U6504

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Networks of protein kinases and phosphatases in the individual phases of contextual fear conditioning in the C57BL/6J mouse.

Goran Mucic et al.

Behavioural brain research, 280, 45-50 (2014-12-03)

Although protein kinases and phosphatases have been reported to be involved in fear memory, information about these signalling molecules in the individual phases of contextual fear conditioning (cFC) is limited. C57BL/6J mice were tested in cFC, sacrificed and hippocampi were

Ammonia-lowering activities and carbamoyl phosphate synthetase 1 (Cps1) induction mechanism of a natural flavonoid.

Kazunari Nohara et al.

Nutrition & metabolism, 12, 23-23 (2015-06-16)

Ammonia detoxification is essential for physiological well-being, and the urea cycle in liver plays a predominant role in ammonia disposal. Nobiletin (NOB), a natural dietary flavonoid, is known to exhibit various physiological efficacies. In the current study, we investigated a

Morphological and proteomic analyses reveal that unsaturated guluronate oligosaccharide modulates multiple functional pathways in murine macrophage RAW264.7 cells.

Xu Xu et al.

Marine drugs, 13(4), 1798-1818 (2015-04-02)

Alginate is a natural polysaccharide extracted from various species of marine brown algae. Alginate-derived guluronate oligosaccharide (GOS) obtained by enzymatic depolymerization has various pharmacological functions. Previous studies have demonstrated that GOS can trigger the production of inducible nitric oxide synthase

Influence of a direct-fed microbial and xylanase enzyme on the dietary energy uptake efficiency and performance of broiler chickens.

Ganapathi Raj Murugesan et al.

Journal of the science of food and agriculture, 95(12), 2521-2527 (2014-11-05)

Efficacy of a multi-strain direct-fed microbial product (PoultryStar(®) ME; PS) and a xylanase enzyme product on the dietary energy utilization efficiency and resulting performance in broiler chickens was evaluated. Apart from performance parameters, cecal and serum metabolites and activities of

Identification of prognosis-related proteins in gingival squamous cell carcinoma by twodimensional gel electrophoresis and mass spectrometry-based proteomics.

Maria Giulia Cristofaro et al.

Annali italiani di chirurgia, 85(6), 518-524 (2015-02-26)

The aim of this study was to identify differentially expressed proteins in oral squamous carcinoma cells that could be potential prognosis-related cancer biomarkers. We compared protein expression patterns from gingival squamous cellc carcinoma (GSCC) tissues and adjacent non-cancerous matched tissues

Comparative Biochemical and Proteomic Analyses of Soybean Seed Cultivars Differing in Protein and Oil Content.

Chul Woo Min et al.

Journal of agricultural and food chemistry, 63(32), 7134-7142 (2015-08-04)

This study develops differential protein profiles of soybean (Glycine max) seeds (cv. Saedanbaek and Daewon) varying in protein (47.9 and 39.2%) and oil (16.3 and 19.7%) content using protamine sulfate (PS) precipitation method coupled with a 2D gel electrophoresis (2DGE)

Proteomic analysis of bovine blastocoel fluid and blastocyst cells.

Pernille Linnert Jensen et al.

Systems biology in reproductive medicine, 60(3), 127-135 (2014-02-27)

The understanding of the early mammalian development is a prerequisite for the advancement of in vitro fertilization and improvement of derivation and culturing of embryonic stem cells. While, whole genome transcriptomic analysis on bovine blastocysts has identified genes active in

Effect of slow-release urea inclusion in diets containing modified corn distillers grains on total tract digestibility and ruminal fermentation in feedlot cattle.

I Ceconi et al.

Journal of animal science, 93(8), 4058-4069 (2015-10-07)

Ruminal degradable intake protein (DIP) deficit may result when cattle are fed diets containing a greater inclusion of processed corn grain and small to moderate inclusion of corn distillers grains (DG). This deficit may arise from greater proportions of rapidly

Lipid phase behaviour under steady state conditions.

Christoffer Aberg et al.

Faraday discussions, 161, 151-166 (2013-06-29)

At the interface between two regions, for example the air-liquid interface of a lipid solution, there can arise non-equilibrium situations. The water chemical potential corresponding to the ambient RH will, in general, not match the water chemical potential of the

Do not drop: mechanical shock in vials causes cavitation, protein aggregation, and particle formation.

Theodore W Randolph et al.

Journal of pharmaceutical sciences, 104(2), 602-611 (2014-11-25)

Industry experience suggests that g-forces sustained when vials containing protein formulations are accidentally dropped can cause aggregation and particle formation. To study this phenomenon, a shock tower was used to apply controlled g-forces to glass vials containing formulations of two

Proteomics approach to examine the cardiotoxic effects of Nemopilema nomurai Jellyfish venom.

Indu Choudhary et al.

Journal of proteomics, 128, 123-131 (2015-07-21)

Nemopilema nomurai is one of the largest species of jellyfish in the world. It blooms mainly offshore of Korea, China, and Japan. Increasing population numbers of N. nomurai is increasing the risk of sea bathers to the jellyfish stings and

Determination of ammonia and urea in urine and of urea in blood by use of an ammonia-selective electrode.

J Georges

Clinical chemistry, 25(11), 1888-1890 (1979-11-01)

I propose a single, quick method for measuring ammonia in urine and urea in plasma and urine. An ammonia-selective electrodie is used, set up on a microcell, which allows use of small sample volumes. Ammonia is measured directly after partial

Detoxification mechanisms of honey bees (Apis mellifera) resulting in tolerance of dietary nicotine.

Esther E du Rand et al.

Scientific reports, 5, 11779-11779 (2015-07-03)

Insecticides are thought to be among the major factors contributing to current declines in bee populations. However, detoxification mechanisms in healthy, unstressed honey bees are poorly characterised. Alkaloids are naturally encountered in pollen and nectar, and we used nicotine as

Quantitative Proteomic Analyses of Molecular Mechanisms Associated with Cytoplasmic Incompatibility in Drosophila melanogaster Induced by Wolbachia.

Lin-Ling Yuan et al.

Journal of proteome research, 14(9), 3835-3847 (2015-07-30)

To investigate the molecular mechanisms of cytoplasmic incompatibility (CI) induced by Wolbachia bacteria in Drosophila melanogaster, we applied an isobaric tags for relative and absolute quantitation (iTRAQ)-based quantitative proteomic assay to identify differentially expressed proteins extracted from spermathecae and seminal

Evaluation of Multi-tRNA Synthetase Complex by Multiple Reaction Monitoring Mass Spectrometry Coupled with Size Exclusion Chromatography.

Seong-Jun Park et al.

PloS one, 10(11), e0142253-e0142253 (2015-11-07)

Eight aminoacyl-tRNA synthetases (M, K, Q, D, R, I, EP and LARS) and three auxiliary proteins (AIMP1, 2 and 3) are known to form a multi-tRNA synthetase complex (MSC) in mammalian cells. We combined size exclusion chromatography (SEC) with reversed-phase

High altitude may alter oxygen availability and renal metabolism in diabetics as measured by hyperpolarized [1-(13)C]pyruvate magnetic resonance imaging.

Christoffer Laustsen et al.

Kidney international, 86(1), 67-74 (2013-12-20)

The kidneys account for about 10% of the whole body oxygen consumption, whereas only 0.5% of the total body mass. It is known that intrarenal hypoxia is present in several diseases associated with development of kidney disease, including diabetes, and

Role of rumen butyrate in regulation of nitrogen utilization and urea nitrogen kinetics in growing sheep.

U Agarwal et al.

Journal of animal science, 93(5), 2382-2390 (2015-05-29)

Butyrate, a major rumen VFA, has been indirectly linked to enhancement of urea recycling on the basis of increased expression of urea transporter in the rumen epithelia of steers fed a rumen butyrate-enhancing diet. Two studies were conducted to quantify

Cognitive Function, Progression of Age-related Behavioral Changes, Biomarkers, and Survival in Dogs More Than 8 Years Old.

T Schütt et al.

Journal of veterinary internal medicine, 29(6), 1569-1577 (2015-10-16)

Canine cognitive dysfunction (CCD) is an age-dependent neurodegenerative condition dominated by changes in behavioral patterns. Cohort studies investigating cognitive status in dogs are lacking. To investigate cognitive function, progression of age-related behavioral changes, survival, and possible biomarkers of CCD in

Systems biology studies of adult paragonimus lung flukes facilitate the identification of immunodominant parasite antigens.

Samantha N McNulty et al.

PLoS neglected tropical diseases, 8(10), e3242-e3242 (2014-10-21)

Paragonimiasis is a food-borne trematode infection acquired by eating raw or undercooked crustaceans. It is a major public health problem in the far East, but it also occurs in South Asia, Africa, and in the Americas. Paragonimus worms cause chronic

Titanium Dioxide Nanoparticle Penetration into the Skin and Effects on HaCaT Cells.

Matteo Crosera et al.

International journal of environmental research and public health, 12(8), 9282-9297 (2015-08-12)

Titanium dioxide nanoparticles (TiO2NPs) suspensions (concentration 1.0 g/L) in synthetic sweat solution were applied on Franz cells for 24 h using intact and needle-abraded human skin. Titanium content into skin and receiving phases was determined. Cytotoxicity (MTT, AlamarBlue(®) and propidium

Assembly and maintenance of the flagellum attachment zone filament in Trypanosoma brucei.

Qing Zhou et al.

Journal of cell science, 128(13), 2361-2372 (2015-05-15)

Adhesion of motile flagella to the cell body in Trypanosoma brucei requires a filamentous cytoskeletal structure termed the flagellum attachment zone (FAZ). Despite its essentiality, the complete molecular composition of the FAZ filament and its roles in FAZ filament assembly

Interaction of ATP with a small heat shock protein from Mycobacterium leprae: effect on its structure and function.

Sandip Kumar Nandi et al.

PLoS neglected tropical diseases, 9(3), e0003661-e0003661 (2015-03-27)

Adenosine-5'-triphosphate (ATP) is an important phosphate metabolite abundantly found in Mycobacterium leprae bacilli. This pathogen does not derive ATP from its host but has its own mechanism for the generation of ATP. Interestingly, this molecule as well as several antigenic

Mesenchymal stem cells reciprocally regulate the M1/M2 balance in mouse bone marrow-derived macrophages.

Dong-Im Cho et al.

Experimental & molecular medicine, 46, e70-e70 (2014-01-11)

Mesenchymal stem cells (MSCs) have been widely studied for their applications in stem cell-based regeneration. During myocardial infarction (MI), infiltrated macrophages have pivotal roles in inflammation, angiogenesis and cardiac remodeling. We hypothesized that MSCs may modulate the immunologic environment to

Increased dialysate MCP-1 is associated with cardiovascular mortality in peritoneal dialysis patients: a prospective observational study.

Kwang Il Ko et al.

American journal of nephrology, 40(4), 291-299 (2014-10-18)

The aim of this study was to investigate the association between the dialysate MCP-1 (dMCP-1) and systemic inflammatory and nutritional markers in peritoneal dialysis (PD) patients. In addition, we examined the prognostic value of dMCP-1 on all-cause or cardiovascular mortality

Proteome-wide screening of the European porcine reproductive and respiratory syndrome virus reveals a broad range of T cell antigen reactivity.

Helen Mokhtar et al.

Vaccine, 32(50), 6828-6837 (2014-05-23)

The porcine reproductive and respiratory syndrome virus (PRRSV) is a rapidly evolving and diversifying pathogen necessitating the development of improved vaccines. Immunity to PRRSV is not well understood although there are data suggesting that virus-specific T cell IFN-γ responses play

In vivo hepatogenic capacity and therapeutic potential of stem cells from human exfoliated deciduous teeth in liver fibrosis in mice.

Takayoshi Yamaza et al.

Stem cell research & therapy, 6, 171-171 (2015-09-12)

Liver transplantation is a gold standard treatment for intractable liver diseases. Because of the shortage of donor organs, alternative therapies have been required. Due to their potential to differentiate into a variety of mature cells, stem cells are considered feasible

Proteome adaptation in cell reprogramming proceeds via distinct transcriptional networks.

Marco Benevento et al.

Nature communications, 5, 5613-5613 (2014-12-11)

The ectopic expression of Oct4, Klf4, c-Myc and Sox2 (OKMS) transcription factors allows reprogramming of somatic cells into induced pluripotent stem cells (iPSCs). The reprogramming process, which involves a complex network of molecular events, is not yet fully characterized. Here

Dot-ELISA Rapid Test Using Recombinant 56-kDa Protein Antigens for Serodiagnosis of Scrub Typhus.

Wuttikon Rodkvamtook et al.

The American journal of tropical medicine and hygiene, 92(5), 967-971 (2015-03-25)

We developed a rapid dot-enzyme-linked immunosorbent assay (dot-ELISA) using the combination of recombinant 56-kDa protein antigens that exhibited broad reactivity with serum antibodies against the four most prevalent strains (Karp, Kato, Gilliam, and TA763) of Orientia tsutsugamushi. The assay is

Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes.

Melissa Baxter et al.

Journal of hepatology, 62(3), 581-589 (2014-12-03)

Hepatocyte-like cells (HLCs), differentiated from pluripotent stem cells by the use of soluble factors, can model human liver function and toxicity. However, at present HLC maturity and whether any deficit represents a true fetal state or aberrant differentiation is unclear

Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity.

Amy H Buck et al.

Nature communications, 5, 5488-5488 (2014-11-26)

In mammalian systems RNA can move between cells via vesicles. Here we demonstrate that the gastrointestinal nematode Heligmosomoides polygyrus, which infects mice, secretes vesicles containing microRNAs (miRNAs) and Y RNAs as well as a nematode Argonaute protein. These vesicles are

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