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Tania Petta et al.
Journal of mass spectrometry : JMS, 50(7), 879-890 (2015-09-10)
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) in the multiple reaction monitoring (MRM) scan mode has been the primary MS method applied for the target identification of specific and minor oxylipids in complex matrices, such as eicosanoids and docosanoids, which are potent
J Reifenrath et al.
Biomedical materials (Bristol, England), 10(4), 045021-045021 (2015-08-13)
For the evaluation of new magnesium-based alloys, many different in vitro and in vivo methods are used. It was the aim of the current study to perform in vitro and in vivo corrosion studies of the new alloy Mg-La-Nd-Zr for
Rachel M Stenger et al.
Clinical and vaccine immunology : CVI, 21(5), 641-650 (2014-03-07)
Knowledge of naturally processed Bordetella pertussis-specific T cell epitopes may help to increase our understanding of the basis of cell-mediated immune mechanisms to control this reemerging pathogen. Here, we elucidate for the first time the dominant major histocompatibility complex (MHC)
Hulda R Jonsdottir et al.
Laboratory investigation; a journal of technical methods and pathology, 95(12), 1418-1428 (2015-09-22)
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with high morbidity and mortality. The cellular source of the fibrotic process is currently under debate with one suggested mechanism being epithelial-to-mesenchymal transition (EMT) in the alveolar region. In this
Xiaofa Qin et al.
Toxicology letters, 232(2), 356-362 (2014-12-03)
Acute and/or chronic alcohol ingestion has been shown to exacerbate the morbidity and mortality rate associated with acute mechanical and/or thermal trauma. While alcohol ingestion can affect many organs and systems, clinical and preclinical studies indicate that alcohol ingestion can
JianCai Zhu et al.
Journal of agricultural and food chemistry, 63(34), 7499-7510 (2015-08-11)
The aroma profile of oolong tea infusions (Dongdingwulong, DDWL; Tieguanyin, TGY; Dahongpao, DHP) were investigated in this study. Gas chromatography-olfactometry (GC-O) with the method of aroma intensity (AI) was employed to investigate the aroma-active compounds in tea infusions. The results
Katherine Camacho Carr et al.
Journal of midwifery & women's health, 49(4), 329-337 (2004-07-09)
Cervical cancer is one of the leading causes of death for middle-aged women in the developing world, yet it is almost completely preventable, if precancerous lesions are identified and treated in a timely manner. Cervical cancer screening based on cytologic
P Palma et al.
The Science of the total environment, 488-489, 208-219 (2014-05-20)
The purpose of this study was to evaluate the potential impact of the pesticides detected in the Alqueva reservoir (Guadiana Basin, South Iberian Peninsula) on the aquatic organisms belonging to this ecosystem. For this purpose, the occurrence and risk assessment
Xin Tang et al.
PLoS computational biology, 10(6), e1003631-e1003631 (2014-06-06)
Traction forces exerted by adherent cells on their microenvironment can mediate many critical cellular functions. Accurate quantification of these forces is essential for mechanistic understanding of mechanotransduction. However, most existing methods of quantifying cellular forces are limited to single cells
Wan Kyu Eo et al.
World journal of gastroenterology, 21(9), 2668-2676 (2015-03-12)
To measure the prognostic significance of absolute monocyte count/absolute lymphocyte count prognostic score (AMLPS) in patients with gastric cancer. We retrospectively examined the combination of absolute monocyte count (AMC) and absolute lymphocyte count (ALC) as prognostic variables in a cohort
Juana Rodríguez et al.
Electrophoresis, 36(14), 1580-1587 (2015-04-16)
A rapid, sensitive, and specific method was developed and validated using a nonaqueous-capillary electrophoresis method with TOF-MS for determination of sunitinib and N-desethyl sunitinib in human urine. In order to avoid ionic suppression a urine samples dilution with methanol 1:10
Rakhshinda Sadiq et al.
Drug and chemical toxicology, 38(2), 152-161 (2014-06-05)
Metallic nanoparticles (NPs) have a variety of applications in different industries including pharmaceutical industry where these NPs are used mainly for image analysis and drug delivery. The increasing interest in nanotechnology is largely associated with undefined risks to the human
Gonca Bulbul et al.
Nanoscale, 7(31), 13230-13238 (2015-07-18)
We report a novel non-enzymatic nanocatalyst based approach to construct an electrochemical aptasensor involving the synergistic contribution of a nanoceria (nCe) tag and graphene oxide (GO). The aptamer was immobilized on the surface of a GO modified electrode. The target
Hendrik Manner et al.
Surgical endoscopy, 29(7), 1888-1896 (2014-10-09)
A prerequisite for endoscopic treatment (ET) of not only mucosal, but also submucosal early adenocarcinoma of the esophagus (EAC) would be a rate of lymph node (LN) metastasis below the mortality rate of esophagectomy (2-5%). The aim of the present
Emilie Degagné et al.
The Journal of clinical investigation, 124(12), 5368-5384 (2014-10-28)
Growing evidence supports a link between inflammation and cancer; however, mediators of the transition between inflammation and carcinogenesis remain incompletely understood. Sphingosine-1-phosphate (S1P) lyase (SPL) irreversibly degrades the bioactive sphingolipid S1P and is highly expressed in enterocytes but downregulated in
Kh Ghanbari et al.
Analytical biochemistry, 473, 53-62 (2015-01-13)
Novel zinc oxide (ZnO) nanosheets and copper oxide (CuxO, CuO, and Cu2O) decorated polypyrrole (PPy) nanofibers (ZnO-CuxO-PPy) have been successfully fabricated for the simultaneous determination of ascorbic acid (AA), dopamine (DA), and uric acid (UA). The morphology and structure of
Bin Xu et al.
Journal of pharmaceutical and biomedical analysis, 114, 447-454 (2015-07-03)
A new method based on a Direct Analysis in Real Time (DART) ionization source coupled with triple quadrupole tandem mass spectrometry has been developed for rapid qualitative and quantitative analyses of 1-deoxynojirimycin (DNJ) in mulberry leaves. Two ions produced from
Shoumin Li et al.
The Journal of surgical research, 199(2), 458-469 (2015-06-30)
The infection of orthopedic implantation devices with Staphylococcus has been a serious concern within the biomaterial community. Treatments are not always successful because of antibiotic-resistant bacteria biofilm infection. Recent studies have shown that combination of antibiotics with low-frequency ultrasound (US)
Nicholas P Vitko et al.
mBio, 6(2) (2015-04-09)
Staphylococcus aureus is a prolific human pathogen capable of causing severe invasive disease with a myriad of presentations. The ability of S. aureus to cause infection is strongly linked with its capacity to overcome the effects of innate immunity, whether
Heloísa H P Oliveira et al.
Ecotoxicology and environmental safety, 122, 106-115 (2015-08-01)
The effects of benzo(a)pyrene (BaP), dichlorodiphenyltrichloroethane (DDT) and tributyltin (TBT) association were investigated through a multi-biomarker approach. Ten Rhamdia quelen fish per group were exposed through intraperitoneal injections either to BaP (0.3; 3 or 30 mg kg(-1)), DDT or TBT
Janneke Keemink et al.
International journal of pharmaceutics, 491(1-2), 78-90 (2015-06-06)
Compound libraries that are screened for biological activity commonly contain heterocycles. Besides potency, drug-like properties need to be evaluated to ensure in vivo efficacy of test compounds. In this context, we determined hepatic and intestinal disposition profiles for 17 heterocyclic
Chaohui Chen et al.
Analytica chimica acta, 880, 1-7 (2015-06-21)
An amplified colorimetric method has been developed for the detection of protein and cancer cells based on the assembly of nucleic acids and proteins for the first time. In this process, the assembly of nucleic acids was triggered by a
Venkata P Mantripragada et al.
Materials science & engineering. C, Materials for biological applications, 42, 506-516 (2014-07-27)
The main objective of this study is to maximize growth factor encapsulation efficiency into microparticles. The novelty of this study is to maximize the encapsulated growth factors into microparticles by minimizing the use of organic solvents and using relatively low
Miklós Guttman et al.
Electrophoresis, 36(11-12), 1305-1313 (2015-03-27)
The human immunodeficiency virus (HIV) envelope glycoprotein (Env) is the primary antigenic feature on the surface of the virus and is of key importance in HIV vaccinology. Vaccine trials with the gp120 subunit of Env are ongoing, with the recent
Gary R Burnett et al.
American journal of dentistry, 26 Spec No A, 10A-14A (2013-07-10)
To evaluate in vitro the ability for an experimental anhydrous 0.454% w/w stannous fluoride dentifrice to occlude dentin tubules. Scanning electron microscopy (SEM) was used to assess tubule occlusion and the resistance of the occlusion to dietary acid in a
Ana Rodriguez-Mateos et al.
Molecular nutrition & food research, 59(8), 1504-1512 (2015-05-20)
An understanding of the pharmacokinetics of structurally related (-)-epicatechin metabolites (SREM) is a prerequisite for considering cocoa flavanols (CF) in the context of dietary recommendations. The objective of this study was to compare the absorption, metabolism, and excretion of SREM
Xianyu Chen et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 970, 121-130 (2014-09-28)
The aim of this study was to develop an analytical method for the quantification of organochlorine (OC), organophosphate (OP), carbamate, and pyrethroid insecticide residues in cow milk, human milk, and baby formula. A total of 25 compounds were included in
Elisabeth Christiansen et al.
The British journal of nutrition, 113(11), 1677-1688 (2015-04-29)
Various foods are associated with effects against metabolic diseases such as insulin resistance and type 2 diabetes; however, their mechanisms of action are mostly unclear. Fatty acids may contribute by acting as precursors of signalling molecules or by direct activity
Pavel Svoboda et al.
Journal of pharmaceutical and biomedical analysis, 114, 62-70 (2015-05-31)
A complete analytical procedure combining optimized tea infusion preparation and validated UHPLC-MS/MS method was developed for routine quantification of eight naturally occurring catechin derivatives in various tea samples. The preparation of tea infusions was optimized in terms of temperature, time
Davor Zeljezic et al.
Chemosphere, 120, 45-51 (2014-06-30)
Agricultural workers are often exposed to high levels of pesticides over prolonged periods of time. We attempted to determine whether exposure to multiple pesticides shortens relative telomere length (RTL) and causes nucleoplasmic bridge (NPB) formation via the mechanism of telomere-end
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