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Choline supplementation restores substrate balance and alleviates complications of Pcyt2 deficiency.
Laila C Schenkel et al.
The Journal of nutritional biochemistry, 26(11), 1221-1234 (2015-08-06)
Choline plays a critical role in systemic lipid metabolism and hepatic function. Here we conducted a series of experiments to investigate the effect of choline supplementation on metabolically altered Pcyt2(+/-) mice. In Pcyt2(+/-) mice, the membrane phosphatidylethanolamine (PE) turnover is
Josè Ramon Moyano-Mendez et al.
Drug development and industrial pharmacy, 40(10), 1300-1307 (2013-07-19)
Trans-resveratrol, a polyphenol extracted from Vitis vinifera, has different beneficial effects following its administration on the skin. Here the potential use of binary systems to enhance in vitro and in vivo activity of trans-resveratrol was investigated. Thus the aqueous solubility
A C McLellan et al.
Analytical biochemistry, 206(1), 12-16 (1992-10-01)
A fluorimetric assay for D-lactate in human blood samples was developed using an endpoint enzymatic assay with D-lactate dehydrogenase from Staphylococcus epidermidis. The intrabatch and interbatch coefficients of variance were 8.7% (n = 4) and 16.6% (n = 4), respectively.
Csaba Ádám et al.
Cell communication and signaling : CCS, 13, 33-33 (2015-07-18)
Cells deploy quality control mechanisms to remove damaged or misfolded proteins. Recently, we have reported that a mutation (R43W) in the Frank-ter Haar syndrome protein Tks4 resulted in aberrant intracellular localization. Here we demonstrate that the accumulation of Tks4(R43W) depends
Maaike Kockx et al.
PloS one, 9(10), e111186-e111186 (2014-10-28)
Dynamins are fission proteins that mediate endocytic and exocytic membrane events and are pharmacological therapeutic targets. These studies investigate whether dynamin II regulates constitutive protein secretion and show for the first time that pharmacological inhibition of dynamin decreases secretion of
Ryan Mailloux et al.
Toxicology, 334, 81-93 (2015-06-13)
Rates of obesity and diabetes mellitus of Arctic populations are increasing due to multiple reasons including a departure from traditional lifestyles and alcohol consumption patterns. These populations are also exposed to a variety of anthropogenic contaminants through consumption of contaminated
Shagufta Perveen et al.
Pharmacognosy magazine, 11(Suppl 1), S1-S5 (2015-06-26)
Literature survey proved the use of the powdered sun-dried bark and roots of Celtis africana for the treatment of cancer in South Africa. The aim of this study was to do further isolation work on the ethyl acetate fraction and
Yuwei Zhu et al.
The Biochemical journal, 470(1), 105-114 (2015-08-08)
UbiG and Coq3 (orthologue in eukaryotes) are SAM-MTases (S-adenosylmethionine-dependent methyltransferases) that catalyse both O-methylation steps in CoQ biosynthesis from prokaryotes to eukaryotes. However, the detailed molecular mechanism by which they function remains elusive. In the present paper, we report that
Rongzeng Liu et al.
BMC biotechnology, 15, 50-50 (2015-06-10)
Plasmin is a serine protease that plays a critical role in fibrinolysis, which is a process that prevents blood clots from growing and becoming problematic. Recombinant human microplasminogen (rhμPlg) is a derivative of plasmin that solely consists of the catalytic
Lia R Edmunds et al.
PloS one, 10(7), e0134049-e0134049 (2015-08-01)
The c-Myc (Myc) oncoprotein and AMP-activated protein kinase (AMPK) regulate glycolysis and oxidative phosphorylation (Oxphos) although often for different purposes. Because Myc over-expression depletes ATP with the resultant activation of AMPK, we explored the potential co-dependency of and cross-talk between
Tina C Roeske et al.
PloS one, 9(11), e111722-e111722 (2014-11-14)
All-trans retinoic acid (ATRA), the main active metabolite of vitamin A, is a powerful signaling molecule that regulates large-scale morphogenetic processes during vertebrate embryonic development, but is also involved post-natally in regulating neural plasticity and cognition. In songbirds, it plays
Forest H Andrews et al.
Biochemistry, 53(27), 4358-4367 (2014-06-24)
The X-ray structure of benzoylformate decarboxylase (BFDC) from Pseudomonas putida ATCC 12633 shows it to be a tetramer. This was believed to be typical of all thiamin diphosphate-dependent decarboxylases until recently when the structure of KdcA, a branched-chain 2-keto acid
Symen Ligthart et al.
PloS one, 10(3), e0118859-e0118859 (2015-03-15)
Pleiotropic genetic variants have independent effects on different phenotypes. C-reactive protein (CRP) is associated with several cardiometabolic phenotypes. Shared genetic backgrounds may partially underlie these associations. We conducted a genome-wide analysis to identify the shared genetic background of inflammation and
Toshitsugu Fujita et al.
PloS one, 10(1), e0116579-e0116579 (2015-01-22)
Accumulating evidence suggests that Pax5 plays essential roles in B cell lineage commitment. However, molecular mechanisms of B cell-specific expression of Pax5 are not fully understood. Here, we applied insertional chromatin immunoprecipitation (iChIP) combined with stable isotope labeling using amino
Lisi Xie et al.
Plant physiology and biochemistry : PPB, 93, 18-28 (2015-03-31)
The UV-B inducible ARIADNE12 (ARI12) gene of Arabidopsis thaliana is a member of the RING-between-RING (RBR) family of E3 ubiquitin ligases for which a novel ubiquitination mechanism was identified in mammalian homologs. This RING-HECT hybrid mechanism needs a conserved cysteine
Mélanie Bonizec et al.
Nucleic acids research, 42(17), 10975-10986 (2014-09-04)
Cdc48/p97 is an evolutionary conserved ubiquitin-dependent chaperone involved in a broad array of cellular functions due to its ability to associate with multiple cofactors. Aside from its role in removing RNA polymerase II from chromatin after DNA damage, little is
Xiaoli Qi et al.
Addiction biology, 20(2), 324-335 (2014-03-13)
Tobacco addiction is characterized by a lack of control over smoking and relapse after periods of abstinence. Smoking cessation leads to a dysphoric state that contributes to relapse to smoking. After the acute withdrawal phase, exposure to stressors increases the
Harshavardhan V Pawar et al.
Journal of pharmaceutical sciences, 103(6), 1720-1733 (2014-04-05)
Wafers combining weight ratios of Polyox with carrageenan (75/25) or sodium alginate (50/50) containing streptomycin and diclofenac were prepared to improve chronic wound healing. Gels were freeze-dried using a lyophilisation cycle incorporating an annealing step. Wafers were characterised for morphology
Emma C Stea et al.
Journal of environmental quality, 44(5), 1556-1567 (2015-10-06)
Surface waters are commonly used as source water for drinking water and irrigation. Knowledge of sources of fecal pollution in source watersheds benefits the design of effective source water protection plans. This study analyzed the relationships between enteric pathogens (
Michael B Gill et al.
The EMBO journal, 34(4), 448-465 (2014-12-05)
Paradoxically, the thymidine kinase (TK) encoded by Kaposi sarcoma-associated herpesvirus (KSHV) is an extremely inefficient nucleoside kinase, when compared to TKs from related herpesviruses. We now show that KSHV-TK, in contrast to HSV1-TK, associates with the actin cytoskeleton and induces
Oliver Simon et al.
Journal of proteomics, 122, 11-25 (2015-04-02)
To increase the efficiency of biocatalysts a thorough understanding of the molecular response of the biocatalyst to precursors, products and environmental conditions applied in bioconversions is essential. Here we performed a comprehensive proteome and phospholipid analysis to characterize the molecular
Pichapak Sriyapai et al.
International journal of molecular sciences, 16(6), 13579-13594 (2015-06-16)
A thermostable esterase gene (hydS14) was cloned from an Actinomadura sp. S14 gene library. The gene is 777 bp in length and encodes a polypeptide of 258 amino acid residues with no signal peptide, no N-glycosylation site and a predicted
Chunyan Zhao et al.
Nanoscale, 7(43), 18239-18249 (2015-10-22)
This study explored the influence of polyethylene glycol-linked multi-walled carbon nanotube (PEG-CNT) films on skeletal myogenic differentiation of human mesenchymal stem cells (hMSCs). PEG-CNT films were prepared with nanoscale surface roughness, orderly arrangement of PEG-CNTs, high hydrophilicity and high mechanical
Maura Poli et al.
Biochemical pharmacology, 92(3), 467-475 (2014-09-23)
Hepcidin is a peptide hormone that controls systemic iron availability and is upregulated by iron and inflammation. Heparins have been shown to be efficient hepcidin inhibitors both in vitro and in vivo, even when their anticoagulant activity has been abolished
Elisabetta Moratti et al.
PloS one, 10(3), e0119110-e0119110 (2015-03-17)
PTPRG is a widely expressed protein tyrosine phosphatase present in various isoforms. Peptides from its extracellular domain have been detected in plasma by proteomic techniques. We aim at characterizing the plasmatic PTPRG (sPTPRG) form and to identify its source. The
Yuan-Yuan Chen et al.
Scientific reports, 5, 11802-11802 (2015-07-03)
The present study aimed to explore the holistic mechanism for the antihypertrophic effect of a compound in Chinese medicine, QiShenYiQi Pills (QSYQ) and the contributions of its components to the effect in rats with cardiac hypertrophy (CH). After induction of
Marie Larousse et al.
Protist, 165(3), 275-292 (2014-04-18)
The plant pathogen Phytophthora parasitica forms a biofilm on the host surface. The biofilm transcriptome is characterized by the expression of PPMUCL1/2/3 (PHYTOPHTHORA PARASITICA MUCIN-LIKE) genes, which we report here to be members of a new, large mucin-like gene family
Juha R Savinainen et al.
Molecular pharmacology, 86(5), 522-535 (2014-08-21)
The primary route of inactivation of the endocannabinoid 2-arachidonoylglycerol in the central nervous system is through enzymatic hydrolysis, mainly carried out by monoacylglycerol lipase (MAGL), along with a small contribution by the α/β-hydrolase domain (ABHD) proteins ABHD6 and ABHD12. Recent
Iliya Lefterov et al.
Neurobiology of disease, 82, 132-140 (2015-06-15)
We have recently demonstrated that short term bexarotene treatment of APP/PS1 mice significantly improves their cognitive performance. While there were no changes in plaque load, or insoluble Aβ levels in brain, biochemical analysis strongly suggested improved clearance of soluble Aβ
Liliana Milani et al.
Biology direct, 10, 22-22 (2015-05-20)
The retention of a genome in mitochondria (mtDNA) has several consequences, among which the problem of ensuring a faithful transmission of its genetic information through generations despite the accumulation of oxidative damage by reactive oxygen species (ROS) predicted by the
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