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V900699
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Ga-Young Lee et al.
Archives of pharmacal research, 38(1), 98-107 (2014-07-06)
In this study, we examined the catalytic activity of CYP106A1 from the Bacillus megaterium American Type Culture Collection 14581 strain. The CYP106A1 gene was cloned from B. megaterium, heterologously expressed in Escherichia coli, and purified. Potential electron partners and possible
Shuai Chen et al.
Histochemistry and cell biology, 144(5), 509-515 (2015-08-01)
Cultivation of oviduct epithelial cells on porous filters fosters in vivo-like morphology and functionality. However, due to the optical properties of the filter materials and the cells' columnar shape, cell quality is hard to assess via light microscopy. In this
R A Rajaratnam et al.
Atherosclerosis, 146(1), 61-64 (1999-09-16)
Squalene, found in earlier studies in human atherosclerotic plaques, was measured in the serum of postmenopausal women with coronary artery disease (CAD) (n = 25) and randomly chosen age-matched healthy controls (n = 30). The squalene concentrations of the whole
Hyun-Gyo Lee et al.
Reproductive sciences (Thousand Oaks, Calif.), 21(9), 1153-1160 (2014-02-28)
Dysregulated cyclin-dependent kinases (CDKs) are considered a potential target for cancer therapy. Flavopiridol is a potent CDK inhibitor. In this study, the antiproliferative effect of the flavonoid compound flavopiridol and its mechanism in human uterine leiomyoma cells were investigated. The
David Landry et al.
Endocrine, 48(3), 957-967 (2014-10-23)
Obesity in men is associated with lower testosterone levels, related to reduced sperm concentration and the development of various diseases with aging. Hormones produced by the adipose tissue may have influences on both metabolism and reproductive function. Among them, the
C Berger et al.
Human reproduction (Oxford, England), 30(4), 800-811 (2015-03-06)
Does ulipristal acetate (UPA) used for emergency contraception (EC) interfere with the human embryo implantation process? UPA, at the dosage used for EC, does not affect human embryo implantation process, in vitro. A single pre-ovulatory dose of UPA (30 mg)
Paul J Toren et al.
Molecular cancer therapeutics, 14(1), 59-69 (2014-10-30)
VT-464 is a novel, nonsteroidal, small-molecule CYP17A1 inhibitor with 17,20-lyase selectivity. This study evaluates the anticancer activity of VT-464 compared with abiraterone (ABI) in castrate-resistant prostate cancer cell lines and xenograft models that are enzalutamide (ENZ)-responsive (C4-2) or ENZ-resistant (MR49C
Viviane M Pascotto et al.
Journal of toxicology and environmental health. Part A, 78(9), 602-616 (2015-05-13)
The Brazilian federal government Agency for Health Surveillance detected pesticide residues in fresh food available for consumers all over the country. The current study investigated the effects of a mixture of some of those pesticides (dichlorvos, dicofol, dieldrin, endosulfan, and
L Marcellin et al.
Human reproduction (Oxford, England), 30(2), 392-405 (2014-11-30)
Are the fetal membranes of women affected with endometriosis similar to those from disease-free women? Decidua of women with endometriosis is able to generate endometriotic-like lesions in contact with the fetal membranes. Eutopic endometrium of women affected with endometriosis presents
Ivanesa Pardo et al.
Breast cancer research : BCR, 16(2), R26-R26 (2014-03-19)
Our efforts to prevent and treat breast cancer are significantly impeded by a lack of knowledge of the biology and developmental genetics of the normal mammary gland. In order to provide the specimens that will facilitate such an understanding, The
Jianxia Sun et al.
Food chemistry, 154, 330-336 (2014-02-13)
1,3-Dichloro-2-propanol (1,3-DCP) is a well-known food processing contaminant that has been shown to impede male reproductive function. However, its mechanism of action remains elusive. In this study, the effects of 1,3-DCP on progesterone production were investigated using the R2C Leydig
Teppei Nakamura et al.
PloS one, 9(6), e100617-e100617 (2014-06-24)
In MRL/MpJ mice, ovarian mast cells (OMCs) are more abundant than in other mouse strains, and tend to distribute beneath the ovarian surface epithelium at birth. This study investigated the factors regulating the appearance of neonatal OMCs in progeny of
Lisa Wessel et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 62(12), 835-845 (2014-08-22)
The impact of progesterone on neuronal tissues in the central (CNS) and peripheral (PNS) nervous system is of significant scientific and therapeutic interest. Glial and neuronal cells of vertebrates express steroidogenic enzymes, and are able to synthesize progesterone de novo
L A Lekatz et al.
Animal reproduction science, 158, 115-125 (2015-05-31)
To examine the effects of maternal metabolizable protein (MP) restriction during late gestation on uterine and umbilical blood flows, conceptus size, and amino acid concentrations in the uterine and umbilical vessels, 11 ewes with singleton pregnancies were assigned to one
Joan-Carles Arce et al.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 30(6), 444-450 (2014-03-01)
The aim was to compare ovarian response and clinical outcome of potential high-responders after stimulation with highly purified menotropin (HP-hMG) or recombinant follicle-stimulating hormone (rFSH) for in vitro fertilisation/intracytoplasmic sperm injection. Retrospective analysis was performed on data collected in two
Maria Gabriela Gasparinho et al.
International journal of surgical pathology, 23(5), 399-403 (2015-04-26)
Lipomatous meningioma is a very rare subtype of metaplastic meningioma. It is defined by the presence of adipocytic-like cells, which are thought to result from lipid accumulation in meningothelial cells or true metaplastic change. We report a case of a
Fangfang Liu et al.
Breast cancer research and treatment, 151(2), 443-451 (2015-05-09)
Invasive micropapillary carcinoma of breast (IMpC) is a special type of breast cancer with frequent lymph node metastasis (LNM) and poor prognosis, while pure mucinous carcinoma of breast (PMC) is generally associated with infrequent LNM and better prognosis. A similar
Prevention of preterm parturition.
Jonathan P Winickoff et al.
The New England journal of medicine, 370(19), 1860-1860 (2014-05-09)
Kazuki Inoue et al.
Biochemical and biophysical research communications, 434(4), 740-745 (2013-04-16)
The pathology of rheumatoid arthritis (RA) is ameliorated during pregnancy and deteriorated after delivery. Thus, female sex hormones could be involved in the pathogenesis of RA. However, the effects of estrogen and progesterone on the development and progression of RA
J Aurich et al.
Domestic animal endocrinology, 52, 11-16 (2015-02-24)
Analysis of salivary cortisol is increasingly used to assess stress responses in horses. Because spontaneous or experimentally induced increases in cortisol concentrations are often relatively small for stress studies, proper controls are needed. This requires an understanding of the factors
Cara M Hueston et al.
Endocrinology, 155(9), 3527-3537 (2014-06-14)
Although progesterone is most commonly regarded in terms of its role in the female estrous cycle, reproductive behavior, and pregnancy, progesterone is also a precursor to corticosterone (CORT) and is released from the adrenal glands of both sexes in response
Effect of ovarian hormones on maturation of dendritic cells from peripheral blood monocytes in dogs.
Viskam Wijewardana et al.
The Journal of veterinary medical science, 77(7), 771-775 (2015-02-27)
Previously, we reported that ovarian hormones affect the immune response against E. coli isolated from the dogs affected with pyometra. In order to investigate mechanisms underlying the immune modulation, we examined the effects of ovarian hormones on the generation of
Elodie Scalici et al.
The Journal of reproductive medicine, 60(7-8), 279-286 (2015-09-19)
To identify risk factors for multiple pregnancies in intrauterine insemination (IUI) cycles with recombinant follicle-stimulating hormone (r-FSH). A retrospective study including 205 IUI cycles with r-FSH which led to clinical pregnancies was conducted. A total of 145, singleton pregnancies and
Britani Nicole Blackstone et al.
Tissue engineering. Part A, 20(19-20), 2746-2755 (2014-04-10)
Autologous engineered skin (ES) offers promise as a treatment for massive full thickness burns. Unfortunately, ES is orders of magnitude weaker than normal human skin causing it to be difficult to apply surgically and subject to damage by mechanical shear
T Tharmalingam-Jaikaran et al.
Reproduction (Cambridge, England), 148(6), 569-580 (2014-09-13)
Follicular fluid (FF), an important microenvironment for the development of oocytes, contains many proteins that are glycosylated with N-linked glycans. This study aimed i) to present an initial analysis of the N-linked glycan profile of bovine FF using hydrophilic interaction
Jia-Ning Xu et al.
The Journal of clinical endocrinology and metabolism, 99(8), 2795-2803 (2014-05-16)
Endometriosis is an estrogen-dependent disease affecting reproductive women. Metformin could have a therapeutic effect on endometriosis through regulation of local estrogen production. The aim of this study was to investigate the molecular and cellular mechanism by which metformin regulates StAR
Jasmina Kercmar et al.
Hormones and behavior, 66(4), 667-673 (2014-09-24)
Sex steroid hormones secreted by gonads influence development and expression of many behaviors including parental behaviors. The capacity to display many behaviors develops under the influence of sex steroid hormones; it begins with gonadal differentiation and lasts through puberty. The
Adriana Knopfelmacher et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 28(9), 1167-1173 (2015-06-27)
The Oncotype DX Breast Cancer Assay for ductal carcinoma in situ is used to determine local recurrence risk in patients with ductal carcinoma in situ. The results help select patients with low-risk ductal carcinoma in situ who could forgo radiation
Yasushi Shigeri et al.
European journal of mass spectrometry (Chichester, England), 21(2), 79-90 (2015-07-17)
Fifty-one reagents (37 hydrazides and 14 hydrazines) were examined to determine if they could function as reactive matrices for the detection of steroids with carbonyl groups in matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). Among these reagents, 3-hydroxy-2-naphthoic acid hydrazide reacted
Achraf Adib et al.
Reproduction (Cambridge, England), 148(4), 403-416 (2014-07-27)
The first ovulation induced by male effect in sheep during seasonal anoestrus usually results in the development of a short cycle that can be avoided by progesterone priming before ram introduction. In elucidating the involvement of the hypothalamic-pituitary-gonadal axis in
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