Merck
CN
高级检索
Chemical Structure Search
Search Within

U1250

应用筛选条件
关键词:'U1250'
显示 31-60 共 1549 条结果 关于 "U1250" 范围 论文
Sabrina Thomas et al.
Biochimica et biophysica acta, 1844(9), 1500-1510 (2014-05-29)
HlyA from Escherichia coli is a member of the repeats in toxin (RTX) protein family, produced by a wide range of Gram-negative bacteria and secreted by a dedicated Type 1 Secretion System (T1SS). RTX proteins are thought to be secreted
Grete Lottrup et al.
European journal of endocrinology, 172(4), 491-499 (2015-01-23)
Testicular adrenal rest tumours (TARTs) are a common finding in patients with congenital adrenal hyperplasia (CAH). These tumours constitute a diagnostic and management conundrum and may lead to infertility. TART cells share many functional and morphological similarities with Leydig cells
Jung Won Lee et al.
Scandinavian journal of gastroenterology, 49(9), 1058-1067 (2014-06-25)
Antimicrobial resistance of Helicobacter pylori is most important factor in eradication success. GenoType HelicoDR test has been developed for rapid detection of antimicrobial resistance. The present study evaluated the clinical usefulness of GenoType HelicoDR test in Korea. To detect 23S
Erin B Taylor et al.
Molecular immunology, 66(2), 126-138 (2015-03-17)
The binding of the lymphocyte specific protein tyrosine kinase (Lck) to T cell co-receptors is required for T cell development and activation. In mammals, Lck initiates signal transduction by binding to CD4 and CD8 co-receptors and phosphorylating ITAMs in the
Uta Praekelt et al.
Journal of medical microbiology, 63(Pt 12), 1595-1607 (2014-09-19)
Enteropathogenic Escherichia coli (EPEC) are a major cause of infant diarrhoea in developing countries and a significant public health issue in industrialized countries. Currently there are no simple tests available for the diagnosis of EPEC. Serology of O-antigens is widely
Mei-An Su et al.
PLoS pathogens, 10(6), e1004196-e1004196 (2014-06-20)
In this study, we used a systems biology approach to investigate changes in the proteome and metabolome of shrimp hemocytes infected by the invertebrate virus WSSV (white spot syndrome virus) at the viral genome replication stage (12 hpi) and the
Amita Jaswal et al.
Indian journal of experimental biology, 53(1), 44-50 (2015-02-14)
Carbon tetrachloride (CCl4) intake damages liver. We evaluated therapeutic potential of aqueous extract of Nigella sativa seeds against CCl4 induced liver damage in rats. The hepatic damage induced by CCl4 @ 1.5 mL/kg, ip was evidenced by a significant increase
Maider Martos et al.
European journal of gastroenterology & hepatology, 26(12), 1380-1384 (2014-09-18)
Resistance to antibiotics is the major cause of treatment failure of Helicobacter pylori (HP) infection. The culture-guided triple therapy (chosen on the basis of a preliminary in-vitro susceptibility test) might help to increase treatment success in high antibiotic resistance regions.
Andreas Tebbe et al.
Rapid communications in mass spectrometry : RCM, 29(9), 795-801 (2015-09-18)
Advanced implementations of mass spectrometry (MS)-based proteomics allow for comprehensive proteome expression profiling across many biological samples. The outcome of such studies critically depends on accurate and precise quantification, which has to be ensured for high-coverage proteome analysis possible on
Sandeep Kumar Misra et al.
Journal of proteome research, 13(12), 6046-6057 (2014-11-11)
Protein phosphorylation is a major mechanism of signal transduction in bacteria. Here, we analyzed the proteome and phosphoproteome of a wild-type strain of the food-borne pathogen Listeria monocytogenes that was grown in either chemically defined medium or rich medium containing
Eleonore Durand et al.
BMC evolutionary biology, 15, 103-103 (2015-06-08)
Long term selection experiments bring unique insights on the genetic architecture of quantitative traits and their evolvability. Indeed, they are utilized to (i) monitor changes in allele frequencies and assess the effects of genomic regions involved traits determinism; (ii) evaluate
Annemieke Dhondt et al.
PloS one, 10(6), e0128634-e0128634 (2015-06-16)
Low molecular weight heparins (LMWHs) are small enough to pass large pore dialysis membranes. Removal of LMWH if injected before the start of the session is possible during high-flux dialysis and hemodiafiltration. The aim of this study was to determine
Susan Schuster et al.
Journal of virology, 88(22), 13447-13459 (2014-09-12)
Insects are a reservoir for many known and novel viruses. We discovered an unknown virus, tentatively named mosinovirus (MoNV), in mosquitoes from a tropical rainforest region in Côte d'Ivoire. The MoNV genome consists of two segments of positive-sense RNA of
Emil Schüler et al.
PloS one, 10(8), e0136204-e0136204 (2015-08-20)
The kidneys are one of the main dose-limiting organs in peptide receptor radionuclide therapy and due to large inter-individual variations in renal toxicity, biomarkers are urgently needed in order to optimize therapy and reduce renal tissue damage. The aim of
N Tamasawa et al.
Lipids, 28(9), 833-836 (1993-09-01)
An analytical method for the determination of cholesterol sulfate (CS) in plasma using gas-liquid chromatography was developed. We measured plasma CS concentrations in patients with liver cirrhosis and hypercholesterolemia as examples of disorders that involve aberrations in cholesterol metabolism. Patients
Guilherme A P de Oliveira et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(21), E2775-E2784 (2015-05-13)
High pressure (HP) or urea is commonly used to disturb folding species. Pressure favors the reversible unfolding of proteins by causing changes in the volumetric properties of the protein-solvent system. However, no mechanistic model has fully elucidated the effects of
Yngvild Bjorlykke et al.
Journal of proteome research, 14(1), 521-530 (2014-11-05)
Patients with carboxyl-ester lipase-maturity-onset diabetes of the young (CEL-MODY) display distinct disease stages toward the development of monogenic diabetes and exocrine pancreatic disease. The finding of differentially increased proteins, some related to MAPK signaling, in a discovery proteomics study of
Megumi Kato et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 31(8), 805-814 (2015-08-11)
To ensure the reliability of amino acid analyses, the National Metrology Institute of Japan of the National Institute of Advanced Industrial Science and Technology (NMIJ/AIST) has developed high-purity certified reference materials (CRMs) for 17 proteinogenic amino acids. These CRMs are
Marvin D Berman et al.
American journal of physiology. Gastrointestinal and liver physiology, 308(1), G42-G55 (2014-11-02)
Metastable and equilibrium phase diagrams for unconjugated bilirubin IXα (UCB) in bile are yet to be determined for understanding the physical chemistry of pigment gallstone formation. Also, UCB is a molecule of considerable biomedical importance because it is a potent
Yanhua Huang et al.
Analytica chimica acta, 877, 90-99 (2015-05-24)
Four kinds of green deep eutectic solvents (DESs) based on choline chloride (ChCl) have been synthesized and coated on the surface of magnetic graphene oxide (Fe3O4@GO) to form Fe3O4@GO-DES for the magnetic solid-phase extraction of protein. X-ray diffraction (XRD), vibrating
Estéfani García-Ríos et al.
BMC genomics, 15, 1059-1059 (2014-12-05)
The wine industry needs better-adapted yeasts to grow at low temperature because it is interested in fermenting at low temperature to improve wine aroma. Elucidating the response to cold in Saccharomyces cerevisiae is of paramount importance for the selection or
Brian T Weinert et al.
The EMBO journal, 34(21), 2620-2632 (2015-09-12)
Acetylation is frequently detected on mitochondrial enzymes, and the sirtuin deacetylase SIRT3 is thought to regulate metabolism by deacetylating mitochondrial proteins. However, the stoichiometry of acetylation has not been studied and is important for understanding whether SIRT3 regulates or suppresses
A M Rumiantsev et al.
Genetika, 49(4), 454-460 (2013-07-23)
Pichia pastoris is a methylotrophic yeast that is widely used for the expression of heterologous proteins. Here, we have investigated the dependence of AOX1 and CAT1 expression on the source of nitrogen. It has shown that the expression of AOX1
Vincenzo De Francesco et al.
Journal of medical microbiology, 63(Pt 5), 748-752 (2014-03-04)
Helicobacter pylori eradication remains a challenge for physicians. Sequential, concomitant and the hybrid regimens have been proposed as novel, more effective therapies. We compare the efficacy of these therapies. Dyspeptic patients referred for upper endoscopy with H. pylori infection were
Yuqin Li et al.
Bioresource technology, 192, 781-791 (2014-08-16)
Proteomics in conjunction with biochemical strategy was employed to unravel regulation of lipid metabolism in the green microalga Chlorella protothecoides by heterotrophy-photoinduction cultivation regime (HPC). Interestingly, HPC triggered transiently synthesis of starch followed by substantial lipid accumulation. And a marked
Susan Yung et al.
Autoimmunity, 48(7), 471-487 (2015-06-24)
Progression to chronic renal failure varies between patients with lupus nephritis. We compared the effects of mycophenolate mofetil (MMF) and cyclophosphamide (CTX), on renal histology and cellular pathways of fibrosis in murine lupus nephritis. Female NZBWF1/J mice were randomized to
Yakov A Lomakin et al.
Molecular immunology, 62(2), 305-314 (2014-02-19)
The mechanisms triggering most of autoimmune diseases are still obscure. Autoreactive B cells play a crucial role in the development of such pathologies and, in particular, production of autoantibodies of different specificities. The combination of deep-sequencing technology with functional studies
Thiago Buno Lima Prando et al.
Journal of ethnopharmacology, 174, 369-378 (2015-09-01)
Although Echinodorus grandiflorus, Cuphea carthagenensis, and Phyllanthus tenellus infusions are used in Brazilian folk medicine due to their possible diuretic effect, none of these species was critically investigated as a diuretic drug. So, the aim of this study was to
Michael Dean Chamberlain et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(34), 10673-10678 (2015-08-12)
An unbiased phosphoproteomic method was used to identify biomaterial-associated changes in the phosphorylation patterns of macrophage-like cells. The phosphorylation differences between differentiated THP1 (dTHP1) cells treated for 10, 20, or 30 min with a vascular regenerative methacrylic acid (MAA) copolymer
Nerea Fernández-Iglesias et al.
Nanoscale, 7(34), 14324-14331 (2015-08-06)
Once nanoparticles enter a biological system, it is known that their surface is instantly covered by the biomolecules present with preference to proteins. This protein corona has been a subject of numerous studies in order to reveal its composition. Besides
2/52