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Feiying Zhang et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 71(2), 710-713 (2008-03-25)
The infrared absorption spectra of the carbonyl stretching vibrations of 6-methylcoumarin (6MC) have been investigated in CCl4/ROH mixtures (CCl4/C2H5OH, CCl4/n-C3H7OH, CCl4/i-C3H7OH, and CCl4/t-C5H11OH). Two types of carbonyl stretching vibration bands for 6MC are found with the change of the mole
Vasanop Vachiramon et al.
Dermatitis : contact, atopic, occupational, drug, 16(3), 136-138 (2005-10-26)
A 49-year-old woman presented with asymptomatic progressive erythema, hyperpigmentation, atrophy, and telangiectasia on her neck. The clinical appearance and histopathology of the skin lesion was consistent with poikiloderma of Civatte. Photopatch-testing with our standard photoallergens yielded a positive reaction to
Erika Parkinson et al.
Toxicological sciences : an official journal of the Society of Toxicology, 142(1), 239-249 (2014-08-26)
The risk of contact sensitization is a major consideration in the development of new formulations for personal care products. However, developing a mechanistic approach for non-animal risk assessment requires further understanding of haptenation of skin proteins by sensitizing chemicals, which
Anuradha Ramoji et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 77(5), 1039-1047 (2010-09-22)
Infrared absorption and Raman spectra (3500-50 cm(-1)) of 3-acetyl-6-bromocoumarin and 3-acetyl-6-methylcoumarin have been measured and interpreted, aided by electronic structure calculations at RHF and B3LYP using 6-31(d, p) basis set. It has been determined that the rotation of the acetyl
Jin-Fang Nie et al.
Talanta, 75(5), 1260-1269 (2008-07-01)
This paper reports a simple, rapid, and effective method for quantitative analysis of 6-methylcoumarin (6-MC) and 7-methoxycoumarin (7-MOC) in cosmetics using excitation-emission matrix (EEM) fluorescence coupled with second-order calibration. After simple pretreatments, the adopted calibration algorithms exploiting the second-order advantage
F X Bernard et al.
Cell biology and toxicology, 16(6), 391-400 (2001-03-20)
The reconstituted human epidermis model SkinEthic was used to evaluate the phototoxicity of topically applied chemicals. For comparison with published data, we first tested a library of 13 nonphototoxic (NPT) and phototoxic (PT) compounds, applied onto SkinEthic reconstituted human epidermal
Masako Kurita et al.
Journal of dermatological science, 45(2), 105-112 (2006-12-05)
The capacity of photosensitizing chemicals with ultraviolet A light (UVA) to induce apoptosis is one of the methods to assess their phototoxic and potentially photoallergic properties, since apoptotic cells may be easily presented by antigen-presenting cells. We examined the photoaggravated
Organoleptic Characteristics of Flavor Materials
Mosciano, G.
Perfumer & Flavorist, 30, 41-41 (2005)
Masatoshi Hoya et al.
Toxicology in vitro : an international journal published in association with BIBRA, 23(5), 911-918 (2009-04-11)
In this study, with the aim of developing a cell-based in vitro photosensitization assay, we examined whether changes of CD86 and CD54 expression on cells of a human monocytic cell line, THP-1, could be used to assess the photosensitizing potential
João Cleverson Gasparetto et al.
PloS one, 10(3), e0118922-e0118922 (2015-03-11)
For decades guaco species have been empirically used for the treatment of respiratory diseases. However, studies have shown that the toxic and therapeutic effects of the main guaco metabolites are dose-dependent, and none clinical study was done to evaluate the
W P Jordan
Contact dermatitis, 8(2), 109-116 (1982-03-01)
This report describes modifications in the techniques used for both the induction and elicitation of photoallergic contact dermatitis (PACD) in the guinea pig. These changes have improved the reliability of this animal as the model of choice for screening chemicals
A Jos et al.
Archives of environmental contamination and toxicology, 56(1), 52-59 (2008-04-09)
The toxicity assessment of chemicals is one of the main issues in the current policies in order to protect the health of the environment and human beings. Food and cosmetic additives have been extensively studied in relation to their toxicity
Barry C Pemberton et al.
Chemical communications (Cambridge, England), 47(22), 6323-6325 (2011-05-05)
Guest induced shape change of the cucurbit[8]uril cavity is likely rate limiting in the supramolecular photocatalytic cycle for CB8 mediated photodimerization of 6-methylcoumarin.
E V Buehler et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 23(7), 689-694 (1985-07-01)
Guinea-pig tests were conducted on a known photocontact allergen, tetrachlorosalicylanilide (TCSA), a known phototoxin, 8-methoxypsoralen, two reportedly weak photoallergens, musk ambrette and 6-methylcoumarin, and a negative control, octylphenoxy polyethoxyethanol (Triton X-15). The data show that under the test conditions used
Gadepalli Narasimha Krishna Kumari et al.
Zeitschrift fur Naturforschung. C, Journal of biosciences, 59(5-6), 405-407 (2008-11-13)
The microbial transformation of coumarin (1) and 6-methyl coumarin (2) using Colletotrichum capsici gave 2-(3'-hydroxypropyl) phenol (3) and 2-(3'-hydroxypropyl)-4-methyl phenol (4). The phytopathogenic fungi effectively reduced the 2H-pyran-2-one moiety of both parent coumarins to respective alcohols.
H C Maguire et al.
The Journal of investigative dermatology, 79(3), 147-152 (1982-09-01)
We have induced photoallergic contact dermatitis in mice to 3,3',4',5 tetrachlorosalicylanilide (TCSA), chlorpromazine and 6-methylcoumarin. These compounds are known to produce photoallergic contact dermatitis in humans. The photoallergic contact dermatitis reaction in the mouse is immunologically specific viz. mice photosensitized
S Kato et al.
Toxicology and applied pharmacology, 81(2), 295-301 (1985-11-01)
6-Methylcoumarin (6-MC), a synthetic fragrance material, has been reported to be photoallergenic both in man and in guinea pigs. To elucidate the possible mechanism of photoallergenicity, 6-MC in ethanolic solution was exposed to 200 joules/cm2 of long-wavelength ultraviolet (UV) ranging
W G Larsen
Journal of the American Academy of Dermatology, 12(1 Pt 1), 1-9 (1985-01-01)
The most common reaction to fragrance materials seen by practicing dermatologists is allergic contact dermatitis. Photodermatitis is occasionally seen, as is contact urticaria, irritation, and depigmentation. Fragrances are the leading cause of allergic contact dermatitis due to cosmetics. The fragrance
G F Gerberick et al.
Photodermatology, photoimmunology & photomedicine, 7(1), 13-19 (1990-02-01)
The development of a contact photoallergic response in animals or humans requires irradiation of the test material. Since consumers are exposed to both UVB and UVA radiation following the use of topically applied products, we have developed a mouse ear
V A DeLeo et al.
Archives of dermatology, 128(11), 1513-1518 (1992-11-01)
Over a 6-year period, 187 patients with a history of photosensitivity were photopatch tested using standard techniques. Seventy-six patients were male and 111 were female. Most patients were white (151 patients). Two thirds of the patients were between the ages
Jong Hee Lee et al.
Photodermatology, photoimmunology & photomedicine, 23(2-3), 73-80 (2007-05-26)
Exposure to ultraviolet radiation (UVR) has been shown to induce cutaneous biological changes and phototoxic reactions. This study was designed to evaluate the usefulness of artificial skin (AS) composed of keratinocytes and melanocytes as an in vitro phototoxicity model for
S K Allen et al.
Biochemical and biophysical research communications, 235(3), 615-618 (1997-06-27)
Use of the fragrance 6-methylcoumarin (6-MC) in cosmetic products has declined significantly due to numerous reports of photoallergic contact dermatitis associated with its use. We have determined that 6-MC undergoes direct photolysis with an estimated half-life of 83 minutes when
B G Lake et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 32(8), 743-751 (1994-08-01)
The mechanism of coumarin-induced hepatotoxicity in the rat has been investigated by comparing the effects of coumarin with those of three coumarin derivatives, namely 3,4-dihydrocoumarin (DHC), 3,4-dimethylcoumarin (3,4-DMC) and 6-methylcoumarin (6-MC). Male Sprague-Dawley rats were fed either control diet or
Barry C Pemberton et al.
Chemical communications (Cambridge, England), 46(2), 225-227 (2009-12-22)
Cucurbit[8]uril (as low as 10 mol%) acts as a supramolecular catalytic nanoreaction vessel and facilitates the photodimerization of coumarins in water leading to syn dimers. Saturation kinetics shows a sigmoidal dependence with a turnover number of 3.4 min(-1) and a
Veenasangeeta Sortur et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 64(2), 301-307 (2006-04-29)
Fourier transform-infrared (4000-400 cm-1) and Raman (3500-50 cm-1) spectral measurements have been made for 6-methyl-4-bromomethylcoumarin. Equilibrium structures, harmonic vibrational frequencies, infrared intensities, and depolarization ratios have been computed at RHF/6-31G* and B3LYP/6-31G* levels of theory. Twisting CH2Br moiety in the
E W Scholes et al.
Photodermatology, photoimmunology & photomedicine, 8(6), 249-254 (1991-12-01)
Guinea pig test methods are the most commonly used and reliable of predictive models for contact photoallergenicity of chemicals. The murine local lymph node assay (LLNA) has been developed recently as an alternative method for the identification of skin-sensitizing chemicals.
Tatsushi Toyooka et al.
The Journal of investigative dermatology, 131(6), 1313-1321 (2011-03-04)
Several light-absorbing chemicals are known to show phototoxic effects involving many kinds of DNA damage, and are suspected of initiating skin cancer. In this study, we clarified that phosphorylated histone H2AX (γ-H2AX) (phosphorylated histone H2AX), which was produced with the
Hayato Nishida et al.
Regulatory toxicology and pharmacology : RTP, 72(3), 578-585 (2015-06-07)
Previously, a non-animal screening approach was proposed for evaluating photosafety of cosmetic ingredients by means of in vitro photochemical and photobiochemical assays; however, complex cosmetic ingredients, such as plant extracts and polymers, could not be evaluated because their molecular weight
[New data on photoallergy].
D Kleniewska et al.
Przeglad dermatologiczny, 70(2), 221-224 (1983-03-01)
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