U7508

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UVRAG mutations associated with microsatellite unstable colon cancer do not affect autophagy

Knaevelsrud H, et al.

Autophagy, 6(7), 863-870 (2010)

UVRAG is required for organ rotation by regulating Notch endocytosis in Drosophila.

Gina Lee et al.

Developmental biology, 356(2), 588-597 (2011-07-07)

Heterotaxy characterized by abnormal left-right body asymmetry causes diverse congenital anomalies. Organ rotation is a crucial developmental process to establish the left-right patterning during animal development. However, the molecular basis of how organ rotation is regulated is poorly understood. Here

Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers

He S

Nature Communications (2015)

UVRAG is required for organ rotation by regulating Notch endocytosis in Drosophila

Lee G, et al.

Developmental Biology, 356(2), 588-597 (2011)

Pietro Di Fazio et al.

Oncotarget, 7(20), 28998-29010 (2016-04-09)

Autophagy is a homeostatic, catabolic degradation process and cell fate essential regulatory mechanism. Protracted autophagy triggers cell death; its aberrant function is responsible for several malignancies. Panobinostat, a potent pan-deacetylase inhibitor, causes endoplasmic reticulum stress-induced cell death. The aim of

UV irradiation resistance-associated gene suppresses apoptosis by interfering with BAX activation.

Yin X

EMBO Reports, 12, 727-734 (2011)

Sorting nexin 5 mediates virus-induced autophagy and immunity.

Xiaonan Dong et al.

Nature, 589(7842), 456-461 (2020-12-18)

Autophagy, a process of degradation that occurs via the lysosomal pathway, has an essential role in multiple aspects of immunity, including immune system development, regulation of innate and adaptive immune and inflammatory responses, selective degradation of intracellular microorganisms, and host

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

Curtis C

Nature, 486, 346-352 (2012)

Echovirus 7 entry into polarized caco-2 intestinal epithelial cells involves core components of the autophagy machinery.

Chonsaeng Kim et al.

Journal of virology, 88(1), 434-443 (2013-10-25)

Echovirus 7 enters polarized Caco-2 intestinal epithelial cells by a clathrin-mediated endocytic process and then moves through the endosomal system before releasing its genome into the cytoplasm. We examined the possible role in virus entry of core components of the

Foot-and-mouth disease virus nonstructural protein 2C interacts with Beclin1, modulating virus replication.

D P Gladue et al.

Journal of virology, 86(22), 12080-12090 (2012-08-31)

Foot-and-mouth disease virus (FMDV), the causative agent of foot-and-mouth disease, is an Apthovirus within the Picornaviridae family. Replication of the virus occurs in association with replication complexes that are formed by host cell membrane rearrangements. The largest viral protein in

Foot-and-mouth disease virus infection suppresses autophagy and NF-кB antiviral responses via degradation of ATG5-ATG12 by 3C

Xuxu Fan et al.

Cell death & disease, 8(1), e2561-e2561 (2017-01-20)

Autophagy-related protein ATG5-ATG12 is an essential complex for the autophagophore elongation in autophagy, which has been reported to be involved in foot-and-mouth disease virus (FMDV) replication. Previous reports show that ATG5-ATG12 positively or negatively regulates type I interferon (IFN-α/β) pathway

UVRAG mutations associated with microsatellite unstable colon cancer do not affect autophagy.

Helene Knævelsrud et al.

Autophagy, 6(7), 863-870 (2010-08-21)

Reduced levels of autophagy correlate with tumorigenesis, and several inducers of autophagy have been found to be tumor suppressors. One such autophagic inducer is the Beclin 1 binding protein UVRAG, a positive regulator of the class III PI3K/Vps34 complex. UVRAG

Endocytosis regulates TDP-43 toxicity and turnover.

Guangbo Liu et al.

Nature communications, 8(1), 2092-2092 (2017-12-14)

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron degenerative disease. ALS-affected motor neurons exhibit aberrant localization of a nuclear RNA binding protein, TDP-43, into cytoplasmic aggregates, which contributes to pathology via unclear mechanisms. Here, we demonstrate that TDP-43 turnover

TPT1 (tumor protein, translationally-controlled 1) negatively regulates autophagy through the BECN1 interactome and an MTORC1-mediated pathway.

Seong-Yeon Bae et al.

Autophagy, 13(5), 820-833 (2017-04-15)

TPT1/TCTP (tumor protein, translationally-controlled 1) is highly expressed in tumor cells, known to participate in various cellular activities including protein synthesis, growth and cell survival. In addition, TPT1 was identified as a direct target of the tumor suppressor TP53/p53 although

Modulation of Pancreatic Neuroendocrine Neoplastic Cell Fate by Autophagy-Mediated Death.

Sami Matrood et al.

Neuroendocrinology, 111(10), 965-985 (2020-10-28)

Autophagic cell death in cancer cells can be mediated by inhibition of deacetylases. Although extensive studies have focused on the autophagic process in cancer, little is known about the role of autophagy in degrading cytosolic and nuclear components of pancreatic

Foot-and-mouth disease virus nonstructural protein 2C interacts with Beclin1, modulating virus replication

Gladue D P, et al.

Journal of Virology, 86(22), 12080-12090 (2012)

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