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M Baro et al.
British journal of cancer, 111(7), 1310-1318 (2014-08-01)
Cetuximab is often combined with radiotherapy in advanced SCCHN. Alternative routes bypassing inhibition of EGFR with cetuximab may overshadow the efficacy of this combination. We undertook this study to investigate a possible role of dasatinib in this scenario. The SCC5
David S Wishart et al.
Nucleic acids research, 37(Database issue), D603-D610 (2008-10-28)
The Human Metabolome Database (HMDB, http://www.hmdb.ca) is a richly annotated resource that is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, nutritionists and members of the metabolomics community. Since its first release in 2007, the
Peng Zhang et al.
Biomaterials, 67, 104-114 (2015-07-27)
A simple PEGylated peptidic nanocarrier, PEG5000-lysyl-(α-Fmoc-ε-Cbz-lysine)2 (PLFCL), was developed for effective co-delivery of doxorubicin (DOX) and dasatinib (DAS) for combination chemotherapy. Significant synergy of DOX and DAS in inhibition of cancer cell proliferation was demonstrated in various types of cancer
Faiyaz Shakeel et al.
Food chemistry, 180, 244-248 (2015-03-15)
The solubility of vanillin in ten different environmentally benign solvents namely water, ethanol, ethylene glycol (EG), ethyl acetate (EA), isopropanol (IPA), propylene glycol (PG), polyethylene glycol-400 (PEG-400), Transcutol, butanol-1 and butanol-2 was measured and correlated at T=(298-318)K. The resulting experimental
Vladimir G Zaikin et al.
European journal of mass spectrometry (Chichester, England), 21(3), 403-411 (2015-08-27)
Some aromatic carbonyl compounds [2,4-dihydroxybenzaldehyde (2,4-DHBA), 2,5- dihydroxyacetophenone (DHAP), 2,3,5-trihydroxybenzaldehyde and 2,4-dinitrobenzaldehyde] were examined as potential reactive matrices for the analysis of mono-, di-, and polyamines by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS). Although all the above compounds readily
Han Li et al.
Microbial cell factories, 12, 4-4 (2013-01-24)
The modern society primarily relies on petroleum and natural gas for the production of fuels and chemicals. One of the major commodity chemicals 1,2-propanediol (1,2-PDO), which has an annual production of more than 0.5 million tons in the United States
Tarek A Ahmed et al.
Life sciences, 110(1), 35-43 (2014-07-06)
First; to develop rabeprazole (RP)-alginate core coated chitosan nanoparticles (NP) utilizing water in oil (W/O) nanoemulsion technique. Second; formulation of transdermal patches loaded RP-NP that avoid drug peroral acid sensitivity and first pass effect. The influence of six factors on
Eliisa Ollikainen et al.
Journal of neuropathology and experimental neurology, 73(9), 855-864 (2014-08-08)
Chronic inflammation contributes to remodeling, degeneration, and rupture of saccular intracranial artery aneurysms. Mast cells are important proinflammatory and proangiogenic cells in chronic inflammatory vascular diseases. Here we studied mast cells and neovascularization in 36 intraoperatively resected aneurysms using histology
Olga Zhernovaya et al.
Journal of biomedical optics, 18(2), 26014-26014 (2013-02-08)
The main limitation of optical imaging techniques for studying biological tissues is light scattering leading to decreasing of transmittance, which lowers the imaging quality. In this case, an immersion method for optical clearing of biological tissues can provide a possible
Martina Seifert et al.
The Journal of surgical research, 193(2), 933-941 (2014-12-03)
Undesirable processes of inflammation, calcification, or immune-mediated reactions are limiting factors in long-term survival of heart valves in patients. In this study, we target the modulatory effects of ice-free cryopreservation (IFC) of xenogeneic heart valve leaflet matrices, without decellularization, on
Robert L Thunhorst et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 308(10), R807-R815 (2015-04-03)
This work examined the effects of age on daily water and sodium ingestion and cardiovascular responses to chronic administration of the mineralocorticoid, aldosterone (ALDO) either alone or together with the glucocorticoid, dexamethasone (DEX). Young (4 mo), adult (12 mo), and
E D Zarnowska et al.
Neuropharmacology, 93, 171-178 (2015-02-15)
Enhancement of tonic inhibition mediated by extrasynaptic α5-subunit containing GABAA receptors (GABAARs) has been proposed as the mechanism by which a variety of anesthetics, including the general anesthetic etomidate, impair learning and memory. Since α5 subunits preferentially partner with β3
Xianyou Wang et al.
Biotechnology and applied biochemistry, 62(2), 186-192 (2014-06-04)
Atherosclerosis (AS) is a progressive disease characterized by endothelial injury and lipid aggregation in the arterial walls. Studies have reported that endothelial progenitor cells (EPCs) derived from the bone marrow (BM) might provide an endogenous repair mechanism by differentiating into
Robbyn K Anand et al.
Journal of the American Chemical Society, 137(2), 776-783 (2015-01-07)
This paper describes the dielectrophoretic (DEP) forces generated by a bipolar electrode (BPE) in a microfluidic device and elucidates the impact of faradaic ion enrichment and depletion (FIE and FID) on electric field gradients. DEP technologies for manipulating biological cells
Yulia Kaluzhny et al.
Alternatives to laboratory animals : ATLA, 43(2), 101-127 (2015-05-23)
The 7th Amendment to the EU Cosmetics Directive and the EU REACH Regulation have reinforced the need for in vitro ocular test methods. Validated in vitro ocular toxicity tests that can predict the human response to chemicals, cosmetics and other
Amelia M Avachat et al.
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 23(3), 276-289 (2015-06-25)
Ellagic acid (EA), a plant polyphenol known for its wide-range of health benefits has limited use due to its low oral bioavailability. In this study, a new self-nanoemulsifying drug delivery system (SNEDDS), based on the phospholipid complex technique, was developed
Roy Bogseth et al.
Journal of the American Society for Mass Spectrometry, 25(11), 1987-1990 (2014-09-25)
Simple alcohols formed protonated acetonitrile adducts containing up to two acetonitrile molecules when analyzed by ESI or APCI in the presence of acetonitrile in the solvent. These acetonitrile adducts underwent dissociation to form a nitrilium ion, also referred to as
Ying-Zheng Zhao et al.
Cancer letters, 330(1), 74-83 (2012-11-29)
Multidrug resistance (MDR) is one of the major reasons for the failure of cancer chemotherapy. A newly reported liposome carrier, propylene glycol liposomes (EPI-PG-liposomes) were made to load epirubicin (EPI) which enhanced EPI absorption in MDR tumor cells to overcome
Yoshinori Onuki et al.
Chemical & pharmaceutical bulletin, 62(10), 989-993 (2014-10-03)
The crystallization of phenytoin occurring after its dilution with infusion fluid is a major concern in the clinical use of injectable phenytoin. To gain further understanding of the crystallization, this study assessed details of the involvement of glucose in this
Hsiu-Mei Chiang et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 72, 154-161 (2014-07-16)
Skin is mainly damaged by genetic and environmental factors such as ultraviolet (UV) light and pollutants. UV light is a well-known factor that causes various types of skin damage and premature aging. Reactive oxygen species (ROS) are commonly involved in
Yu Liu et al.
Physical chemistry chemical physics : PCCP, 17(12), 8258-8265 (2015-03-04)
Thin films of molecular gels formed in a confined space have potential applications in transdermal delivery, artificial skin, molecular electronics, etc. The microstructures and properties of thin gel films can be significantly different from those of their bulk counterparts. However
G A Reichard et al.
Diabetes, 35(6), 668-674 (1986-06-01)
Plasma acetone turnover rates were measured with the primed continuous infusion of 2-[14C]acetone in patients with moderate to severe diabetic ketoacidosis. Plasma acetone turnover rates ranged from 1.52 to 15.9 mumol X kg-1 X min-1 (108-1038 mumol X 1.73 m-2
Jae Kwak et al.
Journal of separation science, 38(14), 2463-2469 (2015-05-07)
Volatile organic compounds were collected and analyzed from a variety of indoor and outdoor air samples to test whether human-derived compounds can be readily detected in the air and if they can be associated with human occupancy or presence. Compounds
Are e-cigarettes safe?
Dina Fine Maron
Scientific American, 310(5), 31-32 (2014-05-03)
G M Angelella et al.
Environmental entomology, 44(3), 562-573 (2015-08-28)
The diversity of vectors and fleeting nature of virus acquisition and transmission renders nonpersistent viruses a challenge to manage. We assessed the importance of noncolonizing versus colonizing vectors with a 2-yr survey of aphids and nonpersistent viruses on commercial pumpkin
Trey Thompson et al.
Pharmacology, biochemistry, and behavior, 133, 7-17 (2015-03-31)
Understanding and effectively treating anxiety disorders are a challenge for both scientists and clinicians. Despite a variety of available therapies, the efficacy of current treatments is still not optimal and adverse side effects can result in non-compliance. Animal models have
H K Vaddi et al.
Journal of pharmaceutical sciences, 91(7), 1639-1651 (2002-07-13)
The respective alcoholic terpenes carvacrol, linalool, and alpha-terpineol were used at 5% w/v in propylene glycol (PG) to increase the in vitro permeation of haloperidol (HP) through human skin. The possible enhancement mechanism was then elucidated with HP-stratum corneum (SC)
Anwar Umar et al.
Journal of ethnopharmacology, 169, 239-243 (2015-05-03)
To study the effects of Cydonia oblonga Miller (COM) total flavonoids (TF) from leaves and fruit on the blood lipid and antioxidant potentials using hyperlipidaemic rat models. Hyperlipidaemic rat models were created with high-lipid emulsion. Rats were distributed into normal
Sarunya Tuntiyasawasdikul et al.
International journal of pharmaceutics, 478(2), 486-495 (2014-12-09)
The aim of this study was to design and develop a suitable monolithic drug-in-adhesive type patch of methoxyflavones from Kaempferia parviflora (K. parviflora) using acrylic polymer Durotak(®) 87-2852. The absence of interaction between components in K. parviflora extract and the
T E Corcoran et al.
Journal of aerosol medicine and pulmonary drug delivery, 27(3), 178-184 (2013-05-15)
Inhaled cyclosporine (CsA) is being investigated as a prophylaxis for lung transplant rejection. Lung deposition and systemic exposure of nebulized CsA in lung transplant patients was evaluated as part of the Phase 3 cyclosporine inhalation solution (CIS) trial (CYCLIST). Ten
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