6375-6384 (2014-07-06)
Dopamine beta-hydroxylase (DBH) is the biosynthetic enzyme catalyzing formation of norepinephrine. Changes in DBH expression or activity have been implicated in the pathogenesis of cardiovascular and neuropsychiatric disorders. Genetic determination of DBH enzymatic activity and its secretion are only incompletely
Dominique Muschter et al.
Arthritis research & therapy, 17, 169-169 (2015-06-25)
Numerous observations indicate that rheumatoid arthritis (RA) has a bone marrow component. In parallel, local synovial changes depend on neuronal components of the peripheral sympathetic nervous system. Here, we wanted to analyze whether collagen II-induced arthritis (CIA) has an impact
Athan C Baillet et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(6), 1535-1547 (2015-01-28)
Chlamydia trachomatis is a sexually transmitted obligate intracellular pathogen that causes inflammatory reactive arthritis, spondylitis, psoriasiform dermatitis, and conjunctivitis in some individuals after genital infection. The immunologic basis for this inflammatory response in susceptible hosts is poorly understood. As ZAP-70(W163C)
Jan Hartinger et al.
Anticancer research, 35(3), 1303-1310 (2015-03-10)
Therapy with 5-fluorouracil (5-FU) and capecitabine is often complicated by skin toxicity (hand-foot syndrome, HFS). Topical application of uridine ointment is beneficial for alleviating HFS and other pyrimidine nucleosides have been described as 5-FU toxicity modulators. We tested pyrimidine nucleosides
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