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Trehalose metabolism in plants
Lunn J E, et al.
The Plant Journal, 79(4), 544-567 (2014)
Yi Hu et al.
Nanoscale, 11(24), 11789-11807 (2019-06-12)
Autophagy may represent a common cellular response to nanomaterials. In the present study, it was demonstrated that zinc oxide nanoparticle (ZON)-elicited autophagy contributes to tumor cell killing by accelerating the intracellular dissolution of ZONs and reactive oxygen species (ROS) generation.
Shing Fung Chow et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 94, 436-449 (2015-07-06)
The influence of critical operating parameters on the Flash Nanoprecipitation (FNP) and resulting material properties of curcumin (CUR) nanoparticles has been evaluated using a confined impinging jets-with-dilution mixer (CIJ-D-M). It has been shown that the mixing rate, molecular weight of
Robert W P Glowacki et al.
Cell host & microbe, 27(1), 79-92 (2020-01-07)
Efficient nutrient acquisition in the human gut is essential for microbial persistence. Although polysaccharides have been well-studied nutrients for the gut microbiome, other resources such as nucleic acids and nucleosides are less studied. We describe several ribose-utilization systems (RUSs) that
Fei Yan et al.
Aging, 13(16), 20229-20245 (2021-09-07)
Cancer cells at the invasive front directly interact with stromal tissue that provides a microenvironment with mechanical, nutrient, and oxygen supply characteristics distinct from those of intratumoral tissues. It has long been known that cancer cells at the invasive front
Vidhi Pareek et al.
Science (New York, N.Y.), 368(6488), 283-290 (2020-04-18)
Metabolons, multiprotein complexes consisting of sequential enzymes of a metabolic pathway, are proposed to be biosynthetic "hotspots" within the cell. However, experimental demonstration of their presence and functions has remained challenging. We used metabolomics and in situ three-dimensional submicrometer chemical
Patricio R Santagapita et al.
Biotechnology progress, 31(3), 791-798 (2015-03-05)
β-Cyclodextrin (β-CD)-grafted dextrans with spacer arms of different length were employed to evaluate the impact of supramolecular interactions on invertase activity. The modified dextrans were used as single additives or combined with trehalose in freeze-dried formulations containing invertase. Enzyme activity
Pedro F Jacob et al.
Current biology : CB, 31(16), 3490-3503 (2021-06-20)
Prior experience of a stimulus can inhibit subsequent acquisition or expression of a learned association of that stimulus. However, the neuronal manifestations of this learning effect, named latent inhibition (LI), are poorly understood. Here, we show that prior odor exposure
Jianhong Ye et al.
Human mutation, 41(8), 1383-1393 (2020-04-26)
Neural tube defects (NTDs) are severe congenital malformations caused by failed neural tube closure. Recently, autophagy is revealed to play a vital role in neuroepithelium development and neurulation. Autophagy and beclin 1 regulator 1 (Ambra1) is a crucial regulator of
Adva Mechaly et al.
Pathogens (Basel, Switzerland), 10(3) (2021-04-04)
Mouse monoclonal antibodies were raised against plague disease biomarkers: the bacterial capsular protein fraction 1 (F1) and the low-calcium response-LcrV virulence factor (Vag). A novel tandem assay, employing BioLayer Interferometry (BLI), enabled the isolation of antibodies against four different epitopes
Pall Thor Ingvarsson et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 87(3), 480-488 (2014-04-15)
One of the main reasons for the unmet medical need for mucosal vaccines is the lack of safe and efficacious mucosal adjuvants. The cationic liposome-based adjuvant system composed of dimethyldioctadecylammonium (DDA) bromide and trehalose 6,6'-dibehenate (TDB) is a versatile adjuvant
M Amdadul Haque et al.
Food chemistry, 177, 8-16 (2015-02-11)
The denaturation kinetics of whey protein isolate (WPI), in the presence and absence of lactose and trehalose, was quantified in a convective air-drying environment. Single droplets of WPI, WPI-lactose and WPI-trehalose were dried in conditioned air (2.5% RH, 0.5m/s air
Qiang Shao et al.
Autophagy, 16(9), 1635-1650 (2019-12-19)
How lysosome and MTORC1 signaling interact remains elusive in terminally differentiated cells. A G4C2 repeat expansion in C9orf72 is the most common cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (C9ALS-FTD). We previously identified a C9orf72-SMCR8-containing complex.
Autophagy-Mediated Secretory Pathway is Responsible for Both Normal and Pathological Tau in Neurons.
Seokjo Kang et al.
Journal of Alzheimer's disease : JAD, 70(3), 667-680 (2019-07-01)
Increased levels of total tau (t-tau) and hyperphosphorylated tau (p-tau) proteins in the cerebrospinal fluid of Alzheimer's disease (AD) patients are well documented and strongly correlate with AD pathology. Recent studies have further shown that human tau can be released
Sabine Ullrich et al.
Pharmaceutical research, 32(8), 2503-2515 (2015-02-06)
Measurement of the kinetic development of shrinkage and cracking of an amorphous trehalose cake as they take place during lyophilization. A novel technique has been developed which monitors a vial in situ during the freeze-drying cycle. The 2-dimensional degrees of
Janani Swaminathan et al.
Journal of liposome research, 24(4), 297-303 (2014-04-09)
The intent of this work was to assess the impact of lyophilization on the encapsulation of salmon calcitonin (sCT) into liposomes. Four different liposomal formulations were investigated, i.e. DPPC:Chol:DSPE-PEG(2000) (75:20:5 and 65:30:5) and DPPC:Chol (80:20 and 66.7:33.3). Lipid films were
Trehalose production: exploiting novel approaches
Schiraldi C, et al.
Trends in Biotechnology, 20(10), 420- 425 (2002)
Eloïse de Tredern et al.
Cell reports, 36(8), 109620-109620 (2021-08-26)
Brain function relies almost solely on glucose as an energy substrate. The main model of brain metabolism proposes that glucose is taken up and converted into lactate by astrocytes to fuel the energy-demanding neuronal activity underlying plasticity and memory. Whether
Ruben Magni et al.
Journal of translational medicine, 13, 346-346 (2015-11-06)
Prompt antibiotic treatment of early stage Lyme borreliosis (LB) prevents progression to severe multisystem disease. There is a clinical need to improve the diagnostic specificity of early stage Lyme assays in the period prior to the mounting of a robust
Sabine Ullrich et al.
Journal of pharmaceutical sciences, 104(1), 155-164 (2014-11-26)
An experimental technique is presented to determine independently shrinkage and cracking in lyophilized amorphous cakes based on photographic imaging of their top surface. An inverse correlation between cake shrinkage and cracking during freeze-drying is seen. Shrinkage relaxes the drying tension
Matthias Erber et al.
International journal of pharmaceutics, 495(2), 692-700 (2015-09-24)
A cryopellet formulation of the diagnostic protein ecarin has been developed that is suitable for use to monitor blood coagulation via in vitro thromboelastometry. The coagulation activity of the ecarin was measured by thromelastometry using whole blood. In aqueous solution
Brandon H Toyama et al.
The Journal of cell biology, 218(2), 433-444 (2018-12-16)
Many adult tissues contain postmitotic cells as old as the host organism. The only organelle that does not turn over in these cells is the nucleus, and its maintenance represents a formidable challenge, as it harbors regulatory proteins that persist
Timothy M O'Shea et al.
Advanced healthcare materials, 4(12), 1802-1812 (2015-06-20)
Hydrogels with covalently incorporated trehalose are synthesized using thiol-ene Michael addition. Trehalose hydrogels afford prolonged stabilization and -controlled release of model enzymes in vitro and in vivo as well as preservation of protein stability under heat and -lyophilization stressors. Strong
Shiyi Tan et al.
Life sciences, 257, 118043-118043 (2020-07-06)
Alveolar macrophages (AMs) are the primary targets of silicosis. Blockade of autophagy may aggravate the apoptosis of AMs. Trehalose (Tre), a transcription factor EB (TFEB) activator, may impact the autophagy-lysosomal system in AMs during silicosis. However, the mechanism by which
Chinwe Duru et al.
Biologicals : journal of the International Association of Biological Standardization, 43(2), 110-116 (2015-01-24)
Lyophilized Influenza antigen reference reagents are a critical resource in the quality control of influenza vaccines. A standard formulation has been used successfully at NIBSC for many years however, following the unexpected occurrence of a collapsed appearance in a particular
Ousamah Younoss Soliman et al.
Journal of pharmaceutical sciences, 109(4), 1581-1593 (2020-01-01)
Messenger RNA (mRNA)-containing nanoparticles were produced by electrostatic complexation with a library of pharmaceutical grade chitosans with different degrees of deacetylation and hyaluronic acids (HAs) (native vs. sulfated). Polymer length (Mn), HA degree of sulfation (DS), and amine to phosphate
Pedro F Jacob et al.
Neuron, 106(6), 977-991 (2020-04-15)
Forming long-term memory (LTM) often requires repetitive experience spread over time. Studies in Drosophila suggest aversive olfactory LTM is optimal after spaced training, multiple trials of differential odor conditioning with rest intervals. Memory after spaced training is frequently compared to
Cody R Ruhl et al.
Cell, 181(2), 293-305 (2020-03-07)
Pulmonary tuberculosis, a disease caused by Mycobacterium tuberculosis (Mtb), manifests with a persistent cough as both a primary symptom and mechanism of transmission. The cough reflex can be triggered by nociceptive neurons innervating the lungs, and some bacteria produce neuron-targeting
Ezgi P Yalcintas et al.
Pharmaceutical research, 37(3), 33-33 (2020-01-17)
Dissolvable microneedle arrays (MNAs) can be used to realize enhanced transdermal and intradermal drug delivery. Dissolvable MNAs are fabricated from biocompatible and water-soluble base polymers, and the biocargo to be delivered is integrated with the base polymer when forming the
Nicolas Barbezier et al.
EMBO molecular medicine, 3(1), 35-49 (2011-01-05)
Oculopharyngeal muscular dystrophy (OPMD) is an adult-onset syndrome characterized by progressive degeneration of specific muscles. OPMD is caused by extension of a polyalanine tract in poly(A) binding protein nuclear 1 (PABPN1). Insoluble nuclear inclusions form in diseased muscles. We have
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