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显示 31-60 共 99 条结果 关于 "V900437" 范围 论文
Shiyan Xiao et al.
The Journal of chemical physics, 137(19), 195101-195101 (2012-11-28)
Ab initio constrained molecular dynamics and metadynamics were employed to investigate the mechanism of proton transfer in guanine-cytosine (GC) and adenine-thymine (AT) base pairs in the gas phase at room temperature. It is shown that double proton transfer (DPT) in
Cai Shen et al.
Chemical communications (Cambridge, England), 49(5), 508-510 (2012-12-04)
Supramolecular patterns formed by adsorption from a liquid of nucleobase-terminated molecular rods on a graphite surface were investigated by scanning tunneling microscopy.
Lakshminarayan M Iyer et al.
Nucleic acids research, 41(16), 7635-7655 (2013-07-03)
Discovery of the TET/JBP family of dioxygenases that modify bases in DNA has sparked considerable interest in novel DNA base modifications and their biological roles. Using sensitive sequence and structure analyses combined with contextual information from comparative genomics, we computationally
Bleomycin, an antibiotic that removes thymine from double-stranded DNA.
W E Müller et al.
Progress in nucleic acid research and molecular biology, 20, 21-57 (1977-01-01)
Diogo Almeida et al.
Physical review letters, 110(2), 023201-023201 (2013-02-07)
Electron transfer in alkali-molecule collisions to gas phase thymine and uracil yielding H- formation is selectively controlled in the energy range between 5.3 and 66.1 eV. By tuning the collision energy, electron transfer from the alkali to partly deuterated thymine
Georgette Moyle-Heyrman et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(50), 20158-20163 (2013-11-28)
Using a recently developed chemical approach, we have generated a genome-wide map of nucleosomes in vivo in Schizosaccharomyces pombe (S. pombe) at base pair resolution. The shorter linker length previously identified in S. pombe is due to a preponderance of
Zhuzhong Cheng et al.
Nuclear medicine communications, 36(9), 914-921 (2015-05-15)
(18)F-Fluorodeoxyglucose ((18)F-FDG), (18)F-fluoro-3'-deoxy-3'-L-fluorothymidine ((18)F-FLT), (18)F-fluoromisonidazole ((18)F-FMISO), and (18)F-AlF-NOTA-PRGD2 ((18)F-RGD) are all commonly used PET tracers for tumor diagnosis based on different mechanisms of tissue uptake. This study compared the ex-vivo biodistribution and PET/computed tomography (CT) imaging studies of these four
[Phage induction, filament formation and thymine deficiency death in Escherichia coli B].
H D Mennigmann
Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. 1. Abt. Medizinisch-hygienische Bakteriologie, Virusforschung und Parasitologie. Originale, 198(1), 282-286 (1965-12-01)
Fang Wang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(9), 1378-1385 (2013-08-16)
Eighteen compounds were isolated by a combination of various chromatographic techniques including column chromatography over macroporous resin, MCI gel, silica gel, and sephadex LH-20 and reversed-phase HPLC. Their structures were elucidated by spectroscopic data analysis as adinoside A (1), stryspinoside
Toni Pfaffeneder et al.
Nature chemical biology, 10(7), 574-581 (2014-05-20)
Ten eleven translocation (Tet) enzymes oxidize the epigenetically important DNA base 5-methylcytosine (mC) stepwise to 5-hydroxymethylcytosine (hmC), 5-formylcytosine and 5-carboxycytosine. It is currently unknown whether Tet-induced oxidation is limited to cytosine-derived nucleobases or whether other nucleobases are oxidized as well.
M Weinfeld et al.
Progress in nucleic acid research and molecular biology, 68, 139-149 (2001-09-14)
The toxic and mutagenic effects of ionizing radiation are believed to be caused by damage to cellular DNA. We have made use of a novel immunoassay for thymine glycol to examine the removal of this lesion from the DNA of
P V Hariharan et al.
Basic life sciences, 5A, 51-59 (1975-01-01)
The selective excision of products of the 5,6-dihydroxy-dihydrothymine type (t') from gamma-irradiated or OSO4-oxidized DNA or synthetic poly[d(A-T)] was observed with crude extracts of Escherichia coli and isolated nuclei from human carcinoma HeLa S-3 and Chinese hamster ovary cells. The
Hiroshi Yamaguchi et al.
Nucleic acids research, 42(6), 4094-4099 (2013-12-29)
We have determined the three-dimensional (3D) structure of DNA duplex that includes tandem Hg(II)-mediated T-T base pairs (thymine-Hg(II)-thymine, T-Hg(II)-T) with NMR spectroscopy in solution. This is the first 3D structure of metallo-DNA (covalently metallated DNA) composed exclusively of 'NATURAL' bases.
Daniel S Hitchcock et al.
Biochemistry, 53(47), 7426-7435 (2014-11-11)
5-Methylcytosine is found in all domains of life, but the bacterial cytosine deaminase from Escherichia coli (CodA) will not accept 5-methylcytosine as a substrate. Since significant amounts of 5-methylcytosine are produced in both prokaryotes and eukaryotes, this compound must eventually
Eva Tyteca et al.
Journal of chromatography. A, 1368, 125-131 (2014-12-03)
In this study, the separation of twelve nucleobases and nucleosides was optimized via chromatogram simulation (i.e., prediction of individual retention times and estimation of the peak widths) with the use of an empirical (reversed-phase) non-linear model proposed by Neue and
Dieter Buyst et al.
Nucleic acids research, 43(1), 51-62 (2014-12-19)
The predictable 3D structure of double-stranded DNA renders it ideally suited as a template for the bottom-up design of functionalized nucleic acid-based active sites. We here explore the use of a 14mer DNA duplex as a scaffold for the precise
Long Ma et al.
Nucleic acids research, 41(9), 4999-5009 (2013-03-26)
The type II restriction endonuclease TseI recognizes the DNA target sequence 5'-G^CWGC-3' (where W = A or T) and cleaves after the first G to produce fragments with three-base 5'-overhangs. We have determined that it is a dimeric protein capable
Metabolism of thymine in tumor tissue: the origins of beta-aminoisobutyric acid.
B S Baliga et al.
Advances in enzyme regulation, 13, 27-36 (1975-01-01)
Ayesha Zia et al.
American journal of hematology, 90(8), 725-731 (2015-05-28)
Oral contraceptive (OCP) induced changes on coagulation are complex with high inter-individual variability. The precise reason for differences in this variability is unknown. We hypothesized that global coagulation assays better delineate these changes and variability in hypercoagulability may be the
Sinéad Currivan et al.
Journal of chromatography. A, 1402, 82-93 (2015-05-30)
Zwitterionic methacrylate based polymeric monolithic columns were prepared in two-step polymerizations, with reduced polymerization times. Characteristic properties such as hydrodynamic permeability, porosity, retention factors, and pore size distribution charts were used for column evaluation. A scaffold column was fabricated by
Xijun Piao et al.
Biochemistry, 52(37), 6313-6323 (2013-08-24)
We report herein the structuring of single-stranded thymine-rich DNA sequences into peptide-DNA hairpin triplex structures via designed melamine-thymine nucleobase recognition. Melamine-displaying α-peptides were synthesized with the general form (EM*)n, where M* denotes a lysine residue side chain derivatized with melamine
Zian Lin et al.
The Analyst, 140(15), 5287-5294 (2015-06-19)
CuFe2O4 magnetic nanocrystal clusters (CuFe2O4 MNCs) were proposed as a new matrix for small molecule analysis by negative ion matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) for the first time. We demonstrated its advantages over conventional organic matrices in
Ruth Guillermo-Lagae et al.
Oncotarget, 6(37), 39594-39606 (2015-10-09)
Ultraviolet radiation B (UVB) is the main cause of DNA damage in epidermal cells; and if not repaired, this DNA damage leads to skin cancer. In earlier studies, we have reported that natural flavonolignan silibinin exerts strong chemopreventive efficacy against
DNA metabolism: bases of DNA repair and regulation.
Adam B Robertson et al.
Nature chemical biology, 10(7), 487-488 (2014-06-18)
Hana Vlčková et al.
Journal of separation science, 37(11), 1297-1307 (2014-03-22)
The retention behavior of a large group of analytes (35) with varied properties (pKa and logP) was studied on eight hydrophilic interaction LC columns with different surfaces, stationary phase chemistries, and types of particles. The acetonitrile content (5-95%), buffer concentration
Ewelina Zarakowska et al.
Mutation research. Genetic toxicology and environmental mutagenesis, 764-765, 58-63 (2013-09-24)
The oxidatively modified DNA base 8-oxo-7,8-dihydroguanine (8-oxoGua) is nontoxic and weakly mutagenic. Here we report on new data suggesting a potential for 8-oxoGua to affect the expression of several genes via epigenetic changes resulting in chromatin relaxation. Using pig thymus
David M Close
The journal of physical chemistry. A, 117(2), 473-480 (2013-01-04)
For the DNA bases the pK(a)'s of the neutral molecules have been measured, and a review article by Steenken provides a convenient summary of the experimental pK(a)'s of the DNA radical ions. The purpose of the present work is to
Steven Kelly et al.
Nucleic acids research, 43(9), 4721-4732 (2015-04-22)
The conventional model for splicing involves excision of each intron in one piece; we demonstrate this inaccurately describes splicing in many human genes. First, after switching on transcription of SAMD4A, a gene with a 134 kb-long first intron, splicing joins
Shilin Cheung et al.
Journal of pharmaceutical and biomedical analysis, 94, 12-18 (2014-02-19)
CE coupled with UV detection was assessed as a possible platform for the chemical identity and purity analysis of positron emission tomography (PET) tracers using [(18)F]FAC and [(18)F]FLT as examples. Representative samples containing mixtures of the tracers plus well-known impurities
Robert N Barnett et al.
Journal of the American Chemical Society, 135(10), 3904-3914 (2013-02-21)
One-electron oxidation of A/T-rich DNA leads to mutations at thymine. Experimental investigation of DNA containing methyl-deuterated thymine reveals a large isotope effect establishing that cleavage of this carbon-hydrogen bond is involved in the rate-determining step of the reaction. First-principles quantum
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