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Yasmin Z Paterson et al.
Stem cell research & therapy, 5(4), 90-90 (2014-08-01)
Autologous mesenchymal stem cells (MSCs) are an attractive concept in regenerative medicine, but their mechanism of action remains poorly defined. No immune response is reported after in vivo injection of allogeneic equine MSCs or embryo-derived stem cells (ESCs) into the
Abhisek Ghosal et al.
American journal of physiology. Gastrointestinal and liver physiology, 309(2), G123-G131 (2015-05-23)
Infection with the nontyphoidal Salmonella is a common cause of food-borne disease that leads to acute gastroenteritis/diarrhea. Severe/prolonged cases of Salmonella infection could also impact host nutritional status, but little is known about its effect on intestinal absorption of vitamins
Luwen Wang et al.
Journal of medical virology, 85(11), 1907-1912 (2013-07-16)
The objective of this study was to evaluate the short-term efficacy and safety of telbivudine therapy as compared to lamivudine therapy in liver failure patients with chronic hepatitis B virus (HBV) infection. These data were collected from 38 liver failure
Yun Ju Chae et al.
Neuroscience letters, 578, 159-164 (2014-07-06)
Trifluoperazine, a trifluoro-methyl phenothiazine derivative, is widely used in the management of schizophrenia and related psychotic disorders. We studied the effects of trifluoperazine on Kv4.3 currents expressed in CHO cells using the whole-cell patch-clamp technique. Trifluoperazine blocked Kv4.3 in a
Sriramkumar Sundaramoorthy et al.
The EMBO journal, 33(22), 2623-2642 (2014-09-27)
Sister chromatid cohesion mediated by the cohesin complex is essential for chromosome segregation during cell division. Using functional genomic screening, we identify a set of 26 pre-mRNA splicing factors that are required for sister chromatid cohesion in human cells. Loss
Ann-Sofie Gustafsson et al.
Mutation research, 769, 1-10 (2015-03-17)
Efficient and correct repair of DNA double-strand break (DSB) is critical for cell survival. Defects in the DNA repair may lead to cell death, genomic instability and development of cancer. The catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is an
Chun-Nun Chao et al.
Journal of translational medicine, 13, 29-29 (2015-01-28)
Diffuse large B-cell lymphoma (DLBCL) is one of the most common types of aggressive B-cell non-Hodgkin lymphoma. About one-third of patients are either refractory to the treatment or experience relapse afterwards, pointing to the necessity of developing other effective therapies
Lukasz Japtok et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(8), 3357-3369 (2015-04-26)
Glucolipotoxic stress has been identified as a key player in the progression of pancreatic β-cell dysfunction contributing to insulin resistance and the development of type 2 diabetes mellitus (T2D). It has been suggested that bioactive lipid intermediates, formed under lipotoxic
Michael A Johnson et al.
Biochimica et biophysica acta, 1833(10), 2334-2347 (2013-06-19)
Actin, a constituent of the cytoskeleton, is now recognized to function in the nucleus in gene transcription, chromatin remodeling and DNA replication/repair. Actin shuttles in and out of the nucleus through the action of transport receptors importin-9 and exportin-6. Here
Yulin Chen et al.
PloS one, 9(9), e108620-e108620 (2014-10-01)
Accumulating evidence indicates that both defects in Treg numbers and/or function as well as resistance of effector T cells to suppression may contribute to the development of human chronic inflammatory diseases. However, which mechanism involved in the progression of atherosclerosis
Yanhui Cai et al.
Journal of immunology (Baltimore, Md. : 1950), 195(10), 4884-4891 (2015-10-04)
To our knowledge, this study demonstrates for the first time that the AIDS virus differentially impacts two distinct subsets of lung macrophages. The predominant macrophages harvested by bronchoalveolar lavage (BAL), alveolar macrophages (AMs), are routinely used in studies on human
Irma Pujol-Autonell et al.
PloS one, 10(6), e0127057-e0127057 (2015-06-04)
The development of new therapies to induce self-tolerance has been an important medical health challenge in type 1 diabetes. An ideal immunotherapy should inhibit the autoimmune attack, avoid systemic side effects and allow β-cell regeneration. Based on the immunomodulatory effects
Yi-Fu Huang et al.
Oncotarget, 5(14), 5808-5818 (2014-07-30)
Oncogene-mediated cellular transformation is a multistep process involving activation of growth-promoting pathways as well as inactivation of tumor suppressors. We recently found that ISGylation of the p53 tumor suppressor is an important novel mechanism to control its stability. Here we
A J Alexander et al.
Journal of pharmaceutical and biomedical analysis, 78-79, 243-251 (2013-03-20)
Dual and triple combinations of antiretroviral drugs are a cornerstone of human immunodeficiency virus type 1 (HIV-1) treatment. Supercritical fluid chromatography (SFC) and reverse phase liquid chromatography (RPLC) methods have been developed for the impurity profiling of a prototype combination
Klas Gustafson et al.
Acta orthopaedica, 85(4), 348-354 (2014-06-17)
Metal-on-metal (MOM) total hip arthroplasties were reintroduced because of the problems with osteolysis and aseptic loosening related to polyethylene wear of early metal-on-polyethylene (MOP) arthroplasties. The volumetric wear rate has been greatly reduced with MOM arthroplasties; however, because of nano-size
Meng Wang et al.
Cancer research, 74(10), 2825-2834 (2014-03-22)
Therapeutics that target the epidermal growth factor receptor (EGFR) can enhance the cytotoxic effects of ionizing radiation (IR). However, predictive genomic biomarkers of this radiosensitization have remained elusive. By screening 40 non-small cell lung cancer cell (NSCLC) lines, we established
Ryan Nattrass et al.
Toxicological sciences : an official journal of the Society of Toxicology, 146(1), 146-156 (2015-04-17)
There are currently no animal models of drug-induced liver injury (DILI) where the adaptive immune system has been shown to damage the liver. Thus, it is difficult to explore the mechanistic basis of the tissue injury. The aim of this
Masayuki Okamoto et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(7), 2942-2958 (2015-02-24)
Cell positioning and neuronal network formation are crucial for proper brain function. Disrupted-in-Schizophrenia 1 (DISC1) is anterogradely transported to the neurite tips, together with Lis1, and functions in neurite extension via suppression of GSK3β activity. Then, transported Lis1 is retrogradely
Siobhan V Glavey et al.
Blood, 124(11), 1765-1776 (2014-07-26)
Glycosylation is a stepwise procedure of covalent attachment of oligosaccharide chains to proteins or lipids, and alterations in this process, especially increased sialylation, have been associated with malignant transformation and metastasis. The role of altered sialylation in multiple myeloma (MM)
Jillian L Rourke et al.
Molecular and cellular endocrinology, 417, 36-51 (2015-09-13)
Chemerin is an adipose-derived hormone that regulates immunity and energy homesotasis. To date, all known chemerin functions have been attributed to activation of the G protein-coupled receptor chemokine-like receptor-1 (CMKLR1). Chemerin is also the only known ligand for a second
H You et al.
Journal of viral hepatitis, 20 Suppl 1, 3-8 (2013-03-15)
Telbivudine, one of the oral anti-hepatitis B virus (HBV) nucleoside analogues, has been used for more than 5 years to treat HBeAg-positive and -negative chronic hepatitis B (CHB) patients. This includes not only global Phase II and III trials, but
Yi Cui et al.
Nucleic acids research, 43(6), 3046-3055 (2015-03-11)
The detailed mechanism for DNA methylation homeostasis relies on an intricate regulatory network with a possible contribution from methyl-CpG-binding domain protein 3 (MBD3). In this study we examine the single-molecule behavior of MBD3 and its functional implication in balancing the
Gyu-Beom Jang et al.
Cancer research, 75(8), 1691-1702 (2015-02-11)
Breast cancer stem cells (BCSC) are resistant to conventional chemotherapy and radiotherapy, which may destroy tumor masses but not all BCSC that can mediate relapses. In the present study, we showed that the level of Wnt/β-catenin signaling in BCSC is
Jian Zhang et al.
Oncology reports, 33(1), 103-110 (2014-10-22)
Programmed cell death 2 (PDCD2) is a highly conserved nuclear protein, and aberrant PDCD2 expression alters cell apoptosis. The present study aimed to investigate PDCD2 expression in gastric cancer. Tissue specimens from 34 gastric cancer patients were collected for analysis
Karen V Evangelista et al.
PLoS neglected tropical diseases, 8(10), e3215-e3215 (2014-10-03)
Leptospirosis is a globally distributed bacterial infectious disease caused by pathogenic members of the genus Leptospira. Infection can lead to illness ranging from mild and non-specific to severe, with jaundice, kidney and liver dysfunction, and widespread endothelial damage. The adhesion
Md Aejazur Rahman et al.
The Journal of biological chemistry, 290(23), 14407-14417 (2015-04-08)
Mycobacterium tuberculosis, the causative agent of tuberculosis, is an ancient pathogen and a major cause of death worldwide. Although various virulence factors of M. tuberculosis have been identified, its pathogenesis remains incompletely understood. TlyA is a virulence factor in several
Shilin Cheung et al.
Journal of pharmaceutical and biomedical analysis, 94, 12-18 (2014-02-19)
CE coupled with UV detection was assessed as a possible platform for the chemical identity and purity analysis of positron emission tomography (PET) tracers using [(18)F]FAC and [(18)F]FLT as examples. Representative samples containing mixtures of the tracers plus well-known impurities
Kit-Yi Leung et al.
Brain : a journal of neurology, 136(Pt 9), 2836-2841 (2013-08-13)
Closure of the neural tube during embryogenesis is a crucial step in development of the central nervous system. Failure of this process results in neural tube defects, including spina bifida and anencephaly, which are among the most common birth defects
Bliss L Tracy et al.
Radiation research, 184(1), 33-45 (2015-06-30)
High linear energy transfer (LET) α particles are important with respect to the carcinogenic risk associated with human exposure to ionizing radiation, most notably to radon and its progeny. Additionally, the potential use of alpha-particle-emitting radionuclides in radiotherapy is increasingly
Whitney E Heavner et al.
Neural development, 9, 27-27 (2014-12-10)
Eye development in vertebrates relies on the critical regulation of SOX2 expression. Humans with mutations in SOX2 often suffer from eye defects including anophthalmia (no eye) and microphthalmia (small eye). In mice, deletion of Sox2 in optic cup progenitor cells
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