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Venkataramanan Subramanian et al.
Journal of proteome research, 13(12), 5431-5451 (2014-10-22)
Chlamydomonas reinhardtii is well adapted to survive under different environmental conditions due to the unique flexibility of its metabolism. Here we report metabolic pathways that are active during acclimation to anoxia, but were previously not thoroughly studied under dark, anoxic
Susan Yung et al.
Autoimmunity, 48(7), 471-487 (2015-06-24)
Progression to chronic renal failure varies between patients with lupus nephritis. We compared the effects of mycophenolate mofetil (MMF) and cyclophosphamide (CTX), on renal histology and cellular pathways of fibrosis in murine lupus nephritis. Female NZBWF1/J mice were randomized to
Yakov A Lomakin et al.
Molecular immunology, 62(2), 305-314 (2014-02-19)
The mechanisms triggering most of autoimmune diseases are still obscure. Autoreactive B cells play a crucial role in the development of such pathologies and, in particular, production of autoantibodies of different specificities. The combination of deep-sequencing technology with functional studies
Lawrence Mok et al.
Proteome science, 13, 25-25 (2015-11-05)
Bats are recognised as an important reservoir for a number of highly pathogenic zoonotic viruses. While many of these viruses cause severe and often fatal disease in humans, bats are able to coexist with these viruses without clinical signs of
S Roberts et al.
Osteoarthritis and cartilage, 23(9), 1622-1626 (2015-05-25)
To evaluate the potential of ADAMTS-4 (aggrecanase -1) activity in synovial fluid (SF) as a biomarker of knee injury and joint disease. We have measured ADAMTS-4 activity in the synovial fluid of 170 orthopaedic patients with different degrees of joint
Yunxiang Dai et al.
Analytical chemistry, 89(15), 7841-7846 (2017-06-28)
Comprehensive understanding of a gene's expression and regulation at the molecular level requires identification of all proteins interacting with the gene. HyCCAPP (Hybridization Capture of Chromatin Associated Proteins for Proteomics) is an approach that uses single-stranded DNA oligonucleotides to capture
H Skärstrand et al.
Clinical and experimental immunology, 179(2), 220-229 (2014-09-03)
Variant-specific zinc transporter 8 autoantibodies (ZnT8A) against either arginine (R) or tryptophan (W) at amino acid (aa) position 325 of the zinc transporter 8 (ZnT8) has been identified in type 1 diabetes (T1D) patients. Reciprocal cross-over tests revealed differences in
Sarah L Perry et al.
Nature communications, 6, 6052-6052 (2015-01-15)
Polyelectrolyte complexes present new opportunities for self-assembled soft matter. Factors determining whether the phase of the complex is solid or liquid remain unclear. Ionic polypeptides enable examination of the effects of stereochemistry on complex formation. Here we demonstrate that chirality
The challenge of complexity and arginine metabolism.
Francesco Saverio Dioguardi
The American journal of clinical nutrition, 98(2), 507-508 (2013-07-23)
C Stewart Gillmor et al.
Development (Cambridge, England), 141(23), 4580-4589 (2014-11-08)
Temporal coordination of developmental programs is necessary for normal ontogeny, but the mechanism by which this is accomplished is still poorly understood. We have previously shown that two components of the Mediator CDK8 module encoded by CENTER CITY (CCT; Arabidopsis
Afonso P Basto et al.
Molecular immunology, 64(1), 36-45 (2014-12-04)
The use of immunogenic formulations targeting pattern recognition receptors towards modulation of immune responses is a promising strategy to develop better vaccines against infectious and malignant diseases. Molecules targeting TLR2 offer interesting properties that are relevant for vaccine development, including
Nan Li et al.
Nature protocols, 8(6), 1155-1168 (2013-05-25)
Activity-based protein profiling (ABPP) is a functional proteomics technique for directly monitoring the expression of active enzymes in cell extracts and living cells. The technique relies on irreversible inhibitors equipped with reactive groups (warheads) that covalently attach to the active
Gro S Johannessen et al.
International journal of environmental research and public health, 12(6), 6919-6932 (2015-06-20)
The aim of this study was to investigate the bacteriological quality of strawberries at harvest and to study risk factors such as irrigation water, soil and picker's hand cleanliness. Four farms were visited during the harvest season in 2012. Samples
Yogananda Maspolim et al.
Chemosphere, 140, 54-62 (2014-08-07)
This study compared reactor performance and the respective microbial community dynamics in the conventional single-stage and 2-phase anaerobic digestion (AD) systems, treating municipal sludge to generate methane. The 2-phase system's COD and VS reduction, and methane production could be maintained
Bing-Rui Zhou et al.
STAR protocols, 2(2), 100396-100396 (2021-04-01)
The chromatosome, a nucleosome bound to a histone H1, is the structural unit of metazoan chromatin. Determination of the high-resolution structure of the chromatosome is challenging due to the dynamic nature of H1 binding. Here, we present a protocol for
Emmely E Treffers et al.
Proteomics, 15(13), 2267-2280 (2015-03-13)
Chikungunya virus (CHIKV) is an arthropod-borne reemerging human pathogen that generally causes a severe persisting arthritis. Since 2005, the virus has infected millions of people during outbreaks in Africa, Indian Ocean Islands, Asia, and South/Central America. Many steps of the
Martina Jokel et al.
Plant & cell physiology, 56(8), 1598-1607 (2015-06-13)
The flavodiiron proteins (FDPs) are involved in the detoxification of oxidative compounds, such as nitric oxide (NO) or O(2) in Archaea and Bacteria. In cyanobacteria, the FDPs Flv1 and Flv3 are essential in the light-dependent reduction of O(2) downstream of
Lihong Zhu et al.
Molecular and cellular neurosciences, 64, 74-83 (2014-05-28)
In our previous study, we reported that luteolin might exert neuroprotective functions by inhibiting the production of proinflammatory mediators, thereby suppressing microglial activation. In this study, we used two-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS) to study the effect
Mi Young Noh et al.
Developmental biology, 399(2), 315-324 (2015-01-24)
Yellow protein (dopachrome conversion enzyme, DCE) is involved in the melanin biosynthetic pathway that significantly accelerates pigmentation reactions in insects. Recent studies have suggested that the insect yellow genes represent a rapidly evolving gene family generating functionally diverse paralogs, but
Junfeng Xu et al.
Molecular & cellular proteomics : MCP, 14(3), 499-509 (2014-12-30)
The neddylation-cullin-RING E3 ligase (CRL) pathway has recently been identified as a potential oncogenic event and attractive anticancer target; however, its underlying mechanisms have not been well elucidated. In this study, RhoB, a well known tumor suppressor, was identified and
Heather S Davies et al.
PloS one, 9(9), e108372-e108372 (2014-09-30)
The salivary mucins that include MUC5B (gel-forming) and MUC7 (non-gel-forming) are major contributors to the protective mucus barrier in the oral cavity, and it is possible that dietary components may influence barrier properties. We show how one dietary compound, the
Karen Louise Thomsen
Danish medical journal, 60(4), B4617-B4617 (2013-05-09)
Catabolism is a serious clinical problem in patients with active inflammation. Under such stressful conditions, the catabolism and loss of tissue nitrogen (N) result from proteolysis and are augmented by an up-regulation of the hepatic capacity to eliminate amino-N via
Angel L Pey et al.
Biochimica et biophysica acta, 1844(9), 1453-1462 (2014-05-02)
Human cystathionine β-synthase (hCBS) is a key enzyme of sulfur amino acid metabolism, controlling the commitment of homocysteine to the transsulfuration pathway and antioxidant defense. Mutations in hCBS cause inherited homocystinuria (HCU), a rare inborn error of metabolism characterized by
Karina Taciana Silva et al.
Journal of proteome research, 14(1), 385-396 (2014-11-05)
Dibenzothiophene (DBT) and its oxidized derivative dibenzothiophene sulfone (DBTO2) are important representatives of polycyclic aromatic hydrocarbons (PAHs). Due to the importance of PAHs in oncogenesis and the lack of toxicological investigations related to DBT and DBTO2, this work proposes to
Jordane Biarc et al.
Journal of chromatography. A, 1397, 81-85 (2015-04-30)
Podocalyxin is a protein present in specialized glomerulus cells called podocytes and may be released in the urine in case of kidney injury. In this context, its quantification could be of great interest in order to monitor glomerular injury. Liquid
Mohammad A Hossain et al.
Journal of proteomics, 108, 133-145 (2014-05-28)
The use of donation after circulatory death (DCD) kidneys for transplantation is increasing. Subsequent delayed graft function is related to ischaemia/reperfusion injury (I/R), warm ischaemia (WI) being one of the main contributing factors. This proteomics study aimed to identify candidate
Microextraction by packed sorbent (MEPS) to analyze catecholamines in innovative biological samples.
Maria Addolorata Saracino et al.
Journal of pharmaceutical and biomedical analysis, 104, 122-129 (2014-12-17)
A new microextraction by packed sorbent (MEPS) procedure coupled to a high-performance liquid chromatographic method has been developed for quantitation of catecholamines (i.e. norepinephrine, epinephrine and dopamine) in innovative biological samples, namely dried plasma and urine spots. Analyses were carried
Vincenzo De Francesco et al.
Journal of medical microbiology, 63(Pt 5), 748-752 (2014-03-04)
Helicobacter pylori eradication remains a challenge for physicians. Sequential, concomitant and the hybrid regimens have been proposed as novel, more effective therapies. We compare the efficacy of these therapies. Dyspeptic patients referred for upper endoscopy with H. pylori infection were
J T Richeson et al.
Journal of animal science, 93(8), 4089-4097 (2015-10-07)
Growth implant efficacy may be affected when administered to nutritionally stressed calves, whereas the procedure may alter health or the humoral immune response to respiratory vaccination. The study objective was to determine the effect of different administration times (d 0
Stephanie J Cole et al.
Infection and immunity, 82(5), 2048-2058 (2014-03-07)
Pseudomonas aeruginosa is an opportunistic human pathogen that is especially adept at forming surface-associated biofilms. P. aeruginosa causes catheter-associated urinary tract infections (CAUTIs) through biofilm formation on the surface of indwelling catheters. P. aeruginosa encodes three extracellular polysaccharides, PEL, PSL
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