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Eric G Meissner et al.
Hepatology (Baltimore, Md.), 61(3), 790-801 (2014-09-10)
Hepatitis C virus (HCV) modulates intrahepatic cholesterol biosynthetic pathways to promote viral replication. Chronic HCV infection is associated with altered metabolism, including dyslipidemia and insulin resistance (IR), which contributes to disease progression and influences response to therapy. To further understand
Darrell C Bessette et al.
PloS one, 10(5), e0125232-e0125232 (2015-05-15)
Basal-like and triple negative breast cancer (TNBC) share common molecular features, poor prognosis and a propensity for metastasis to the brain. Amplification of epidermal growth factor receptor (EGFR) occurs in ~50% of basal-like breast cancer, and mutations in the epidermal
Nada Lukkahatai et al.
Biological research for nursing, 17(4), 373-383 (2015-05-28)
Fibromyalgia syndrome (FMS), a chronic musculoskeletal condition characterized by diffuse pain, fatigue, sleep impairment, and cognitive dysfunction, is associated with significant functional disability. Its underlying biological mechanisms are unknown. This study investigated differentially expressed genes between women with FMS and
Kimberly N Herman et al.
Journal of biochemical and molecular toxicology, 28(12), 568-577 (2014-08-29)
Elevated levels of reactive oxygen species (ROS) can be induced by exposure to various chemicals and radiation. One type of damage in DNA produced by ROS is modification of guanine to 7,8-dihydro-8-oxoguanine (8-oxoG). This particular alteration to the chemistry of
Sujoy Ghosh et al.
Scientific reports, 5, 11272-11272 (2015-07-16)
2-Dimensional structures with swift optical response have several technological advantages, for example they could be used as components of ultrafast light modulators, photo-detectors, and optical switches. Here we report on the fast photo switching behavior of thin films of liquid
Daniel G Beach et al.
Analytical and bioanalytical chemistry, 407(28), 8397-8409 (2015-09-24)
The neurotoxin β-N-methylamino-L-alanine (BMAA) has been reported in cyanobacteria and shellfish, raising concerns about widespread human exposure. However, inconsistent results for BMAA analysis have led to controversy. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is the most appropriate method for analysis of
Silvia Berto et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 149, 75-82 (2015-05-06)
The charge-transfer complexes have scientific relevance because this type of molecular interaction is at the basis of the activity of pharmacological compounds and because the absorption bands of the complexes can be used for the quantification of electron donor molecules.
Zhan Shu et al.
The European journal of neuroscience, 40(2), 2320-2328 (2014-04-29)
The dopamine (DA) terminal fields in the rat dorsal striatum (DS) and nucleus accumbens core (NAcc) are organized as patchworks of domains that exhibit distinct kinetics of DA release and clearance. The present study used fast-scan cyclic voltammetry recordings of
Anna C Denicol et al.
PloS one, 10(7), e0133587-e0133587 (2015-07-22)
Sex affects function of the developing mammalian embryo as early as the preimplantation period. There were two goals of the current objective. The first was to determine the degree and nature of differences in gene expression between female and male
Lucie E Charrier et al.
Scientific reports, 5, 17699-17699 (2015-12-04)
The human apical protein CRB3 (Crb3 in mouse) organizes epithelial cell polarity. Loss of CRB3 expression increases the tumorogenic potential of cultured epithelial cells and favors metastasis formation in nude mice. These data emphasize the need of in vivo models
Paulami Pal et al.
Drug development and industrial pharmacy, 41(7), 1095-1099 (2014-07-02)
The main objective of this study is to develop a safer non-invasive treatment for nail infections since the current treatment regimen has drawbacks like, incidence of systemic side-effects and higher cost. Proposed topical treatment on the other hand can drastically
Zachary C Dobbin et al.
Oncotarget, 5(18), 8750-8764 (2014-09-12)
A cornerstone of preclinical cancer research has been the use of clonal cell lines. However, this resource has underperformed in its ability to effectively identify novel therapeutics and evaluate the heterogeneity in a patient's tumor. The patient-derived xenograft (PDX) model
P Darkhal et al.
International journal of obesity (2005), 39(8), 1292-1299 (2015-04-15)
The objective of this study was to assess the activity of anti-inflammatory cytokine IL-13 (interleukin-13) in blocking high-fat diet-induced obesity and obesity-associated insulin resistance and liver steatosis. C57BL/6 mice were fed a high-fat diet and received hydrodynamic delivery of plasmids
Roomina Jahroomishirazi et al.
Cells, tissues, organs, 200(2), 141-152 (2015-05-23)
Mesenchymal stem cells (MSCs) have great promise in the field of regenerative medicine due to their differentiation potential into several lineages. Besides the bone marrow, MSCs can be obtained from the dermis, which represents a large stem cell reservoir in
Bo-Liang Zhao et al.
Organic & biomolecular chemistry, 13(46), 11351-11361 (2015-10-02)
A bifunctional squaramide catalysed aza-Michael/Michael cascade reaction between nitroalkenes and tosylaminomethyl enones or enoates has been developed. This organocatalytic cascade reaction provides easy access to highly functionalized chiral pyrrolidines with a broad substrate scope, giving the desired products in good
Craig C Carson et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(9), 2167-2176 (2015-05-03)
IL2 inducible T-cell kinase (ITK) promoter CpG sites are hypomethylated in melanomas compared with nevi. The expression of ITK in melanomas, however, has not been established and requires elucidation. An ITK-specific monoclonal antibody was used to probe sections from deidentified
Aditya Kapil Valiveti et al.
Chemico-biological interactions, 237, 125-132 (2015-06-14)
A series of mono pyridinium oximes linked with arenylacetamides as side chains were synthesized and their in vitro reactivation potential was evaluated against human acetylcholinesterase (hAChE) inhibited by organophosphorus inhibitors (OP) such as sarin, VX and tabun. The reactivation data
João Cavaleiro Rufo et al.
Journal of toxicology and environmental health. Part A, 78(13-14), 904-914 (2015-07-15)
Children spend a large part of their time at schools, which might be reflected as chronic exposure. Ultrafine particles (UFP) are generally associated with a more severe toxicity compared to fine and coarse particles, due to their ability to penetrate
Noriko Tonomura et al.
PLoS genetics, 11(2), e1004922-e1004922 (2015-02-03)
Dogs, with their breed-determined limited genetic background, are great models of human disease including cancer. Canine B-cell lymphoma and hemangiosarcoma are both malignancies of the hematologic system that are clinically and histologically similar to human B-cell non-Hodgkin lymphoma and angiosarcoma
W Zhao et al.
Gene therapy, 22(8), 645-652 (2015-04-15)
Interleukin-5 (IL-5) increases the secretion of natural T15/EO6 IgM antibodies that inhibit the uptake of oxidized low-density lipoprotein (LDL) by macrophages. This study aimed to determine whether macrophage-specific expression of IL-5 in LDL receptor-deficient mice (Ldlr(-/-)) could improve cholesterol metabolism
Parsa Erfani et al.
Epigenetics, 10(6), 496-507 (2015-05-23)
Several signaling pathways important for the proliferation and growth of brain cells are pathologically dysregulated in gliomas, including the epidermal growth factor receptor (EGFR). Expression of EGFR is high in neural progenitors during development and in gliomas but decreases significantly
Rahmi Oklu et al.
Journal of neurointerventional surgery, 6(7), 541-546 (2013-09-06)
Evaluation of the pathogenic mechanisms underlying Cushing disease (CD) is limited partly by the inaccessibility of the pituitary gland for biopsy. We used bilateral inferior petrosal sinus sampling (BIPSS), the gold standard in diagnosing pituitary sources of CD, to obtain
Narendra P Singh et al.
Molecular pharmacology, 87(5), 842-854 (2015-03-11)
Prenatal exposure to diethylstilbestrol (DES) is known to cause an increased susceptibility to a wide array of clinical disorders in humans. Previous studies from our laboratory demonstrated that prenatal exposure to DES induces thymic atrophy and apoptosis in the thymus.
Jan Rybniker et al.
Nature communications, 6, 7659-7659 (2015-07-15)
Better antibiotics capable of killing multi-drug-resistant Mycobacterium tuberculosis are urgently needed. Despite extensive drug discovery efforts, only a few promising candidates are on the horizon and alternative screening protocols are required. Here, by testing a panel of FDA-approved drugs in
Wenjing Guo et al.
Antonie van Leeuwenhoek, 107(4), 1017-1027 (2015-01-30)
Carotenoids are a naturally occurring and widely distributed group of pigments that provide protection against photooxidation and inactivate free radicals due to their highly conjugated double-bond systems. Phytoene dehydrogenation is the first rate-limiting step in the carotenoid biosynthetic pathway. Phytoene
P Liu et al.
Journal of pharmaceutical sciences, 85(3), 320-325 (1996-03-01)
This paper demonstrates the usefulness of an equilibria-cotransport model for understanding the isopropyl alcohol-enhanced transport of an ionizable model compound, terbutaline in its sulfate salt form, through human skin in vitro. With the same isopropyl alcohol concentrations (0 - 80%
Seyedeh Hoda Alavizadeh et al.
International journal of pharmaceutics, 473(1-2), 326-333 (2014-07-23)
SPI-077, cisplatin stealth liposome, is the best illustration of poor cisplatin release from liposomes and the subsequent negligible therapeutic activity. For this reason, optimizing drug release kinetics is desirable. In this report, cisplatin was encapsulated in liposomes composed of different
Dongdong Qin et al.
Scientific reports, 5, 11267-11267 (2015-06-11)
Non-human primates offer unique opportunities to study the development of depression rooted in behavioral and physiological abnormalities. This study observed adult female rhesus macaques within social hierarchies and aimed to characterize the physiological and brain abnormalities accompanying depressive-like behavior. The
Jessica B Dwyer et al.
Clinica chimica acta; international journal of clinical chemistry, 415, 245-249 (2012-11-20)
Alcohol ketoacidosis is a frequently missed diagnosis, but is well described in the literature. We present a case of ketoacidosis, likely alcohol ketoacidosis, in a 40 y-old chronic alcoholic patient. The detection of trace serum isopropanol prompted a discussion of
Diane C Munday et al.
The Journal of pharmacy and pharmacology, 67(3), 300-318 (2014-12-24)
The aim of this study was to quantitatively characterise the mitochondrial proteome of airway epithelial cells infected with human respiratory syncytial virus (HRSV), a major cause of paediatric illness. Quantitative proteomics, underpinned by stable isotope labelling with amino acids in
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