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Petronella E Deetman et al.
Transplantation, 99(5), 1009-1015 (2014-11-14)
Little is known about optimal protein intake after transplantation. The aim of this study was to prospectively investigate associations of urinary urea excretion, a marker for protein intake, with graft failure and mortality in renal transplant recipients (RTR) and potential
Yan Dong et al.
Scientific reports, 5, 12668-12668 (2015-08-04)
Oral squamous cell carcinoma (OSCC) is usually preceded by the oral premalignant lesions, mainly oral leukoplakia (OLK) after repeated insults of carcinogens, tobacco. B(a)P and DMBA are key carcinogens in tobacco smoke. In the present study, for the first time
Valerio Leoni et al.
Clinical chemistry and laboratory medicine, 42(2), 186-191 (2004-04-06)
24S-Hydroxycholesterol (24OHC) and 27-hydroxycholesterol (27OHC) are two structurally similar oxysterols of different origins--the former almost exclusively formed in the brain and the latter formed to a lesser extent in the brain than in most other organs. HYPOTHESIS TO BE TESTED:
Iván Pastor-Fernández et al.
Veterinary parasitology, 207(3-4), 203-215 (2015-01-13)
Currently there are no effective vaccines for the control of bovine neosporosis. During the last years several subunit vaccines based on immunodominant antigens and other proteins involved in adhesion, invasion and intracellular proliferation of Neospora caninum have been evaluated as
Shahanavaj Khan et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 20(8), 1319-1326 (2015-11-14)
Cobalt oxide nanoparticles (Co3O4-NPs) were synthesized using simple urea-based thermal decomposition method. Phase purity and particle size of as-synthesized nanoparticles were characterized through X-ray diffraction pattern (XRD) and transmission electron microscopy. Through XRD morphology of the Co3O4-NPs was found to
Jennifer Fostel et al.
Pharmacogenomics, 7(3), 441-454 (2006-04-14)
To identify biomarkers of chronic fatigue syndrome (CFS) and related disorders through analysis of microarray data, pathology test results and self-report symptom profiles. To empirically derive the symptom domains of the illnesses, factor analysis was performed on responses to self-report
Ali Akal et al.
Indian journal of ophthalmology, 62(6), 671-674 (2014-07-10)
Resistive index (RI) is an indirect measurement of blood flow resistance that can be used to evaluate vascular damage in ophthalmologic disease. The purpose of this study was to evaluate the association between RI values of orbital arteries using the
Zhonghua Liu et al.
Electrophoresis, 36(17), 2002-2016 (2015-06-04)
Fuzhuan brick tea has received increasing attention in recent years owing to its benefits for nonalcoholic fatty liver disease (NAFLD) and associated metabolic syndrome. For exploring the ameliorative mechanism, the liver proteomes from three groups of rats fed either a
Xiyu Ouyang et al.
Journal of chromatography. A, 1380, 139-145 (2015-01-13)
For the first time a comprehensive two-dimensional liquid chromatography (LC×LC) system coupled with a high resolution time-of-flight mass spectrometer (HR-ToF MS) was developed and applied for analysis of emerging toxicants in wastewater effluent. The system was optimized and validated using
Leticia Monin et al.
The Journal of clinical investigation, 125(12), 4699-4713 (2015-11-17)
Parasitic helminth worms, such as Schistosoma mansoni, are endemic in regions with a high prevalence of tuberculosis (TB) among the population. Human studies suggest that helminth coinfections contribute to increased TB susceptibility and increased rates of TB reactivation. Prevailing models
Stephanie Brown et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(11), 3205-3210 (2015-02-13)
The monoterpene indole alkaloids are a large group of plant-derived specialized metabolites, many of which have valuable pharmaceutical or biological activity. There are ∼3,000 monoterpene indole alkaloids produced by thousands of plant species in numerous families. The diverse chemical structures
Chen-Ching Yuan et al.
Archives of biochemistry and biophysics, 568, 16-27 (2015-01-21)
The flight muscles (DLM1) of the Hawkmoth, Manduca sexta are synchronous, requiring a neural spike for each contraction. Stress/strain curves of skinned DLM1 showed hysteresis indicating the presence of titin-like elastic proteins. Projectin and kettin are titin-like proteins previously identified
Giovanna Cenini et al.
Free radical biology & medicine, 76, 89-95 (2014-08-26)
Down syndrome (DS) is one of the most common causes of intellectual disability, owing to trisomy of all or part of chromosome 21. DS is also associated with the development of Alzheimer disease (AD) neuropathology after the age of 40
Jiyoung Han et al.
Mycobiology, 43(3), 272-279 (2015-11-06)
To screen molecular chaperones similar to small heat shock proteins (sHsps), but without α-crystalline domain, heat-stable proteins from Schizosaccharomyces pombe were analyzed by 2-dimensional electrophoresis and matrix assisted laser desorption/ionization time-of-flight mass spectrometry. Sixteen proteins were identified, and four recombinant
Cristina De Ceglie et al.
Food chemistry, 176, 396-402 (2015-01-28)
High protein content sport nutritional supplements are found as powder products containing, as ingredients, amino acids and proteins with important nutritional values as milk, soy and egg proteins. An EU Food Supplements Directive (2002) requires that supplements should be safe
Anna Otte et al.
International journal of oncology, 45(3), 1151-1158 (2014-06-28)
A recently established cellular model for the rare small cell carcinoma of the ovary hypercalcemic type (SCCOHT-1) was characterized in comparison to ovarian adenocarcinoma cells (NIH:OVCAR-3 and SK-OV-3). The different cancer populations exhibited a common sensitivity in acidic pH milieu
E Pasmant et al.
Oncogene, 34(5), 631-638 (2014-01-29)
Constitutional dominant loss-of-function mutations in the SPRED1 gene cause a rare phenotype referred as neurofibromatosis type 1 (NF1)-like syndrome or Legius syndrome, consisted of multiple café-au-lait macules, axillary freckling, learning disabilities and macrocephaly. SPRED1 is a negative regulator of the
Dan Shen et al.
The New phytologist, 204(3), 577-594 (2014-08-19)
Verticillium longisporum, a soil-borne pathogenic fungus, causes vascular disease in oilseed rape (Brassica napus). We proposed that plant microRNAs (miRNAs) are involved in the plant-V. longisporum interaction. To identify oilseed rape miRNAs, we deep-sequenced two small RNA libraries made from
Ilaria Fiorentino et al.
Experimental cell research, 330(2), 240-247 (2014-09-24)
Nanoparticle (NPs) delivery systems in vivo promises to overcome many obstacles associated with the administration of drugs, vaccines, plasmid DNA and RNA materials, making the study of their cellular uptake a central issue in nanomedicine. The uptake of NPs may
Marcin M Grzybowski et al.
Journal of medical microbiology, 64(10), 1201-1207 (2015-08-06)
Toxoplasmosis is one of the most common parasitic diseases worldwide and it poses a serious challenge regarding prevention, diagnosis and therapy. The commonly used diagnostic methods are mostly based on the detection of specific antibodies in sera. Since they are
Judit Cubedo et al.
Translational research : the journal of laboratory and clinical medicine, 164(3), 209-222 (2014-04-09)
High-density lipoprotein (HDL) functionality, which is closely associated with its composition and transport capabilities, determines its role in atheroprotection. During acute phase processes, HDL seems to lose its anti-inflammatory and cytoprotective properties. In this study, we hypothesized that after an
Zhou Liu et al.
Cell transplantation, 24(7), 1265-1281 (2014-05-27)
Transplantation of bone marrow mesenchymal stem cells (MSCs) promotes functional recovery in multiple sclerosis (MS) patients and in a murine model of MS. However, there is only a modicum of information on differentiation of grafted MSCs into oligodendrocyte-like cells in
Chiung-Yao Fang et al.
Virology, 483, 1-12 (2015-05-11)
During polyomavirus infection, the viral DNA adopts histones from host cells and forms minichromosomes as an important part of the viral life cycle. However, the detailed mechanisms of this histone incorporation remain unclear. Here, we profiled the histone posttranslational modifications
Frazer I Heinis et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 309(4), R368-R377 (2015-05-29)
The hearts of mammalian hibernators maintain contractile function in the face of severe environmental stresses during winter heterothermy. To enable survival in torpor, hibernators regulate the expression of numerous genes involved in excitation-contraction coupling, metabolism, and stress response pathways. Understanding
Qian Chen et al.
Journal of proteome research, 14(4), 1831-1842 (2015-03-03)
The menstrual cycle of the female uterus leads to periodic changes of the endometrium. These changes are important for developing the endometrial receptivity and for achieving competency of embryo implantation. However, the molecular events underlying the endometrial receptivity process remain
Sanghyun Kim et al.
Nucleic acids research, 43(13), 6579-6586 (2015-06-06)
VirE2 is the major secreted protein of Agrobacterium tumefaciens in its genetic transformation of plant hosts. It is co-expressed with a small acidic chaperone VirE1, which prevents VirE2 oligomerization. After secretion into the host cell, VirE2 serves functions similar to
Milaim Pepaj et al.
Scandinavian journal of clinical and laboratory investigation, 74(4), 358-365 (2014-04-04)
Transmembrane protein 27 (Tmem27), which is expressed in pancreatic β-cells, plays an important role in insulin secretion and pancreatic β-cell proliferation. Analysis of the INS-1 cell proteome using stable isotope labeling by amino acids in cell culture (SILAC) in combination
Michaela Herrmann et al.
European biophysics journal : EBJ, 44(7), 503-512 (2015-05-29)
Bilayer mechanical properties are not only of crucial importance to the mechanism of action of mechanosensation in lipid membranes but also affect preparative laboratory tasks such as membrane-protein refolding. We report this for coupled refolding and bilayer insertion of outer membrane
Dara P O'Halloran et al.
Infection and immunity, 83(4), 1598-1609 (2015-02-04)
The immunoglobulin binding protein A (SpA) of Staphylococcus aureus is synthesized as a precursor with a C-terminal sorting signal. The sortase A enzyme mediates covalent attachment to peptidoglycan so that SpA is displayed on the surface of the bacterium. Protein
Mun Chiang Chan et al.
PloS one, 10(7), e0132004-e0132004 (2015-07-07)
As part of the cellular adaptation to limiting oxygen availability in animals, the expression of a large set of genes is activated by the upregulation of the hypoxia-inducible transcription factors (HIFs). Therapeutic activation of the natural human hypoxic response can
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