V106

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关键词:'V106'

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Effect of formulation variables on verapamil hydrochloride release from hydrated HPMC matrices

Ramrez C, et al.

Journal of the Mexican Chemical Society, 48(4), 326-331 (2004)

Rapid Ring-Opening Metathesis Polymerization of Monomers Obtained from Biomass-Derived Furfuryl Amines and Maleic Anhydride.

Anna Blanpain et al.

ChemSusChem, 12(11), 2393-2401 (2019-04-06)

Well-controlled and extremely rapid ring-opening metathesis polymerization of unusual oxanorbornene lactam esters by Grubbs third-generation catalyst is used to prepare a range of bio-based homo- and copolymers. Bio-derived oxanorbornene lactam monomers were prepared at room temperature from maleic anhydride and

Embryonic stem cell-derived cardiomyocytes as a model system to study cardioprotective effects of dexamethasone in doxorubicin cardiotoxicity

Farokhpour M, et al.

Toxicology in vitro, 23(7), 1422-1428 (2009)

Assessment of the chemotherapeutic potential of a new camptothecin derivative, ZBH-1205

Wu D, et al.

Archives of Biochemistry and Biophysics, 604(1), 74-85 (2016)

Formulation and evaluation of once daily sustained release matrix tablet of verapamil hydrochloride

Ray B and Gupta MM

Journal of Drug Delivery and Therapeutics, 3(1) (2013)

Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1.

Kamil Nosol et al.

Proceedings of the National Academy of Sciences of the United States of America, 117(42), 26245-26253 (2020-10-07)

ABCB1 detoxifies cells by exporting diverse xenobiotic compounds, thereby limiting drug disposition and contributing to multidrug resistance in cancer cells. Multiple small-molecule inhibitors and inhibitory antibodies have been developed for therapeutic applications, but the structural basis of their activity is

The activity of verapamil as a resistance modifier in vitro in drug resistant human tumour cell lines is not stereospecific.

J A Plumb et al.

Biochemical pharmacology, 39(4), 787-792 (1990-02-15)

The L-isomer of verapamil is a more potent calcium antagonist than the D-isomer. We have examined the two stereoisomers of verapamil for their ability to increase the chemosensitivity in vitro of three drug resistant cell lines (2780AD, MCF7/AdrR and H69LX10).

FTIR microspectroscopy defines early drug resistant human hepatocellular carcinoma (HepG2) cells.

Cholpajsorn Junhom et al.

Experimental cell research, 340(1), 71-80 (2015-12-29)

Characterization and identification of cancer cell, chemotherapy, resistance is important for both routine cancer therapy and trouble-shooting the medication treatment regimen. Present techniques for characterizing cancer cell resistance require multiple methods and steps, which are time-consuming and expensive. We present

The effect of verapamil on the transport of peptides across the blood-brain barrier in rats: kinetic evidence for an apically polarized efflux mechanism.

E G Chikhale et al.

The Journal of pharmacology and experimental therapeutics, 273(1), 298-303 (1995-04-01)

When the blood-brain barrier (BBB) transport of a series of model peptides that varied in their physicochemical properties (lipophilicity, size and hydrogen-bonding potential) was determined using an in situ rat brain perfusion technique, an unexpected increase in flux with increasing

Effect of valine 106 on structure-function relation of cytosolic human thymidine kinase. Kinetic properties and oligomerization pattern of nine substitution mutants of V106.

Hanne Frederiksen et al.

European journal of biochemistry, 271(11), 2248-2256 (2004-05-22)

Information on the regulation and structure-function relation of enzymes involved in DNA precursor synthesis is pivotal, as defects in several of these enzymes have been found to cause depletion or deletion of mitochondrial DNA resulting in severe diseases. Here, the

Rapid methods for high-throughput detection of sulfoxides.

Janna Shainsky et al.

Applied and environmental microbiology, 75(14), 4711-4719 (2009-05-26)

Enantiopure sulfoxides are prevalent in drugs and are useful chiral auxiliaries in organic synthesis. The biocatalytic enantioselective oxidation of prochiral sulfides is a direct and economical approach for the synthesis of optically pure sulfoxides. The selection of suitable biocatalysts requires

Transforming growth factor beta 1: secondary structure as determined by heteronuclear magnetic resonance spectroscopy.

S J Archer et al.

Biochemistry, 32(4), 1164-1171 (1993-02-02)

Virtually complete backbone NMR signal assignments have been reported for transforming growth factor beta 1 (TGF-beta 1) [Archer et al. (1993) Biochemistry (preceding paper in this issue)]. Herein we report the secondary structure of the protein in solution on the

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