V900699

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关键词:'V900699'

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Disturbances in Maternal Steroidogenesis and Appearance of Intrauterine Growth Retardation at High-Altitude Environments Are Established from Early Pregnancy. Effects of Treatment with Antioxidant Vitamins.

Victor H Parraguez et al.

PloS one, 10(11), e0140902-e0140902 (2015-11-13)

Pregnancies at high-altitudes are influenced by hypoxia and oxidative stress and frequently affected by IUGR. However, a common thought is that early pregnant women visiting altitude have no major complications for gestation development, since IUGR is developed during the second

Chronic high-dose creatine has opposing effects on depression-related gene expression and behavior in intact and sex hormone-treated gonadectomized male and female rats.

Patricia J Allen et al.

Pharmacology, biochemistry, and behavior, 130, 22-33 (2015-01-07)

Creatine is an antioxidant, neuromodulator and key regulator of energy metabolism shown to improve depressive symptoms in humans and animals, especially in females. To better understand the pharmacological effects of creatine, we examined its influence on depression-related hippocampal gene expression

Kinetics of human sperm acrosomal exocytosis.

C M Sosa et al.

Molecular human reproduction, 21(3), 244-254 (2014-12-03)

The acrosome reaction is a unique event in the lifespan of sperm characterized by the exocytosis of the acrosomal content and the release of hybrid vesicles formed by patches of the outer acrosomal membrane and the plasma membrane. This unique

Granulosa cell-derived induced pluripotent stem cells exhibit pro-trophoblastic differentiation potential.

Ching-Yu Chuang et al.

Stem cell research & therapy, 6, 14-14 (2015-04-19)

Human induced pluripotent stem cells (hiPSCs) have been derived from various somatic cell types. Granulosa cells, a group of cells which surround oocytes and are obtained from the (normally discarded) retrieved egg follicles of women undergoing infertility treatment, are a

Fibroblast growth factor signalling in multiple sclerosis: inhibition of myelination and induction of pro-inflammatory environment by FGF9.

Maren Lindner et al.

Brain : a journal of neurology, 138(Pt 7), 1875-1893 (2015-04-25)

Remyelination failure plays an important role in the pathophysiology of multiple sclerosis, but the underlying cellular and molecular mechanisms remain poorly understood. We now report actively demyelinating lesions in patients with multiple sclerosis are associated with increased glial expression of

Vitrification of day 3 cleavage-stage embryos yields better clinical outcome in comparison with vitrification of day 2 cleavage-stage embryos.

Fengli Chi et al.

Zygote (Cambridge, England), 23(2), 169-176 (2013-08-24)

The objective of this retrospective study was to determine an optimal time point for vitrification of cleavage-stage human embryos. This study included patients who were undergoing day 2 or day 3 vitrified-warmed cleavage-stage embryo transfer at the In Vitro Fertilization

Attenuating activity of the ovary on LH response to GnRH during the follicular phase of the cycle.

Marina Dimitraki et al.

Clinical endocrinology, 80(3), 439-443 (2013-08-06)

Oestradiol sensitizes the pituitary to GnRH, while gonadotrophin surge attenuating factor (GnSAF) may oppose this action. Using the LH response to GnRH during treatment with FSH as an in vivo bioassay for GnSAF, we tested the hypothesis that the augmented

MEF2 Cooperates With Forskolin/cAMP and GATA4 to Regulate Star Gene Expression in Mouse MA-10 Leydig Cells.

Caroline Daems et al.

Endocrinology, 156(7), 2693-2703 (2015-04-11)

In Leydig cells, steroidogenic acute regulatory protein (STAR) participates in cholesterol shuttling from the outer to the inner mitochondrial membrane, the rate-limiting step in steroidogenesis. Steroid hormone biosynthesis and steroidogenic gene expression are regulated by LH, which activates various signaling

Feeding distiller’s grains as an energy source to gestating and lactating beef heifers: Impact on female progeny growth, puberty attainment, and reproductive processes.

P J Gunn et al.

Journal of animal science, 93(2), 746-757 (2014-12-31)

This study compared postweaning growth, puberty attainment, and reproductive processes of female progeny (n = 33) born to Angus-Simmental beef heifers treated with either a control diet or a diet in which dried distiller’s grains with solubles (DDGS) were fed

Analysis of oxysterols and vitamin D metabolites in mouse brain and cell line samples by ultra-high-performance liquid chromatography-atmospheric pressure photoionization-mass spectrometry.

Linda Ahonen et al.

Journal of chromatography. A, 1364, 214-222 (2014-09-11)

We have developed an ultra-high-performance liquid chromatography-atmospheric pressure photoionization-tandem mass spectrometric (UHPLC-APPI-MS/MS) method for the simultaneous quantitative analyses of several oxysterols and vitamin D metabolites in mouse brain and cell line samples. An UHPLC-APPI-high resolution mass spectrometric (UHPLC-APPI-HRMS) method that

Decreased allopregnanolone induced by hormonal contraceptives is associated with a reduction in social behavior and sexual motivation in female rats.

Francesca Santoru et al.

Psychopharmacology, 231(17), 3351-3364 (2014-04-15)

Allopregnanolone is a neurosteroid involved in depression, memory, social, and sexual behavior. We have previously demonstrated that treatment with a combination of ethinylestradiol (EE) and levonorgestrel (LNG), two compounds frequently used in hormonal contraception, decreased brain allopregnanolone concentrations. These changes

Corifollitropin alfa compared with follitropin beta in poor responders undergoing ICSI: a randomized controlled trial.

E M Kolibianakis et al.

Human reproduction (Oxford, England), 30(2), 432-440 (2014-12-11)

Does substituting 150 µg corifollitropin alfa for 450 IU follitropin beta during the first 7 days of ovarian stimulation in proven poor responders, result in retrieval of a non-inferior number (<1.5 fewer) of cumulus oocyte complexes (COCs)? A single s.c.

Cross-sectional associations of acylation stimulating protein (ASP) and adipose tissue gene expression with estradiol and progesterone in pre- and postmenopausal women.

Reza Rezvani et al.

Clinical endocrinology, 81(5), 736-745 (2014-07-22)

Sex steroid hormones play an important regulatory role in fat metabolism and obesity. We hypothesized involvement of interactions between ovarian hormones with acylation stimulating protein (ASP). In 392 women with wide age (18-69 years) and body size (BMI: 17 to 90 kg/m(2)

A Longitudinal Study of Growth, Sex Steroids, and IGF-1 in Boys With Physiological Gynecomastia.

Mikkel G Mieritz et al.

The Journal of clinical endocrinology and metabolism, 100(10), 3752-3759 (2015-08-20)

Physiological gynecomastia is common and affects a large proportion of otherwise healthy adolescent boys. It is thought to be caused by an imbalance between estrogen and testosterone, although this is rarely evident in analyses of serum. This study aimed to

Allopregnanolone levels and seizure frequency in progesterone-treated women with epilepsy.

Andrew G Herzog et al.

Neurology, 83(4), 345-348 (2014-06-20)

To determine whether allopregnanolone (AP) may mediate seizure reduction in progesterone-treated women with epilepsy. The NIH Progesterone Trial compared the efficacy of adjunctive cyclic natural progesterone therapy vs placebo treatment of intractable seizures in 294 subjects, randomized 2:1 to progesterone

Effect of a 'progestin only' contraceptive on platelet aggregation in a Pakistani set of population.

Nasir Ali Afsar et al.

Journal of Ayub Medical College, Abbottabad : JAMC, 17(3), 21-25 (2005-12-03)

Safe use of progestin-only hormonal preparations has remained quite controversial though they are being employed in various disorders very commonly. These hormones result in a number of adverse effects in the body, the most drastic being predisposition to higher risk

GATA4 knockdown in MA-10 Leydig cells identifies multiple target genes in the steroidogenic pathway.

Francis Bergeron et al.

Reproduction (Cambridge, England), 149(3), 245-257 (2014-12-17)

GATA4 is an essential transcription factor required for the initiation of genital ridge formation, for normal testicular and ovarian differentiation at the time of sex determination, and for male and female fertility in adulthood. In spite of its crucial roles

Reduced expression and growth inhibitory activity of the aging suppressor klotho in epithelial ovarian cancer.

Irina Lojkin et al.

Cancer letters, 362(2), 149-157 (2015-04-02)

Klotho is an anti-aging transmembrane protein, which can be shed and function as a hormone. Accumulating data indicate klotho as a tumor suppressor in a wide array of malignancies, and we identified klotho as an inhibitor of the insulin-like growth

The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase.

Marc M Schumacher et al.

eLife, 4 (2015-03-06)

Schnyder corneal dystrophy (SCD) is an autosomal dominant disorder in humans characterized by abnormal accumulation of cholesterol in the cornea. SCD-associated mutations have been identified in the gene encoding UBIAD1, a prenyltransferase that synthesizes vitamin K2. Here, we show that

Bioadhesive emulsions for control release of progesterone resistant to vaginal fluids clearance.

Maria Campaña-Seoane et al.

International journal of pharmaceutics, 477(1-2), 495-505 (2014-12-03)

The aim of this study is to propose that mucoadhesive vaginal emulsions can be able to resist the clearance effect of vaginal fluid and to have an effective control release of progesterone. With this goal, silicon derivative, cyclomethicone pentamer, was

Adiponectin influences progesterone production from MA-10 Leydig cells in a dose-dependent manner.

David Landry et al.

Endocrine, 48(3), 957-967 (2014-10-23)

Obesity in men is associated with lower testosterone levels, related to reduced sperm concentration and the development of various diseases with aging. Hormones produced by the adipose tissue may have influences on both metabolism and reproductive function. Among them, the

Effects of ulipristal acetate on human embryo attachment and endometrial cell gene expression in an in vitro co-culture system.

C Berger et al.

Human reproduction (Oxford, England), 30(4), 800-811 (2015-03-06)

Does ulipristal acetate (UPA) used for emergency contraception (EC) interfere with the human embryo implantation process? UPA, at the dosage used for EC, does not affect human embryo implantation process, in vitro. A single pre-ovulatory dose of UPA (30 mg)

Differential regulation of receptivity in two uterine horns of a recipient mouse following asynchronous embryo transfer.

Shi-Jie Li et al.

Scientific reports, 5, 15897-15897 (2015-11-05)

Receptivity is a limited time in which uterine endometrium can establish a successful dialogue with blastocyst. This study was to investigate the effect of asynchronous embryo transfer on uterine receptivity in mice. Embryos under different stages were transferred into two

Upregulation of RHOXF2 and ODF4 Expression in Breast Cancer Tissues.

Golnesa Kazemi-Oula et al.

Cell journal, 17(3), 471-477 (2015-10-16)

During the past decade, the importance of biomarker discovery has been highlighted in many aspects of cancer research. Biomarkers may have a role in early detection of cancer, prognosis and survival evaluation as well as drug response. Cancer-testis antigens (CTAs)

Engineering the ovarian cycle using in vitro follicle culture.

Robin M Skory et al.

Human reproduction (Oxford, England), 30(6), 1386-1395 (2015-03-19)

Can cultured follicles model the ovarian cycle, including follicular- and luteal-phase hormone synthesis patterns and ovulation? Under gonadotrophin stimulation, murine follicles grown in an encapsulated three-dimensional system ovulate in vitro and murine and human follicle hormone synthesis mimics follicular and

Fibronectin stimulates human sperm capacitation through the cyclic AMP/protein kinase A pathway.

E Martínez-León et al.

Human reproduction (Oxford, England), 30(9), 2138-2151 (2015-06-26)

Does fibronectin (Fn) stimulate the sperm capacitation process in humans? Fibronectin stimulates human sperm capacitation. Capacitation is a process that occurs in the oviduct. It has been suggested that some molecules present in the oviductal fluid and cells as well

'Stealth' lipid-based formulations: poly(ethylene glycol)-mediated digestion inhibition improves oral bioavailability of a model poorly water soluble drug.

Orlagh M Feeney et al.

Journal of controlled release : official journal of the Controlled Release Society, 192, 219-227 (2014-07-25)

For over 20years, stealth drug delivery has been synonymous with nanoparticulate formulations and intravenous dosing. The putative determinants of stealth in these applications are the molecular weight and packing density of a hydrophilic polymer (commonly poly(ethylene glycol) (PEG)) that forms

New aspects of progesterone interactions with the actin cytoskeleton and neurosteroidogenesis in the cerebellum and the neuronal growth cone.

Lisa Wessel et al.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 62(12), 835-845 (2014-08-22)

The impact of progesterone on neuronal tissues in the central (CNS) and peripheral (PNS) nervous system is of significant scientific and therapeutic interest. Glial and neuronal cells of vertebrates express steroidogenic enzymes, and are able to synthesize progesterone de novo

The immune system in menopause: pros and cons of hormone therapy.

Mimi Ghosh et al.

The Journal of steroid biochemistry and molecular biology, 142, 171-175 (2013-09-18)

With aging, a general decline in immune function is observed leading to immune-senescence. Several of these changes are gender specific affecting postmenopausal women. Menopause is a normal part of a woman's lifecycle and consists of a series of body changes

Novel role for PINX1 as a coregulator of nuclear hormone receptors.

Maria Yamilet Noriega-Reyes et al.

Molecular and cellular endocrinology, 414, 9-18 (2015-07-19)

Estrogen receptor alpha (ERα) has an established role in breast cancer biology. Transcriptional activation by ERα is a multistep process influenced by coactivator and corepressor proteins. This work shows that Pin2 interacting protein 1 (PINX1) interacts with the N-terminal domain

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