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Satoru Watanabe et al.
Acta haematologica, 133(1), 83-88 (2014-08-30)
In some previous studies, vitamin B12 treatment showed immunomodulatory effects and restored the immunological abnormalities in patients with pernicious anemia (PA). In the present study, peripheral blood T cell subsets, including regulatory T cells (T(reg)s), were examined before and after
Theodoros Michelakos et al.
Journal of aging and health, 25(4), 589-616 (2013-04-10)
To summarize existing evidence on the effect of serum folate and vitamin B12 levels on cognitive impairment among elders via a meta-analysis, also including unpublished data from a cross-sectional study of seniors ( > 65 years) residing in Velestino, Greece.
Stephen D Merrigan et al.
American journal of clinical pathology, 141(5), 702-705 (2014-04-10)
To systematically assess five automated cobalamin assays for intrinsic factor binding antibody (IFBA)-induced interference using pooled serum. Six pools created from IFBA-negative and IFBA-positive serum representing low, normal, and high cobalamin concentrations were analyzed before and after polyethylene glycol (PEG)
Roy Lardenoije et al.
Progress in neurobiology, 131, 21-64 (2015-06-15)
Epigenetics is a quickly growing field encompassing mechanisms regulating gene expression that do not involve changes in the genotype. Epigenetics is of increasing relevance to neuroscience, with epigenetic mechanisms being implicated in brain development and neuronal differentiation, as well as
Tomohiro Bito et al.
FEBS open bio, 4, 722-729 (2014-08-28)
In this study, we showed that cyanocobalamin dodecylamine, a ribose 5'-carbamate derivative of cyanocobalamin, was absorbed and accumulated to significant levels by Caenorhabditis elegans and was not further metabolized. The levels of methylmalonic acid and homocysteine, which serve as indicators
P Satora et al.
Journal of applied microbiology, 119(3), 736-743 (2015-07-15)
To investigate the synthesis of selected bioactive compounds in various strains belonging to the Arthrospira genus. The synthesis of vitamin C, polyphenols, vitamin B12, fatty acids and selected volatile compounds (acetone and acetaldehyde) was investigated in six strains belonging to
Dezhi Kang et al.
Science translational medicine, 7(293), 293ra103-293ra103 (2015-06-26)
Various diseases have been linked to the human microbiota, but the underlying molecular mechanisms of the microbiota in disease pathogenesis are often poorly understood. Using acne as a disease model, we aimed to understand the molecular response of the skin
Haibing He et al.
International journal of pharmaceutics, 493(1-2), 451-459 (2015-08-09)
To improve the oral absorption of insulin, a novel carrier of Vitamin B12 (VB12) gel core solid lipid nanopaticles (Gel-Core-SLN, GCSLN) was designed with a gel core, lipid matrix and VB12-coated surface. VB12-stearate was synthesized and characterized by infrared spectroscopy
Jae Hoon Moon et al.
Stroke, 46(4), 1024-1030 (2015-03-05)
We investigated the association between cardiovascular risk factors, including carotid intima-media thickness (CIMT), and future risk of mild cognitive impairment (MCI) and dementia in elderly subjects. We conducted a population-based prospective study as a part of the Korean Longitudinal Study
M Dogru et al.
Allergologia et immunopathologia, 43(6), 579-583 (2015-03-23)
Methylenetetrahydrofolate Reductase (MTHFR) polymorphisms by impairing folate metabolism may influence the development of allergic diseases. The results of studies evaluating the relationship between MTHFR polymorphisms and atopic disease are controversial. The aim of this study was to investigate the association
Dieuwertje E G Kok et al.
Clinical epigenetics, 7, 121-121 (2015-11-17)
Folate and its synthetic form folic acid function as donor of one-carbon units and have been, together with other B-vitamins, implicated in programming of epigenetic processes such as DNA methylation during early development. To what extent regulation of DNA methylation
Martin Risch et al.
BMC geriatrics, 15, 82-82 (2015-07-15)
The vitamin B12 and folate status in nonanaemic healthy older persons needs attention the more so as decrease in levels may be anticipated from reduced haematinic provision and/or impaired intestinal uptake. A total of 1143 subjectively healthy Swiss midlands participants
Mikyoung Ji et al.
Extremophiles : life under extreme conditions, 19(4), 863-874 (2015-06-24)
Glutathione reductases catalyze the reduction of oxidized glutathione (glutathione disulfide, GSSG) using NADPH as the substrate to produce reduced glutathione (GSH), which is an important antioxidant molecule that helps maintain the proper reducing environment of the cell. A recombinant form
Thomas Lanzicher et al.
Scientific reports, 5, 13388-13388 (2015-09-02)
Atomic force microscopy (AFM) cell loading/unloading curves were used to provide comprehensive insights into biomechanical behavior of cardiomyocytes carrying the lamin A/C (LMNA) D192G mutation known to cause defective nuclear wall, myopathy and severe cardiomyopathy. Our results suggested that the
Regan L Bailey et al.
The American journal of clinical nutrition, 98(2), 460-467 (2013-06-28)
No consensus exists about which cutoff point should be applied for serum vitamin B-12 (SB-12) concentrations to define vitamin B-12 status in population-based research. The study's aim was to identify whether a change point exists at which the relation between
Matthew A A Grant et al.
The ISME journal, 8(7), 1418-1427 (2014-02-14)
The growth dynamics of populations of interacting species in the aquatic environment is of great importance, both for understanding natural ecosystems and in efforts to cultivate these organisms for industrial purposes. Here we consider a simple two-species system wherein the
Illuminating the black box of B12 biosynthesis.
Harry A Dailey
Proceedings of the National Academy of Sciences of the United States of America, 110(37), 14823-14824 (2013-08-27)
A Bøyum et al.
Scandinavian journal of immunology, 80(6), 390-397 (2014-10-28)
The homeostatic control of the redox system (the redoxome) in mammalian cells depends upon a large number of interacting molecules, which tend to buffer the electronegativity of cells against oxidants or reductants. Some of these components kill - at high
Luciana Hannibal et al.
Clinical chemistry and laboratory medicine, 51(3), 477-488 (2012-12-18)
The causes of cobalamin (B12, Cbl) deficiency are multifactorial. Whether nutritional due to poor dietary intake, or functional due to impairments in absorption or intracellular processing and trafficking events, the major symptoms of Cbl deficiency include megaloblastic anemia, neurological deterioration
Pallavi K Choudhary et al.
Journal of bacteriology, 195(22), 5186-5195 (2013-09-17)
The strategic adaptation of prokaryotes in polluted niches involves the efficient regulation of their metabolism. The obligate anaerobe and metabolically versatile Desulfitobacterium hafniense reductively dechlorinates halogenated organic compounds (so-called organohalides). Some D. hafniense strains carry out organohalide respiration (OHR), a
Inong R Gunanti et al.
The Journal of nutrition, 144(12), 2027-2033 (2014-11-21)
Micronutrient status may be a contributing factor to the development of childhood obesity in many industrializing countries passing the nutritional transition. The few studies investigating associations between serum concentrations of vitamin B and intake of B vitamins with adiposity, however
Anthony Mézière et al.
The journals of gerontology. Series A, Biological sciences and medical sciences, 69(12), 1576-1585 (2014-07-27)
Cobalamin deficiency is responsible for hematological, neurological, neurocognitive, and neuropsychiatric impairments and is a risk factor for cardiovascular diseases, particularly in the elderly people. In order to determine B12 status in old inpatients, a total number of 14,904 hospitalized patients
Managing severe anemia when the patient is a Jehovah's Witness.
Shannon Lynn et al.
JAAPA : official journal of the American Academy of Physician Assistants, 26(4), 24-24 (2013-04-25)
Katsumi Shibata et al.
Bioscience, biotechnology, and biochemistry, 78(12), 2102-2109 (2014-08-15)
We previously reported that mild food restriction induces a reduction in tryptophan-nicotinamide conversion, which helps to explain why death secondary to pellagra is pandemic during the hungry season. In this study, we investigated the levels of B-group vitamins in the
Quantitative hopanoid analysis enables robust pattern detection and comparison between laboratories.
C-H Wu et al.
Geobiology, 13(4), 391-407 (2015-04-14)
Hopanoids are steroid-like lipids from the isoprenoid family that are produced primarily by bacteria. Hopanes, molecular fossils of hopanoids, offer the potential to provide insight into environmental transitions on the early Earth, if their sources and biological functions can be
Clinical practice. Vitamin B12 deficiency.
Sally P Stabler
The New England journal of medicine, 368(2), 149-160 (2013-01-11)
Nor A Mohd-Shukri et al.
Nutrients, 7(10), 8431-8443 (2015-10-13)
The health behaviours of pregnant women with very severe obesity are not known, though these women are at high risk of pregnancy complications. We carried out a prospective case-control study including 148 very severely obese (BMI >40 kg/m²) and 93
Bamini Gopinath et al.
The American journal of clinical nutrition, 98(1), 129-135 (2013-05-03)
Epidemiologic evidence of a relation between serum total homocysteine (tHcy), vitamin B-12, and folate and age-related macular degeneration (AMD) is inconsistent and unresolved. In this cohort study, we aimed to investigate associations between intakes and serum concentrations of folate and
Rony Dev et al.
Cancer, 120(10), 1586-1593 (2014-03-01)
A high frequency of hypogonadism has been reported in male patients with advanced cancer. The current study was performed to evaluate the association between low testosterone levels, symptom burden, and survival in male patients with cancer. Of 131 consecutive male
Zhihong Gong et al.
International journal of cancer, 134(6), 1422-1435 (2013-09-03)
African American (AA) women are more likely than European American (EA) women to be diagnosed with breast cancer at younger ages and to develop poor prognosis tumors. However, these racial differences are largely unexplained. Folate and other methyl-group nutrients may
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