W327700

应用筛选条件

关键词:'W327700'

显示 1-26 共 26 条结果关于 "W327700" 范围论文

Reduced voluntary running performance is associated with impaired coordination as a result of muscle satellite cell depletion in adult mice.

Janna R Jackson et al.

Skeletal muscle, 5, 41-41 (2015-11-19)

Satellite cells, or muscle stem cells, have been thought to be responsible for all muscle plasticity, but recent studies using genetically modified mouse models that allow for the conditional ablation of satellite cells have challenged this dogma. Results have confirmed

Mitochondrial dysfunction and respiratory chain defects in a rodent model of methotrexate-induced enteritis.

V K Kolli et al.

Human & experimental toxicology, 33(10), 1051-1065 (2013-12-19)

The efficacy of methotrexate (MTX), a widely used chemotherapeutic drug, is limited by its gastrointestinal toxicity and the mechanism of which is not clear. The present study investigates the possible role of mitochondrial damage in MTX-induced enteritis. Small intestinal injury

Cecal succinate elevated by some dietary polyphenols may inhibit colon cancer cell proliferation and angiogenesis.

Tomoaki Haraguchi et al.

Journal of agricultural and food chemistry, 62(24), 5589-5594 (2014-05-27)

This study demonstrated that 0.5% dietary rutin, ellagic acid, or curcumin markedly increased cecal succinate levels in rats fed a high-fat diet, whereas catechin, caffeic acid, and quercetin did not. Other organic acids were modestly or hardly affected by polyphenols.

Serially coupling hydrophobic interaction and reversed-phase chromatography with simultaneous gradients provides greater coverage of the metabolome.

Jennifer Haggarty et al.

Metabolomics : Official journal of the Metabolomic Society, 11(5), 1465-1470 (2015-09-15)

The serial coupling of a reversed-phase liquid chromatography (RPLC) column to a hydrophilic interaction liquid chromatography (HILIC) column has been developed in recent years for the detection of polar and nonpolar metabolites. TCA intermediates, bile acid standards and numerous polar

Making succinate more successful.

Potera C.

Environmental Health Perspectives, 113(12), A832-A832 null

Some ferrocenyl chalcones as useful candidates for cancer treatment.

Vašková Janka et al.

In vitro cellular & developmental biology. Animal, 51(9), 964-974 (2015-05-29)

Although knowledge of cancer management is extensive, mortality is not currently declining in this area. It is therefore important to implement a long-term strategy that would aim to prevent these serious diseases. Ferrocene-related organometallic compounds are promising candidates for design

Symmorphosis through dietary regulation: a combinatorial role for proteolysis, autophagy and protein synthesis in normalising muscle metabolism and function of hypertrophic mice after acute starvation.

Henry Collins-Hooper et al.

PloS one, 10(3), e0120524-e0120524 (2015-03-26)

Animals are imbued with adaptive mechanisms spanning from the tissue/organ to the cellular scale which insure that processes of homeostasis are preserved in the landscape of size change. However we and others have postulated that the degree of adaptation is

ATGL-mediated triglyceride turnover and the regulation of mitochondrial capacity in skeletal muscle.

Ruth C R Meex et al.

American journal of physiology. Endocrinology and metabolism, 308(11), E960-E970 (2015-04-09)

Emerging evidence indicates that skeletal muscle lipid droplets are an important control point for intracellular lipid homeostasis and that regulating fatty acid fluxes from lipid droplets might influence mitochondrial capacity. We used pharmacological blockers of the major triglyceride lipases, adipose

Phenotype consequences of myophosphorylase dysfunction: insights from the McArdle mouse model.

Astrid Brull et al.

The Journal of physiology, 593(12), 2693-2706 (2015-04-16)

This is the first study to analyse the effect of muscle glycogen phosphorylase depletion in metabolically different muscle types. In McArdle mice, muscle glycogen phosphorylase is absent in both oxidative and glycolytic muscles. In McArdle mice, the glycogen debranching enzyme

Quantitative hopanoid analysis enables robust pattern detection and comparison between laboratories.

C-H Wu et al.

Geobiology, 13(4), 391-407 (2015-04-14)

Hopanoids are steroid-like lipids from the isoprenoid family that are produced primarily by bacteria. Hopanes, molecular fossils of hopanoids, offer the potential to provide insight into environmental transitions on the early Earth, if their sources and biological functions can be

The short-term toxic effects of TiO₂nanoparticles toward bacteria through viability, cellular respiration, and lipid peroxidation.

Ayca Erdem et al.

Environmental science and pollution research international, 22(22), 17917-17924 (2015-07-15)

To better understand the potential impacts of metal oxide nanoparticles (NPs) on Gram(+) Bacillus subtilis and Gram(-) Escherichia coli (K12) bacteria, eight different nanosized titanium dioxide (TiO2) suspensions with five different concentrations were used. Water quality parameters (pH, temperature, and

Pivotal roles of p53 transcription-dependent and -independent pathways in manganese-induced mitochondrial dysfunction and neuronal apoptosis.

Chunhua Wan et al.

Toxicology and applied pharmacology, 281(3), 294-302 (2014-12-03)

Chronic exposure to excessive manganese (Mn) has been known to lead to neuronal loss and a clinical syndrome resembling idiopathic Parkinson's disease (IPD). p53 plays an integral role in the development of various human diseases, including neurodegenerative disorders. However, the

Fenaroli's Handbook of Flavor Ingredients, 485-485 null

Frequencies of myohistological mitochondrial changes in patients with mitochondrial DNA deletions and the common m.3243A>G point mutation.

Charlotte Maria Zierz et al.

Neuropathology : official journal of the Japanese Society of Neuropathology, 35(2), 130-136 (2014-11-08)

Frequencies of typical myohistological changes such as ragged red fibers (RRF) and cytochrome c oxidase (COX)-deficient fibers have been suggested to be dependent on underlying mitochondrial DNA (mtDNA) defect. However, there are no systematic studies comparing frequencies of myohistological changes

Predictive Studies Suggest that the Risk for the Selection of Antibiotic Resistance by Biocides Is Likely Low in Stenotrophomonas maltophilia.

María Blanca Sánchez et al.

PloS one, 10(7), e0132816-e0132816 (2015-07-23)

Biocides are used without restriction for several purposes. As a consequence, large amounts of biocides are released without any control in the environment, a situation that can challenge the microbial population dynamics, including selection of antibiotic resistant bacteria. Previous work

Effect of Polypurine Reverse Hoogsteen Hairpins on Relevant Cancer Target Genes in Different Human Cell Lines.

Xenia Villalobos et al.

Nucleic acid therapeutics, 25(4), 198-208 (2015-06-05)

We studied the ability of polypurine reverse Hoogsteen hairpins (PPRHs) to silence a variety of relevant cancer-related genes in several human cell lines. PPRHs are hairpins formed by two antiparallel polypurine strands bound by intramolecular Hoogsteen bonds linked by a

Toxicity of copper on isolated liver mitochondria: impairment at complexes I, II, and IV leads to increased ROS production.

Mir-Jamal Hosseini et al.

Cell biochemistry and biophysics, 70(1), 367-381 (2014-04-03)

Oxidative damage has been implicated in disorders associated with abnormal copper metabolism and also Cu(2+) overloading states. Besides, mitochondria are one of the most important targets for Cu(2+), an essential redox transition metal, induced hepatotoxicity. In this study, we aimed

Mcl-1 is an important therapeutic target for oral squamous cell carcinomas.

Santanu Maji et al.

Oncotarget, 6(18), 16623-16637 (2015-05-27)

Oral and oropharyngeal cancers are the sixth most common cancers worldwide. Despite intensive investigation, oral squamous cell carcinomas (OSCC) represent a clinical challenge resulting in significant morbidity and mortality. Resistance to cell death is common in OSCC and is often

C-phycocyanin prevents cisplatin-induced mitochondrial dysfunction and oxidative stress.

Berenice Fernández-Rojas et al.

Molecular and cellular biochemistry, 406(1-2), 183-197 (2015-05-15)

The potential of C-phycocyanin (C-PC) to prevent cisplatin (CP)-induced kidney mitochondrial dysfunction was determined in CD-1 male mice. The CP-induced mitochondrial dysfunction was characterized by ultrastructural abnormalities and by decrease in the following parameters in isolated kidney mitochondria: adenosine diphosphate

Peptic ulcer hemorrhage combined with acute gout: analyses of treatment in 136 cases.

Zhenglei Xu et al.

International journal of clinical and experimental medicine, 8(4), 6193-6199 (2015-07-02)

This study aims to compare the safety and curative effect of celecoxib and small-dose methylprednisolone sodium succinate in patients with peptic ulcer hemorrhage combined with acute gout. In this randomized, controlled trial, a total of 136 patients with peptic ulcer

Increased oxidative stress and mitochondrial dysfunction in zucker diabetic rat liver and brain.

Haider Raza et al.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 35(3), 1241-1251 (2015-03-15)

The Zucker diabetic fatty (ZDF, FA/FA) rat is a genetic model of type 2 diabetes, characterized by insulin resistance with progressive metabolic syndrome. We have previously demonstrated mitochondrial dysfunction and oxidative stress in the heart, kidneys and pancreas of ZDF

Bacteriophages of wastewater foaming-associated filamentous Gordonia reduce host levels in raw activated sludge.

Mei Liu et al.

Scientific reports, 5, 13754-13754 (2015-09-10)

Filamentous bacteria are a normal and necessary component of the activated sludge wastewater treatment process, but the overgrowth of filamentous bacteria results in foaming and bulking associated disruptions. Bacteriophages, or phages, were investigated for their potential to reduce the titer

A high-performance liquid chromatography-tandem mass spectrometry-based targeted metabolomics kidney dysfunction marker panel in human urine.

Jacek Klepacki et al.

Clinica chimica acta; international journal of clinical chemistry, 446, 43-53 (2015-04-15)

Previous studies have examined and documented fluctuations in urine metabolites in response to disease processes and drug toxicity affecting glomerular filtration, tubule cell metabolism, reabsorption, oxidative stress, purine degradation, active secretion and kidney amino acylase activity representative of diminished renal

Epigallocatechin-3-gallate suppresses cell proliferation and promotes apoptosis and autophagy in oral cancer SSC-4 cells.

Alexandra Iulia Irimie et al.

OncoTargets and therapy, 8, 461-470 (2015-03-12)

Epigallocatechin-3-gallate (EGCG) is the major bioactive component of green tea. Our experimental data indicated that EGCG treatment suppresses cell proliferation of SSC-4 human oral squamous cell carcinoma (OSCC), the effect being dose- and time-dependent. In parallel was observed the activation

Retro-translocation of mitochondrial intermembrane space proteins.

Piotr Bragoszewski et al.

Proceedings of the National Academy of Sciences of the United States of America, 112(25), 7713-7718 (2015-06-10)

The content of mitochondrial proteome is maintained through two highly dynamic processes, the influx of newly synthesized proteins from the cytosol and the protein degradation. Mitochondrial proteins are targeted to the intermembrane space by the mitochondrial intermembrane space assembly pathway

Sortase Enzyme-Mediated Generation of Site-Specifically Conjugated Antibody Drug Conjugates with High In Vitro and In Vivo Potency.

Roger R Beerli et al.

PloS one, 10(7), e0131177-e0131177 (2015-07-02)

Antibody drug conjugates (ADCs) have recently been proven to be highly potent anti-tumor drugs, typically exceeding the efficacy of conventional monoclonal antibodies (mAbs). ADCs are currently produced by chemical conjugation of a small-molecule toxin to the mAb through lysine or

1/1