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TR0100
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Zhen-Juan Yin et al.
Frontiers in physiology, 9, 1654-1654 (2018-12-06)
Diapause is a complex physiological adaptation phenotype, and the transcription factor Forkhead-box O (FoxO) is a prime candidate for activating many of its diverse regulatory signaling pathways. Hormone signaling regulates nymphal diapause in Laodelphax striatellus. Here, the function of the
Sara N Vallerie et al.
PloS one, 3(9), e3151-e3151 (2008-09-06)
It has been established that c-Jun N-terminal kinase 1 (JNK1) is essential to the pathogenesis of insulin resistance and type 2 diabetes. Although JNK influences inflammatory signaling pathways, it remains unclear whether its activity in macrophages contributes to adipose tissue
Kejing Zeng et al.
Endocrinology, 158(2), 277-292 (2016-12-15)
We found previously that short-term curcumin gavage stimulated mouse hepatic fibroblast growth factor 21 (Fgf21) expression. Here we conducted mechanistic exploration and investigated the potential pathophysiological relevance on this regulation. Fgf21 stimulation was observed at messenger RNA and protein levels
Mi Hae Seo et al.
PloS one, 11(12), e0166913-e0166913 (2016-12-03)
The aim of this study is to investigate whether the beneficial effect of exendin-4 on hepatic steatosis is mediated by β-catenin signaling. After the HepG2 human hepatoma cells were treated with PA for 24 hours, total triglycerides levels were increased
Qingming Dong et al.
Biology of sex differences, 9(1), 40-40 (2018-09-12)
Patients with metabolic syndrome, who are characterized by co-existence of insulin resistance, hypertension, hyperlipidemia, and obesity, are also prone to develop non-alcoholic fatty liver disease (NAFLD). Although the prevalence and severity of NAFLD is significantly greater in men than women
Yu-Hsuan Chen et al.
Nature communications, 12(1), 1322-1322 (2021-02-28)
The ubiquitin-proteasome system (UPS) and autophagy are two major quality control processes whose impairment is linked to a wide variety of diseases. The coordination between UPS and autophagy remains incompletely understood. Here, we show that ubiquitin ligase UBE3C and deubiquitinating
Dianaly T Au et al.
Mediators of inflammation, 2018, 7902841-7902841 (2018-12-14)
Hepatic inflammation is associated with the development of insulin resistance, which can perpetuate the disease state and may increase the risk of metabolic syndrome and diabetes. Despite recent advances, mechanisms linking hepatic inflammation and insulin resistance are still unclear. The
Jinmi Lee et al.
Cell stress & chaperones, 23(4), 629-638 (2018-06-24)
Lipin-1 performs dual function during lipid metabolism, i.e., it functions as a transcriptional coactivator and as a phosphatidate phosphatase during triglyceride biosynthesis. We investigated whether exendin-4 prevented endoplasmic reticulum (ER) stress-induced hepatic steatosis and whether the protective effects of exendin-4
B J Bradford et al.
Journal of dairy science, 87(11), 3800-3807 (2004-10-16)
The effects of dietary starch fermentability on plasma metabolites and hormones, milk production, and milk fatty acid profile were evaluated in a crossover study. Thirty-two multiparous Holstein cows (121 +/- 48 d in milk, 41 +/- 9 kg/d 3.5% fat-corrected
Tina Seidu et al.
The Journal of endocrinology, 250(2), 49-65 (2021-06-02)
Hyperandrogenemia (HA) is a hallmark of polycystic ovary syndrome (PCOS) and is an integral element of non-alcoholic fatty liver disease (NALFD) in females. Administering low-dose dihydrotestosterone (DHT) induced a normal weight PCOS-like female mouse model displaying NAFLD. The molecular mechanism
Kathryn E Wellen et al.
Cell, 129(3), 537-548 (2007-05-08)
Metabolic and inflammatory pathways crosstalk at many levels, and, while required for homeostasis, interaction between these pathways can also lead to metabolic dysregulation under conditions of chronic stress. Thus, we hypothesized that mechanisms might exist to prevent overt inflammatory responses
Yun-Li Wu et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 44(6), 2243-2255 (2017-12-20)
Liver fatty acid-binding protein (FABP1) is a key regulator of hepatic lipid metabolism. MicroRNAs (miRNAs) are thought to be involved in nonalcoholic fatty liver disease (NAFLD), and the underlying mechanism is largely unclear. We investigated whether miRNAs influence hepatocyte steatosis
Xinran Ma et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(39), 14289-14294 (2014-09-17)
Aging is associated with increased adiposity and diminished thermogenesis, but the critical transcription factors influencing these metabolic changes late in life are poorly understood. We recently demonstrated that the winged helix factor forkhead box protein A3 (Foxa3) regulates the expansion
Hui-Yu Liu et al.
The Journal of biological chemistry, 284(40), 27090-27100 (2009-08-06)
Subjects with type 1 diabetes mellitus (T1DM) eventually develop insulin resistance and other features of T2DM such as cardiovascular disorders. The exact mechanism has been not been completely understood. In this study, we tested the hypothesis that excessive or inappropriate
Mette Johannsen Mandøe et al.
Nutrition & diabetes, 8(1), 2-2 (2018-01-14)
After digestion, dietary triacylglycerol stimulates incretin release in humans, mainly through generation of 2-monoacylglycerol, an agonist for the intestinal G protein-coupled receptor 119 (GPR119). Enhanced incretin release may have beneficial metabolic effects. However, dietary fat may promote weight gain and
Gianluca Grassia et al.
Cardiovascular research, 84(3), 485-493 (2009-07-14)
Bindarit is an original compound with peculiar anti-inflammatory activity due to a selective inhibition of a subfamily of inflammatory chemokines, including the monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8. In this study, we investigated the effect of bindarit on neointima
Wanshan Feng et al.
Pharmaceutics, 13(9) (2021-09-29)
Oral sesame oil-based formulation facilitates the delivery of poorly water-soluble drug cannabidiol (CBD) to the lymphatic system and blood circulation. However, this natural oil-based formulation also leads to considerable variability in absorption of CBD. In this work, the performance of
Xiong Ma et al.
Journal of hepatology, 49(5), 821-830 (2008-08-05)
Dietary factors and intestinal bacteria play an important role in the rapidly increasing incidence of obesity and its associated conditions, such as steatosis and insulin resistance. In the current study, we evaluated the effect of probiotics, and their mechanisms on
Edem1 activity in the fat body regulates insulin signalling and metabolic homeostasis in Drosophila.
Himani Pathak et al.
Life science alliance, 4(8) (2021-06-19)
In Drosophila, nutrient status is sensed by the fat body, a functional homolog of mammalian liver and white adipocytes. The fat body conveys nutrient information to insulin-producing cells through humoral factors which regulate Drosophila insulin-like peptide levels and insulin signalling.
Qiuyu Wang et al.
Nature metabolism, 1(2), 251-260 (2019-09-20)
Thermogenesis is an important contributor to whole body energy expenditure and metabolic homeostasis. Although circulating factors that promote energy expenditure are known, endocrine molecules that suppress energy expenditure have remained largely elusive. Here we show that Tsukushi (TSK) is a
Young Mok Lee et al.
Hepatology (Baltimore, Md.), 56(5), 1719-1729 (2012-03-17)
Glycogen storage disease type Ia (GSD-Ia), which is characterized by impaired glucose homeostasis and chronic risk of hepatocellular adenoma (HCA), is caused by deficiencies in the endoplasmic reticulum (ER)-associated glucose-6-phosphatase-α (G6Pase-α or G6PC) that hydrolyzes glucose-6-phosphate (G6P) to glucose. G6Pase-α
Yi-Long Huang et al.
Antioxidants (Basel, Switzerland), 10(4) (2021-05-01)
Nonalcoholic fatty liver disease (NAFLD) and its more severe form, nonalcoholic steatohepatitis (NASH), are the most common chronic liver diseases worldwide. However, drugs to treat NAFLD and NASH are an unmet clinical need. This study sought to provide evidence that
Mikael Larsson et al.
Journal of lipid research, 59(4), 706-713 (2018-02-17)
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1), an endothelial cell protein, binds LPL in the subendothelial spaces and transports it to the capillary lumen. In Gpihbp1-/- mice, LPL remains stranded in the subendothelial spaces, causing hypertriglyceridemia, but how Gpihbp1-/- mice
Alice Gadau et al.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 237, 110332-110332 (2019-08-29)
Urbanization influences food quality and availability for many wild species, but our knowledge of the consequences urbanization has on the nutritional physiology of these animals is currently limited. To fill this gap, we captured House Sparrows (Passer domesticus) from rural
S A Durward-Akhurst et al.
Chemosphere, 218, 652-661 (2018-12-05)
Equine Metabolic Syndrome (EMS) is characterized by abnormalities in insulin regulation, increased adiposity and laminitis, and has several similarities to human metabolic syndrome. A large amount of environmental variability in the EMS phenotype is not explained by commonly measured factors
Kimberly A Stowe et al.
FEBS letters, 580(17), 4282-4287 (2006-07-13)
Triglyceride turnover in the isolated C57/BL6 mouse heart was measured by dynamic 13C edit-(1)H observe NMR and the rate of fatty acid oxidation was determined by 13C NMR isotopomer analysis. In the presence of a physiological mixture of substrates, energy
Dong Li et al.
Molecular medicine reports, 14(4), 3878-3886 (2016-09-08)
S100 calcium-binding protein B (S100B) is expressed and released by adipocytes, and is positively correlated with body mass index, however, the direct effects of S100B on adipocytes remain unclear. Bone marrow‑derived mesenchymal stem cells have the capacity to differentiate into osteoblasts
Larissa Eiselein et al.
PloS one, 10(12), e0145523-e0145523 (2015-12-29)
Studies have suggested a link between the transforming growth factor beta 1 (TGF-β1) signaling cascade and the stress-inducible activating transcription factor 3 (ATF3). We have demonstrated that triglyceride-rich lipoproteins (TGRL) lipolysis products activate MAP kinase stress associated JNK/c-Jun pathways resulting
Frank K Huynh et al.
Journal of inherited metabolic disease, 41(1), 59-72 (2017-07-21)
Several inherited metabolic disorders are associated with an accumulation of reactive acyl-CoA metabolites that can non-enzymatically react with lysine residues to modify proteins. While the role of acetylation is well-studied, the pathophysiological relevance of more recently discovered acyl modifications, including
Alwin de Jong et al.
Frontiers in cardiovascular medicine, 7, 604821-604821 (2021-02-16)
Background: Inflammatory stimuli induced by NF-kB drive atherosclerotic lesion formation. The epigenetic P300/CBP associated factor (PCAF) post-transcriptionally acetylates FoxP3, which is required for regulatory T-cell (Treg) differentiation and immune modulation. We hypothesize that PCAF deficiency affects atherosclerosis via regulation of
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