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Positive propylene glycol result in a patient with ethylene glycol poisoning.
Zengliu Su et al.
Clinical chemistry, 60(4), 697-698 (2014-04-01)
Tae Hwan Kim et al.
Journal of chromatographic science, 53(7), 1100-1106 (2014-12-20)
Chloroacetamide (CAA) is a preservative used in various cosmetic, personal care and household products. Due to the hazard potential for allergic reaction and reproductive toxicity, CAA is being considered a high priority for screening assessment and toxicological re-evaluation. This study
Swati Pund et al.
International journal of pharmaceutics, 487(1-2), 148-156 (2015-04-15)
The present study is a mechanistic validation of 'proof of concept' of effective topical delivery of leflunomide (LFD) nanoemulgel for localized efficient treatment of psoriatic lesions as well as melanoma affected skin regions. Hyperproliferation of keratinocytes in psoriasis and symbiotic
Yellela S R Krishnaiah et al.
International journal of pharmaceutics, 475(1-2), 110-122 (2014-08-05)
The effect of process variability on physicochemical characteristics and in vitro performance of qualitatively (Q1) and quantitatively (Q2) equivalent generic acyclovir topical dermatological creams was investigated to develop a matrix of standards for determining their in vitro bioequivalence with reference
R Brucks et al.
Pharmaceutical research, 6(8), 697-701 (1989-08-01)
The objective of this study was to develop an in vitro method to investigate the effect of ultrasound on the in vitro absorption of ibuprofen from a propylene glycol/water vehicle through human epidermis. A diffusion cell was modified so ultrasound
Rachit Jain et al.
Journal of industrial microbiology & biotechnology, 42(7), 1049-1055 (2015-05-08)
Establishment of novel metabolic pathways for biosynthesis of chemicals, fuels and pharmaceuticals has been demonstrated in Escherichia coli due to its ease of genetic manipulation and adaptability to varying oxygen levels. E. coli growing under microaerobic condition is known to
R Mateus et al.
International journal of pharmaceutics, 444(1-2), 106-108 (2013-01-30)
Confocal Raman spectroscopy (CRS) is a novel approach which has been used to determine stratum corneum thickness and to profile endogenous skin components. However, the utility of this technique for probing drug disposition in vivo has not been explored to
Ryan Mailloux et al.
Toxicology, 334, 81-93 (2015-06-13)
Rates of obesity and diabetes mellitus of Arctic populations are increasing due to multiple reasons including a departure from traditional lifestyles and alcohol consumption patterns. These populations are also exposed to a variety of anthropogenic contaminants through consumption of contaminated
Georgeta Coneac et al.
AAPS PharmSciTech, 16(4), 889-904 (2015-01-17)
The aim of the present investigation was to develop and evaluate microemulsion-loaded hydrogels (MEHs) for the topical delivery of fluconazole (FZ). The solubility of FZ in oils, surfactants and cosurfactants was evaluated to identify the components of the microemulsion. The
Mesut Arici et al.
Journal of microencapsulation, 31(7), 654-666 (2014-05-28)
The objective of this study is to develop a new textile-based drug delivery system containing naproxen (NAP) microparticles and to evaluate the potential of the system as the carrier of NAP for topical delivery. Microparticles were prepared by spray-drying using
Agnieszka Anna Rolinska et al.
Pain management nursing : official journal of the American Society of Pain Management Nurses, 16(4), 493-498 (2014-12-18)
The aim of the present study was to determine whether applying obstetric gel, a noninvasive method of pain management that is safe both for the mother and the child, during labor influences delivery satisfaction by facilitating pain management and decreasing
Kuppusamy Swaminathan Suganthi et al.
Journal of nanoscience and nanotechnology, 14(6), 4602-4607 (2014-04-18)
Experiments were performed on the preparation and characterization of CuO-propylene glycol nanofluids. The influence of nanoparticle concentration and temperature on nanofluid viscosity reveals existence of a range of nanoparticle concentration and temperature in which the viscosity of nanofluid is lower
Sara El Hoss et al.
The Biochemical journal, 468(3), 401-407 (2015-07-15)
Although the protease inhibitor (PI) Lopimune has proven to be effective, no studies have examined the side effects of Lopimune on mitochondrial bioenergetics in hepatocytes. The objective of the present study is to evaluate mitochondrial respiration, production of reactive oxygen
Li Wang et al.
Hepatology (Baltimore, Md.), 61(2), 486-496 (2014-09-10)
Defective autophagy is implicated in the pathogenesis of nonalcoholic fatty liver diseases (NAFLD) through poorly defined mechanisms. Cardiolipin is a mitochondrial phospholipid required for bioenergetics and mitophagy from yeast to mammals. Here we investigated a role for ALCAT1 in the
Thunjiradasiree Kojarunchitt et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 89, 74-81 (2014-12-08)
Thermoresponsive, particle-loaded, Poloxamer 407 (P407)-Pluronic-R® (25R4) or chitosan-methyl cellulose (MC) formulations were developed as single-dose, sustained release vaccines. The sol-gels, loaded either with a particulate vaccine (cubosomes) or soluble antigen (ovalbumin) and adjuvants (Quil A and monophosphoryl lipid A), were
Ying-Zheng Zhao et al.
International journal of pharmaceutics, 454(1), 302-309 (2013-07-09)
Curcumin shows effective anti-inflammatory activities but is seldom used in clinic because of its poor solubility in water and vulnerablity to sunshine ultraviolet effect. Novel lipid vesicles have been developed as carriers for skin delivery. In this paper, lipid vesicles-propylene
Swetha Rudraiah et al.
Toxicology, 325, 85-95 (2014-09-07)
Flavin-containing monooxygenase-3 (FMO3) catalyzes metabolic reactions similar to cytochrome P450 monooxygenase, however, most metabolites of FMO3 are considered non-toxic. Recent findings in our laboratory demonstrated Fmo3 gene induction following toxic acetaminophen (APAP) treatment in mice. The goal of this study
Larissa G P Langhi et al.
PloS one, 10(10), e0141516-e0141516 (2015-10-29)
Intrathymic lipid-laden multilocular cells (LLMC) are known to express pro-inflammatory factors that might regulate functional activity of the thymus. However, the phenotype of age-associated intrathymic LLMC is still controversial. In this study, we evaluated LLMC density in the aging thymus
Evan R Goldfischer et al.
Neurourology and urodynamics, 34(1), 37-43 (2013-10-18)
To assess the efficacy and safety of oxybutynin transdermal gel 3% (OTG3%), with propylene glycol for enhanced skin permeation, in patients with urinary incontinence (UI). In this phase 3 study, 626 patients ≥18 years old with urgency and/or mixed UI
Nerine T Joseph et al.
The Journal of endocrinology, 202(1), 179-190 (2009-04-22)
Two GnRH isoforms (cGnRH-I and GnRH-II) and two GnRH receptor subtypes (cGnRH-R-I and cGnRH-R-III) occur in chickens. Differential roles for these molecules in regulating gonadotrophin secretion or other functions are unclear. To investigate this we cloned cGnRH-R-III from a broiler
Propylene glycol and glycerol concentration in ultrasound gel.
David Belavy et al.
Regional anesthesia and pain medicine, 38(1), 75-76 (2012-12-25)
Manuela R Martinefski et al.
Liver international : official journal of the International Association for the Study of the Liver, 34(7), 1040-1048 (2013-10-15)
Intrahepatic cholestasis of pregnancy is a high-risk liver disease given the eventual deleterious consequences that may occur in the foetus. It is accepted that the abnormal accumulation of hydrophobic bile acids in maternal serum are responsible for the disease development.
Henrika Wickström et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 75, 91-100 (2015-03-31)
The aim of this study was to prepare printable inks of the poorly water soluble drug indomethacin (IMC), fabricate printed systems with flexible doses and investigate the effect of ink excipients on the printability, dissolution rate and the solid state
Chunfeng Wang et al.
Materials science & engineering. C, Materials for biological applications, 45, 261-269 (2014-12-11)
Lipase from Candida rugosa (CRL) was chemically and physically immobilized onto four types of rod-shaped mesoporous silica (RSMS). RSMS prepared using surfactant P123 and poly(ethylene glycol) as co-templates was functionalized with (3-aminopropyl)triethoxysilane (APTES) to obtain P-RSMS by post-synthesis grafting. Tetraethoxysilane
Quan Chi et al.
Luminescence : the journal of biological and chemical luminescence, 30(7), 990-995 (2015-02-03)
The chemiluminescence (CL) of lucigenin (Luc(2+)) can be enhanced by different alcohols in alkaline solution. The effect of different fatty alcohols on the CL of lucigenin was related to the carbon chain length and the number of hydroxyl groups. Glycerol
Janina Seubert et al.
PloS one, 9(5), e98347-e98347 (2014-05-31)
Scented cosmetic products are used across cultures as a way to favorably influence one's appearance. While crossmodal effects of odor valence on perceived attractiveness of facial features have been demonstrated experimentally, it is unknown whether they represent a phenomenon specific
María Gabriela Pacios et al.
Journal of investigative and clinical dentistry, 3(4), 264-270 (2012-11-07)
To evaluate the in vitro action of vehicles alone and with calcium hydroxide against different bacterial species. Agar plates were inoculated with the microbial suspensions, and wells were made and filled with the calcium hydroxide pastes and the vehicles used
Rong-Yao Wang et al.
Physical chemistry chemical physics : PCCP, 15(9), 3313-3319 (2013-01-31)
Understanding the role of kinetics in fiber network microstructure formation is of considerable importance in engineering gel materials to achieve their optimized performances/functionalities. In this work, we present a new approach for kinetic-structure analysis for fibrous gel materials. In this
M E Parente et al.
International journal of cosmetic science, 37(5), 511-518 (2015-04-10)
The use of bioadhesive hydrogels for skin care presents important advantages such as long residence times on the application site and reduced product administration frequency. The aim of the present work was to develop bioadhesive hydrogels for skin application, using
Maria Pina Rosato et al.
Theriogenology, 79(3), 508-516 (2012-12-12)
This study was designed to improve current freezing protocols for rabbit sperm by examining: (1) the toxicity of different permeable cryoprotectants (CPAs) used for standard vapor freezing (conventional freezing); (2) the feasibility of ultrarapid nonequilibrium freezing (vitrification) of sperm in
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