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Kyeong-Ah Jung et al.
Toxicology letters, 218(1), 39-49 (2013-01-12)
Transcription factor NF-E2-related factor 2 (NRF2) plays a crucial role in the cellular defense against oxidative/electrophilic stress by up-regulating multiple antioxidant genes. Numerous studies with genetically modified animals have demonstrated that Nrf2 is a sensitivity determining factor upon the exposure
David P Kuipers et al.
Biochimie, 95(2), 258-263 (2012-09-27)
The corneal epithelial tissue is a layer of rapidly growing cells that are highly glycolytic and express GLUT1 as the major glucose transporter. It has been shown that GLUT1 in L929 fibroblast cells and other cell lines can be acutely
Tomasz Kostrzewa et al.
Anticancer research, 39(2), 745-749 (2019-02-04)
Protein tyrosine phosphatase (PTP1B) is a potential target for the treatment of type 2 diabetes and cancer. Curcumin and cinnamaldehyde have been previously reported to have antidiabetic and anticancer potentials. The aim of this study was to investigate the effect
Wen-Xian Du et al.
Journal of agricultural and food chemistry, 60(32), 7799-7804 (2012-07-27)
The addition of plant essential oils to edible films and coatings has been shown to protect against bacterial pathogens and spoilage while also enhancing sensory properties of foods. This study evaluated the effect of adding 0.5 and 0.75% carvacrol (active
Thobeka Kente et al.
Journal of nanoscience and nanotechnology, 13(7), 4990-4995 (2013-08-02)
This paper reports on the synthesis and use of nanostructures of gallium nitride (GaN NSs) and nitrogen doped carbon spheres (NCSs) as support materials for the hydrogenation of cinnamaldehyde. This study provides the first investigation of GaN as a catalyst
Wei Chen et al.
Journal of food protection, 78(8), 1488-1495 (2015-07-30)
The objective of this study was to investigate the antimicrobial activities of carvacrol, cinnamaldehyde, and lauric arginate (LAE) against Salmonella in a low water activity (aw ) glycerol-sucrose model and in peanut paste with different fat concentrations. Salmonella Tennessee was
Magnus Bruze et al.
Journal of the American Academy of Dermatology, 48(2), 194-200 (2003-02-13)
Axillary dermatitis is common and overrepresented in individuals with contact allergy to fragrances. Many individuals suspect their deodorants to be the incriminating products. Our aim was to investigate the significance of cinnamic aldehyde in deodorants for the development of axillary
Josefin Larsson et al.
Journal of natural products, 68(7), 985-991 (2005-07-26)
Recently various attempts have been made to increase the efficacy and precision of chemical libraries used in high-throughput screening (HTS) drug discovery approaches. One such approach is ChemGPS, which provides a defined chemical space for prescreening evaluation of chemical compound
Cristina Avonto et al.
Toxicology and applied pharmacology, 289(2), 177-184 (2015-10-13)
Skin sensitization is an important toxicological end-point in the risk assessment of chemical allergens. Because of the complexity of the biological mechanisms associated with skin sensitization, integrated approaches combining different chemical, biological and in silico methods are recommended to replace
Mariana Albano et al.
Microbial pathogenesis, 126, 231-238 (2018-11-16)
The search for new antimicrobial drugs has been necessary due to the increased bacterial resistance to antibiotics currently in use, and natural products play an important role in this field. The aim of this study was to evaluate the in
Antimicrobial activity of cinnamon and clove oils under modified atmosphere conditions
Matan N, et al
International Journal of Food Microbiology, 107(2), 180-185 (2006)
Yuuki Taguchi et al.
Medical molecular morphology, 46(1), 8-13 (2013-01-18)
We examined the viability and morphology of Candida albicans under experimental conditions after treatment with varying concentrations of cinnamaldehyde, the major component of cassia (Cinnamomum cassia), using XTT assay, fluorescent microscopy, scanning electron microscopy, and thin-section electron microscopy. At 10 μg/ml
Rebeca Caires et al.
Nature communications, 6, 8095-8095 (2015-08-28)
Hyaluronan (HA) is present in the extracellular matrix of all body tissues, including synovial fluid in joints, in which it behaves as a filter that buffers transmission of mechanical forces to nociceptor nerve endings thereby reducing pain. Using recombinant systems
Yasuko Tamura et al.
Journal of nutritional science and vitaminology, 58(1), 9-13 (2012-09-26)
Cinnamaldehyde (CNA), a pungent compound in cinnamon or dried bark of cassia, is a TRPA1 agonist. The effect of 0.1-1.0% CNA on pair-fed mice with high fat and high sucrose (HFS) diet for 1 mo was investigated. The total food
Jung-Hoon Kim et al.
Archives of pharmacal research, 38(1), 52-62 (2014-03-13)
This study was designed for quality assessment of Gyejibokryeong-hwan (GBH) preparations using the simultaneous determination of 11 marker compounds such as gallic acid, oxypaeoniflorin, amygdalin, albiflorin, paeoniflorin, benzoic acid, coumarin, cinnamic acid, benzoylpaeoniflorin, cinnamaldehyde, and paeonol using HPLC-PDA and chemometric
Che-Hong Chen et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(10), 3074-3079 (2015-02-26)
Correcting a genetic mutation that leads to a loss of function has been a challenge. One such mutation is in aldehyde dehydrogenase 2 (ALDH2), denoted ALDH2*2. This mutation is present in ∼ 0.6 billion East Asians and results in accumulation
The genetic toxicology of cinnamaldehyde.
T Neudecker
Mutation research, 277(3), 173-185 (1992-09-01)
Michael Bandell et al.
Neuron, 41(6), 849-857 (2004-03-30)
Six members of the mammalian transient receptor potential (TRP) ion channels respond to varied temperature thresholds. The natural compounds capsaicin and menthol activate noxious heat-sensitive TRPV1 and cold-sensitive TRPM8, respectively. The burning and cooling perception of capsaicin and menthol demonstrate
Xueqiang Qi et al.
Dalton transactions (Cambridge, England : 2003), 43(24), 9283-9295 (2014-05-14)
Core-shell RuPt (Ru core-Pt shell) and PtRu (Pt core-Ru shell) nanoparticles were prepared by decomposing in a two-step procedure a ruthenium ([Ru(COD)(COT)] (COD = 1,5-cyclooctadiene, COT = 1,3,5-cyclooctatriene)) and a platinum complex ([Pt2(dba)3] (dba = dibenzylideneacetone) or [Pt(CH3)2(COD)]) in the
Narae Shin et al.
Small (Weinheim an der Bergstrasse, Germany), 16(30), e2001469-e2001469 (2020-06-25)
A bioelectronic skin device based on nociceptive ion channels in nanovesicles is developed for the detection of chemical cold-pain stimuli and cold environments just like human somesthetic sensory systems. The human transient receptor potential ankyrin 1 (hTRPA1) is involved in
Suresh Kumar et al.
Cardiovascular diabetology, 11, 95-95 (2012-08-14)
This study was made to investigate the antidiabetic, antioxidant and hypolipidemic potential of Cinnamomum tamala, (Buch.-Ham.) Nees & Eberm (Tejpat) oil (CTO) in streptozotocin (STZ) induced diabetes in rats along with evaluation of chemical constituents. The GC-MS (Gas chromatography-mass spectrometry)
Ji-Hyun Lee et al.
Bioscience, biotechnology, and biochemistry, 79(1), 68-73 (2014-09-25)
To use blood released from slaughtering houses, a porcine plasma protein (PPP)/nanoclay composite film was prepared. The tensile strength and elongation at break values of the PPP composite film with 5% nanoclay were 10.01 MPa and 6.55%, respectively. The PPP composite
Andre Loquercio et al.
Journal of food science, 80(10), N2305-N2315 (2015-09-17)
Trans-cinnamaldehyde incorporated chitosan-alginate nanoparticles were synthesized using the ionic gelation and polyelectrolyte complexation technique. Alginate, chitosan, calcium chloride, and trans-cinnamaldehyde at predetermined concentrations were complexed electrostatically to optimize particle size and loading efficiency. A final methodology using optimized processing parameters
A toxicologic and dermatologic assessment of cinnamyl alcohol, cinnamaldehyde and cinnamic acid when used as fragrance ingredients.
D Bickers et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 43(6), 799-836 (2005-04-07)
Hongbo Li et al.
Molecules (Basel, Switzerland), 20(4), 6022-6032 (2015-04-09)
Cinnamaldehyde (CA) is marginally soluble in water, making it challenging to evenly disperse it in foods, and resulting in lowered anti-A. flavus efficacy. In the present study, nano-dispersed CA (nano-CA) was prepared to increase its aqueous solubility. Free and nano-dispersed
Susumu Ohkawara et al.
The Journal of toxicological sciences, 37(4), 831-835 (2012-08-07)
Methylglyoxal (MG) is an endogenous carbonyl compound that is produced in large quantity under hyperglycemic conditions, which are believed to contribute to the development of diabetic neuropathy. However, the mechanism by which this occurs and the molecular targets of MG
Eden Arazi et al.
Frontiers in pharmacology, 11, 704-704 (2020-06-09)
Potassium K2P ("leak") channels conduct current across the entire physiological voltage range and carry leak or "background" currents that are, in part, time- and voltage-independent. The activity of K2P channels affects numerous physiological processes, such as cardiac function, pain perception
Jeff Defalco et al.
Bioorganic & medicinal chemistry letters, 20(1), 276-279 (2009-12-01)
AP18 1 was recently disclosed as an antagonist of the TRPA1 receptor by the research group of Patapoutian. However, no detailed structure-activity relationships around 1 have been disclosed. Thus, a small number of oximes related to AP18 were examined in
A Hallier et al.
Journal of dairy science, 96(3), 1447-1454 (2013-01-15)
Over the past few years, the use of essential oils in breeding has been gaining ground because of their wide range of application, especially in terms of antimicrobial activity, and the current emphasis on the use of natural compounds, particularly
Yoonjee Chang et al.
International journal of food microbiology, 244, 19-26 (2017-01-08)
LysSA97 is an endolysin encoded by the bacteriophage SA97, the genome sequence of which has been recently revealed. LysSA97 has lytic activity against a variety of Staphylococcus strains that cause foodborne illness. In order to improve its potential as a
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